The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
The HY5-PIF Regulatory Module Coordinates Light and Temperature Control of Photosynthetic Gene Transcription
Open accessAbstract
The ability to interpret daily and seasonal alterations in light and temperature signals is essential for plant survival. This is particularly important during seedling establishment when the phytochrome photoreceptors activate photosynthetic pigment production for photoautotrophic growth. Phytochromes accomplish this partly through the suppression of phytochrome interacting factors (PIFs), negative regulators of chlorophyll and carotenoid biosynthesis. While the bZIP transcription factor long hypocotyl 5 (HY5), a potent PIF antagonist, promotes photosynthetic pigment accumulation in response to light. Here we demonstrate that by directly targeting a common promoter cis-element (G-box), HY5 and PIFs form a dynamic activation-suppression transcriptional module responsive to light and temperature cues. This antagonistic regulatory module provides a simple, direct mechanism through which environmental change can redirect transcriptional control of genes required for photosynthesis and photoprotection. In the regulation of photopigment biosynthesis genes, HY5 and PIFs do not operate alone, but with the circadian clock. However, sudden changes in light or temperature conditions can trigger changes in HY5 and PIFs abundance that adjust the expression of common target genes to optimise photosynthetic performance and growth.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PHOTOPROTECTION REVISITED:Genetic and Molecular Approaches
Niyogi, K. K. (1999) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.50.1.333 · Cited by 1,933
Targeted destabilization of HY5 during light-regulated development of Arabidopsis
Osterlund, M. T., Hardtke, C. S., Wei, N., & Deng, X. W. (2000) · Nature · doi:10.1038/35013076 · Cited by 1,359
A molecular framework for light and gibberellin control of cell elongation
de Lucas, M., Davière, J.-M., Rodríguez-Falcón, M., Pontin, M., Iglesias-Pedraz, J. M., Lorrain, S., Fankhauser, C., Blázquez, M. A., Titarenko, E., & Prat, S. (2008) · Nature · doi:10.1038/nature06520 · Cited by 1,319
Lee, J., He, K., Stolc, V., Lee, H., Figueroa, P., Gao, Y., Tongprasit, W., Zhao, H., Lee, I., & Deng, X. W. (2007) · The Plant Cell · doi:10.1105/tpc.106.047688 · Cited by 1,004
PIFs: pivotal components in a cellular signaling hub
Leivar, P., & Quail, P. H. (2011) · Trends in Plant Science · doi:10.1016/j.tplants.2010.08.003 · Cited by 972
Light-Regulated Plant Growth and Development
Kami, C., Lorrain, S., Hornitschek, P., & Fankhauser, C. (2010) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)91002-8 · Cited by 927
Phytochrome functions in Arabidopsis development
Franklin, K. A., & Quail, P. H. (2010) · Journal of Experimental Botany · doi:10.1093/jxb/erp304 · Cited by 848
Crystal structure of plant photosystem I
Ben-Shem, A., Frolow, F., & Nelson, N. (2003) · Nature · doi:10.1038/nature02200 · Cited by 838
Oyama, T., Shimura, Y., & Okada, K. (1997) · Genes & Development · doi:10.1101/gad.11.22.2983 · Cited by 833
Lorrain, S., Allen, T., Duek, P. D., Whitelam, G. C., & Fankhauser, C. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2007.03341.x · Cited by 812
Cited by
Molecular Regulation of Plant Responses to Environmental Temperatures
Ding, Y., Shi, Y., & Yang, S. (2020) · Molecular Plant · doi:10.1016/j.molp.2020.02.004 · Cited by 787
Molecular mechanisms underlying phytochrome-controlled morphogenesis in plants
Legris, M., Ince, Y. Ç., & Fankhauser, C. (2019) · Nature Communications · doi:10.1038/s41467-019-13045-0 · Cited by 429
Stanley, L., & Yuan, Y.-W. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01017 · Cited by 253
Griffin, J. H. C., & Toledo-Ortiz, G. (2022) · Journal of Experimental Botany · doi:10.1093/jxb/erac220 · Cited by 34
Self-citation
Metadata
- Authors
- Toledo-Ortiz, G., Johansson, H., Lee, K. P., Bou-Torrent, J., Stewart, K., Steel, G., Rodríguez-Concepción, M., & Halliday, K. J.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-06-12
- Volume
- 10
- Issue
- 6
- Pages
- e1004416
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2072695931
- Cited by
- 494
- References
- 75
- FWCI
- 25.23
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The HY5-PIF Regulatory Module Coordinates Light and Temperature Control of Photosynthetic Gene Transcription. https://app.cochat.ai/papers/10.1371/journal.pgen.1004416
- The paper
- Toledo-Ortiz, G., Johansson, H., Lee, K. P., Bou-Torrent, J., Stewart, K., Steel, G., Rodríguez-Concepción, M., & Halliday, K. J. (2014). The HY5-PIF Regulatory Module Coordinates Light and Temperature Control of Photosynthetic Gene Transcription. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1004416
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
