Turing Patterns Inside Cells.
Open accessAbstract
Concentration gradients inside cells are involved in key processes such as cell division and morphogenesis. Here we show that a model of the enzymatic step catalized by phosphofructokinase (PFK), a step which is responsible for the appearance of homogeneous oscillations in the glycolytic pathway, displays Turing patterns with an intrinsic length-scale that is smaller than a typical cell size. All the parameter values are fully consistent with classic experiments on glycolytic oscillations and equal diffusion coefficients are assumed for ATP and ADP. We identify the enzyme concentration and the glycolytic flux as the possible regulators of the pattern. To the best of our knowledge, this is the first closed example of Turing pattern formation in a model of a vital step of the cell metabolism, with a built-in mechanism for changing the diffusion length of the reactants, and with parameter values that are compatible with experiments. Turing patterns inside cells could provide a check-point that combines mechanical and biochemical information to trigger events during the cell division process.
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Turing patterns have been suggested in biological systems across scale, from intra-cellular processes to neuronal network organization.
“Turing patterns have been suggested in biological systems across scale, e.g. from intra-cellular processes [42] to neuronal network organization.”
From Cytoskeletal signaling: is memory encoded in microtubule lattices by CaMKII phosphorylation? (2012) · cites this paper as [42]
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- [27]Strier DE 2002 PhD thesis, Universidad de Buenos Aires.
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- Authors
- Strier, D. E., & Ponce Dawson, S.
- Affiliations
- Université Libre de Bruxelles (BE)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-10-17
- Volume
- 2
- Issue
- 10
- Pages
- e1053
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2013944
- OpenAlex
- W1977083964
- Cited by
- 37
- References
- 30
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 5 · 2012: 1
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires) (publishedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Greater South Information System
- Funders
- Santa Fe Institute
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Agencia Nacional de Promoción Científica y Tecnológica (CONICET)
- Secretaría de Ciencia y Técnica, Universidad de Buenos Aires
- Topics
- Physical Sciences › Computer Science › Computer Networks and Communications › Nonlinear Dynamics and Pattern Formation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Keywords
- Turing patterns, phosphofructokinase, glycolytic oscillations, cellular metabolism, cell division, morphogenesis, diffusion length, glycolytic flux, enzyme concentration
- MeSH terms
- Adenosine Diphosphate, Adenosine Triphosphate, Biophysics, Catalysis, Cell Division, Diffusion, Glycolysis, Models, Biological, Models, Chemical, Models, Theoretical, Morphogenesis, Oscillometry, Phosphofructokinases
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