Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS

Krug, Lisa; Chatterjee, Nabanita; Borges-Monroy, Rebeca; Hearn, Stephen; Liao, Wen-Wei; Morrill, Kathleen; Prazak, Lisa; Rozhkov, Nikolay; Theodorou, Delphine; Hammell, Molly; Dubnau, Josh

doi:10.1371/journal.pgen.1006635

Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two incurable neurodegenerative disorders that exist on a symptomological spectrum and share both genetic underpinnings and pathophysiological hallmarks. Functional abnormality of TAR DNA-binding protein 43 (TDP-…