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Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria
Open accessAbstract
Mycobacteria possess different type VII secretion (T7S) systems to secrete proteins across their unusual cell envelope. One of these systems, ESX-5, is only present in slow-growing mycobacteria and responsible for the secretion of multiple substrates. However, the role of ESX-5 substrates in growth and/or virulence is largely unknown. In this study, we show that esx-5 is essential for growth of both Mycobacterium marinum and Mycobacterium bovis. Remarkably, this essentiality can be rescued by increasing the permeability of the outer membrane, either by altering its lipid composition or by the introduction of the heterologous porin MspA. Mutagenesis of the first nucleotide-binding domain of the membrane ATPase EccC5 prevented both ESX-5-dependent secretion and bacterial growth, but did not affect ESX-5 complex assembly. This suggests that the rescuing effect is not due to pores formed by the ESX-5 membrane complex, but caused by ESX-5 activity. Subsequent proteomic analysis to identify crucial ESX-5 substrates confirmed that all detectable PE and PPE proteins in the cell surface and cell envelope fractions were routed through ESX-5. Additionally, saturated transposon-directed insertion-site sequencing (TraDIS) was applied to both wild-type M. marinum cells and cells expressing mspA to identify genes that are not essential anymore in the presence of MspA. This analysis confirmed the importance of esx-5, but we could not identify essential ESX-5 substrates, indicating that multiple of these substrates are together responsible for the essentiality. Finally, examination of phenotypes on defined carbon sources revealed that an esx-5 mutant is strongly impaired in the uptake and utilization of hydrophobic carbon sources. Based on these data, we propose a model in which the ESX-5 system is responsible for the transport of cell envelope proteins that are required for nutrient uptake. These proteins might in this way compensate for the lack of MspA-like porins in slow-growing mycobacteria.
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“ESX-5 was suggested to be crucial for nutrient uptake and for the export of members of the PE and PPE protein families (9,32,33).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [33]
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Metadata
- Authors
- Ates, L. S., Ummels, R., Commandeur, S., van der Weerd, R., Sparrius, M., Weerdenburg, E., Alber, M., Kalscheuer, R., Piersma, S. R., Abdallah, A. M., Abd El Ghany, M., Abdel-Haleem, A. M., Pain, A., Jiménez, C. R., Bitter, W., & Houben, E. N. G.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Heinrich Heine University Düsseldorf (DE)
- King Abdullah University of Science and Technology (SA)
- Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Houben, Edith N.G.
- ORCID
- Venue
- PLOS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-05-04
- Volume
- 11
- Issue
- 5
- Pages
- e1005190
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- PMC
- PMC4418733
- OpenAlex
- W1508212288
- Cited by
- 185
- References
- 80
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 15 · 2023: 10 · 2022: 21 · 2021: 18 · 2020: 18 · 2019: 18 · 2018: 15 · 2017: 11 · 2016: 19 · 2015: 7
- FWCI
- 13.47
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- journal article
- Language
- en
- Update notices
- correction (2015-05-29)
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- VU Research Portal (publishedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Jürgen Manchot Stiftung
- European Federation of Pharmaceutical Industries and Associations (FP7/20072013)
- European Commission (115337, 2007–2013, FP7 2007-2013, FP7/2007)
- Innovative Medicines Initiative (FP7/2007‐2013, 115337)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Keywords
- type VII secretion system, Mycobacterium marinum, Mycobacterium bovis, outer membrane permeability, slow-growing mycobacteria, transposon insertion site sequencing
- MeSH terms
- Type VII Secretion Systems, Ampicillin, Bacterial Proteins, Cell Membrane Permeability, Chromatography, Liquid, DNA Transposable Elements, DNA, Bacterial, Mutation, Mycobacterium bovis, Mycobacterium tuberculosis, Gene Expression Regulation, Bacterial, Sequence Analysis, DNA, Mycobacterium marinum, Drug Resistance, Bacterial, Tandem Mass Spectrometry
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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