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Efficacy and Safety of Praziquantel, Tribendimidine and Mebendazole in Patients with Co-infection of Clonorchis sinensis and Other Helminths
Open accessAbstract
BACKGROUND: Both tribendimidine and mebendazole are broad-spectrum drugs for anti-intestinal nematodes. We aim to assess the efficacy and safety of tribendimidine and mebendazole in patients with co-infection of Clonorchis sinensis and other helminths. METHOD: We performed a randomized open-label trial in Qiyang, People's Republic of China. Eligible participants were randomly assigned to one of four groups: (i) a single dose of 400 mg tribendimidine, (ii) 200 mg tribendimidine twice daily, (iii) 75 mg/kg praziquantel divided in four doses within 2 days, and (iv) a single dose of 400 mg mebendazole. Cure rates and egg reduction rates were assessed, and adverse events were monitored after treatments. Uncured patients accepted the second treatment with the same drugs after the first treatment. RESULTS: 156 patients were eligible for the study. Results from the first treatment showed that the cure rates of single-dose tribendimidine and praziquantel against C. sinensis were 50% and 56.8%, respectively; the single-dose tribendimidine achieved the cure rate of 77.8% in the treatment for hookworm, which was significantly higher than that of praziquantel; Low cure rates were obtained in the treatment of single-dose tribendimidine against Ascaris lumbricoides and Trichuris trichiura (28.6% and 23.1%). Results of the second treatment illustrated the cure rates of tribendimidine and praziquantel against C. sinensis were 78.1% and 75%, respectively. Most adverse events were mild and transient. Adverse events caused by tribendimidine were significantly less than praziquantel. CONCLUSION: Single-dose tribendimidine showed similar efficacy against C. sinensis as praziquantel with less adverse events, and achieved significantly higher cure rate in the treatment for hookworm than those of praziquantel and mebendazole. Low cure rates, which were still higher than other drugs, were obtained in the treatment of single-dose tribendimidine against Ascaris lumbricoides and Trichuris trichiura. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN55086560.
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“A single dose of mebendazole (100 mg) was ineffective against C. sinensis infection [18]”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [18]
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Citations
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Qian, M., Utzinger, J., Keiser, J., & Zhou, X. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60313-0 · Cited by 321
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Metadata
- Authors
- Xu, L.-L., Jiang, B., Duan, J.-H., Zhuang, S.-F., Liu, Y.-C., Zhu, S.-Q., Zhang, L.-P., Zhang, H.-B., Xiao, S.-H., & Zhou, X.-N.
- Affiliations
- National Institute for Parasitic Diseases (CN)
- Hunan Provincial Center for Disease Control and Prevention (CN)
- Corresponding author
- Zhou, Xiao-Nong
- Venue
- PLoS Neglected Tropical Diseases
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-08-14
- Volume
- 8
- Issue
- 8
- Pages
- e3046
- ISSN
- 1935-2727 (ISSN-L)
- 1935-2735
- PMC
- PMC4133228
- OpenAlex
- W2089764328
- Cited by
- 41
- References
- 39
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 1
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS neglected tropical diseases (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Greater South Information System
- Funders
- Centers for Disease Control and Prevention
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- Clonorchis sinensis, praziquantel, tribendimidine, mebendazole, helminth co-infection, intestinal nematodes, hookworm, Ascaris lumbricoides, Trichuris trichiura, cure rate, egg reduction rate, drug safety, anthelmintic efficacy, single-dose therapy, retreatment
- MeSH terms
- Adult, Animals, Anthelmintics, Ascariasis, Clonorchiasis, Female, Helminthiasis, Humans, Male, Mebendazole, Middle Aged, Phenylenediamines, Praziquantel, Coinfection
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- Xu, L.-L., Jiang, B., Duan, J.-H., Zhuang, S.-F., Liu, Y.-C., Zhu, S.-Q., Zhang, L.-P., Zhang, H.-B., Xiao, S.-H., & Zhou, X.-N. (2014). Efficacy and Safety of Praziquantel, Tribendimidine and Mebendazole in Patients with Co-infection of Clonorchis sinensis and Other Helminths. PLoS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0003046
