The Balance between Plasmacytoid DC versus Conventional DC Determines Pulmonary Immunity to Virus Infections
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BACKGROUND: Respiratory syncytial virus (RSV) infects nearly all infants by age 2 and is a leading cause of bronchiolitis. RSV may employ several mechanisms to induce immune dysregulation, including dendritic cell (DC) modulation during the immune response to RSV. METHODS AND FINDINGS: Expansion of cDC and pDC by Flt3L treatment promoted an anti-viral response with reduced pathophysiology characterized by decreased airway hyperreactivity, reduced Th2 cytokines, increased Th1 cytokines, and a reduction in airway inflammation and mucus overexpression. These protective aspects of DC expansion could be completely reversed by depleting pDCs during the RSV infection. Expansion of DCs by Flt3L treatment enhanced in CD8+ T cell responses, which was reversed by depletion of pDC. CONCLUSIONS: These results indicate that a balance between cDC and pDC in the lung and its lymph nodes is crucial for the outcome of a pulmonary infection. Increased pDC numbers induced by Flt3L treatment have a protective impact on the nature of the overall immune environment.
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RSV inhibits IRF-3 activation.
“IRF-3 activation is inhibited by RSV (273) and parainfluenza viruses (165).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [273]
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The airway epithelium: soldier in the fight against respiratory viruses
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- Authors
- Smit, J. J., Lindell, D. M., Boon, L., Kool, M., Lambrecht, B. N., & Lukacs, N. W.
- Affiliations
- University of Michigan (US)
- Polpharma Biologics (Netherlands) (NL)
- Erasmus MC (NL)
- Corresponding author
- Lukacs, Nicholas W.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-03-05
- Volume
- 3
- Issue
- 3
- Pages
- e1720
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2249704
- OpenAlex
- W2121946255
- Cited by
- 93
- References
- 43
- Citations by year
- 2024: 1 · 2022: 3 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 8 · 2014: 2 · 2013: 8 · 2012: 15
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- RePub (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Amgen
- National Institutes of Health (AI036302)
- National Institute of Allergy and Infectious Diseases (AI-036302, AI-073876, R01AI036302, R01AI073876, R29AI036302)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- respiratory syncytial virus, plasmacytoid dendritic cells, myeloid dendritic cells, Flt3L, dendritic cell expansion, bronchiolitis, Th1/Th2 cytokines, airway hyperresponsiveness, CD8+ T cell responses, lung immunity, viral infection
- MeSH terms
- Animals, Bone Marrow, Dendritic Cells, Female, Flow Cytometry, Humans, Infant, Lung, Lymph Nodes, Membrane Proteins, Mice, Inbred BALB C, Cytokines, Respiratory Syncytial Virus, Human, Respiratory Syncytial Virus Infections, CD8-Positive T-Lymphocytes, Mice
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