DNA vaccines: ready for prime time?

Continuous cultures of fused cells secreting antibody of predefined specificity

Köhler, G., & Milstein, C. (1975) · Nature · doi:10.1038/256495a0 · Cited by 17,200 · see citing works

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

Ulmer, J. B., Donnelly, J., Parker, S. E., Rhodes, G. H., Felgner, P. L., Dwarki, V., Gromkowski, S. H., Deck, R. R., DeWitt, C. M., Friedman, A., et al. (1993) · Science · doi:10.1126/science.8456302 · Cited by 2,318 · see citing works

Genetic immunization is a simple method for eliciting an immune response

Tang, D.-C. C., DeVit, M. J., & Johnston, S. A. (1992) · Nature · doi:10.1038/356152a0 · Cited by 1,504 · see citing works

Codon bias and heterologous protein expression

Gustafsson, C., Govindarajan, S., & Minshull, J. (2004) · Trends in Biotechnology · doi:10.1016/j.tibtech.2004.04.006 · Cited by 1,330 · see citing works

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

Gorman, C. M., Merlino, G. T., Willingham, M. C., Pastan, I. H., & Howard, B. H. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.22.6777 · Cited by 1,298 · see citing works

Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity

Shiver, J. W., Fu, T., Chen, L., Casimiro, D. R., Davies, M.-E., Evans, R. K., Zhang, Z., Simon, A. J., Trigona, W. L., Dubey, S. A., et al. (2002) · Nature · doi:10.1038/415331a · Cited by 1,173 · see citing works

A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus

Boshart, M., Weber, F., Jahn, G., DORSCHHLER, K., Fleckenstein, B. W., & Schaffner, W. (1985) · Cell · doi:10.1016/s0092-8674(85)80025-8 · Cited by 1,140 · see citing works

DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.

Fynan, E. F., Webster, R. G., FULLER, D. H., Haynes, J. R., Santoro, J. C., & Robinson, H. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11478 · Cited by 1,116 · see citing works

DNA VACCINES

Donnelly, J., Ulmer, J. B., Shiver, J. W., & Liu, M. A. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.617 · Cited by 985 · see citing works

Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans.

Nabel, G. J., Nabel, E. G., Yang, Z., Fox, B. A., Plautz, G. E., Gao, X., Huang, L., Shu, S., Gordon, D., & Chang, A. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11307 · Cited by 882 · see citing works

Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination

Barouch, D. H., Santra, S., Schmitz, J. E., Kuroda, M. J., Fu, T., Wagner, W., Bilska, M., Craiu, A., Zheng, X. X., Krivulka, G. R., et al. (2000) · Science · doi:10.1126/science.290.5491.486 · Cited by 881 · see citing works

Induction of Antigen-Specific Cytotoxic T Lymphocytes in Humans by a Malaria DNA Vaccine

Wang, R., Doolan, D. L., Le, T. P., Hedstrom, R. C., Coonan, K., Charoenvit, Y., Jones, T. R., Hobart, P. M., Margalith, M., Ng, J., et al. (1998) · Science · doi:10.1126/science.282.5388.476 · Cited by 833 · see citing works

DNA–based immunization by in vivo transfection of dendritic cells

Condon, C., Watkins, S. C., Celluzzi, C. M., Thompson, K., & Falo, L. D. (1996) · Nature Medicine · doi:10.1038/nm1096-1122 · Cited by 820 · see citing works

The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants

Moreau, P., Hen, R., Wasylyk, B., Everett, R., Gaub, M. P., & Chambon, P. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.22.6047 · Cited by 761 · see citing works

Gene inoculation generates immune responses against human immunodeficiency virus type 1.

Wang, B., Ugen, K. E., Srikantan, V., Agadjanyan, M. G., Dang, K., Refaeli, Y., Sato, A. I., Boyer, J., Williams, W. V., & Weiner, D. B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4156 · Cited by 655 · see citing works

First Human Trial of a DNA-Based Vaccine for Treatment of Human Immunodeficiency Virus Type 1 Infection: Safety and Host Response

MacGregor, R. R., Boyer, J., Ugen, K. E., Lacy, K. E., Gluckman, S. J., Bagarazzi, M. L., Chattergoon, M. A., Baine, Y., Higgins, T. J., Ciccarelli, R. B., et al. (1998) · The Journal of Infectious Diseases · doi:10.1086/515613 · Cited by 640 · see citing works

Cationic liposome-mediated gene transfer.

Gao, X., & Huang, L. (1995) · PubMed · Cited by 620 · see citing works

Predominant Role for Directly Transfected Dendritic Cells in Antigen Presentation to CD8+ T Cells after Gene Gun Immunization

Porgador, A., Irvine, K. R., Iwasaki, A., Barber, B. H., Restifo, N. P., & Germain, R. N. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.6.1075 · Cited by 560 · see citing works

Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans

McConkey, S. J., Reece, W. H. H., Moorthy, V., Webster, D. P., Dunachie, S. J., Butcher, G. A., Vuola, J. M., Blanchard, T. J., Gothard, P., Watkins, K., et al. (2003) · Nature Medicine · doi:10.1038/nm881 · Cited by 553 · see citing works

Electrochemotherapy: results of cancer treatment using enhanced delivery of bleomycin by electroporation

Gothelf, A., Mir, L. M., & Gehl, J. (2003) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(03)00073-2 · Cited by 549 · see citing works

Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6

Kozak, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.9.2482 · Cited by 478 · see citing works

DNA vaccines: precision tools for activating effective immunity against cancer

Rice, J., Ottensmeier, C. H. H., & Stevenson, F. K. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2326 · Cited by 412 · see citing works

A Rational Strategy to Design Multiepitope Immunogens Based on Multiple Th Lymphocyte Epitopes

Livingston, B. D., Crimi, C., Newman, M. J., Higashimoto, Y., Appella, E., Sidney, J., & Sette, A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5499 · Cited by 363 · see citing works

An Improved Plasmid DNA Expression Vector for Direct Injection into Skeletal Muscle

Hartikka, J., Sawdey, M., Cornefert-Jensen, F., Margalith, M., Barnhart, K. M., Nolasco, M., Vahlsing, H. L., Meek, J., Marquet, M., Hobart, P. M., et al. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.10-1205 · Cited by 328 · see citing works

Phase 1 Safety and Immunogenicity Evaluation of a Multiclade HIV‐1 Candidate Vaccine Delivered by a Replication‐Defective Recombinant Adenovirus Vector

Catanzaro, A. T., Koup, R. A., Roederer, M., Bailer, R. T., Enama, M. E., Moodie, Z., Gu, L., Martin, J. E., Novik, L., Chakrabarti, B. K., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/509258 · Cited by 319 · see citing works

Development of a xenogeneic DNA vaccine program for canine malignant melanoma at the Animal Medical Center

Bergman, P. J., Camps‐Palau, M. A., McKnight, J. A., Leibman, N. F., Craft, D. M., Leung, C., Liao, J., Rivière, I., Sadelain, M., Hohenhaus, A. E., et al. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.08.027 · Cited by 298 · see citing works

Potential DNA Vaccine Integration into Host Cell Genome

Nichols, W. W., Ledwith, B. J., Manam, S., & Troilo, P. J. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44729.x · Cited by 268 · see citing works

Heterologous and Homologous Protection Against Influenza A by DNA Vaccination: Optimization of DNA Vectors

Montgomery, D. L., Shiver, J. W., Leander, K. R., Perry, H. C., Friedman, A., Martinez, D., Ulmer, J. B., Donnelly, J., & Liu, M. A. (1993) · DNA and Cell Biology · doi:10.1089/dna.1993.12.777 · Cited by 262 · see citing works

A polymer library approach to suicide gene therapy for cancer

Anderson, D. G., Peng, W., Akinc, A., Hossain, N., Kohn, A., Padera, R. F., Langer, R., & Sawicki, J. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407218101 · Cited by 258 · see citing works

Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers

Le, T. P., Coonan, K., Hedstrom, R. C., Charoenvit, Y., Sedegah, M., Epstein, J. E., Kumar, S., Wang, R., Doolan, D. L., Maguire, J. D., et al. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00407-7 · Cited by 243 · see citing works

Phase 1 Safety and Immunogenicity Evaluation of a Multiclade HIV‐1 DNA Candidate Vaccine

Graham, B. S., Koup, R. A., Roederer, M., Bailer, R. T., Enama, M. E., Moodie, Z., Martin, J. E., McCluskey, M., Chakrabarti, B. K., Lamoreaux, L., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/509259 · Cited by 222 · see citing works

Plasmid DNA Vaccines: Investigation of Integration into Host Cellular DNA following Intramuscular Injection in Mice

Ledwith, B. J., Manam, S., Troilo, P. J., Barnum, A. B., Pauley, C. J., Griffiths, T. G., Harper, L. B., Beare, C. M., Bagdon, W., & Nichols, W. W. (2000) · Intervirology · doi:10.1159/000053993 · Cited by 219 · see citing works

Immunization of non-human primates with DNA vaccines

Liu, M. (1997) · Vaccine · doi:10.1016/s0264-410x(96)00280-0 · Cited by 215 · see citing works

Effect of Plasmid DNA Vaccine Design and In Vivo Electroporation on the Resulting Vaccine-Specific Immune Responses in Rhesus Macaques

Luckay, A., Sidhu, M. K., Kjeken, R., Megati, S., Chong, S.-Y., Roopchand, V., Garcia-Hand, D., Abdullah, R., Braun, R. P., Montefiori, D. C., et al. (2007) · Journal of Virology · doi:10.1128/jvi.00055-07 · Cited by 203 · see citing works

Human Clinical Trials of Plasmid DNA Vaccines

Liu, M. A., & Ulmer, J. B. (2005) · Advances in genetics · doi:10.1016/s0065-2660(05)55002-8 · Cited by 198 · see citing works

Phase 1 safety and immune response studies of a DNA vaccine encoding hepatitis B surface antigen delivered by a gene delivery device

Tacket, C. O. (1999) · Vaccine · doi:10.1016/s0264-410x(99)00094-8 · Cited by 195 · see citing works

The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells.

Nchinda, G., Kuroiwa, J., Oks, M., Trumpfheller, C., Park, C., Huang, Y.-X., Hannaman, D., Schlesinger, S., Mizenina, O., Nussenzweig, M., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34224 · Cited by 192 · see citing works

Optimization of transcriptional regulatory elements for constructing plasmid vectors

Xu, Z., Mizuguchi, H., Ishii‐Watabe, A., et al. (2001) · Gene · doi:10.1016/s0378-1119(01)00550-9 · Cited by 184 · see citing works

Plasmid DNA Vaccines: Tissue Distribution and Effects of DNA Sequence, Adjuvants and Delivery Method on Integration into Host DNA

Manam, S., Ledwith, B. J., Barnum, A. B., Troilo, P. J., Pauley, C. J., Harper, L. B., Griffiths, T. G., Niu, Z., Denisova, L., Follmer, T. T., et al. (2000) · Intervirology · doi:10.1159/000053994 · Cited by 183 · see citing works

Naked DNA and Adenoviral Immunizations for Immunotherapy of Prostate Cancer: A Phase I/II Clinical Trial

Mincheff, M. S., Tchakarov, S., Zoubak, S., et al. (2000) · European Urology · doi:10.1159/000020281 · Cited by 183 · see citing works

Coimmunization with an Optimized IL-15 Plasmid Results in Enhanced Function and Longevity of CD8 T Cells That Are Partially Independent of CD4 T Cell Help

Kutzler, M. A., Robinson, T. M., Chattergoon, M. A., Choo, D. K., Choo, A. Y., Choe, P. Y., Ramanathan, M. P., Parkinson, R. M., Kudchodkar, S. B., Tamura, Y., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.112 · Cited by 182 · see citing works

Smallpox DNA vaccine delivered by novel skin electroporation device protects mice against intranasal poxvirus challenge

Hooper, J. W., Golden, J. W., Ferro, A. M., et al. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.11.017 · Cited by 181 · see citing works

Gene-based vaccines: recent technical and clinical advances

Ulmer, J. B., Wahrén, B., & Liu, M. A. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.03.007 · Cited by 174 · see citing works

Microparticle-based technologies for vaccines

O’Hagan, D. T., Singh, M., & Ulmer, J. B. (2006) · Methods · doi:10.1016/j.ymeth.2006.05.017 · Cited by 172 · see citing works

The Cutter Incident, 50 Years Later

Offit, P. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmp048180 · Cited by 170 · see citing works

Intradermal/subcutaneous immunization by electroporation improves plasmid vaccine delivery and potency in pigs and rhesus macaques

Hirao, L. A., Wu, L., Khan, A. S., Satishchandran, A., Draghia, R., & Weiner, D. B. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.10.041 · Cited by 168 · see citing works

Efficacy of an infectious hematopoietic necrosis (IHN) virus DNA vaccine in Chinook Oncorhynchus tshawytscha and sockeye O. nerka salmon

Garver, K., LaPatra, S., & Kurath, G. (2005) · Diseases of Aquatic Organisms · doi:10.3354/dao064013 · Cited by 165 · see citing works

A Human T-Cell Leukemia Virus Type 1 Regulatory Element Enhances the Immunogenicity of Human Immunodeficiency Virus Type 1 DNA Vaccines in Mice and Nonhuman Primates

Barouch, D. H., Yang, Z., Kong, W., Korioth-Schmitz, B., Sumida, S. M., Truitt, D. M., Kishko, M., Arthur, J. C., Miura, A., Mascola, J. R., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.14.8828-8834.2005 · Cited by 160 · see citing works

Preclinical and clinical progress of particle-mediated DNA vaccines for infectious diseases

FULLER, D. H., Loudon, P. T., & Schmaljohn, C. S. (2006) · Methods · doi:10.1016/j.ymeth.2006.05.022 · Cited by 152 · see citing works

Poly-l-lysine-coated nanoparticles: A potent delivery system to enhance DNA vaccine efficacy

Minigo, G., Scholzen, A., Tang, C. K., Hanley, J. C., Kalkanidis, M., Pietersz, G. A., Apostolopoulos, V., & Plebanski, M. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.09.086 · Cited by 151 · see citing works

Electroporated DNA Vaccine Clears Away Multifocal Mammary Carcinomas in Her-2/neuTransgenic Mice

Quaglino, E., Iezzi, M., Mastini, C., Amici, A. R. D., Pericle, F., Carlo, E. D., Pupa, S. M., Giovanni, C. D., Spadaro, M., Curcio, C., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2962 · Cited by 150 · see citing works

Combined effects of IL-12 and electroporation enhances the potency of DNA vaccination in macaques

Hirao, L. A., Wu, L., Khan, A. S., et al. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.02.036 · Cited by 146 · see citing works

Induction of Inflammation byWest Nile virusCapsid through the Caspase-9 Apoptotic Pathway

Yang, J.-S., Ramanathan, M. P., Muthumani, K., et al. (2002) · Emerging infectious diseases · doi:10.3201/eid0812.020224 · Cited by 146 · see citing works

Enhancement of cellular immune response to a prostate cancer DNA vaccine by intradermal electroporation

Roos, A., Moreno, S., Leder, C., Pavlenko, M., KING, A. D., & Pisa, P. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.08.005 · Cited by 140 · see citing works

Heterosubtypic Protection against Pathogenic Human and Avian Influenza Viruses via In Vivo Electroporation of Synthetic Consensus DNA Antigens

Laddy, D. J., Yan, J., Kutzler, M. A., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002517 · Cited by 140 · see citing works

Low-frequency ultrasound as a transcutaneous immunization adjuvant

Tezel, A., Paliwal, S., Shen, Z., & Mitragotri, S. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.02.027 · Cited by 139 · see citing works

Escherichia coli strains that allow antibiotic-free plasmid selection and maintenance by repressor titration

Cranenburgh, R. M. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.5.e26 · Cited by 132 · see citing works

Effect of Codon Optimization on Expression Levels of a Functionally Folded Malaria Vaccine Candidate in Prokaryotic and Eukaryotic Expression Systems

Yadava, A., & Ockenhouse, C. F. (2003) · Infection and Immunity · doi:10.1128/iai.71.9.4961-4969.2003 · Cited by 130 · see citing works

Codon optimization reveals critical factors for high level expression of two rare codon genes in Escherichia coli: RNA stability and secondary structure but not tRNA abundance

Wu, X., Jörnvall, H., Berndt, K. D., & Oppermann, U. C. T. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.091 · Cited by 122 · see citing works

DNA-loaded biodegradable microparticles as vaccine delivery systems and their interaction with dendritic cells

Jilek, S., Merkle, H. P., & Walter, E. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.09.010 · Cited by 119 · see citing works

Liposome-entrapped plasmid DNA: characterisation studies

Perrie, Y. (2000) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(00)00055-6 · Cited by 118 · see citing works

Immunologic responses to West Nile virus in vaccinated and clinically affected horses

Davidson, A. H., Traub‐Dargatz, J. L., Rodeheaver, R. M., et al. (2005) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.2005.226.240 · Cited by 118 · see citing works

In vivo electroporation of plasmids encoding GM-CSF or interleukin-2 into existing B16 melanomas combined with electrochemotherapy induces long-term antitumour immunity

Heller, L. C., Pottinger, C., Jaroszeski, M. J., Gilbert, R., & Heller, R. F. (2000) · Melanoma Research · doi:10.1097/00008390-200012000-00010 · Cited by 118 · see citing works

Codon Optimization of Gene Fragments Encoding Plasmodium falciparum Merzoite Proteins Enhances DNA Vaccine Protein Expression and Immunogenicity in Mice

Narum, D. L., Kumar, S., Rogers, W. O., Fuhrmann, S. R., Liang, H., Oakley, M. S., Taye, A., Sim, B. K. L., & Hoffman, S. L. (2001) · Infection and Immunity · doi:10.1128/iai.69.12.7250-7253.2001 · Cited by 117 · see citing works

Immunogenicity of novel consensus-based DNA vaccines against avian influenza

Laddy, D. J., Yan, J., Corbitt, N., et al. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.01.063 · Cited by 115 · see citing works

Codon optimization and mRNA amplification effectively enhances the immunogenicity of the hepatitis C virus nonstructural 3/4A gene

Frelin, L., Ahlén, G., Alheim, M., Weiland, O., Barnfield, C., Liljeström, P., & Sällberg, M. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302184 · Cited by 114 · see citing works

Codon Usage Optimization of HIV Type 1 Subtype C gag , pol , env , and nef Genes: In Vitro Expression and Immune Responses in DNA-Vaccinated Mice

Gao, F., Li, Y., Decker, J. M., Peyerl, F. W., Bibollet‐Ruche, F., Rodenburg, C. M., Chen, Y., Shaw, D. R., Allen, S., Musonda, R. M., et al. (2003) · AIDS Research and Human Retroviruses · doi:10.1089/088922203769232610 · Cited by 113 · see citing works

Studies of a prophylactic HIV-1 vaccine candidate based on modified vaccinia virus Ankara (MVA) with and without DNA priming: Effects of dosage and route on safety and immunogenicity

Peters, B. S., Jaoko, W. G., Vardas, E., et al. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.11.016 · Cited by 112 · see citing works

Needle-free epidermal powder immunization

Chen, D., Maa, Y., & Haynes, J. R. (2002) · Expert Review of Vaccines · doi:10.1586/14760584.1.3.265 · Cited by 111 · see citing works

Novel Phage Display-Based Subtractive Screening To Identify Vaccine Candidates ofBrugia malayi

Munirathinam, G., Rao, K. V. N., He, Y.-X., et al. (2004) · Infection and Immunity · doi:10.1128/iai.72.8.4707-4715.2004 · Cited by 109 · see citing works

Biodistribution of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar, without Integration, despite Differing Plasmid Backbones or Gene Inserts

Sheets, R., Stein, J., Manetz, T. S., et al. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj169 · Cited by 107 · see citing works

Polymeric nano- and microparticle technologies for oral gene delivery

Bhavsar, M. D., & Amiji, M. M. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.4.3.197 · Cited by 105 · see citing works

Electroporation as a “Prime/Boost” Strategy for Naked DNA Vaccination against a Tumor Antigen

Buchan, S. L., Grønevik, E., Mathiesen, I., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6292 · Cited by 103 · see citing works

Relative contributions of codon usage, promoter efficiency and leader sequence to the antigen expression and immunogenicity of HIV-1 Env DNA vaccine

Wang, S., Farfán-Arribas, D. J., Shen, S., et al. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.08.023 · Cited by 102 · see citing works

Safety, Tolerability, and Lack of Antibody Responses After Administration of a Pf CSP DNA Malaria Vaccine via Needle or Needle-Free Jet Injection, and Comparison of Intramuscular and Combination Intramuscular/Intradermal Routes

Epstein, J. E., Gorak, E. J., Charoenvit, Y., et al. (2002) · Human Gene Therapy · doi:10.1089/10430340260201644 · Cited by 100 · see citing works

Immune Responses and Protection Obtained by Oral Immunization with Rotavirus VP4 and VP7 DNA Vaccines Encapsulated in Microparticles

Herrmann, J. E., Chen, S. C., Jones, D. H., Tinsley-Bown, A., Fynan, E. F., Greenberg, H. B., & Farrar, G. H. (1999) · Virology · doi:10.1006/viro.1999.9751 · Cited by 98 · see citing works

Ancestral and consensus envelope immunogens for HIV-1 subtype C

Kothe, D. L., Li, Y., Decker, J. M., Bibollet‐Ruche, F., Zammit, K. P., Salazar, M. G., Chen, Y., Weng, Z., Weaver, E. A., Gao, F., et al. (2006) · Virology · doi:10.1016/j.virol.2006.05.011 · Cited by 96 · see citing works

High expression of naked plasmid DNA in muscles of young rodents

Dankó, I. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.9.1435 · Cited by 92 · see citing works

The HIV-1 Env Protein Signal Sequence Retards Its Cleavage and Down-regulates the Glycoprotein Folding

Li, Y., Luo, L., Thomas, D. Y., et al. (2000) · Virology · doi:10.1006/viro.2000.0357 · Cited by 91 · see citing works

HIV vaccine development by computer assisted design: the GAIA vaccine

Groot, A. S. D., Marcon, L., Bishop, E. A., et al. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.01.097 · Cited by 89 · see citing works

Prophylactic anti-tumor effects in a B cell lymphoma model with DNA vaccines delivered on polyethylenimine (PEI) functionalized PLGA microparticles

Kasturi, S. P., Qin, H., Thomson, K. S., et al. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.006 · Cited by 88 · see citing works

Modulation of the Immune Response Induced by Gene Electrotransfer of a Hepatitis C Virus DNA Vaccine in Nonhuman Primates

Capone, S., Zampaglione, I., Vitelli, A., Pezzanera, M., Kierstead, L. S., Burns, J., Ruggeri, L., Arcuri, M., Cappelletti, M., Meola, A., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7462 · Cited by 85 · see citing works

Vaxfectin™-Formulated Influenza DNA Vaccines Encoding NP and M2 Viral Proteins Protect Mice against Lethal Viral Challenge

Jimenez, G. S., Planchon, R., Wei, Q., et al. (2007) · Human Vaccines · doi:10.4161/hv.3.5.4175 · Cited by 85 · see citing works

Codon Optimization of the Tat Antigen of Human Immunodeficiency Virus Type 1 Generates Strong Immune Responses in Mice following Genetic Immunization

Ramakrishna, L., Anand, K. K., Mohankumar, K. M., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.17.9174-9189.2004 · Cited by 84 · see citing works

Live attenuated AIDS viruses as vaccines: promise or peril?

Ruprecht, R. M. (1999) · Immunological Reviews · doi:10.1111/j.1600-065x.1999.tb01335.x · Cited by 83 · see citing works

Plasmid DNA vaccines: assay for integration into host genomic DNA.

Ledwith, B. J., Manam, S., Troilo, P. J., Barnum, A. B., Pauley, C. J., Griffiths, T. G., Harper, L. B., Schock, H. B., Zhang, H., Faris, J. E., et al. (2000) · PubMed · Cited by 80 · see citing works

DNA fusion gene vaccines against cancer: from the laboratory to the clinic

Stevenson, F. K., Rice, J., Ottensmeier, C. H. H., Thirdborough, S. M., & Zhu, D. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00145.x · Cited by 78 · see citing works

Induction of mucosal IgA by a novel jet delivery technique for HIV-1 DNA

Lundholm, P. (1999) · Vaccine · doi:10.1016/s0264-410x(98)00404-6 · Cited by 78 · see citing works

Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteins

Kothe, D. L., Decker, J. M., Li, Y., et al. (2006) · Virology · doi:10.1016/j.virol.2006.10.017 · Cited by 76 · see citing works

Potent immunogenicity of an HIV-1 gag–pol fusion DNA vaccine delivered by in vivo electroporation

Otten, G. R., Schaefer, M. E., Doe, B., et al. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.08.017 · Cited by 76 · see citing works

Clinical safety and efficacy of a powdered Hepatitis B nucleic acid vaccine delivered to the epidermis by a commercial prototype device

Roberts, L. K., Barr, L. J., FULLER, D. H., et al. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.05.026 · Cited by 75 · see citing works

Enhanced Cellular Immune Responses Elicited by an Engineered HIV-1 Subtype B Consensus-based Envelope DNA Vaccine

Yan, J., Yoon, H., Kumar, S., et al. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300036 · Cited by 75 · see citing works

Intranasal immunization with liposome-encapsulated plasmid DNA encoding influenza virus hemagglutinin elicits mucosal, cellular and humoral immune responses

Wang, D., Christopher, M. E., Nagata, L. P., et al. (2004) · Journal of Clinical Virology · doi:10.1016/j.jcv.2004.09.013 · Cited by 74 · see citing works

Skin targeted DNA vaccine delivery using electroporation in rabbits

Medi, B. M., & Singh, J. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.035 · Cited by 73 · see citing works

Development of a DNA-MVA/HIVA vaccine for Kenya

Hanke, T., McMichael, A. J., Mwau, M., et al. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00085-3 · Cited by 73 · see citing works

Enhanced Potency of Plasmid DNA Microparticle Human Immunodeficiency Virus Vaccines in Rhesus Macaques by Using a Priming-Boosting Regimen with Recombinant Proteins

Otten, G. R., Schaefer, M. E., Doe, B., Liu, H., Srivastava, I. K., Megede, J. Z., Kazzaz, J., Lian, Y., Singh, M., Ugozzoli, M., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.13.8189-8200.2005 · Cited by 72 · see citing works

Safety and Immune Responses to a DNA‐Based Human Immunodeficiency Virus (HIV) Type I Env/Rev Vaccine in HIV‐Infected Recipients: Follow‐up Data

MacGregor, R. R., Boyer, J., Ciccarelli, R. B., et al. (2000) · The Journal of Infectious Diseases · doi:10.1086/315199 · Cited by 71 · see citing works

Protection against influenza virus infection in mice immunized by administration of hemagglutinin-expressing DNAs with electroporation

Kadowaki, S.-E., Chen, Z., Asanuma, H., et al. (2000) · Vaccine · doi:10.1016/s0264-410x(00)00087-6 · Cited by 70 · see citing works

Intradermal immunization with novel plasmid DNA-coated nanoparticles via a needle-free injection device

Cui, Z., Baizer, L., & Mumper, R. J. (2003) · Journal of Biotechnology · doi:10.1016/s0168-1656(03)00029-4 · Cited by 70 · see citing works

Puncture-Mediated Gene Transfer to the Skin

Ciernik, I. F., Ciernik, B. H. K., & Carbone, D. P. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.8-893 · Cited by 69 · see citing works

Enhancement of Immunity by a DNA Melanoma Vaccine against TRP2 with CCL21 as an Adjuvant

Yamano, T., Kaneda, Y., Huang, S. S., et al. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.05.018 · Cited by 67 · see citing works

Microneedles for transdermal drug delivery: a minireview

Vandervoort, J. (2007) · Frontiers in bioscience · doi:10.2741/2794 · Cited by 67 · see citing works

Guidance for Industry: Considerations for Plasmid DNA Vaccines for Infectious Disease Indications

(2007) · Biotechnology Law Report · doi:10.1089/blr.2007.9905 · Cited by 67 · see citing works

Electrochemotherapy a novel approach to the treatment of metastatic nodules on the skin and subcutaneous tissues

Giardino, R., Fini, M., Bonazzi, V., Cadossi, R., Nicolini, A., & Carpi, A. (2006) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.07.016 · Cited by 65 · see citing works

Strategies for improved formulation and delivery of DNA vaccines to veterinary target species

den Hurk, S. V. D. L., Babiuk, S., & Babiuk, L. A. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00140.x · Cited by 64 · see citing works

Cure of Mammary Carcinomas in Her-2 Transgenic Mice through Sequential Stimulation of Innate (Neoadjuvant Interleukin-12) and Adaptive (DNA Vaccine Electroporation) Immunity

Spadaro, M., Ambrosino, E., Iezzi, M., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1873 · Cited by 64 · see citing works

Immunostimulatory DNA as a vaccine adjuvant

Higgins, D., Marshall, J. D., Traquina, P., Nest, G. V., & Livingston, B. D. (2007) · Expert Review of Vaccines · doi:10.1586/14760584.6.5.747 · Cited by 62 · see citing works

DNA/MVA Vaccine for HIV Type 1: Effects of Codon-Optimization and the Expression of Aggregates or Virus-Like Particles on the Immunogenicity of the DNA Prime

Smith, J. M., Amara, R. R., Campbell, D. T., Xu, Y., Patel, M., Sharma, S., Butera, S. T., Ellenberger, D. L., Yi, H. L., Chennareddi, L. S., et al. (2004) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2004.20.1335 · Cited by 60 · see citing works

Plasmid encoding papillomavirus Type 16 (HPV16) DNA constructed with codon optimization improved the immunogenicity against HPV infection

Cheung, Y.-K., Cheng, S. C.-S., Sin, F. W.-Y., et al. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.07.010 · Cited by 60 · see citing works

mRNA secondary structure at start AUG codon is a key limiting factor for human protein expression in Escherichia coli

Zhang, W., Xiao, W., Wei, H., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.07.209 · Cited by 57 · see citing works

Confocal and probe microscopy to study gene transfection mediated by cationic liposomes with a cationic cholesterol derivative

Nakanishi, M. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00207-1 · Cited by 57 · see citing works

Antibiotic-Free Plasmid Stabilization by Operator-Repressor Titration for Vaccine Delivery by Using Live Salmonella enterica Serovar Typhimurium

Garmory, H. S., Leckenby, M. W., Griffin, K. F., Elvin, S. J., Taylor, R. R., Hartley, M. G., Hanak, J. A. J., Williamson, E. D., & Cranenburgh, R. M. (2005) · Infection and Immunity · doi:10.1128/iai.73.4.2005-2011.2005 · Cited by 57 · see citing works

Safety and tolerability of recombinant modified vaccinia virus Ankara expressing an HIV-1 gag/multiepitope immunogen (MVA.HIVA) in HIV-1-infected persons receiving combination antiretroviral therapy

Dorrell, L., Williams, P., Suttill, A., et al. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.01.005 · Cited by 56 · see citing works

A novel antibiotic free plasmid selection system: Advances in safe and efficient DNA therapy

Mairhofer, J., Pfaffenzeller, I., Merz, D., & Grabherr, R. M. (2007) · Biotechnology Journal · doi:10.1002/biot.200700141 · Cited by 56 · see citing works

The Hybrid Cytomegalovirus Enhancer/Chicken β-Actin Promoter along with Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances the Protective Efficacy of DNA Vaccines

Garg, S., Oran, A. E., Hon, H., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.550 · Cited by 54 · see citing works

Generation of a Consensus Sequence from Prevalent and Incident HIV-1 Infections in West Africa to Guide AIDS Vaccine Development

Ellenberger, D. L., Li, B., Lupo, L. D., et al. (2002) · Virology · doi:10.1006/viro.2002.1577 · Cited by 54 · see citing works

Strong cellular and humoral immune responses induced by transcutaneous immunization with HBsAg DNA–cationic deformable liposome complex

Wang, J., Hu, J., Li, F., et al. (2007) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00584.x · Cited by 54 · see citing works

Promoter Sequences of Varicella-Zoster Virus Glycoprotein I Targeted by Cellular Transactivating Factors Sp1 and USF Determine Virulence in Skin and T Cells in SCIDhu Mice In Vivo

Ito, H., Sommer, M. H., Zerboni, L., et al. (2002) · Journal of Virology · doi:10.1128/jvi.77.1.489-498.2003 · Cited by 53 · see citing works

Electric pulses applied prior to intramuscular DNA vaccination greatly improve the vaccine immunogenicity

Peng, B., Zhao, Y., Xu, L., et al. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.11.042 · Cited by 53 · see citing works

Efficient vaccination by intradermal or intramuscular inoculation of plasmid DNA expressing hepatitis B surface antigen under desmin promoter/enhancer control

Kwissa, M. (2000) · Vaccine · doi:10.1016/s0264-410x(00)00030-x · Cited by 52 · see citing works

Plasmid-mediated growth hormone-releasing hormone efficacy in reducing disease associated with Mycoplasma hyopneumoniae and porcine reproductive and respiratory syndrome virus infection1

Thacker, E., Holtkamp, D., Khan, A. S., et al. (2006) · Journal of Animal Science · doi:10.2527/2006.843733x · Cited by 50 · see citing works

Synergistic Effect of Formulated Plasmid and Needle-Free Injection for Genetic Vaccines

Anwer, K., Earle, K. A., Shi, M., et al. (1999) · Pharmaceutical Research · doi:10.1023/a:1018834305079 · Cited by 48 · see citing works

DNA electroporation prime and protein boost strategy enhances humoral immunity of tuberculosis DNA vaccines in mice and non-human primates

Li, Z., Zhang, H., Fan, X., et al. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.08.021 · Cited by 47 · see citing works

Prospects of HIV Env Modification as an Approach to HIV Vaccine Design

Hu, S.-L., & Stamatatos, L. (2007) · Current HIV Research · doi:10.2174/157016207782418542 · Cited by 46 · see citing works

In vivo electroporation of skeletal muscles increases the efficacy of Japanese encephalitis virus DNA vaccine

Wu, C., Lee, S., Huang, H.-W., et al. (2003) · Vaccine · doi:10.1016/j.vaccine.2003.10.011 · Cited by 46 · see citing works

Lipid-coated polyplexes for targeted gene delivery to ovarian carcinoma cells

Mastrobattista, E., Kapel, R. H., Eggenhuisen, M. H., Roholl, P. J. M., Crommelin, D. J. A., Hennink, W. E., & Storm, G. (2001) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700311 · Cited by 44 · see citing works

Induction of gp120-specific protective immune responses by genetic vaccination with linear polyethylenimine–plasmid complex

Garzón, M. R., Berraondo, P., Crettaz, J. S., et al. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.09.009 · Cited by 43 · see citing works

Topical application of HIV DNA vaccine with cytokine-expression plasmids induces strong antigen-specific immune responses

Liu, L., Watabe, S., Yang, J., Hamajima, K., Ishii, N., Hagiwara, E., Onari, K., Xin, K.-Q., & Okuda, K. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00324-3 · Cited by 43 · see citing works

Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation

Dobaño, C., Widera, G., Rabussay, D., et al. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.06.036 · Cited by 42 · see citing works

Needle-Free Jet Injection of a Mixture of Japanese Encephalitis DNA and Protein Vaccines: A Strategy to Effectively Enhance Immunogenicity of the DNA Vaccine in a Murine Model

Imoto, J.-I., & Konishi, E. (2005) · Viral Immunology · doi:10.1089/vim.2005.18.205 · Cited by 40 · see citing works

A single HBsAg DNA vaccination in combination with electroporation elicits long-term antibody responses in sheep

Babiuk, S., Tsang, C., den Hurk, S. V. D. L., et al. (2006) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2006.10.003 · Cited by 39 · see citing works

Risk Potential of the Chromosomal Insertion of Foreign DNA

Kurth, R. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44739.x · Cited by 39 · see citing works

Recognition of Variant HIV-1 Epitopes from Diverse Viral Subtypes by Vaccine-Induced CTL

McKinney, D. M., Skvoretz, R., Livingston, B. D., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1941 · Cited by 38 · see citing works

Safety and immunogenicity of intramuscular and intravaginal delivery of HIV‐1 DNA constructs to infant chimpanzees

Bagarazzi, M. L., Boyer, J., Javadian, M. A., et al. (1997) · Journal of Medical Primatology · doi:10.1111/j.1600-0684.1997.tb00316.x · Cited by 38 · see citing works

Definitive toxicology and biodistribution study of a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 (HIV-1) vaccine in rabbits

Pal, R., YU, Q., WANG, S., et al. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.07.112 · Cited by 37 · see citing works

HIV-1 prophylactic vaccine comprised of topical DermaVir prime and protein boost elicits cellular immune responses and controls pathogenic R5 SHIV162P3

Cristillo, A. D., Lisziewicz, J., He, L., et al. (2007) · Virology · doi:10.1016/j.virol.2007.04.012 · Cited by 37 · see citing works

Overview of biological effects of addition of DNA molecules to cells

Temin, H. M. (1990) · Journal of Medical Virology · doi:10.1002/jmv.1890310105 · Cited by 37 · see citing works

Cationic polymers that enhance the performance of HbsAg DNA in vivo

Bos, G. W., Kanellos, T., Crommelin, D. J. A., Hennink, W. E., & Howard, C. R. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.06.020 · Cited by 36 · see citing works

Design of multi-epitope, analogue-based cancer vaccines

Fikes, J. D., & Sette, A. (2003) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.3.6.985 · Cited by 36 · see citing works

Computational prediction of the cross‐reactive neutralizing epitope corresponding to the monoclonal antibody b12 specific for HIV‐1 gp120

Bublil, E. M., Yeger‐Azuz, S., & Gershoni, J. M. (2006) · The FASEB Journal · doi:10.1096/fj.05-5509rev · Cited by 34 · see citing works

Protective immunization against melanoma by gp100 DNA–HVJ-liposome vaccine

Zhou, W.-Z., Kaneda, Y., Huang, S. K., et al. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300998 · Cited by 33 · see citing works

Vaccinia expression of secreted proteins: tissue plasminogen activator signal sequence enhances expression and immunogenicity of Ag85

Malin, A. S., Huygen, K., Content, J., Mackett, M., Brandt, L., Andersen, P. L., Smith, S. M., & Dockrell, H. M. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)01323-x · Cited by 30 · see citing works

Comparative study of immune responses induced after immunization with plasmids encoding the HIV-1 Nef protein under the control of the CMV-IE or the muscle-specific desmin promoter

Cazeaux, N. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00310-9 · Cited by 29 · see citing works

Cross-Clade Protection Induced by Human Immunodeficiency Virus-1 DNA Immunogens Expressing Consensus Sequences of Multiple Genes and Epitopes From Subtypes A, B, C, and FGH

Malm, M., Rollman, E., Ustav, M., et al. (2005) · Viral Immunology · doi:10.1089/vim.2005.18.678 · Cited by 28 · see citing works

Enhanced immunogenicity of microencapsulated multiepitope DNA vaccine encoding T and B cell epitopes of foot-and-mouth disease virus in mice

Wang, F., He, X., Jiang, L., Ren, D., He, Y., Li, D., & Sun, S. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.11.042 · Cited by 28 · see citing works

DNA vaccines: capacity to induce auto-immunity and tolerance.

Klinman, D. M., Takeshita, F., Kamstrup, S., et al. (2000) · PubMed · Cited by 28 · see citing works

A fusogenic peptide expressed on the surface of Salmonella enterica elicits CTL responses to a dengue virus epitope

Lurı́a-Pérez, R., Cedillo‐Barrón, L., Santos‐Argumedo, L., et al. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.03.047 · Cited by 26 · see citing works

Delivery of DNA Vaccines Using Electroporation

Babiuk, S., den Hurk, S. V. D. L., & Babiuk, L. A. (2006) · Humana Press eBooks · doi:10.1385/1-59745-168-1:73 · Cited by 26 · see citing works

The efficacy of electroporated plasmid vaccines correlates with long-term antigen production in vivo

Miller, M., Rekas, G., Dayball, K., et al. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.01.019 · Cited by 23 · see citing works

Muscle specific versus ubiquitous expression of Gag based HIV-1 DNA vaccines: a comparative analysis

Bojak, A., Hammer, D., Wolf, H., et al. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00081-6 · Cited by 23 · see citing works

Immunogenicity Testing of a Novel Engineered HIV-1 Envelope Gp140 DNA Vaccine Construct

Kumar, S., Yan, J., Muthumani, K., et al. (2006) · DNA and Cell Biology · doi:10.1089/dna.2006.25.383 · Cited by 22 · see citing works

DNA vaccines: safety aspect assessment and regulation.

Medjitna, T. D. E., Stadler, C., Bruckner, L., et al. (2006) · PubMed · Cited by 21 · see citing works

Immunogenicity in mice of a cationic microparticle-adsorbed plasmid DNA encoding Japanese encephalitis virus envelope protein

Kaur, R., Rauthan, M., & Vrati, S. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.01.040 · Cited by 21 · see citing works

Enhancement of DNA vaccine-induced immune responses by a 72-bp element from SV40 enhancer

Li, H., Liu, Y., Li, D., et al. (2007) · Chinese Medical Journal · doi:10.1097/00029330-200703020-00012 · Cited by 15 · see citing works

Induction of HIV-specific memory T-cell responses by topical DermaVir vaccine

Calarota, S. A., Weiner, D. B., Lori, F., et al. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.01.024 · Cited by 13 · see citing works

Preparation and Characterization of a Monoclonal Antibody Against CKLF1 Using DNA Immunization with In Vivo Electroporation

Chen, Y., Zhang, T., Li, T., et al. (2005) · Hybridoma · doi:10.1089/hyb.2005.24.305 · Cited by 11 · see citing works

Multiple RNA splicing and the presence of cryptic RNA splice donor and acceptor sites may contribute to low expression levels and poor immunogenicity of potential DNA vaccines containing the env gene of equine infectious anemia virus (EIAV)

Zhou, W., Cook, R. F., Cook, S. J., et al. (2002) · Veterinary Microbiology · doi:10.1016/s0378-1135(02)00099-8 · Cited by 11 · see citing works

Assuring the Quality, Safety, and Efficacy of DNA Vaccines

Robertson, J. S., & Griffiths, E. (2006) · Humana Press eBooks · doi:10.1385/1-59745-168-1:363 · Cited by 11 · see citing works

Regulatory Issues in the Use of DNA Vaccines

Minor, P. D. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44742.x · Cited by 9 · see citing works

Analysis of Humoral Immunity of Hepatitis D Virus DNA Vaccine Generated in Mice by Using Different Dosage, Gene Gun Immunization, and In Vivo Electroporation

Shiau, Y.-T., Huang, Y., Wu, J., et al. (2006) · Journal of the Chinese Medical Association · doi:10.1016/s1726-4901(09)70104-2 · Cited by 9 · see citing works

European Union guidance on the quality, safety and efficacy of DNA vaccines and regulatory requirements.

Robertson, J. S., & Cichutek, K. (2000) · PubMed · Cited by 8 · see citing works

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

Kowalski, P. S., Rudra, A., Miao, L., & Anderson, D. G. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.02.012 · Cited by 1,127 · see citing works

Nonviral delivery of self-amplifying RNA vaccines

Geall, A. J., Verma, A., Otten, G. R., Shaw, C. A., Hekele, A., Banerjee, K., Cu, Y., Beard, C. W., Brito, L. A., Krucker, T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209367109 · Cited by 675 · see citing works

Self-amplifying RNA vaccines for infectious diseases

Bloom, K., van den Berg, F., & Arbuthnot, P. (2021) · Gene Therapy · doi:10.1038/s41434-020-00204-y · Cited by 487 · see citing works

COVID-19 vaccines: The status and perspectives in delivery points of view

Chung, J. Y., Thone, M. N., & Kwon, Y. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.011 · Cited by 375 · see citing works

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

Brito, L. A., Chan, M., Shaw, C. A., Hekele, A., Carsillo, T., Schaefer, M., Archer, J., Seubert, A., Otten, G. R., Beard, C. W., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.133 · Cited by 338 · see citing works

Engineering patient-specific cancer immunotherapies

Scheetz, L., Park, K. S., Li, Q., Lowenstein, P. R., Castro, M. G., Schwendeman, A., & Moon, J. J. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0436-x · Cited by 208 · see citing works

Potent Immune Responses in Rhesus Macaques Induced by Nonviral Delivery of a Self-amplifying RNA Vaccine Expressing HIV Type 1 Envelope With a Cationic Nanoemulsion

Bogers, W. M., Oostermeijer, H., Mooij, P., Koopman, G., Verschoor, E. J., Davis, D., Ulmer, J. B., Brito, L. A., Cu, Y., Banerjee, K., et al. (2015) · Journal of Infectious Diseases · doi:10.1093/infdis/jiu522 · Cited by 181 · see citing works

Immunogenicity and protective efficacy induced by self-amplifying mRNA vaccines encoding bacterial antigens

Maruggi, G., Chiarot, E., Giovani, C., Buccato, S., Bonacci, S., Frigimelica, E., Margarit, I., Geall, A., Bensi, G., & Maione, D. (2017) · Vaccine · doi:10.1016/j.vaccine.2016.11.040 · Cited by 149 · see citing works

An overview of rational design of mRNA-based therapeutics and vaccines

To, K. K. W., & Cho, W. C. S. (2021) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2021.1935859 · Cited by 110 · see citing works

Vaccination into the Dermal Compartment: Techniques, Challenges, and Prospects

Hettinga, J., & Carlisle, R. (2020) · Vaccines · doi:10.3390/vaccines8030534 · Cited by 72 · see citing works

The NTS-DBL2X region of VAR2CSA induces cross-reactive antibodies that inhibit adhesion of several Plasmodium falciparum isolates to chondroitin sulfate A

Bigey, P., Gnidehou, S., Doritchamou, J., Quiviger, M., Viwami, F., Couturier, A., Salanti, A., Nielsen, M. A., Scherman, D., Deloron, P., et al. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir499 · Cited by 63 · see citing works

Targeting aging and age-related diseases with vaccines

Wu, R., Sun, F., Zhang, W., Ren, J., & Liu, G.-H. (2024) · Nature Aging · doi:10.1038/s43587-024-00597-0 · Cited by 66 · see citing works

Immunotherapeutic advances in glioma management: The rise of vaccine‐based approaches

Andrew Awuah, W., Shah, M. H., Tan, J. K., Ranganathan, S., Sanker, V., Darko, K., Tenkorang, P. O., Adageba, B. B., Ahluwalia, A., Shet, V., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70013 · Cited by 14 · see citing works

Licensure: if not now, when?

Hamid, M. Y., & Hix, B. A. (2014) · PubMed

Multistate Licensure: Opportunities for Nurses to Practice in New Ways

Shaffer, F. A., & SHEETS, V. R. (2001) · Nursing Administration Quarterly · doi:10.1097/00006216-200101000-00008

Characteristics and attitudes toward mandatory licensure of dietitians among respondents to a northwest tri-state survey

Jenks, J. A., Mayerle, N. E., Schmidt, K., et al. (1994) · Journal of the American Dietetic Association · doi:10.1016/0002-8223(94)91884-8

State-by-State Variations in PA Licensure: A Policy Analysis

Miller, E. E. (2018) · Journal of Medical Regulation · doi:10.30770/2572-1852-104.4.14 · Cited by 1 · see citing works

Review of ADA licensure policy

(1977) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1977.0549 · Cited by 1 · see citing works