Considering Usual Medical Care in Clinical Trial Design

Dawson, Liza; Zarin, Deborah A.; Emanuel, Ezekiel J.; Friedman, Lawrence M.; Chaudhari, Bimal; Goodman, Steven N.

doi:10.1371/journal.pmed.1000111

Cited by 93Statistical Methods in Clinical TrialsHealth Systems, Economic Evaluations, Quality of LifeAdvanced Causal Inference Techniques

Considering Usual Medical Care in Clinical Trial Design

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Dawson, Liza, Zarin, Deborah A., Emanuel, Ezekiel J., Friedman, Lawrence M., Chaudhari, Bimal, Goodman, Steven N.·2009·PLoS Medicine

DOI 10.1371/journal.pmed.1000111PMC PMC2746285

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The choice of comparator has important implications for trial ethics, recruitment, results, and interpretation.
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Authors: Dawson, L., Zarin, D. A., Emanuel, E. J., Friedman, L. M., Chaudhari, B., & Goodman, S. N.
Affiliations: National Institutes of Health (US)
Washington University in St. Louis (US)
Johns Hopkins University (US)
Corresponding author: Dawson, Liza
ORCID: Dawson, Liza
Zarin, Deborah A.
Chaudhari, Bimal
Goodman, Steven N.
Venue: PLoS Medicine
Publisher: Public Library of Science (PLoS)
Published: 2009-09-29
Volume: 6
Issue: 9
Pages: e1000111
ISSN: 1549-1277 (ISSN-L)
1549-1676
DOI: 10.1371/journal.pmed.1000111
PMC: PMC2746285
OpenAlex: W2139454298
Cited by: 93
References: 50
Citations by year: 2026: 3 · 2025: 7 · 2024: 17 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 15 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 1
FWCI: 3.32
Type: journal article
Language: en
Open access: gold
doi.org
Licence: public-domain
creativecommons.org/publicdomain/zero/1.0/ (unspecified)
Locations: PLoS Medicine (publishedVersion, public-domain)
PubMed Central (publishedVersion, public-domain)
PubMed (publishedVersion)
Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: U.S. Department of Health and Human Services
National Institutes of Health
National Heart, Lung, and Blood Institute
Topics: Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
Keywords: usual care, clinical trial design, health policy
MeSH terms: Attitude of Health Personnel, Clinical Trials as Topic, Humans, Practice Patterns, Physicians', Research Design, Evidence-Based Medicine

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Considering Usual Medical Care in Clinical Trial Design

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