Cited by 377Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

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Serotonin and Depression: A Disconnect between the Advertisements and the Scientific Literature

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Lacasse, Jeffrey R, Leo, Jonathan·2005·PLoS Medicine

DOI 10.1371/journal.pmed.0020392PMC PMC1277931

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Selective serotonin reuptake inhibitors (SSRIs) versus other antidepressants for depression
Geddes, J. R., Freemantle, N., Mason, J. M., Eccles, M., & Boynton, J. R. (1999) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001851 · Cited by 109
Retracted
J Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818
Effects of exercise training on older patients with major depression
Blumenthal, J. A., Babyak, M. A., Moore, K. A., Craighead, W. E., Herman, S., Khatri, P., Waugh, R., Napolitano, M. A., Forman, L. M., Appelbaum, M., et al. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.19.2349 · Cited by 1,277 · cited 1×
“org 1213 randomized controlled trial [21].”
The Biochemistry of Affective Disorders
Coppen, A. (1967) · British Journal of Psychiatry · doi:10.1192/bjp.113.504.1237 · Cited by 1,230
Cognitive Therapy vs Medications in the Treatment of Moderate to Severe Depression
DeRubeis, R. J., Hollon, S. D., Amsterdam, J. D., Shelton, R. C., Young, P. R., Salomon, R. M., O’Reardon, J. P., Lovett, M. L., Gladis, M. M., Brown, L. L., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.4.409 · Cited by 989
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(2005) · Choice Reviews Online · doi:10.5860/choice.42-5297 · Cited by 878
Influence of Patients’ Requests for Direct-to-Consumer Advertised Antidepressants
Kravitz, R. L., Epstein, R. M., Feldman, M. D., Franz, C. E., Azari, R. S., Wilkes, M. S., Hinton, L., & Franks, P. J. (2005) · JAMA · doi:10.1001/jama.293.16.1995 · Cited by 581
Is mood chemistry?
Castrén, E. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1629 · Cited by 563
Toward a Philosophical Structure for Psychiatry
Kendler, K. S. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.3.433 · Cited by 563
Effect of Hypericum perforatum (St John's Wort) in Major Depressive Disorder
Hypericum Depression Trial Study Group (2002) · JAMA · doi:10.1001/jama.287.14.1807 · Cited by 480

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Murphy, 1998, J Clin Psychiatry, 59, 4
Moncrieff, 2005, Cochrane Database Syst Rev, 2004, CD003012
Geddes, 2005, Cochrane Database Syst Rev, 2000, CD002791
Schatzberg, 2000, J Clin Psychiatry, 61, 31
Dubvosky, 2003, The American psychiatric textbook of clinical psychiatry, 4th ed, 439
Mintzes, 2003, CMAJ, 169, 405
Delgado, 2000, J Clin Psychiatry, 61, 5
Kramer, 2002 July 7, The New York Times, 8

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References
(2008) · Wiley eBooks · doi:10.1002/9781118265666.refs
Mood Disorders
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Mental Illness
Wasserman, T. H., & Wasserman, L. D. (2016) · Springer eBooks · doi:10.1007/978-3-319-30910-1_9
Antidepressant prescribing
Nichols, J. (2011) · British Journal of General Practice · doi:10.3399/bjgp11x561276
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Self-citation
Most Prescribed Pharmaceuticals and Related Endpoints
Jjemba, P. K. (2018) · Wiley eBooks · doi:10.1002/9781119312321.ch2
References
(2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802852-0.16001-3
Antidepressant prescribing
Rathbone, P. (2011) · British Journal of General Practice · doi:10.3399/bjgp11x561267
Awareness on the Methods to Overcome Depression among Undergraduate Students in An University Hospital Setting
Hiranya.S1, V. V. P. (2020) · Indian Journal of Forensic Medicine & Toxicology · doi:10.37506/ijfmt.v14i4.12420
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Dong, M. N. T. K. T. (2018) · theses.fr (ABES) · doi:10.70675/a7dbfb58z251cz4ff1z929ez333caaa06eb8
Safe Deprescribing of Antidepressants
(2024) · Wiley eBooks · doi:10.1002/9781394291052.mdg002
Antidepressant Medication and Psychotherapy: Why It Matters
Chiesa, M. (2024) · British Journal of Psychotherapy · doi:10.1111/bjp.12938
Saúde mental, neuroculturas, e racionalidade neoliberal
Reigada, C. L. D. L., & Maximino, C. (2024) · Sociedade e Cultura · doi:10.5216/sec.v27.78350
Popular, personal and public data: Article-level metrics at PLoS
Hull, D. (2009) · doi:10.59350/40x7z-99018
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Maß, R. (2025) · Manuale zu Testverfahren und Fragebögen · doi:10.1007/978-3-662-71227-6_5
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Vasic, S. (2025) · Journal of Mental Health Counseling · doi:10.17744/mehc.47.2.02
A Summary of Research on the Effectiveness of Antidepressants and Psychotherapy
Conner, M. (2006)
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Kaplan, R. M. (2026) · Translational Behavioral Medicine · doi:10.1093/tbm/ibag013
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Maß, R., Backhaus, K., & Unkelbach, B. K. (2026) · Psychiatrische Praxis · doi:10.1055/a-2892-1260
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BindingDB (2023) · UC San Diego · doi:10.7270/q2222zr4
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Authors: Lacasse, J. R., & Leo, J.
Affiliations: Florida State University (US)
Corresponding author: Leo, Jonathan
ORCID: Lacasse, Jeffrey R
Leo, Jonathan
Venue: PLoS Medicine
Publisher: Public Library of Science (PLoS)
Published: 2005-11-08
Volume: 2
Issue: 12
Pages: e392
ISSN: 1549-1277 (ISSN-L)
1549-1676
DOI: 10.1371/journal.pmed.0020392
PMC: PMC1277931
OpenAlex: W1987639251
Cited by: 377
References: 35
Citations by year: 2026: 10 · 2025: 9 · 2024: 12 · 2023: 22 · 2022: 12 · 2021: 19 · 2020: 23 · 2019: 10 · 2018: 15 · 2017: 18 · 2016: 14 · 2015: 28 · 2014: 18 · 2013: 24 · 2012: 20
FWCI: 10.03
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS Medicine (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: serotonin, depression, pharmaceutical advertising, pharmaceutical marketing, scientific evidence, selective serotonin reuptake inhibitors, antidepressants
MeSH terms: Advertising, Antidepressive Agents, Community Participation, Depression, Humans, Serotonin, United States, United States Food and Drug Administration, Randomized Controlled Trials as Topic, Selective Serotonin Reuptake Inhibitors

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Serotonin and Depression: A Disconnect between the Advertisements and the Scientific Literature

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