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GTPase Activity and Neuronal Toxicity of Parkinson's Disease–Associated LRRK2 Is Regulated by ArfGAP1
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The G2019S mutation in LRRK2 increases its kinase activity in vitro and in vivo.
“the most prominent pathogenic mutation (G2019S) situated within the kinase domain increases its activity in vitro as well as in vivo”
From Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations (2020) · cites this paper as [10]
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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
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Rivero-Ríos, P., Romo-Lozano, M., Fernández, B., Fdez, E., & Hilfiker, S. (2020) · Cells · doi:10.3390/cells9071719 · Cited by 38
Metadata
- Authors
- Stafa, K., Trancikova, A., Webber, P. J., Glauser, L., West, A. B., & Moore, D. J.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-02-09
- Volume
- 8
- Issue
- 2
- Pages
- e1002526
- ISSN
- 1553-7404
- PMC
- PMC3280333
- Cited by
- 127
- References
- 2
- Language
- en
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