MicroRNA Expression Profiling of Oligodendrocyte Differentiation from Human Embryonic Stem Cells
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The hsa-miR-221/222 family was enriched both in neurons and microglia.
“The hsa-miR-221/222 family, involved in neuroinflammation [49][50][51] , was enriched both in neurons and microglia (Supplementary Figure 2e).”
From Human brain microRNAs exhibit cell-type specificity and age dependence (2026) · cites this paper as [50]
The role of microRNAs in human oligodendrocyte precursor cells is poorly understood.
“However, the role of miRs in human OPCs is poorly understood.”
From Regulation of miRNA 219 and miRNA Clusters 338 and 17-92 in Oligodendrocytes (2012) · cites this paper as Letzen et al., 2010
miR-219-5p and miR-219-2-3p are readily detected in acutely isolated human A2B5+ cells.
“However, miR-219-5p and miR-219-2-3p were readily detected in acutely isolated human A2B5+ cells, in contrast to the previously reported in Ols derived from embryonic stem cells (Letzen et al., 2010; Figure 2H).”
From Regulation of miRNA 219 and miRNA Clusters 338 and 17-92 in Oligodendrocytes (2012) · cites this paper as Letzen et al., 2010
The current data provides evidence for the expression of miR-219, miR-338, and miR-17-92 clusters in acutely isolated-adult brain OLs in marked contrast to what was observed with human OLs derived from embryonic stem cells.
“The current data provides evidence for the expression of miR-219, miR-338, and miR-17-92 clusters in acutely isolated-adult brain OLs in marked contrast to what was observed with human OLs derived from embryonic stem cells (Letzen et al., 2010).”
From Regulation of miRNA 219 and miRNA Clusters 338 and 17-92 in Oligodendrocytes (2012) · cites this paper as Letzen et al., 2010
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Cites
Regulation of miRNA expression during neural cell specification
Smirnova, L., Gräfe, A., Seiler, A., Schumacher, S., Nitsch, R., & Wulczyn, F. G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03978.x · Cited by 707 · see citing works
Identification of Dynamically Regulated MicroRNA and mRNA Networks in Developing Oligodendrocytes
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Babenko, O., Kovalchuk, I., & Metz, G. A. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.013 · Cited by 513 · see citing works
Bujalka, H., Koenning, M., Jackson, S., Perreau, V. M., Pope, B., Hay, C. M., Mitew, S., Hill, A. F., Lu, Q. R., Wegner, M., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001625 · Cited by 271 · see citing works
“Recent reports indicate that its expression may be influenced by the coordinated activity of Olig2 and Brg1 [3] and by posttranscriptional regulation by miRNAs [37].”
BackgroundAblation of Dicer from Murine Schwann Cells Increases Their Proliferation while Blocking Myelination
Bremer, J., O'Connor, T., Tiberi, C., Rehrauer, H., Weis, J., & Aguzzi, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012450 · Cited by 87 · see citing works
Regulation of miRNA 219 and miRNA Clusters 338 and 17-92 in Oligodendrocytes
de Faria Jr., O., Cui, Q.-L., Bin, J. M., Bull, S.-J., Kennedy, T. E., Bar-Or, A., Antel, J. P., Colman, D. R., & Dhaunchak, A. S. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00046 · Cited by 54 · see citing works
Human brain microRNAs exhibit cell-type specificity and age dependence
Dubnov, S., Laski, L., Zchut, I., Avidan, O., Bennett, E. R., Greenberg, D. S., Turjeman, A., Nitzan, M., Paldor, I., & Soreq, H. (2026) · doi:10.64898/2026.01.04.697535
- Authors
- Letzen, B. S., Liu, C., Thakor, N. V., Gearhart, J. D., All, A. H., & Kerr, C. L.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-05-05
- Volume
- 5
- Issue
- 5
- Pages
- e10480
- ISSN
- 1932-6203
- PMC
- PMC2864763
- Cited by
- 107
- References
- 2
- Language
- en
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