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Emerging Anti-Inflammatory Pharmacotherapy and Cell-Based Therapy for Lymphedema

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Local inhibition of elastase reduces EMILIN1 cleavage reactivating lymphatic vessel function in a mouse lymphoedema model

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Lymphatic Collecting Vessel: New Perspectives on Mechanisms of Contractile Regulation and Potential Lymphatic Contractile Pathways to Target in Obesity and Metabolic Diseases

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Adrenomedullin Haploinsufficiency Predisposes to Secondary Lymphedema

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Topical captopril: a promising treatment for secondary lymphedema

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A chronic and latent lymphatic insufficiency follows recovery from acute lymphedema in the rat foreleg

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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may reduce the risk of developing cancer-related lymphedema following axillary lymph node dissection (ALND)

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The Kinetics of Lymphatic Dysfunction and Leukocyte Expansion in the Draining Lymph Node during LTB4 Antagonism in a Mouse Model of Lymphedema

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Lymphatic-draining nanoparticles deliver Bay K8644 payload to lymphatic vessels and enhance their pumping function

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Pharmacotherapy Agents in Lymphedema Treatment: A Systematic Review

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The microenvironment of secondary lymphedema. The key to finding effective treatments?

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Ca2+release-activated Ca2+channels are responsible for histamine-induced Ca2+entry, permeability increase, and interleukin synthesis in lymphatic endothelial cells

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A systematic review of pharmacologic and cell-based therapies for treatment of lymphedema (2010-2021)

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Intestinal Lymphatic Dysfunction in Kidney Disease

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PPARγ agonist treatment reduces fibroadipose tissue in secondary lymphedema by exhausting fibroadipogenic PDGFRα+ mesenchymal cells

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New and Emerging Treatments for Lymphedema

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Metformin Eliminates Lymphedema in Mice by Alleviating Inflammation and Fibrosis: Implications for Human Therapy

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Modulation of Lymphangiogenesis: A New Target for Aspirin and Other Nonsteroidal Anti‐inflammatory Agents? A Systematic Review

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Molecular pathways involved in lymphedema: Hydroxytyrosol as a candidate natural compound for treating the effects of lymph accumulation

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Therapeutic Potential of Mesenchymal Stem Cells for Postmastectomy Lymphedema: A Literature Review

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Real‐time in vivo imaging collagen in lymphedematous skin using multiphoton microscopy

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Hyaluronidase treatment of acute lymphedema in a mouse tail model.

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Histological features of skin and subcutaneous tissue in patients with breast cancer who have received neoadjuvant chemotherapy and their relationship to post-treatment edema

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Effects of Sodium Selenite Injection on Serum Metabolic Profiles in Women Diagnosed with Breast Cancer-Related Lymphedema—Secondary Analysis of a Randomized Placebo-Controlled Trial Using Global Metabolomics

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Mechanics of Lymphatic Pumping and Lymphatic FunctionPreprint

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Biologically active lipids in the regulation of lymphangiogenesis in disease states

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Characterization of Immune Cell Infiltration and Collagen Type III Disorganization in Human Secondary Lymphedema: A Case-control Study

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Dietary supplements in lymphedema

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Clinical Relevance of Animal Models of Lymphatic Dysfunction and Lymphedema

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Frontiers in Oncologic Reconstruction

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The role of exercise in promoting lymphangiogenesis and extracellular matrix synthesis in lymphedema-induced tissue injury

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Metformin Use and Risk of Breast Cancer-Related Lymphedema: A Retrospective Analysis

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Lymphedema and Lymphatic-dependent Immune Dysfunction

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Proteomic profiling of lymphedema development in mouse model

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Lymphedema

Mehrara, B. J., Coriddi, M. R., Dayan, J. H., & Kataru, R. P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-65381-7.00044-7 · Cited by 4 · see citing works

Pathophysiology and Molecular Research in Lymphedema

Kiwanuka, E., & Mehrara, B. J. (2022) · Springer eBooks · doi:10.1007/978-3-030-93039-4_3 · Cited by 5 · see citing works

Subcutaneous administration of ketoprofen delays Ehrlich solid tumor growth in mice

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Lymphatic pumping and pathological consequences of its dysfunction

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Genetics and lymphoedema: a future yet to be fully discovered

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Epigenetic reprogramming via EZH2 inhibition rescues fibroadipose pathogenesis in secondary lymphedema through activating PPARγ signaling

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Similarities and differences in the clinical features and management of primary lymphedema and kaposiform hemangioendothelioma associated with lymphedema in children

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Therapeutic Management of Breast Cancer Related Upper Limb Lymphedema

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Lymphatic biology and medicine

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Keratinocytes coordinate inflammatory responses and regulate development of secondary lymphedemaPreprint

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Breast Cancer-Related Lymphedema: A Review of Management and Innovative Surgical Techniques

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Exploratory Evaluation of Topical Tacrolimus for Prevention of Breast Cancer-Related Arm Lymphedema: A Multicenter Non-Randomized Pilot Study

Hansen, F. G., Jørgensen, M. G., Ingwersen, K. G., Kjær, C., Carstensen, L. F., Tambour, M., Gram, B., Thomsen, J. B., & Sørensen, J. A. (2025) · Cancers · doi:10.3390/cancers17233753 · Cited by 2 · see citing works

Pharmacotherapy agents in prevention and treatment of breast cancer-related lymphedema: a systematic scoping review

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Critical role of keratinocytes and protease‐activated receptor 2 in secondary lymphedema development

Park, H. J., Pal, S., Chen, X., Shin, J., Nores, G. D. G., Baik, J. E., Stull-Lane, A. R., Book, A. J., Clement, C. C., Encarnacion, E. M., et al. (2026) · Clinical and Translational Medicine · doi:10.1002/ctm2.70682 · Cited by 1 · see citing works

Pathophysiology and Molecular Research in Lymphedema

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Effect of Goreisan, a Traditional Japanese Medicine, on Rat Hindlimb Lymphedema

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Investigative strategies on lymphatic vessel modulation for treating lymphedema in future medicine

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New and Emerging Therapies for Lymphedema: Part I

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Correction: CD4+ Cells Regulate Fibrosis and Lymphangiogenesis in Response to Lymphatic Fluid Stasis

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Cyperus rotundus root extract inhibits progress of lymphedema in mouse tail modelPreprint

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Pilot studies demonstrate the potential benefits of antiinflammatory therapy in human lymphedema

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Brief Report: Treatment of Tumor Necrosis Factor–Transgenic Mice With Anti–Tumor Necrosis Factor Restores Lymphatic Contractions, Repairs Lymphatic Vessels, and May Increase Monocyte/Macrophage Egress

Bouta, E. M., Kuzin, I. I., Bentley, K. L. D. M., Wood, R. W., Rahimi, H., Ji, R., Ritchlin, C. T., Bottaro, A., Xing, L., & Schwarz, E. M. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40047 · Cited by 55 · see citing works

Du‐Huo‐Ji‐Sheng‐Tang Attenuates Inflammation of TNF‐Tg Mice Related to Promoting Lymphatic Drainage Function

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Preliminary Report: The Relevance of Tumor Necrosis Factor-α in Acquired Primary Lymphedema—A Histopathological Investigation

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The anti-inflammatory effects of ketoprofen in animal experiments.

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