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Biogenesis of small RNAs in animals

Kim, V. Narry, Han, Jinju, Siomi, Mikiko C.·2009·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm2632
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Abstract

Small RNAs of 20-30 nucleotides can target both chromatin and transcripts, and thereby keep both the genome and the transcriptome under extensive surveillance. Recent progress in high-throughput sequencing has uncovered an astounding landscape of small RNAs in eukaryotic cells. Various small RNAs of distinctive characteristics have been found and can be classified into three classes based on their biogenesis mechanism and the type of Argonaute protein that they are associated with: microRNAs (miRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs) and Piwi-interacting RNAs (piRNAs). This Review summarizes our current knowledge of how these intriguing molecules are generated in animal cells.

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  • Both ∼80-nucleotide-long pre-miR-128 hairpins form different stem-loop structures but yield identical mature miR-128-3p after processing by DICER.

    “Crucially, although both ∼80-nucleotide-long pre-miR-128 form different stem-loop structures, they yield identical mature miR-128-3p after processing by DICER.1,23,26”

    From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [23]

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Metadata

Authors
Kim, V. N., Han, J., & Siomi, M. C.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2009-02
Volume
10
Issue
2
Pages
126-139
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/nrm2632
Cited by
2,814
References
10
Language
en
Licence
www.springer.com/tdm (tdm)

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