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The Hygiene Hypothesis and Its Inconvenient Truths about Helminth Infections

Briggs, Neima, Weatherhead, Jill, Sastry, K. Jagannadha, Hotez, Peter J.·2016·PLOS Neglected Tropical Diseases

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  1. H Okada, 2010, The “hygiene hypothesis” for autoimmune and allergic diseases: an update, Clin Exp Immunol, 160, 1, 10.1111/j.1365-2249.2010.04139.x · DOI
  2. JH Droste, 2000, Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease?, Clin Exp Allergy, 30, 1547, 10.1046/j.1365-2222.2000.00939.x · DOI
  3. NA Molodecky, 2012, Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review, Gastroenterology, 142, 46, 10.1053/j.gastro.2011.10.001 · DOI · Paper page
  4. DE Elliott, 2007, Helminths as governors of immune-mediated inflammation, Int J Parasitol, 37, 457, 10.1016/j.ijpara.2006.12.009 · DOI
  5. LJ Wammes, 2014, Helminth therapy or elimination: epidemiological, immunological, and clinical considerations, Lancet Infect Dis, 14, 1150, 10.1016/S1473-3099(14)70771-6 · DOI
  6. PJ Hotez, 2014, The global burden of disease study 2010: interpretation and implications for the neglected tropical diseases, PLoS Negl Trop Dis, 8, e2865, 10.1371/journal.pntd.0002865 · DOI
  7. S Brooker, 2010, Estimating the global distribution and disease burden of intestinal nematode infections: adding up the numbers—a review, Int J Parasitol, 40, 1137, 10.1016/j.ijpara.2010.04.004 · DOI
  8. P Hotez, 2014, Helminth infections: a new global women’s health agenda, Obstet Gynecol, 123, 155, 10.1097/AOG.0000000000000025 · DOI
  9. PJ Hotez, 2009, Rescuing the bottom billion through control of neglected tropical diseases, Lancet (London, England), 373, 1570, 10.1016/S0140-6736(09)60233-6 · DOI
  10. RL Pullan, 2014, Global numbers of infection and disease burden of soil transmitted helminth infections in 2010, Parasit Vectors, 7, 37, 10.1186/1756-3305-7-37 · DOI
  11. JE Weatherhead, 2015, Worm Infections in Children, Pediatr Rev, 36, 341, 10.1542/pir.36-8-341 · DOI
  12. PJ Cooper, 2015, Cohort Profile: The Ecuador Life (ECUAVIDA) study in Esmeraldas Province, Ecuador, Int J Epidemiol, 44, 1517, 10.1093/ije/dyu128 · DOI · Paper page
  13. J Leonardi-Bee, 2006, Asthma and current intestinal parasite infection: systematic review and meta-analysis, Am J Respir Crit Care Med, 174, 514, 10.1164/rccm.200603-331OC · DOI · Paper page
  14. BH Ransom, 1919, A Newly Recognized Cause Of Pulmonary Disease—Ascaris lumbricoides, J Am Med Assoc, 73, 1210, 10.1001/jama.1919.02610420038013 · DOI
  15. AP Gelpi, 1967, Seasonal pneumonitis with eosinophilia. A study of larval ascariasis in Saudi Arabs, Am J Trop Med Hyg, 16, 646, 10.4269/ajtmh.1967.16.646 · DOI · Paper page
  16. E Buendía, 2015, The IgE response to Ascaris molecular components is associated with clinical indicators of asthma severity, World Allergy Organ J, 8, 8, 10.1186/s40413-015-0058-z · DOI
  17. V Ahumada, 2015, IgE responses to Ascaris and mite tropomyosins are risk factors for asthma, Clin Exp Allergy, 45, 1189, 10.1111/cea.12513 · DOI · Paper page
  18. CA Figueiredo, 2010, Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network, Infect Immun, 78, 3160, 10.1128/IAI.01228-09 · DOI
  19. I Hagel, 2007, Infection by Ascaris lumbricoides and bronchial hyper reactivity: an outstanding association in Venezuelan school children from endemic areas, Acta Trop, 103, 231, 10.1016/j.actatropica.2007.06.010 · DOI
  20. C Rîpă, Sensitization to ascaris lumbricoides and asthma severity in children, Rev medico-chirurgicală̆ a Soc Medici şi Nat din Iaşi, 115, 387
  21. LJ Palmer, 2002, Ascaris lumbricoides infection is associated with increased risk of childhood asthma and atopy in rural China, Am J Respir Crit Care Med, 165, 1489, 10.1164/rccm.2107020 · DOI
  22. LC Rodrigues, 2008, Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood, Clin Exp Allergy, 38, 1769, 10.1111/j.1365-2222.2008.03027.x · DOI · Paper page
  23. M Wördemann, 2008, Association of atopy, asthma, allergic rhinoconjunctivitis, atopic dermatitis and intestinal helminth infections in Cuban children, Trop Med Int Health, 13, 180, 10.1111/j.1365-3156.2007.01988.x · DOI
  24. MCF Almeida, 2012, The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial, J Parasitol Res, 2012, 296856
  25. NR Lynch, 1993, Effect of anthelmintic treatment on the allergic reactivity of children in a tropical slum, J Allergy Clin Immunol, 92, 404, 10.1016/0091-6749(93)90119-Z · DOI
  26. PH Gazzinelli-Guimarães, 2013, Parasitological and immunological aspects of early Ascaris spp. infection in mice, Int J Parasitol, 43, 697, 10.1016/j.ijpara.2013.02.009 · DOI
  27. DS Nogueira, 2016, Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice, PLoS Negl Trop Dis, 10, e0004382, 10.1371/journal.pntd.0004382 · DOI
  28. L Guo, 2015, Innate immunological function of TH2 cells in vivo, Nat Immunol, 16, 1051, 10.1038/ni.3244 · DOI
  29. S Katoh, 2003, A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia, J Clin Invest, 111, 1563, 10.1172/JCI16583 · DOI
  30. CH King, 2008, The unacknowledged impact of chronic schistosomiasis, Chronic Illn, 4, 65, 10.1177/1742395307084407 · DOI
  31. DA Bundy, 1986, Epidemiological aspects of Trichuris and trichuriasis in Caribbean communities, Trans R Soc Trop Med Hyg, 80, 706, 10.1016/0035-9203(86)90369-X · DOI
  32. DA Bundy, 1989, Trichuris and trichuriasis in humans, Adv Parasitol, 28, 107, 10.1016/S0065-308X(08)60332-2 · DOI
  33. C Nokes, 1992, Moderate to heavy infections of Trichuris trichiura affect cognitive function in Jamaican school children, Parasitology, 104, 539, 10.1017/S0031182000063800 · DOI
  34. ES Cooper, 1990, Growth suppression in the Trichuris dysentery syndrome, Eur J Clin Nutr, 44, 285
  35. ES Cooper, “Catch-up” growth velocities after treatment for Trichuris dysentery syndrome, Trans R Soc Trop Med Hyg, 89, 653, 10.1016/0035-9203(95)90430-1 · DOI
  36. RK Grencis, 1997, Production of an interferon-gamma homologue by an intestinal nematode: functionally significant or interesting artefact?, Parasitology, 115, S101, 10.1017/S0031182097002114 · DOI
  37. CS Potten, 1997, The intestinal epithelial stem cell: the mucosal governor, Int J Exp Pathol, 78, 219, 10.1046/j.1365-2613.1997.280362.x · DOI
  38. T Mizoshita, 2013, Colon Mucosa Exhibits Loss of Ectopic MUC5AC Expression in Patients with Ulcerative Colitis Treated with Oral Tacrolimus, ISRN Gastroenterol, 2013, 304894, 10.1155/2013/304894 · DOI
  39. SZ Hasnain, 2010, Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection, Gastroenterology, 138, 1763, 10.1053/j.gastro.2010.01.045 · DOI
  40. SE Levison, 2010, Colonic transcriptional profiling in resistance and susceptibility to trichuriasis: phenotyping a chronic colitis and lessons for iatrogenic helminthosis, Inflamm Bowel Dis, 16, 2065, 10.1002/ibd.21326 · DOI
  41. LD McVay, 2006, Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis, J Clin Invest, 116, 2914, 10.1172/JCI28121 · DOI
  42. MG Nair, 2008, Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation, J Immunol, 181, 4709, 10.4049/jimmunol.181.7.4709 · DOI
  43. SE Levison, 2013, Genetic analysis of the Trichuris muris-induced model of colitis reveals QTL overlap and a novel gene cluster for establishing colonic inflammation, BMC Genomics, 14, 127, 10.1186/1471-2164-14-127 · DOI
  44. H Helmby, 2001, Interleukin (IL)-18 promotes the development of chronic gastrointestinal helminth infection by downregulating IL-13, J Exp Med, 194, 355, 10.1084/jem.194.3.355 · DOI
  45. TT Pizarro, 1999, IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn’s disease: expression and localization in intestinal mucosal cells, J Immunol, 162, 6829, 10.4049/jimmunol.162.11.6829 · DOI
  46. G Monteleone, 1999, Bioactive IL-18 expression is up-regulated in Crohn’s disease, J Immunol, 163, 143, 10.4049/jimmunol.163.1.143 · DOI
  47. R Nowarski, 2015, Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis, Cell, 163, 1444, 10.1016/j.cell.2015.10.072 · DOI
  48. RM Maizels, 2003, Immune regulation by helminth parasites: cellular and molecular mechanisms, Nat Rev Immunol, 3, 733, 10.1038/nri1183 · DOI
  49. J V Weinstock, 2014, Helminth infections decrease host susceptibility to immune-mediated diseases, J Immunol, 193, 3239, 10.4049/jimmunol.1400927 · DOI
  50. MC Starr, 2011, Soil-transmitted helminthiasis in the United States: A systematic review—1940–2010, Am J Trop Med Hyg, 85, 680, 10.4269/ajtmh.2011.11-0214 · DOI
  51. PJ Hotez, 2009, Toxocariasis: America’s most common neglected infection of poverty and a helminthiasis of global importance?, PLoS Negl Trop Dis, 3, e400, 10.1371/journal.pntd.0000400 · DOI
  52. KY Won, 2008, National seroprevalence and risk factors for Zoonotic Toxocara spp. infection, Am J Trop Med Hyg, 79, 552, 10.4269/ajtmh.2008.79.552 · DOI
  53. K Mazur-Melewska, 2015, Pulmonary presentation of Toxocara sp. infection in children, Pneumonol Alergol Pol, 83, 250
  54. L Li, 2014, Asthma and toxocariasis, Ann Allergy Asthma Immunol, 113, 187, 10.1016/j.anai.2014.05.016 · DOI
  55. MG Walsh, 2011, Toxocara infection and diminished lung function in a nationally representative sample from the United States population, Int J Parasitol, 41, 243, 10.1016/j.ijpara.2010.09.006 · DOI
  56. N Sharghi, 2001, Environmental exposure to Toxocara as a possible risk factor for asthma: a clinic-based case-control study, Clin Infect Dis, 32, E111, 10.1086/319593 · DOI
  57. JR Feary, 2010, Experimental hookworm infection: a randomized placebo-controlled trial in asthma, Clin Exp Allergy, 40, 299, 10.1111/j.1365-2222.2009.03433.x · DOI · Paper page
  58. P Bager, 2010, Trichuris suis ova therapy for allergic rhinitis: a randomized, double-blind, placebo-controlled clinical trial, J Allergy Clin Immunol, 125, 123, 10.1016/j.jaci.2009.08.006 · DOI
  59. J Feary, 2009, Safety of hookworm infection in individuals with measurable airway responsiveness: a randomized placebo-controlled feasibility study, Clin Exp Allergy, 39, 1060, 10.1111/j.1365-2222.2009.03187.x · DOI
  60. AM Croft, 2012, Helminth therapy (worms) for allergic rhinitis, Cochrane database Syst Rev, 4, CD009238
  61. RW Summers, 2005, Trichuris suis therapy in Crohn’s disease, Gut, 54, 87, 10.1136/gut.2004.041749 · DOI · Paper page
  62. RW Summers, 2003, Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease, Am J Gastroenterol, 98, 2034, 10.1111/j.1572-0241.2003.07660.x · DOI
  63. RW Summers, 2005, Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial, Gastroenterology, 128, 825, 10.1053/j.gastro.2005.01.005 · DOI · Paper page
  64. SK Garg, 2014, Helminth therapy (worms) for induction of remission in inflammatory bowel disease, Cochrane database Syst Rev, 1, CD009400
  65. HJ Van Kruiningen, 2005, Potential danger in the medical use of Trichuris suis for the treatment of inflammatory bowel disease, Inflamm Bowel Dis, 11, 515, 10.1097/01.MIB.0000160369.47671.a2 · DOI
  66. JM Craig, 2014, Helminths in the lungs, Parasite Immunol, 36, 463, 10.1111/pim.12102 · DOI
  67. WJ Sandborn, 2013, Randomised clinical trial: the safety and tolerability of Trichuris suis ova in patients with Crohn’s disease, Aliment Pharmacol Ther, 38, 255, 10.1111/apt.12366 · DOI
  68. J Croese, 2006, A proof of concept study establishing Necator americanus in Crohn’s patients and reservoir donors, Gut, 55, 136, 10.1136/gut.2005.079129 · DOI · Paper page
  69. HJ McSorley, 2011, Suppression of inflammatory immune responses in celiac disease by experimental hookworm infection, PLoS ONE, 6, e24092, 10.1371/journal.pone.0024092 · DOI
  70. P Loke, 2015, Can Helminth Infection Reverse Microbial Dysbiosis?, Trends Parasitol, 31, 534, 10.1016/j.pt.2015.10.001 · DOI
  71. J Croese, 2015, Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease, J Allergy Clin Immunol, 135, 508, 10.1016/j.jaci.2014.07.022 · DOI
  72. J Correale, 2007, Association between parasite infection and immune responses in multiple sclerosis, Ann Neurol, 61, 97, 10.1002/ana.21067 · DOI
  73. JO Fleming, 2011, Probiotic helminth administration in relapsing-remitting multiple sclerosis: a phase 1 study, Mult Scler, 17, 743, 10.1177/1352458511398054 · DOI
  74. H Helmby, 2009, Helminths and our immune system: friend or foe?, Parasitol Int, 58, 121, 10.1016/j.parint.2009.02.001 · DOI
  75. H Helmby, 2015, Human helminth therapy to treat inflammatory disorders—where do we stand?, BMC Immunol, 16, 12, 10.1186/s12865-015-0074-3 · DOI · Paper page
  76. W Parker, 2014, The "hygiene hypothesis" for allergic disease is a misnomer, BMJ, 349, g5267, 10.1136/bmj.g5267 · DOI
  77. EM Brown, 2013, A fresh look at the hygiene hypothesis: how intestinal microbial exposure drives immune effector responses in atopic disease, Semin Immunol, 25, 378, 10.1016/j.smim.2013.09.003 · DOI
  78. B Zhan, 2014, Advancing a multivalent “Pan-anthelmintic” vaccine against soil-transmitted nematode infections, Expert Rev Vaccines, 13, 321, 10.1586/14760584.2014.872035 · DOI

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Metadata

Authors
Briggs, N., Weatherhead, J., Sastry, K. J., & Hotez, P. J.
Venue
PLOS Neglected Tropical Diseases
Published
2016-09-15
Volume
10
Issue
9
Pages
e0004944
ISSN
1935-2735
Cited by
53
References
1
Language
en

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Briggs, N., Weatherhead, J., Sastry, K. J., & Hotez, P. J. (2016). The Hygiene Hypothesis and Its Inconvenient Truths about Helminth Infections. PLOS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0004944