Regulation of kainate receptor subunit mRNA by stress and corticosteroids in the rat hippocampus
Open accessAbstract
Kainate receptors are a class of ionotropic glutamate receptors that have a role in the modulation of glutamate release and synaptic plasticity in the hippocampal formation. Previous studies have implicated corticosteroids in the regulation of these receptors and recent clinical work has shown that polymorphisms in kainate receptor subunit genes are associated with susceptibility to major depression and response to anti-depressant treatment. In the present study we sought to examine the effects of chronic stress and corticosteroid treatments upon the expression of the mRNA of kainate receptor subunits GluR5-7 and KA1-2. Our results show that, after 7 days, adrenalectomy results in increased expression of hippocampal KA1, GluR6 and GluR7 mRNAs, an effect which is reversed by treatment with corticosterone in the case of KA1 and GluR7 and by aldosterone treatment in the case of GluR6. 21 days of chronic restraint stress (CRS) elevated the expression of the KA1 subunit, but had no effect on the expression of the other subunits. Similarly, 21 days of treatment with a moderate dose of corticosterone also increased KA1 mRNA in the dentate gyrus, whereas a high corticosterone dose has no effect. Our results suggest an interaction between hippocampal kainate receptor composition and the hypothalamic-pituitary-adrenal (HPA) axis and show a selective chronic stress induced modulation of the KA1 subunit in the dentate gyrus and CA3 that has implications for stress-induced adaptive structural plasticity.
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Schizophrenics express significantly reduced kainate receptors in the hippocampus.
“and schizophrenics have been found express significantly reduced kainate receptors in this region (Hunter et al., 2009;Benes et al., 2001).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Hunter et al., 2009
High glucocorticoid inputs from the adrenal gland to the hippocampus reduce the expression of kainate receptors.
“Furthermore, high glucocorticoid inputs from the adrenal gland to the hippocampus reduce the expression of kainate receptors, and schizophrenics have been found express significantly reduced kainate receptors in this region (Hunter et al., 2009;Benes et al., 2001).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Hunter et al., 2009
Adrenalectomy leads to increased expression of GRIK2 in the dentate gyrus and CA3, and of GRIK3 in DG.
“Adrenalectomy (lowering corticosteroid levels) leads to increased expression of GRIK2 in the dentate gyrus (DG) and CA3, and of GRIK3 in DG (Hunter et al., 2009) (although no change has also been reported for GRIK2 in CA3 (Joëls et al., 1996)).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Hunter et al., 2009
Chronic corticosterone treatment leads to lower expression of GRIK3 and GRIK4 in hippocampal structures, although no changes were noted for GRIK2 or GRIK5.
“Similarly, chronic treatment leads to lower expression of GRIK3 and GRIK4 in hippocampal structures, although no changes were noted for GRIK2 or GRIK5 (Hunter et al., 2009).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Hunter et al., 2009
MR binding has been reported both to lower and raise GRIK2 levels in the hippocampus.
“MR binding has been reported both to lower and raise GRIK2 levels in the hippocampus (Hunter et al., 2009;Joëls et al., 1996).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Hunter et al., 2009
Glucocorticoids differentially modulate the expression of kainate receptor mRNA in the hippocampus depending on whether MRs or GRs are bound.
“Glucocorticoids differentially modulate the expression of kainate receptor mRNA in the hippocampus depending on whether MRs or GRs are bound (Joëls et al., 1996;Hunter et al., 2009).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Hunter et al., 2009
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- Authors
- Hunter, R. G., Bellani, R., Bloss, E., Costa, A., McCarthy, K., & McEwen, B. S.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- Hunter, Richard G.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-01-30
- Volume
- 4
- Issue
- 1
- Pages
- e4328
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2627898
- OpenAlex
- W2023004166
- Cited by
- 40
- References
- 46
- Citations by year
- 2025: 1 · 2024: 2 · 2021: 4 · 2020: 3 · 2019: 1 · 2016: 3 · 2014: 5 · 2013: 2 · 2012: 3
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institutes of Health (MH41256)
- National Institute of Mental Health (MH-41256, MH-15125, R37MH041256, T32MH015125, MH065749, R01MH041256, F32MH065749)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- kainate receptors, GluR5, GluR6, chronic restraint stress, corticosterone, aldosterone, adrenalectomy, hippocampus, dentate gyrus, CA3, hypothalamic-pituitary-adrenal axis, mRNA expression, synaptic plasticity, major depressive disorder
- MeSH terms
- Adrenalectomy, Aldosterone, Animals, Anti-Inflammatory Agents, Corticosterone, Gene Expression Regulation, Neuronal Plasticity, Restraint, Physical, RNA, Messenger, Stress, Psychological, Kainic Acid Receptors, Dentate Gyrus, Protein Subunits, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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