The atopic march: current insights into skin barrier dysfunction and epithelial cell‐derived cytokines
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Summary: Atopic dermatitis often precedes the development of other atopic diseases. The atopic march describes this temporal relationship in the natural history of atopic diseases. Although the pathophysiological mechanisms that underlie this relationship are poorly understood, epidemiological and genetic data have suggested that the skin might be an important route of sensitization to allergens. Animal models have begun to elucidate how skin barrier defects can lead to systemic allergen sensitization. Emerging data now suggest that epithelial cell‐derived cytokines such as thymic stromal lymphopoietin ( TSLP ), IL ‐33, and IL ‐25 may drive the progression from atopic dermatitis to asthma and food allergy. This review focuses on current concepts of the role of skin barrier defects and epithelial cell‐derived cytokines in the initiation and maintenance of allergic inflammation and the atopic march.
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The role of the innate immune system in the early phase of atopic dermatitis was demonstrated using animal models and is likely of clinical relevance in infancy.
“The role of the innate immune system in the early phase of AD was demonstrated using animal models52–54 and is likely of clinical relevance in infancy55.”
From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [55]
The Introduction says atopic dermatitis often begins in infancy, and section 6.1 reports an epithelial-derived cytokine in human atopic-dermatitis lesions and its role in mouse models of skin inflammation. These passages make clinical relevance in infancy plausible, but the copy does not establish the role of innate immunity specifically in the early phase of infant atopic dermatitis. The animal-model demonstration is attached to other citations in the citing sentence. (LLM, conf=0.79)
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- Authors
- Han, H., Roan, F., & Ziegler, S. F.
- Affiliations
- Benaroya Research Institute (US)
- University of Washington (US)
- Corresponding author
- Ziegler, Steven F.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2017-06-28
- Volume
- 278
- Issue
- 1
- Pages
- 116-130
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC5492959
- OpenAlex
- W2728647913
- Cited by
- 285
- References
- 235
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 27 · 2023: 25 · 2022: 41 · 2021: 39 · 2020: 42 · 2019: 39 · 2018: 28 · 2017: 8
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Foundation for the National Institutes of Health (R01AI068731, R01AI124220, U19AI125378)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- atopic march, atopic dermatitis, skin barrier dysfunction, thymic stromal lymphopoietin, IL-33, IL-25, allergen sensitization, allergic inflammation, asthma, food allergy, animal models
- MeSH terms
- Allergens, Animals, Dermatitis, Atopic, Environment, Epithelial Cells, Humans, Immune Tolerance, Immunization, Immunotherapy, Skin, Cytokines, Genetic Predisposition to Disease
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