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Cited by 1,051Neurobiology and Insect Physiology ResearchNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

The neuronal architecture of the mushroom body provides a logic for associative learning

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Aso, Yoshinori, Hattori, Daisuke, Yu, Yang, Johnston, Rebecca M, Iyer, Nirmala A, Ngo, Teri-TB, Dionne, Heather, Abbott, LF +3 more·2014·eLife
DOI 10.7554/elife.04577PMC PMC4273437
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Abstract

We identified the neurons comprising the Drosophila mushroom body (MB), an associative center in invertebrate brains, and provide a comprehensive map describing their potential connections. Each of the 21 MB output neuron (MBON) types elaborates segregated dendritic arbors along the parallel axons of ∼2000 Kenyon cells, forming 15 compartments that collectively tile the MB lobes. MBON axons project to five discrete neuropils outside of the MB and three MBON types form a feedforward network in the lobes. Each of the 20 dopaminergic neuron (DAN) types projects axons to one, or at most two, of the MBON compartments. Convergence of DAN axons on compartmentalized Kenyon cell–MBON synapses creates a highly ordered unit that can support learning to impose valence on sensory representations. The elucidation of the complement of neurons of the MB provides a comprehensive anatomical substrate from which one can infer a functional logic of associative olfactory learning and memory.

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  • The five MB lobes on the right hemisphere are further divided into 15 compartments (α1-3, α'1-3, β1-2, β'1-2, and γ1-5) by the mushroom body output neurons (MBONs) and dopaminergic neurons (DANs).

    “The five MB lobes on the right hemisphere are further divided into 15 compartments (α1–3, α’1–3, β1–2, β’1–2, and γ1–5) (Tanaka et al., 2008; Aso et al., 2014) by the mushroom body output neurons (MBONs) and dopaminergic neurons (DANs).”

    From A connectome and analysis of the adult Drosophila central brain (2020) · cites this paper as Aso et al., 2014

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Authors
Aso, Y., Hattori, D., Yu, Y., Johnston, R. M., Iyer, N. A., Ngo, T.-T., Dionne, H., Abbott, L., Axel, R., Tanimoto, H., & Rubin, G. M.
Affiliations
  • Howard Hughes Medical Institute (US)
  • Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, United States
  • Max Planck Society (DE)
Corresponding author
  • Aso, Yoshinori
  • Rubin, Gerald M
ORCID
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2014-12-23
Volume
3
Pages
e04577-e04577
ISSN
2050-084X (ISSN-L)
DOI
10.7554/elife.04577
PMC
PMC4273437
OpenAlex
W2117794907
Cited by
1,051
References
9
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FWCI
25.31
Type
journal article
Language
en
Open access
Licence
Locations
  • eLife (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Max Planck Digital Library (submittedVersion, other-oa)
  • MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders
  • Howard Hughes Medical Institute (Janelia Visiting Scientist Program)
  • Gatsby Charitable Foundation (Gatsby Initiative Fund in Brain Circuitry at Columbia University)
  • Swartz Foundation
  • Bundesministerium für Bildung und Forschung (Bernstein Focus Neurobiology of Learning 01GQ0932)
  • Max-Planck-Gesellschaft
  • Deutsche Forschungsgemeinschaft (TA 552/5-1)
  • Japan Society for the Promotion of Science (MEXT/JSPS KAKENHI 25890003, 26120705, 26119503 and 26250001)
  • Naito Foundation
  • Jane Coffin Childs Memorial Fund for Medical Research
  • G Harold and Leila Y. Mathers Foundation
  • Simons Foundation
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
mushroom body, Drosophila, associative learning, olfactory memory, Kenyon cells, mushroom body output neurons, dopaminergic neurons, neuronal connectivity, dendritic branching, feedforward neural networks, valence
MeSH terms
Animals, Association Learning, Brain, Cell Compartmentation, Dendrites, Drosophila melanogaster, Logic, Models, Neurological, Olfactory Pathways, Sensory Receptor Cells, Smell, Neurotransmitter Agents, Mushroom Bodies, Cell Shape, Green Fluorescent Proteins, Dopaminergic Neurons

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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