Regulation of kainate receptor subunit mRNA by stress and corticosteroids in the rat hippocampus
Open accessAbstract
Kainate receptors are a class of ionotropic glutamate receptors that have a role in the modulation of glutamate release and synaptic plasticity in the hippocampal formation. Previous studies have implicated corticosteroids in the regulation of these receptors and recent clinical work has shown that polymorphisms in kainate receptor subunit genes are associated with susceptibility to major depression and response to anti-depressant treatment. In the present study we sought to examine the effects of chronic stress and corticosteroid treatments upon the expression of the mRNA of kainate receptor subunits GluR5-7 and KA1-2. Our results show that, after 7 days, adrenalectomy results in increased expression of hippocampal KA1, GluR6 and GluR7 mRNAs, an effect which is reversed by treatment with corticosterone in the case of KA1 and GluR7 and by aldosterone treatment in the case of GluR6. 21 days of chronic restraint stress (CRS) elevated the expression of the KA1 subunit, but had no effect on the expression of the other subunits. Similarly, 21 days of treatment with a moderate dose of corticosterone also increased KA1 mRNA in the dentate gyrus, whereas a high corticosterone dose has no effect. Our results suggest an interaction between hippocampal kainate receptor composition and the hypothalamic-pituitary-adrenal (HPA) axis and show a selective chronic stress induced modulation of the KA1 subunit in the dentate gyrus and CA3 that has implications for stress-induced adaptive structural plasticity.
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Schizophrenics express significantly reduced kainate receptors in the hippocampus.
“and schizophrenics have been found express significantly reduced kainate receptors in this region (Hunter et al., 2009;Benes et al., 2001).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Hunter et al., 2009
High glucocorticoid inputs from the adrenal gland to the hippocampus reduce the expression of kainate receptors.
“Furthermore, high glucocorticoid inputs from the adrenal gland to the hippocampus reduce the expression of kainate receptors, and schizophrenics have been found express significantly reduced kainate receptors in this region (Hunter et al., 2009;Benes et al., 2001).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Hunter et al., 2009
Adrenalectomy leads to increased expression of GRIK2 in the dentate gyrus and CA3, and of GRIK3 in DG.
“Adrenalectomy (lowering corticosteroid levels) leads to increased expression of GRIK2 in the dentate gyrus (DG) and CA3, and of GRIK3 in DG (Hunter et al., 2009) (although no change has also been reported for GRIK2 in CA3 (Joëls et al., 1996)).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Hunter et al., 2009
Chronic corticosterone treatment leads to lower expression of GRIK3 and GRIK4 in hippocampal structures, although no changes were noted for GRIK2 or GRIK5.
“Similarly, chronic treatment leads to lower expression of GRIK3 and GRIK4 in hippocampal structures, although no changes were noted for GRIK2 or GRIK5 (Hunter et al., 2009).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Hunter et al., 2009
MR binding has been reported both to lower and raise GRIK2 levels in the hippocampus.
“MR binding has been reported both to lower and raise GRIK2 levels in the hippocampus (Hunter et al., 2009;Joëls et al., 1996).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Hunter et al., 2009
Glucocorticoids differentially modulate the expression of kainate receptor mRNA in the hippocampus depending on whether MRs or GRs are bound.
“Glucocorticoids differentially modulate the expression of kainate receptor mRNA in the hippocampus depending on whether MRs or GRs are bound (Joëls et al., 1996;Hunter et al., 2009).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Hunter et al., 2009
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Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Hollmann, M., & Heinemann, S. F. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.000335 · Cited by 4,056 · see citing works
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087 · see citing works
Self-citationStress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons
Watanabe, Y., Gould, E., & McEwen, B. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)91597-8 · Cited by 1,212 · see citing works
Self-citationThe acute effects of corticosteroids on cognition: integration of animal and human model studies
LUPIEN, S., & MCEWEN, B. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00004-0 · Cited by 1,024 · see citing works
Self-citationIntraventricular kainic acid preferentially destroys hippocampal pyramidal cells
Nadler, J. V., Perry, B. W., & Cotman, C. W. (1978) · Nature · doi:10.1038/271676a0 · Cited by 745 · see citing works
Selective Loss of Hippocampal Granule Cells in the Mature Rat Brain After Adrenalectomy
Sloviter, R. S., Valiquette, G., Abrams, G., Ronk, E. C., Sollas, A. L., Paul, L. A., & Neubort, S. (1989) · Science · doi:10.1126/science.2911756 · Cited by 526 · see citing works
A complex mosaic of high-affinity kainate receptors in rat brain
Wisden, W., & Seeburg, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03582.1993 · Cited by 472 · see citing works
Beneyto, M., Kristiansen, L. V., Oni-Orisan, A., McCullumsmith, R. E., & Meador-Woodruff, J. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301312 · Cited by 408 · see citing works
Regulation of glutamate release by presynaptic kainate receptors in the hippocampus
Chittajallu, R., Vignes, M., Dev, K. K., Barnes, J. M., Collingridge, G. L., & Henley, J. M. (1996) · Nature · doi:10.1038/379078a0 · Cited by 394 · see citing works
Lowy, M. T., Gault, L. M., & Yamamoto, B. K. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb09839.x · Cited by 343 · see citing works
Contractor, A., Swanson, G. T., & Heinemann, S. F. (2001) · Neuron · doi:10.1016/s0896-6273(01)00191-x · Cited by 317 · see citing works
Distribution of the mineralocorticoid and the glucocorticoid receptor mRNAs in the rat hippocampus
Eekelen, J. A. M. V., Jiang, W., de Kloet, E. R., & Bohn, M. C. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210113 · Cited by 316 · see citing works
Kainic acid neurotoxicity toward hippocampal formation: Dependence on specific excitatory pathways
Nadler, J. V., & Cuthbertson, G. J. (1980) · Brain Research · doi:10.1016/0006-8993(80)90865-3 · Cited by 281 · see citing works
Presynaptic Kainate Receptor Mediation of Frequency Facilitation at Hippocampal Mossy Fiber Synapses
Schmitz, D., Mellor, J. R., & Nicoll, R. A. (2001) · Science · doi:10.1126/science.1057105 · Cited by 268 · see citing works
Genetic Markers of Suicidal Ideation Emerging During Citalopram Treatment of Major Depression
Laje, G., Paddock, S., Manji, H. K., Rush, A. J., Wilson, A. F., Charney, D. S., & McMahon, F. J. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06122018 · Cited by 213 · see citing works
Subunit Composition of Kainate Receptors in Hippocampal Interneurons
Mulle, C., Sailer, A., Swanson, G. T., Brana, C., O'Gorman, S., Bettler, B., & Heinemann, S. F. (2000) · Neuron · doi:10.1016/s0896-6273(00)00126-4 · Cited by 210 · see citing works
Glucocorticoids and stress: permissive and suppressive actions
MUNCK, A., & NÁRAY‐FEJES‐TÓTH, A. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39221.x · Cited by 209 · see citing works
Woolley, C. S., Gould, E., Sakai, R. R., Spencer, R. L., & McEwen, B. S. (1991) · Brain Research · doi:10.1016/0006-8993(91)90207-c · Cited by 197 · see citing works
Self-citationAssociation of GRIK4 With Outcome of Antidepressant Treatment in the STAR*D Cohort
Paddock, S., Laje, G., Charney, D. S., Rush, A. J., Wilson, A. F., Sorant, A. J. M., Lipsky, R. H., Wisniewski, S. R., Manji, H., & McMahon, F. J. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06111790 · Cited by 192 · see citing works
Han, F., Ozawa, H., Matsuda, K., Nishi, M., & Kawata, M. (2005) · Neuroscience Research · doi:10.1016/j.neures.2004.12.013 · Cited by 178 · see citing works
Luine, V. N., Spencer, R. L., & McEwen, B. S. (1993) · Brain Research · doi:10.1016/0006-8993(93)90193-q · Cited by 168 · see citing works
Self-citationAssociation of GRIK4 With Outcome of Antidepressant Treatment in the STAR*D Cohort
Ballenger, J. C. (2009) · Yearbook of Psychiatry and Applied Mental Health · doi:10.1016/s0084-3970(08)79086-8 · Cited by 167 · see citing works
Gould, E., & McEwen, B. S. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90138-o · Cited by 164 · see citing works
Self-citationMagariños, A. M., Orchinik, M., & McEwen, B. S. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00882-8 · Cited by 163 · see citing works
Self-citationDistribution of Kainate Receptor Subunits at Hippocampal Mossy Fiber Synapses
Darstein, M., Petralia, R. S., Swanson, G. T., Wenthold, R. J., & Heinemann, S. F. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-22-08013.2003 · Cited by 148 · see citing works
Neuroscience and Hormesis: Overview and General Findings
Calabrese, E. J. (2008) · Critical Reviews in Toxicology · doi:10.1080/10408440801981957 · Cited by 121 · see citing works
Presynaptic Kainate Receptors in the Hippocampus
Kullmann, D. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00507-4 · Cited by 109 · see citing works
Reagan, L. P., Gorovits, N., Hoskin, E. K., Alves, S. E., Katz, E. B., Grillo, C. A., Piroli, G. G., McEwen, B. S., & Charron, M. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051629798 · Cited by 106 · see citing works
Self-citationNishi, M., Tanaka, M., Matsuda, K., Sunaguchi, M., & Kawata, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5495-03.2004 · Cited by 96 · see citing works
Lauri, S. E., Delany, C. M., Clarke, V. R. J., Bortolotto, Z. A., Ornstein, P. L., Isaac, J. T. R., & Collingridge, G. L. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00152-6 · Cited by 93 · see citing works
Watanabe, Y., Weiland, N. G., & McEwen, B. S. (1995) · Brain Research · doi:10.1016/0006-8993(95)00235-i · Cited by 79 · see citing works
Self-citationBlackwood, D., Pickard, B. S., Thomson, P. A., Evans, K. L., Porteous, D. J., & Muir, W. J. (2007) · Neurotoxicity Research · doi:10.1007/bf03033484 · Cited by 74 · see citing works
Schiffer, H. H., & Heinemann, S. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30374 · Cited by 71 · see citing works
Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function
Raudensky, J., & Yamamoto, B. K. (2007) · Brain Research · doi:10.1016/j.brainres.2006.12.002 · Cited by 63 · see citing works
Regulation of CART mRNA by stress and corticosteroids in the hippocampus and amygdala
Hunter, R. G., Bellani, R., Bloss, E. B., Costa, A. P. C., Romeo, R. D., & McEwen, B. S. (2007) · Brain Research · doi:10.1016/j.brainres.2007.03.042 · Cited by 61 · see citing works
Self-citationGlucocorticoid Regulation of GLT-1 Glutamate Transporter Isoform Expression in the Rat Hippocampus
Autry, A. E., Grillo, C. A., Piroli, G. G., Rothstein, J. D., McEwen, B. S., & Reagan, L. P. (2006) · Neuroendocrinology · doi:10.1159/000096092 · Cited by 49 · see citing works
Self-citationWüllner, U., Standaert, D. G., Testa, C. M., Penney, J. B., & Young, A. B. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00645-8 · Cited by 45 · see citing works
Kainate Receptors and Mossy Fiber LTP
Bortolotto, Z. A., Nisticò, R., More, J. C. A., Jane, D. E., & Collingridge, G. L. (2005) · NeuroToxicology · doi:10.1016/j.neuro.2005.02.004 · Cited by 43 · see citing works
Androgens Are Neuroprotective in the Dentate Gyrus of Adrenalectomized Female Rats
Frye, C. A., & McCormick, C. M. (2000) · Stress · doi:10.3109/10253890009001122 · Cited by 43 · see citing works
Strutz‐Seebohm, N., Seebohm, G., Shumilina, E. V., Mack, A. F., Wagner, H., Lampert, A., Grahammer, F., Henke, G., Just, L., Skutella, T., et al. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.079624 · Cited by 43 · see citing works
Regulation of CART mRNA in the rat nucleus accumbens via D3 dopamine receptors
Hunter, R. G., Jones, D. C., Vicentic, A., Hue, G., Rye, D. B., & Kuhar, M. J. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.12.007 · Cited by 39 · see citing works
Self-citationde Montigny, C., Weiss, M., & Ouellette, J. (1987) · Experimental Brain Research · doi:10.1007/bf00235983 · Cited by 29 · see citing works
Corticosteroid actions on the expression of kainate receptor subunit mRNAs in rat hippocampus
Joëls, M., Bosma, A., Hendriksen, H., Diegenbach, P. C., & Kamphuis, W. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00267-v · Cited by 26 · see citing works
Adrenal hormone effects on hippocampal excitatory amino acid binding
Clark, A. S., & Cotman, C. W. (1992) · Brain Research · doi:10.1016/0006-8993(92)91202-p · Cited by 25 · see citing works
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- Authors
- Hunter, R. G., Bellani, R., Bloss, E., Costa, A., McCarthy, K., & McEwen, B. S.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- Hunter, Richard G.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-01-30
- Volume
- 4
- Issue
- 1
- Pages
- e4328
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2627898
- OpenAlex
- W2023004166
- Cited by
- 40
- References
- 46
- Citations by year
- 2025: 1 · 2024: 2 · 2021: 4 · 2020: 3 · 2019: 1 · 2016: 3 · 2014: 5 · 2013: 2 · 2012: 3
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institutes of Health (MH41256)
- National Institute of Mental Health (MH-41256, MH-15125, R37MH041256, T32MH015125, MH065749, R01MH041256, F32MH065749)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- kainate receptors, GluR5, GluR6, chronic restraint stress, corticosterone, aldosterone, adrenalectomy, hippocampus, dentate gyrus, CA3, hypothalamic-pituitary-adrenal axis, mRNA expression, synaptic plasticity, major depressive disorder
- MeSH terms
- Adrenalectomy, Aldosterone, Animals, Anti-Inflammatory Agents, Corticosterone, Gene Expression Regulation, Neuronal Plasticity, Restraint, Physical, RNA, Messenger, Stress, Psychological, Kainic Acid Receptors, Dentate Gyrus, Protein Subunits, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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