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Cited by 112Asthma and respiratory diseasesAllergic Rhinitis and SensitizationOccupational exposure and asthma

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Exercise-Induced Bronchospasm and Atopy in Ghana: Two Surveys Ten Years Apart

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Addo-Yobo, Emmanuel O. D, Woodcock, Ashley, Allotey, Adorkor, Baffoe-Bonnie, Benjamin, Strachan, David, Custovic, Adnan·2007·PLoS Medicine
DOI 10.1371/journal.pmed.0040070PMC PMC1808098
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Abstract

BACKGROUND: Asthma and allergic diseases have increased in the developed countries. It is important to determine whether the same trends are occurring in the developing countries in Africa. We aimed to determine the time trend in the prevalence of exercise-induced bronchospasm (EIB) and atopic sensitisation over a ten-year period in Ghanaian schoolchildren. METHODS AND FINDINGS: Two surveys conducted using the same methodology ten years apart (1993 and 2003) among schoolchildren aged 9-16 years attending urban rich (UR), urban poor (UP), and rural (R) schools. Exercise provocation consisted of free running for six minutes. Children were skin tested to mite, cat, and dog allergen. 1,095 children were exercised in 1993 and 1,848 in 2003; 916 were skin tested in 1993 and 1,861 in 2003. The prevalence of EIB increased from 3.1% (95% CI 2.2%-4.3%) to 5.2% (4.3%-6.3%); absolute percentage increase 2.1% (95% CI 0.6%-3.5%, p < 0.01); among UR, UP, and R children EIB had approximately doubled from 4.2%, 1.4%, and 2.2% to 8.3%, 3.0% and 3.9% respectively. The prevalence of sensitisation had also doubled from 10.6%, 4.7%, and 4.4% to 20.2%, 10.3%, and 9.9% (UR, UP, and R respectively). Mite sensitisation remained unchanged (5.6% versus 6.4%), but sensitisation to cat and dog increased considerably from 0.7% and 0.3% to 4.6% and 3.1%, respectively. In the multiple logistic regression analysis, sensitisation (odds ratio [OR] 1.77, 95% CI 1.12-2.81), age (OR 0.88, 95% CI 0.79-0.98), school (the risk being was significantly lower in UP and R schools: OR 0.40, 95% CI 0.23-0.68 and OR 0.54, 95% CI 0.34-0.86, respectively) and year of the study (OR 1.73, 95% CI 1.13-2.66) remained significant and independent associates of EIB. CONCLUSIONS: The prevalence of both EIB and sensitisation has approximately doubled over the ten-year period amongst 9- to 16-year-old Ghanaian children irrespective of location, with both EIB and atopy being more common among the UR than the UP and R children.

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Research works printed but not linked: 24

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Metadata

Authors
Addo-Yobo, E. O. D., Woodcock, A., Allotey, A., Baffoe-Bonnie, B., Strachan, D., & Custovic, A.
Affiliations
  • University of Manchester (GB)
  • Komfo Anokye Teaching Hospital (GH)
  • St George's, University of London (GB)
ORCID
Venue
PLoS Medicine
Publisher
Public Library of Science (PLoS)
Published
2007-02-27
Volume
4
Issue
2
Pages
e70
ISSN
  • 1549-1277 (ISSN-L)
  • 1549-1676
DOI
10.1371/journal.pmed.0040070
PMC
PMC1808098
OpenAlex
W2067348379
Cited by
112
References
24
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 5 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 10
FWCI
4.25
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
  • St George's Online Research Archive (St George's University of London) (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Wellcome Trust (066247)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Keywords
exercise-induced bronchoconstriction, atopic sensitization, asthma prevalence trends, elementary school students, Ghana, urban-rural differences, socioeconomic status, mite allergens, skin testing, urban poor children, rural children
MeSH terms
Adolescent, Allergens, Animals, Asthma, Exercise-Induced, Cats, Child, Dogs, Exercise Test, Ghana, Health Surveys, Humans, Hypersensitivity, Mites, Rural Population, Skin Tests, Urban Population, Prevalence

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