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Effective Chikungunya Virus-like Particle Vaccine Produced in Insect Cells
Open accessAbstract
The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe disease in humans and represents a serious public health threat in countries where Aedes spp mosquitoes are present. This study describes for the first time the successful production of CHIKV virus-like particles (VLPs) in insect cells using recombinant baculoviruses. This well-established expression system is rapidly scalable to volumes required for epidemic responses and proved well suited for processing of CHIKV glycoproteins and production of enveloped VLPs. Herein we show that a single immunization with 1 µg of non-adjuvanted CHIKV VLPs induced high titer neutralizing antibody responses and provided complete protection against viraemia and joint inflammation upon challenge with the Réunion Island CHIKV strain in an adult wild-type mouse model of CHIKV disease. CHIKV VLPs produced in insect cells using recombinant baculoviruses thus represents as a new, safe, non-replicating and effective vaccine candidate against CHIKV infections.
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Citations
Cites
DNA vaccines: ready for prime time?
Kutzler, M. A., & Weiner, D. B. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2432 · Cited by 1,077
Cited by
Bioengineering virus‐like particles as vaccines
Lua, L. H. L., Connors, N. K., Sainsbury, F., Chuan, Y. P., Wibowo, N., & Middelberg, A. P. J. (2014) · Biotechnology and Bioengineering · doi:10.1002/bit.25159 · Cited by 355
Metadata
- Authors
- Metz, S. W., Gardner, J., Geertsema, C., Le, T. T., Goh, L., Vlak, J. M., Suhrbier, A., & Pijlman, G. P.
- Venue
- PLoS Neglected Tropical Diseases
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-03-14
- Volume
- 7
- Issue
- 3
- Pages
- e2124
- ISSN
- 1935-2727 (ISSN-L)
- 1935-2735
- OpenAlex
- W2138880157
- Cited by
- 163
- References
- 1
- FWCI
- 18.59
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Effective Chikungunya Virus-like Particle Vaccine Produced in Insect Cells. https://app.cochat.ai/papers/10.1371/journal.pntd.0002124
- The paper
- Metz, S. W., Gardner, J., Geertsema, C., Le, T. T., Goh, L., Vlak, J. M., Suhrbier, A., & Pijlman, G. P. (2013). Effective Chikungunya Virus-like Particle Vaccine Produced in Insect Cells. PLoS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0002124
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
