The DOI matches its Crossref record; 43 of the 45 references it cites were found in a registry or an index.
Characterization of Lethal Zika Virus Infection in AG129 Mice
Open accessAbstract
BACKGROUND: Mosquito-borne Zika virus (ZIKV) typically causes a mild and self-limiting illness known as Zika fever, which often is accompanied by maculopapular rash, headache, and myalgia. During the current outbreak in South America, ZIKV infection during pregnancy has been hypothesized to cause microcephaly and other diseases. The detection of ZIKV in fetal brain tissue supports this hypothesis. Because human infections with ZIKV historically have remained sporadic and, until recently, have been limited to small-scale epidemics, neither the disease caused by ZIKV nor the molecular determinants of virulence and/or pathogenicity have been well characterized. Here, we describe a small animal model for wild-type ZIKV of the Asian lineage. METHODOLOGY/PRINCIPAL FINDINGS: Using mice deficient in interferon α/β and Ɣ receptors (AG129 mice), we report that these animals were highly susceptible to ZIKV infection and disease, succumbing within seven to eight days. Rapid viremic dissemination was observed in visceral organs and brain; but only was associated with severe pathologies in the brain and muscle. Finally, these results were consistent across challenge routes, age of mice, and inoculum doses. These data represent a mouse model for ZIKV that is not dependent on adapting ZIKV to intracerebral passage in mice. CONCLUSIONS/SIGNIFICANCE: Foot pad injection of AG129 mice with ZIKV represents a biologically relevant model for studying ZIKV infection and disease development following wild-type virus inoculation without the requirement for adaptation of the virus or intracerebral delivery of the virus. This newly developed Zika disease model can be exploited to identify determinants of ZIKV virulence and reveal molecular mechanisms that control the virus-host interaction, providing a framework for rational design of acute phase therapeutics and for vaccine efficacy testing.
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“Although NHPs are suitable for studying ZIKV pathogenesis and therapeutics/vaccine development, they are expensive [21].”
From ICR suckling mouse model of Zika virus infection for disease modeling and drug validation (2018) · cites this paper as [21]
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“AG129 and Irf3/5/7 TKO mice are the immunocompromised mice which were permissive to different strain ZIKV infection and vulnerable to ZIKV-relative pathology and lethality [10, 21, 30, 31].”
From ICR suckling mouse model of Zika virus infection for disease modeling and drug validation (2018) · cites this paper as [21]
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“In this regard, small animal models are a better choice for studying ZIKV [10, 21].”
From ICR suckling mouse model of Zika virus infection for disease modeling and drug validation (2018) · cites this paper as [21]
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Cites
Smithburn, K. C. (1952) · The Journal of Immunology · doi:10.4049/jimmunol.69.2.223 · Cited by 3,553
Zika Virus Outbreak on Yap Island, Federated States of Micronesia
Duffy, M. R., Chen, T.-H., Hancock, W. T., Powers, A. M., Kool, J. L., Lanciotti, R. S., Pretrick, M., Marfel, M., Holzbauer, S., Dubray, C. L., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0805715 · Cited by 3,130
Zika Virus Associated with Microcephaly
Mlakar, J., Korva, M., Tul, N., Popović, M., Poljšak-Prijatelj, M., Mraz, J., Kolenc, M., Resman Rus, K., Vesnaver Vipotnik, T., Fabjan Vodušek, V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1600651 · Cited by 2,884
Zika Virus (I). Isolations and serological specificity
Dick, G. W. A., Kitchen, S. F., & Haddow, A. J. (1952) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(52)90042-4 · Cited by 2,698
Lanciotti, R. S., Kosoy, O. L., Laven, J. J., Velez, J. O., Lambert, A. J., Johnson, A. J., Stanfield, S. M., & Duffy, M. R. (2008) · Emerging infectious diseases · doi:10.3201/eid1408.080287 · Cited by 2,173
Biology of Zika Virus Infection in Human Skin Cells
Hamel, R., Dejarnac, O., Wichit, S., Ekchariyawat, P., Neyret, A., Luplertlop, N., Perera-Lecoin, M., Surasombatpattana, P., Talignani, L., Frédéric Thomas, A., et al. (2015) · Journal of Virology · doi:10.1128/jvi.00354-15 · Cited by 1,245
Zika Virus Outbreak, Bahia, Brazil
Campos, G. S., Bandeira, A. C., & Sardi, S. I. (2015) · Emerging infectious diseases · doi:10.3201/eid2110.150847 · Cited by 1,150
Hayes, E. B. (2009) · Emerging infectious diseases · doi:10.3201/eid1509.090442 · Cited by 889
Zika Virus, French Polynesia, South Pacific, 2013
Cao‐Lormeau, V., Roche, C., Teissier, A., Robin, E., Berry, A.-L., Mallet, H., Sall, A. A., & Musso, D. (2014) · Emerging infectious diseases · doi:10.3201/eid2006.140138 · Cited by 876
Zika virus (II). Pathogenicity and physical properties
Dick, G. W. A. (1952) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(52)90043-6 · Cited by 690
Flagged first, then by citations
2 of the 45 references couldn’t be matched to a known paper.
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Modified mRNA vaccines protect against zika virus infection
Richner, J. M., Himansu, S., Dowd, K. A., Butler, S. L., Salazar, V., Fox, J. M., Julander, J. G., Tang, W. W., Shresta, S., Pierson, T. C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.017 · Cited by 909
Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise
Miner, J. J., Cao, B., Govero, J., Smith, A. M., Fernández, E., Cabrera, O. H., Garber, C., Elam-Noll, M., Klein, R. S., Noguchi, K. K., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.008 · Cited by 811
Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling
Grant, A., Ponia, S. S., Tripathi, S., Balasubramaniam, V. R. M. T., Miorin, L., Sourisseau, M., Schwarz, M. C., Sánchez‐Seco, M. P., Evans, M. J., Best, S. M., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.05.009 · Cited by 789
Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection
Stettler, K., Beltramello, M., Espinosa, D. A., Graham, V., Cassotta, A., Bianchi, S., Zatta, F., Minola, A., Jaconi, S., Mele, F., et al. (2016) · Science · doi:10.1126/science.aaf8505 · Cited by 750
Krauer, F., Riesen, M., Revéiz, L., Oladapo, O. T., Martínez-Vega, R. A., Porgo, T. V., Haefliger, A., Broutet, N. J. N., Low, N. N., & WHO Zika Causality Working Group (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002203 · Cited by 517
Metadata
- Authors
- Aliota, M. T., Caine, E. A., Walker, E. C., Larkin, K. E., Camacho, E., & Osorio, J. E.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Osorio, Jorge E.
- Venue
- PLoS neglected tropical diseases
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-04-19
- Volume
- 10
- Issue
- 4
- Pages
- e0004682
- ISSN
- 1935-2727 (ISSN-L)
- 1935-2735
- PMC
- PMC4836712
- OpenAlex
- W2338703441
- Cited by
- 322
- References
- 45
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 16 · 2023: 19 · 2022: 19 · 2021: 25 · 2020: 28 · 2019: 37 · 2018: 50 · 2017: 63 · 2016: 42
- FWCI
- 63.46
- Type
- journal article
- Language
- en
- Update notices
- correction (2016-05-23)
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS neglected tropical diseases (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repositorio Institucional Universidad de Sucre (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Allergy and Infectious Diseases (R21 AI117413-01, T32AI055397)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Keywords
- Zika virus, AG129 mice, virulence factors, viremia, neuropathology, muscle pathology, mosquito-borne arboviruses, vaccine efficacy evaluation, microcephaly
- MeSH terms
- Zika Virus Infection, Interferon gamma Receptor, Animals, Brain, Death, Disease Models, Animal, Muscles, Viremia, Receptors, Interferon, Mice, Knockout, Mice, Receptor, Interferon alpha-beta
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