The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Effects of Non-Thermal Plasma on Mammalian Cells
Open accessAbstract
Thermal plasmas and lasers have been widely used in medicine to cut, ablate and cauterize tissues through heating; in contrast, non-thermal plasma produces no heat, so its effects can be selective. In order to exploit the potential for clinical applications, including wound healing, sterilization, blood coagulation, and cancer treatment, a mechanistic understanding of the interaction of non-thermal plasma with living tissues is required. Using mammalian cells in culture, it is shown here that non-thermal plasma created by dielectric barrier discharge (DBD) has dose-dependent effects that range from increasing cell proliferation to inducing apoptosis. It is also shown that these effects are primarily due to formation of intracellular reactive oxygen species (ROS). We have utilized γ-H2AX to detect DNA damage induced by non-thermal plasma and found that it is initiated by production of active neutral species that most likely induce formation of organic peroxides in cell medium. Phosphorylation of H2AX following non-thermal plasma treatment is ATR dependent and ATM independent, suggesting that plasma treatment may lead to replication arrest or formation of single-stranded DNA breaks; however, plasma does not lead to formation of bulky adducts/thymine dimers.
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Cites
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
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Apoptosis, oncosis, and necrosis. An overview of cell death.
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Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo
Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.905 · Cited by 2,422
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Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
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Adachi, T., Tanaka, H., Nonomura, S., Hara, H., Kondo, S.-I., & Hori, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.11.014 · Cited by 334
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Toyokuni, S. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.401 · Cited by 96
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Metadata
- Authors
- Kalghatgi, S., Kelly, C. M., Cerchar, E., Torabi, B., Alekseev, O., Fridman, A., Friedman, G., & Azizkhan-Clifford, J.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-01-21
- Volume
- 6
- Issue
- 1
- Pages
- e16270
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2058181209
- Cited by
- 508
- References
- 34
- FWCI
- 28.73
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kalghatgi, S., Kelly, C. M., Cerchar, E., Torabi, B., Alekseev, O., Fridman, A., Friedman, G., & Azizkhan-Clifford, J. (2011). Effects of Non-Thermal Plasma on Mammalian Cells. PLoS ONE. https://doi.org/10.1371/journal.pone.0016270
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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