The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Adult Stromal Cells Derived from Human Adipose Tissue Provoke Pancreatic Cancer Cell Death both In Vitro and In Vivo
Open accessAbstract
BACKGROUND: Normal tissue homeostasis is maintained by dynamic interactions between epithelial cells and their microenvironment. Disrupting this homeostasis can induce aberrant cell proliferation, adhesion, function and migration that might promote malignant behavior. Indeed, aberrant stromal-epithelial interactions contribute to pancreatic ductal adenocarcinoma (PDAC) spread and metastasis, and this raises the possibility that novel stroma-targeted therapies represent additional approaches for combating this malignant disease. The aim of the present study was to determine the effect of human stromal cells derived from adipose tissue (ADSC) on pancreatic tumor cell proliferation. PRINCIPAL FINDINGS: Co-culturing pancreatic tumor cells with ADSC and ADSC-conditioned medium sampled from different donors inhibited cancer cell viability and proliferation. ADSC-mediated inhibitory effect was further extended to other epithelial cancer-derived cell lines (liver, colon, prostate). ADSC conditioned medium induced cancer cell necrosis following G1-phase arrest, without evidence of apoptosis. In vivo, a single intra-tumoral injection of ADSC in a model of pancreatic adenocarcinoma induced a strong and long-lasting inhibition of tumor growth. CONCLUSION: These data indicate that ADSC strongly inhibit PDAC proliferation, both in vitro and in vivo and induce tumor cell death by altering cell cycle progression. Therefore, ADSC may constitute a potential cell-based therapeutic alternative for the treatment of PDAC for which no effective cure is available.
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Cites
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Cited by
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The Potential of Adipose Stem Cells in Regenerative Medicine
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Adipose-derived stromal cells: their identity and uses in clinical trials, an update
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Self-citationMesenchymal stem cell secretome and regenerative therapy after cancer
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“Cervical cancer Hela Human SA No effect on survival [34]”
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Metadata
- Authors
- Cousin, B., Ravet, E., Poglio, S., De Toni, F., Bertuzzi, M., Lulka, H., Touil, I., André, M., Grolleau, J.-L., Péron, J.-M., Chavoin, J.-P., Bourin, P., Pénicaud, L., Casteilla, L., Buscail, L., & Cordelier, P.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-07-17
- Volume
- 4
- Issue
- 7
- Pages
- e6278
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2044233644
- Cited by
- 255
- References
- 56
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Adult Stromal Cells Derived from Human Adipose Tissue Provoke Pancreatic Cancer Cell Death both In Vitro and In Vivo. https://app.cochat.ai/papers/10.1371/journal.pone.0006278
- The paper
- Cousin, B., Ravet, E., Poglio, S., De Toni, F., Bertuzzi, M., Lulka, H., Touil, I., André, M., Grolleau, J.-L., Péron, J.-M., Chavoin, J.-P., Bourin, P., Pénicaud, L., Casteilla, L., Buscail, L., & Cordelier, P. (2009). Adult Stromal Cells Derived from Human Adipose Tissue Provoke Pancreatic Cancer Cell Death both In Vitro and In Vivo. PLoS ONE. https://doi.org/10.1371/journal.pone.0006278
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