The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability
Open accessAbstract
Animals acquire predictive values of sensory stimuli through reinforcement. In the brain of Drosophila melanogaster, activation of two types of dopamine neurons in the PAM and PPL1 clusters has been shown to induce aversive odor memory. Here, we identified the third cell type and characterized aversive memories induced by these dopamine neurons. These three dopamine pathways all project to the mushroom body but terminate in the spatially segregated subdomains. To understand the functional difference of these dopamine pathways in electric shock reinforcement, we blocked each one of them during memory acquisition. We found that all three pathways partially contribute to electric shock memory. Notably, the memories mediated by these neurons differed in temporal stability. Furthermore, combinatorial activation of two of these pathways revealed significant interaction of individual memory components rather than their simple summation. These results cast light on a cellular mechanism by which a noxious event induces different dopamine signals to a single brain structure to synthesize an aversive memory.
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Cites
Elastix: a toolbox for intensity-based medical image registration
Klein, S., Staring, M., Murphy, K., Viergever, M. A., & Pluim, J. (2010) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2009.2035616 · Cited by 4,311
Frost, W. N., Castellucci, V. F., Hawkins, R. D., & Kandel, E. R. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.8266 · Cited by 334
Cited by
The neuronal architecture of the mushroom body provides a logic for associative learning
Aso, Y., Hattori, D., Yu, Y., Johnston, R. M., Iyer, N. A., Ngo, T.-T., Dionne, H., Abbott, L., Axel, R., Tanimoto, H., et al. (2014) · eLife · doi:10.7554/elife.04577 · Cited by 1,051
Self-citationA Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster
Zheng, Z., Lauritzen, J. S., Perlman, E., Robinson, C. G., Nichols, M., Milkie, D., Torrens, O., Price, J., Fisher, C. B., Sharifi, N., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.019 · Cited by 1,050
Layered reward signalling through octopamine and dopamine in Drosophila
Burke, C. J., Huetteroth, W., Owald, D., Perisse, E., Krashes, M. J., Das, G., Gohl, D., Silies, M., Certel, S., & Waddell, S. (2012) · Nature · doi:10.1038/nature11614 · Cited by 614
Coordinated and compartmentalized neuromodulation shapes sensory processing in Drosophila
Cohn, R., Morantte, I., & Ruta, V. (2015) · Cell · doi:10.1016/j.cell.2015.11.019 · Cited by 430
Activity of Defined Mushroom Body Output Neurons Underlies Learned Olfactory Behavior in Drosophila
Owald, D., Felsenberg, J., Talbot, C. B., Das, G., Perisse, E., Huetteroth, W., & Waddell, S. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.025 · Cited by 401
Metadata
- Authors
- Aso, Y., Herb, A., Ogueta, M., Siwanowicz, I., Templier, T., Friedrich, A. B., Ito, K., Scholz, H., & Tanimoto, H.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-07-12
- Volume
- 8
- Issue
- 7
- Pages
- e1002768
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W1978530827
- Cited by
- 308
- References
- 2
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- gold
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