The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
Melatonin Promotes Oligodendroglial Maturation of Injured White Matter in Neonatal Rats
Open accessAbstract
OBJECTIVE: To investigate the effects of melatonin treatment in a rat model of white matter damage (WMD) in the developing brain. Additionally, we aim to delineate the cellular mechanisms of melatonin effect on the oligodendroglial cell lineage. METHODS: A unilateral ligation of the uterine artery in pregnant rat at the embryonic day 17 induces fetal hypoxia and subsequent growth restriction (GR) in neonatal pups. GR and control pups received a daily intra-peritoneal injection of melatonin from birth to post-natal day (P) 3. RESULTS: Melatonin administration was associated with a dramatic decrease in microglial activation and astroglial reaction compared to untreated GR pups. At P14, melatonin prevented white matter myelination defects with an increased number of mature oligodendrocytes (APC-immunoreactive) in treated GR pups. Conversely, melatonin was not found to be associated with an increased density of total oligodendrocytes (Olig2-immunoreactive), suggesting that melatonin is able to promote oligodendrocyte maturation but not proliferation. These effects appear to be melatonin-receptor dependent and were reproduced in vitro. INTERPRETATION: These data suggest that melatonin has a strong protective effect on developing damaged white matter through decreased microglial activation and oligodendroglial maturation leading to a normalization of the myelination process. Consequently, melatonin should be a considered as an effective neuroprotective candidate not only in perinatal brain damage but also in inflammatory and demyelinating diseases observed in adults.
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“promotes oligodendroglial maturation in the newborn rat with abnormal white matter related to fetal hypoxia.105”
From Autism risk factors: genes, environment, and gene-environment interactions (2012) · cites this paper as [105]
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Metadata
- Authors
- Olivier, P., Fontaine, R. H., Loron, G., Van Steenwinckel, J., Biran, V., Massonneau, V., Kaindl, A., Dalous, J., Charriaut-Marlangue, C., Aigrot, M.-S., Pansiot, J., Verney, C., Gressens, P., & Baud, O.
- Affiliations
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Baud, Olivier
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-09-22
- Volume
- 4
- Issue
- 9
- Pages
- e7128
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2742165
- OpenAlex
- W1966357480
- Cited by
- 119
- References
- 37
- Citations by year
- 2025: 3 · 2024: 7 · 2023: 5 · 2022: 11 · 2021: 17 · 2020: 6 · 2019: 8 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 9 · 2012: 9
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Update notices
- correction (2009-10-15)
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Ikaria
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique (UMR 7101)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- melatonin, oligodendrocyte maturation, white matter injury, fetal hypoxia, growth restriction, uterine artery ligation, myelination, microglial activation, astroglial reaction, APC, Olig2, neuroprotection, perinatal brain injury, melatonin receptors
- MeSH terms
- Animals, Animals, Newborn, Brain, Cells, Cultured, Immunohistochemistry, Melatonin, Microscopy, Fluorescence, Nerve Fibers, Myelinated, Oligodendroglia, RNA, Messenger, Time Factors, Rats, Sprague-Dawley, Gene Expression Regulation, Developmental, Cell Lineage, Rats
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