The DOI matches its Crossref record; 46 of the 48 references it cites were found in a registry or an index.
History Shaped the Geographic Distribution of Genomic Admixture on the Island of Puerto Rico
Open accessAbstract
Contemporary genetic variation among Latin Americans human groups reflects population migrations shaped by complex historical, social and economic factors. Consequently, admixture patterns may vary by geographic regions ranging from countries to neighborhoods. We examined the geographic variation of admixture across the island of Puerto Rico and the degree to which it could be explained by historic and social events. We analyzed a census-based sample of 642 Puerto Rican individuals that were genotyped for 93 ancestry informative markers (AIMs) to estimate African, European and Native American ancestry. Socioeconomic status (SES) data and geographic location were obtained for each individual. There was significant geographic variation of ancestry across the island. In particular, African ancestry demonstrated a decreasing East to West gradient that was partially explained by historical factors linked to the colonial sugar plantation system. SES also demonstrated a parallel decreasing cline from East to West. However, at a local level, SES and African ancestry were negatively correlated. European ancestry was strongly negatively correlated with African ancestry and therefore showed patterns complementary to African ancestry. By contrast, Native American ancestry showed little variation across the island and across individuals and appears to have played little social role historically. The observed geographic distributions of SES and genetic variation relate to historical social events and mating patterns, and have substantial implications for the design of studies in the recently admixed Puerto Rican population. More generally, our results demonstrate the importance of incorporating social and geographic data with genetics when studying contemporary admixed populations.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
![Figure 2 Goodness of fit of the regression model of historic variables on African ancestry. Local R2 values were calculated using a geographically weighted regression (GWR) model [48] and interpolation plots showed geographical variation in the accuracy of the regression model.](/paper-figures/1634f6399247455c8ae5147bd76e5b86/history-shaped-the-geographic-distribution-of-genomic-admixture-on-the-island-of-figure-2.jpg)
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Further stratification of individuals by their self-reported population affiliation (e.g., “Mexican,” “Puerto Rican,” or “Dominican”) reveals a diversity in genetic ancestry, consistent with previous work studying these populations (see Figure S5 and Table S5).10,20,24,25,68,69”
From The genetic ancestry of African Americans, Latinos, and European Americans across the United States (2015) · cites this paper as [68]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Inference of Population Structure Using Multilocus Genotype Data
Pritchard, J. K., Stephens, M., & Donnelly, P. (2000) · Genetics · doi:10.1093/genetics/155.2.945 · Cited by 33,871
Falush, D., Stephens, M., & Pritchard, J. K. (2003) · Genetics · doi:10.1093/genetics/164.4.1567 · Cited by 8,006
The Analysis of Spatial Association by Use of Distance Statistics
Getis, A., & Ord, J. K. (1992) · Geographical Analysis · doi:10.1111/j.1538-4632.1992.tb00261.x · Cited by 6,276
Geographically Weighted Regression: The Analysis of Spatially Varying Relationships
Fotheringham, A. S., Brunsdon, C., & Charlton, M. E. (2002) · doi:10.25405/ncl.34562610 · Cited by 3,939
The History and Geography of Human Genes
Cavalli-Sforza, L. L., Menozzi, P., & Piazza, A. (2018) · Princeton University Press eBooks · doi:10.2307/j.ctv301gjp · Cited by 3,175
The Interpretation of Statistical Maps
Moran, P. A. P. (1948) · Journal of the Royal Statistical Society Series B (Statistical Methodology) · doi:10.1111/j.2517-6161.1948.tb00012.x · Cited by 2,936
History and Geography of Human Genes
Piazza, A. (1994) · Advances in forensic haemogenetics · doi:10.1007/978-3-642-78782-9_1 · Cited by 1,639
Genes mirror geography within Europe
Novembre, J., Johnson, T., Bryc, K., Kutalik, Z., Boyko, A. R., Auton, A., Indap, A., King, K. S., Bergmann, S., Nelson, M. R., et al. (2008) · Nature · doi:10.1038/nature07331 · Cited by 1,479
The effects of human population structure on large genetic association studies
Marchini, J., Cardon, L. R., Phillips, M. S., & Donnelly, P. (2004) · Nature Genetics · doi:10.1038/ng1337 · Cited by 869
Mapping Human Genetic Diversity in Asia
Abdulla, M. A., Ahmed, I., Assawamakin, A., Bhak, J., Brahmachari, S. K., Calacal, G. C., Chaurasia, A., Chen, C.-H., Chen, J., Chen, Y.-T., et al. (2009) · Science · doi:10.1126/science.1177074 · Cited by 707
Research works printed but not linked: 1
- EH Isaaks, 1989, Applied geostatistics. New York: Oxford University Press., xix, 561
Cited by
Sorted by citations
The genetic ancestry of African Americans, Latinos, and European Americans across the United States
Bryc, K., Durand, E. Y., Macpherson, J. M., Reich, D., & Mountain, J. L. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.11.010 · Cited by 712
Genomic Ancestry of North Africans Supports Back-to-Africa Migrations
Henn, B. M., Botigué, L. R., Gravel, S., Wang, W., Brisbin, A., Byrnes, J. K., Fadhlaoui-Zid, K., Zalloua, P. A., Moreno-Estrada, A., Bertranpetit, J., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002397 · Cited by 331
Reconstructing the population genetic history of the Caribbean
Moreno-Estrada, A., Gravel, S., Zakharia, F., McCauley, J. L., Byrnes, J. K., Gignoux, C. R., Ortiz-Tello, P. A., Martínez, R. J., Hedges, D. J., Morris, R. W., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003925 · Cited by 327
Self-citationGalanter, J., Fernández-López, J. C., Gignoux, C. R., Barnholtz‐Sloan, J. S., Fernández–Rozadilla, C., Vía, M., Hidalgo‐Miranda, A., Contreras, A. V., Uribe-Figueroa, L., Raska, P., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002554 · Cited by 305
Self-citationInterethnic admixture and the evolution of Latin American populations
Salzano, F. M., & Sans, M. (2014) · Genetics and Molecular Biology · doi:10.1590/s1415-47572014000200003 · Cited by 249
Vitamin D Insufficiency and Severe Asthma Exacerbations in Puerto Rican Children
Brehm, J. M., Acosta‐Pérez, E., Klei, L., Roeder, K., Barmada, M. M., Boutaoui, N., Forno, E., Kelly, R., Paul, K., Sylvia, J. S., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201203-0431oc · Cited by 224
Reconstructing Native American Migrations from Whole-Genome and Whole-Exome Data
Gravel, S., Zakharia, F., Moreno‐Estrada, A., Byrnes, J., Muzzio, M., Rodríguez-Flores, J. L., Kenny, E. E., Gignoux, C. R., Maples, B. K., Guiblet, W. M., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1004023 · Cited by 181
Self-citationHeterogeneity in Genetic Admixture across Different Regions of Argentina
Avena, S. A., Vía, M., Ziv, E., Pérez‐Stable, E. J., Gignoux, C. R., Dejean, C. B., Huntsman, S., Torres-Mejı́a, G., Dutil, J., Matta, J. L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034695 · Cited by 153
Self-citationGenetic ancestry influences asthma susceptibility and lung function among Latinos
Pino-Yanes, M. D. M., Thakur, N., Gignoux, C. R., Galanter, J., Roth, L. A., Eng, C. S., Nishimura, K. K., Oh, S. S., Vora, H., Huntsman, S., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.07.053 · Cited by 119
Self-citationVariability in Cancer Risk and Outcomes Within US Latinos by National Origin and Genetic Ancestry
Stern, M. C., Fejerman, L., Das, R., Setiawan, V. W., Cruz-Correa, M. R., Pérez‐Stable, E. J., & Figueiredo, J. C. (2016) · Current Epidemiology Reports · doi:10.1007/s40471-016-0083-7 · Cited by 101
Self-citationAdhikari, K., Mendoza‐Revilla, J., Chacón-Duque, J. C., Fuentes‐Guajardo, M., & Ruiz‐Linares, A. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.09.003 · Cited by 104
Patterns of Admixture and Population Structure in Native Populations of Northwest North America
Verdu, P., Pemberton, T. J., Laurent, R., Kemp, B. M., González‐Oliver, A., Gorodezky, C., Hughes, C. E., Shattuck, M. R., Petzelt, B., Mitchell, J., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004530 · Cited by 93
Teruel, B. M., Parra, E. J., Fuentes-Smith, E., Salas, A., Buttenschøn, H. N., Demontis, D., Torres, M. L., Padrón, L. C. M., Gómez-Cabezas, E. J., Álvarez‐Iglesias, V., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004488 · Cited by 93
The spectrum of BRCA1 and BRCA2 alleles in Latin America and the Caribbean: a clinical perspective
Dutil, J., Golubeva, V. A., Pacheco‐Torres, A. L., Diaz-Zabala, H. J., Matta, J. L., & Monteiro, Á. N. A. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3629-3 · Cited by 87
Harris, A. M., Garud, N. R., & DeGiorgio, M. (2018) · Genetics · doi:10.1534/genetics.118.301502 · Cited by 87
Ancestry-Dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity
Szpiech, Z. A., Mak, A. C. Y., White, M. J., Hu, D., Eng, C. S., Burchard, E. G., & Hernandez, R. D. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.08.011 · Cited by 66
Self-citationMapping of disease-associated variants in admixed populations
Shriner, D., Adeyemo, A., Ramos, E., Chen, G., & Rotimi, C. N. (2011) · Genome biology · doi:10.1186/gb-2011-12-5-223 · Cited by 67
Vergara, C., Murray, T., Rafaels, N. M., Lewis, R., Campbell, M., Foster, C., Gao, L., Faruque, M. U., Oliveira, R. R., Carvalho, E. M., et al. (2013) · Genetic Epidemiology · doi:10.1002/gepi.21702 · Cited by 63
The peopling of the African continent and the diaspora into the new world
Campbell, M. C., Hirbo, J. B., Townsend, J. P., & Tishkoff, S. A. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.09.003 · Cited by 56
Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes
Razali, R., Rodríguez-Flores, J. L., Ghorbani, M., Naeem, H., Aamer, W., ALIYEV, E. E., Jubran, A., Qatar Genome Project Management, Ismail, S. I., Al‐Muftah, W., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25287-y · Cited by 55
Ancient DNA Reconstructs the Genetic Legacies of Precontact Puerto Rico Communities
Nieves-Colón, M. A., Pestle, W. J., Reynolds, A. W., Llamas, B., Castro, C. D. L. F., Fowler, K., Skerry, K. M., Crespo-Torres, E. F., Bustamante, C. D., & Stone, A. C. (2019) · Molecular Biology and Evolution · doi:10.1093/molbev/msz267 · Cited by 52
Factors associated with breast cancer in Puerto Rican women
Morales, L., Alvarez-Garriga, C., Matta, J. L., Ortíz, C., Vergne, Y., Vargas, W., Acosta, H., Ramírez, J., Pérez‐Mayoral, J., & Bayona, M. (2013) · Journal of Epidemiology and Global Health · doi:10.1016/j.jegh.2013.08.003 · Cited by 48
Genetic Ancestry Analysis Reveals Misclassification of Commonly Used Cancer Cell Lines
Hooker, S. E., Woods‐Burnham, L., Bathina, M., Lloyd, S. M., Gorjala, P., Mitra, R., Nonn, L., Kimbro, K. S., & Kittles, R. A. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-18-1132 · Cited by 48
Genetic Ancestry and Risk of Mortality among U.S. Latinas with Breast Cancer
Fejerman, L., Hu, D., Huntsman, S., John, E. M., Stern, M. C., Haiman, C. A., Pérez‐Stable, E. J., & Ziv, E. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-2014 · Cited by 43
Self-citationEthnic Diversity and Warfarin Pharmacogenomics
Asiimwe, I. G., & Pirmohamed, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.866058 · Cited by 44
Mapping the Human Reference Genome’s Missing Sequence by Three-Way Admixture in Latino Genomes
Genovese, G., Handsaker, R. E., Li, H., Kenny, E. E., & McCarroll, S. A. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.07.002 · Cited by 40
Graydon, J. S., Claudio, K., Baker, S. H., Kocherla, M., Ferreira, M., Roche-Lima, A., Rodríguez-Maldonado, J., Duconge-Soler, J., & Ruaño, G. (2019) · Biomarkers in Medicine · doi:10.2217/bmm-2018-0392 · Cited by 42
Vilar, M. G., Melendez, C., Sanders, A., Walia, A., Gaieski, J. B., Owings, A. C., & Schurr, T. G. (2014) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22569 · Cited by 39
Identification of the prevalent BRCA1 and BRCA2 mutations in the female population of Puerto Rico
Dutil, J., Colon-Colon, J. L., Matta, J. L., Sutphen, R., & Echenique, M. M. (2012) · Cancer Genetics · doi:10.1016/j.cancergen.2012.04.002 · Cited by 37
Pharmacogenetics of drug-metabolizing enzymes in US Hispanics
Claudio‐Campos, K., Duconge-Soler, J., Cadilla, C. L., & Ruaño, G. (2014) · Drug Metabolism and Personalized Therapy · doi:10.1515/dmdi-2014-0023 · Cited by 37
A Novel Admixture-Based Pharmacogenetic Approach to Refine Warfarin Dosing in Caribbean Hispanics
Duconge-Soler, J., Ramos, A. S., Claudio‐Campos, K., Rivera-Miranda, G. C., Bermúdez-Bosch, L., Renta, J. Y., Cadilla, C. L., Cruz, I., Feliu, J. F., Vergara, C., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0145480 · Cited by 36
Libiger, O., & Schork, N. J. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2012.00322 · Cited by 32
Amezcua, L., Beecham, A. H., Delgado, S. R., Chinea, A. R., Burnett, M., Manrique, C. P., Gomez, R., Comabella, M., Montalbán, X., Ortega, M. R., et al. (2018) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.646 · Cited by 30
Fejerman, L., Stern, M. C., Ziv, E., John, E. M., Torres-Mejı́a, G., Hines, L. M., Wolff, R. K., Wang, W., Baumgartner, K. B., Giuliano, A. R., et al. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt110 · Cited by 29
Self-citationDiaz-Zabala, H. J., Ortiz, A. P., Garland, L., Jones, K. M., Pérez, C. M., Mora, E., Arroyo, N., Oleksyk, T. K., Echenique, M. M., Matta, J. L., et al. (2018) · Cancers · doi:10.3390/cancers10110419 · Cited by 26
Self-citationPrevalence and clinical features of multiple sclerosis in Latin America
Ojeda, E., Díaz-Cortes, D., Rosales, D., Duarte-Rey, C., Anaya, J., & Rojas‐Villarraga, A. (2012) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2012.11.028 · Cited by 24
The RSPH4A Gene in Primary Ciliary Dyskinesia
Jesus-Rojas, W. D., Meléndez-Montañez, J. M., Muñiz‐Hernández, J., Marra-Nazario, A., Alvarado-Huerta, F., Santos-López, A., Ramos-Benítez, M. J., & Mosquera, R. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031936 · Cited by 23
Woods‐Burnham, L., Basu, A., Ross, C. K. C., Love, A., Yates, C. C., León, M. A. D., Roy, S., & Casiano, C. A. (2017) · The Prostate · doi:10.1002/pros.23437 · Cited by 22
Dye, T., Tavárez, Z. Q., Perez-Ramos, J. G., Fernandez, I. D., Vega, C. V., Ocasio, D. V., Avendaño, E., Cordero, N. R. C., DiMare, C., Dozier, A. M., et al. (2021) · Journal of Community Genetics · doi:10.1007/s12687-021-00538-z · Cited by 21
Genetic ancestry and prostate cancer susceptibility SNPs in Puerto Rican and African American men
Ramírez, M. I., Kittles, R. A., Wang, X., Salgado-Montilla, J. L., Nogueras‐González, G. M., Sánchez‐Ortiz, R. F., Guerrios, L., Rivera, K., Shah‐Williams, E., Prokhorova, I. N., et al. (2017) · The Prostate · doi:10.1002/pros.23368 · Cited by 21
Claudio‐Campos, K., Labastida, A., Ramos, A. S., Gaedigk, A., Renta-Torres, J., Padilla, D., Rivera-Miranda, G. C., Scott, S. A., Ruaño, G., Cadilla, C. L., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00347 · Cited by 23
Craniometric variation and ancestry estimation in two contemporary Caribbean populations
Herrera, M. D., & Tallman, S. D. (2019) · Forensic Science International · doi:10.1016/j.forsciint.2019.110013 · Cited by 20
Germline variants in cancer genes in high-risk non-BRCA patients from Puerto Rico
Dutil, J., Teer, J. K., Golubeva, V. A., Yoder, S., Tong, W. L., Arroyo, N., Karam, R., Echenique, M. M., Matta, J. L., & Monteiro, Á. N. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-54170-6 · Cited by 19
The cervical microbiota of Hispanics living in Puerto Rico is nonoptimal regardless of HPV status
Vargas-Robles, D., Romaguera, J., Alvarado-Vélez, I., Tosado-Rodríguez, E. L., Dominicci-Maura, A., Sánchez, M. M., Wiggin, K. J., Gilbert, J. A., Martínez‐Ferrer, M., Forney, L. J., et al. (2023) · mSystems · doi:10.1128/msystems.00357-23 · Cited by 20
The Genetics of Primary Ciliary Dyskinesia in Puerto Rico
Jesus-Rojas, W. D., Muñiz‐Hernández, J., Alvarado-Huerta, F., Meléndez-Montañez, J. M., Santos-López, A., & Mosquera, R. A. (2022) · Diagnostics · doi:10.3390/diagnostics12051127 · Cited by 18
Levran, O., Awolesi, O., Shen, P., Adelson, M., & Kreek, M. J. (2012) · Human Genomics · doi:10.1186/1479-7364-6-2 · Cited by 18
Biogeographic Ancestry and Socioeconomic Outcomes in the Americas: A Meta-Analysis
Kirkegaard, E. O. W., Wang, M., & Fuerst, J. G. R. (2017) · Mankind Quarterly · doi:10.46469/mq.2017.57.3.10 · Cited by 17
Geographic substructure in craniometric estimates of admixture for contemporary American populations
Algee‐Hewitt, B. F. B. (2017) · American Journal of Physical Anthropology · doi:10.1002/ajpa.23267 · Cited by 14
Haasl, R. J., McCarty, C. A., & Payseur, B. A. (2012) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.258 · Cited by 16
Salgado-Montilla, J. L., Rodríguez-Cabán, J. L., Garcia, J. S., Sánchez‐Ortiz, R. F., & Ramírez, M. I. (2017) · Archives in Cancer Research · doi:10.21767/2254-6081.1000148 · Cited by 15
Núñez-Marrero, Á. R., Arroyo, N., Godoy, L. J., Rahman, M. Z., Matta, J. L., & Dutil, J. (2020) · Oncotarget · doi:10.18632/oncotarget.27707 · Cited by 15
The Puerto Rico Alzheimer Disease Initiative (PRADI): A Multisource Ascertainment Approach
Feliciano‐Astacio, B. E., Celis, K., Ramos, J. D., Rajabli, F., Adams, L. D., Rodríguez, A., Rodríguez, V., Bussies, P. L., Sierra, C., Manrique, P., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00538 · Cited by 14
Smit, A. K., Collazo-Roman, M., Vadaparampil, S. T., Valavanis, S., Rio, J. D., Soto, B. L., Flores, I., Dutil, J., & Kanetsky, P. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-64019-y · Cited by 14
Breast Cancer and DNA Repair Capacity: Association With Use of Multivitamin and Calcium Supplements.
Vergne, Y., Matta, J. L., Morales, L., Vargas, W., Alvarez-Garriga, C., & Bayona, M. (2013) · PubMed · Cited by 14
Campos, M., Pomeroy, J. J., Mays, M. H., Lopez, A., & Palacios, C. S. (2020) · Contemporary Clinical Trials · doi:10.1016/j.cct.2020.106185 · Cited by 14
Genetic Structure and Forensic Feature of 38 X-Chromosome InDels in the Henan Han Chinese Population
Zhang, L., Zhu, Z., Du, W., Li, S., & Liu, C. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2021.805936 · Cited by 13
Admixture and Ethno-Specific Alleles: Missing Links for Global Pharmacogenomics
Duconge-Soler, J., & Ruaño, G. (2016) · Pharmacogenomics · doi:10.2217/pgs-2016-0115 · Cited by 13
Alves, R., Mendes, T., Pinto, J., & Correia, N. (2025) · Specialty journal of Pharmacognosy Phytochemistry and Biotechnology · doi:10.51847/3jxe52pnli · Cited by 12
Montes‐Rodríguez, I. M., Soto‐Salgado, M., Torres‐Cintrón, C. R., Tomassini-Fernandini, J. C., Suarez, E. L., Clavell, L. A., & Cadilla, C. L. (2023) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-22-1227 · Cited by 12
Do Hispanic Men Have Worse Outcomes After Radical Prostatectomy? Results From SEARCH
Guerrios‐Rivera, L., Howard, L. E., Klaassen, Z. W. A., Terris, M. K., Cooperberg, M. R., Amling, C. L., Kane, C. J., Aronson, W. J., & Freedland, S. J. (2020) · Urology · doi:10.1016/j.urology.2020.10.043 · Cited by 9
Dysregulation of DNA Methylation and Epigenetic Clocks in Prostate Cancer among Puerto Rican Men
Berglund, A., Matta, J. L., Encarnación-Medina, J., Ortíz, C., Dutil, J., Linares, R., Marcial, J., Abreu-Takemura, C., Moreno, N., Putney, R. M., et al. (2021) · Biomolecules · doi:10.3390/biom12010002 · Cited by 9
Why admixture matters in genetically-guided therapy: missed targets in the COAG and EU-PACT trials.
Duconge-Soler, J., Cadilla, C. L., Seip, R. L., & Ruaño, G. (2015) · PubMed · Cited by 9
Anthropological genetic insights on Caribbean population history
Nieves-Colón, M. A. (2022) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.21935 · Cited by 8
Erdei, E., Sheng, H., Maestas, E., Mackey, A. J., White, K. A., Li, L., Dong, Y., Taylor, J., Berwick, M., & Morse, D. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023950 · Cited by 8
Soto, Algee-Hewitt, Morante, Slice, & Steadman, D. W. (2018) · Human Biology · doi:10.13110/humanbiology.90.3.02 · Cited by 7
Guidelines for genetic ancestry inference created through roundtable discussions
Wagner, J. K., Yu, J., Fullwiley, D., Moore, C., Wilson, J. F., Bamshad, M. J., & Royal, C. D. M. (2023) · Human Genetics and Genomics Advances · doi:10.1016/j.xhgg.2023.100178 · Cited by 8
Nieves-Colón, M. A., Ulrich, E. C., Chen, L., Colón, G. A. T., Clemente, M. R., Integra, L. C. P. S., & Torres, J. B. (2024) · American Journal of Biological Anthropology · doi:10.1002/ajpa.25029 · Cited by 5
Odierna, D. H., Afable, A., Ikediobi, O. N., Beattie, M. S., Knight, S. J., Ko, M., Wilson, A., & Ponce, N. A. (2011) · Personalized Medicine · doi:10.2217/pme.11.67 · Cited by 5
Diaz-Zabala, H. J., Nieves-Colón, M. A., & Martínez‐Cruzado, J. C. (2017) · Human Biology · doi:10.13110/humanbiology.89.2.04 · Cited by 5
Self-citationHernández-Suárez, D. F., Tomassini-Fernandini, J. C., Cuevas, A., Rosario-Berrios, A. N., Nuñez-Medina, H., Padilla-Arroyo, D., Rivera, N., Liriano, J., Vega-Roman, R., Renta, J. Y., et al. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15061115 · Cited by 5
The genetic ancestry of African, Latino, and European Americans across the United StatesPreprint
Bryc, K., Durand, E., Macpherson, J. M., Reich, D., & Mountain, J. L. (2014) · bioRxiv · doi:10.1101/009340 · Cited by 7
Gómez‐Moreno, R., González‐Pons, M., Soto‐Salgado, M., Cruz-Correa, M. R., & Baerga‐Ortiz, A. (2019) · Diseases · doi:10.3390/diseases7010016 · Cited by 4
Jesus-Rojas, W. D., Jesús, D. R.-D., Nieves, A. M., Mosquera, R. A., & Martínez‐Cruzado, J. C. (2021) · Cureus · doi:10.7759/cureus.17673 · Cited by 4
Self-citationExploring the legacy of African and Indigenous Caribbean admixture in Puerto Rico
Winful, T., McCormack, K., Mueller, E., Chen, L., (COPI), L. C. P. S. I., Clemente, M. R., & Torres, J. B. (2023) · American Journal of Biological Anthropology · doi:10.1002/ajpa.24814 · Cited by 4
Massey, S. E. (2017) · Annals of Human Genetics · doi:10.1111/ahg.12185 · Cited by 3
da Silva, T. M., Fiaccone, R., Kehdy, F., Tarazona-Santos, E., Rodrigues, L., Costa, G. N. O., Figueiredo, C., Alcântara-Neves, N., & Barreto, M. (2018) · SSM: Population Health · doi:10.1016/j.ssmph.2018.03.006 · Cited by 2
de Moura, R. R., Balbino, V. D. Q., Crovella, S., & Brandão, L. A. C. (2015) · European Journal of Human Genetics · doi:10.1038/ejhg.2015.184 · Cited by 3
Enright, P. (2011) · Respirology · doi:10.1111/j.1440-1843.2011.01980.x · Cited by 3
Derieux-Cruz, J., Rodríguez-Padilla, M., Pérez, Y., Andújar, L. A., Ruiz-Deyá, G., Matta, J. L., Marzán‐Rodríguez, M., & Jiménez-Chávez, J. (2025) · Healthcare · doi:10.3390/healthcare13212749 · Cited by 2
Porter, T. D., del Valle, M. M., & Kucheryavykh, L. Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094947 · Cited by 2
The Role of Pyk2 Kinase in Glioblastoma Progression and Therapeutic Targeting
Kucheryavykh, L. Y., & Kucheryavykh, Y. V. (2025) · Cancers · doi:10.3390/cancers17162611 · Cited by 2
Pharmacogenomics in Latin American Populations
Botton, M. R., Campos, K. C., Duconge-Soler, J., & Scott, S. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812626-4.00012-7 · Cited by 2
Murillo, M., Elías-Boneta, A. R., García‐Rodríguez, O., & Toro, M. J. (2020) · PubMed · Cited by 2
de Queiroz, E. M., Barbosa, P. O., Cândido, A. P. C., Castro, I. M., Machado-Coelho, G. L. L., Leite, T. M., Pereira, R. W., & de Freitas, R. N. (2016) · Journal of Endocrinology and Metabolism · doi:10.14740/jem383w · Cited by 2
Genetic Ancestry and Breast Cancer Subtypes in Hispanic/Latina Women
Tamayo, L. I., Day-Friedland, E., Zavala, V. A., Marker, K. M., & Fejerman, L. (2022) · Springer eBooks · doi:10.1007/978-3-031-14436-3_7 · Cited by 3
Self-citationTise, M. L. (2014) · Digital Commons - University of South Florida (University of South Florida) · Cited by 2
Race/Ethnicity and Clinical Prediction Algorithms for Childhood Asthma
Witonsky, J. I., & Burchard, E. G. (2023) · NEJM Evidence · doi:10.1056/evide2300187 · Cited by 2
Self-citationDo Hispanic Puerto Rican men have worse outcomes after radical prostatectomy? Results from SEARCH
Guerrios‐Rivera, L., Janes, J. L., Hoedt, A. M. D., Klaassen, Z. W. A., Terris, M. K., Cooperberg, M. R., Amling, C. L., Kane, C. J., Aronson, W. J., Fowke, J. H., et al. (2024) · Cancer Medicine · doi:10.1002/cam4.7012 · Cited by 1
Dye, T., Tavárez, Z. Q., Rivera, I., & Cordero, N. R. C. (2024) · Social Science & Medicine · doi:10.1016/j.socscimed.2024.117437 · Cited by 1
López, J. J., Jang, W., Lee, S., & Omomowo, K. E. (2026) · Journal of Racial and Ethnic Health Disparities · doi:10.1007/s40615-026-03134-4 · Cited by 1
Les enjeux anthropologiques du mélange génétique
Gourjon, G. (2012) · Bulletins et Mémoires de la Société d anthropologie de Paris · doi:10.1007/s13219-012-0071-5 · Cited by 1
Admixture Indicative Interval (AII): a new approach to assess trends in genetic admixture
Gourjon, G., Saliba‐Serre, B., & Degioanni, A. (2014) · Genetica · doi:10.1007/s10709-014-9792-3 · Cited by 1
Arroyo, J. P. (2013) · Digital Commons - University of South Florida (University of South Florida) · Cited by 1
Bringing Lung Function Prediction Equations to Diverse Populations
Galanter, J. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201706-1181ed · Cited by 1
Self-citationPesta, B. J., Fuerst, J. G. R., Piffer, D., & Kirkegaard, E. O. W. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.24.312074 · Cited by 1
Diaz-Zabala, H. J., Nieves-Colón, M. A., & Martínez‐Cruzado, J. C. (2017) · Human Biology · doi:10.1353/hub.2017.0009
Self-citationVargas-Robles, D., Romaguera, J., Alvarado-Vélez, I., Tosado-Rodríguez, E. L., Dominicci-Maura, A., Sánchez, M. M., Wiggin, K. J., Gilbert, J. A., Martínez‐Ferrer, M., Forney, L. J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.05.539619
Moneró-Paredes, M., Feliu-Maldonado, R. A., Carrasquillo, K., González, P. A., Rogozin, I. B., Roche-Lima, A., & Duconge-Soler, J. (2023) · Genes · doi:10.3390/genes14091813
The Genetic Paradigm of Hereditary Breast and Ovarian Cancer (HBOC) in the Afro-Caribbean Population
Cerbon, D. A., Taylor, D., Coelho, P. B., Rodríguez, E., Schlumbrecht, M. P., Hurley, J. E., & George, S. H. L. (2024) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2024051599
Warren, R. L., Birol, İ., & Initiative, C. H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.10.658783
Metadata
- Authors
- Via, M., Gignoux, C. R., Roth, L. A., Fejerman, L., Galanter, J., Choudhry, S., Toro-Labrador, G., Viera-Vera, J., Oleksyk, T. K., Beckman, K., Ziv, E., Risch, N., Burchard, E. G., & Martínez-Cruzado, J. C.
- Affiliations
- University of California, San Francisco (US)
- University of Minnesota (US)
- Kaiser Permanente (US)
- Corresponding author
- Burchard, Esteban González
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-01-31
- Volume
- 6
- Issue
- 1
- Pages
- e16513
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3031579
- OpenAlex
- W2055697761
- Cited by
- 105
- References
- 48
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 10 · 2018: 5 · 2017: 10 · 2016: 5 · 2015: 4 · 2014: 11 · 2013: 10 · 2012: 9
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by)
- Funders
- American Thoracic Society
- Tobacco-Related Disease Research Program
- Flight Attendant Medical Research Institute
- National Institutes of Health (ES015794, AI077439)
- University of California, San Francisco
- National Heart, Lung, and Blood Institute (R01HL088133, HL078885, HL088133, R01HL078885)
- National Institute of General Medical Sciences (T32GM007546)
- National Institute of Allergy and Infectious Diseases (U19AI077439)
- National Institute of Environmental Health Sciences (R01ES015794, ES015794)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Social Sciences › Anthropology › Race, Genetics, and Society
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- genetic admixture, Puerto Rican population, African ancestry, European ancestry, Native American ancestry, socioeconomic status, ancestry informative markers, admixed populations
- MeSH terms
- Genetics, Population, Geography, Humans, Puerto Rico, Social Behavior, Genome, Human, Racial Groups
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
