The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Three-Dimensional Neurophenotyping of Adult Zebrafish Behavior
Open accessAbstract
The use of adult zebrafish (Danio rerio) in neurobehavioral research is rapidly expanding. The present large-scale study applied the newest video-tracking and data-mining technologies to further examine zebrafish anxiety-like phenotypes. Here, we generated temporal and spatial three-dimensional (3D) reconstructions of zebrafish locomotion, globally assessed behavioral profiles evoked by several anxiogenic and anxiolytic manipulations, mapped individual endpoints to 3D reconstructions, and performed cluster analysis to reconfirm behavioral correlates of high- and low-anxiety states. The application of 3D swim path reconstructions consolidates behavioral data (while increasing data density) and provides a novel way to examine and represent zebrafish behavior. It also enables rapid optimization of video tracking settings to improve quantification of automated parameters, and suggests that spatiotemporal organization of zebrafish swimming activity can be affected by various experimental manipulations in a manner predicted by their anxiolytic or anxiogenic nature. Our approach markedly enhances the power of zebrafish behavioral analyses, providing innovative framework for high-throughput 3D phenotyping of adult zebrafish behavior.
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Cites
The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio)
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The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review
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Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish
Egan, R. J., Bergner, C. L., Hart, P. C., Cachat, J. M., Canavello, P. R., Elegante, M. F., Elkhayat, S. I., Bartels, B. K., Tien, A. K., Tien, D. H., et al. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.06.022 · Cited by 1,376
Self-citationZebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation
Rihel, J., Prober, D. A., Arvanites, A., Lam, K., Zimmerman, S., Jang, S., Haggarty, S. J., Kokel, D., Rubin, L. L., Peterson, R. T., et al. (2010) · Science · doi:10.1126/science.1183090 · Cited by 778
Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects
Gerlai, R., Lahav, M., Guo, S., & Rosenthal, A. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00422-6 · Cited by 774
Choleris, E. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00011-2 · Cited by 758
Measuring behavioral and endocrine responses to novelty stress in adult zebrafish
Cachat, J., Stewart, A., Grossman, L., Gaikwad, S., Kadri, F., Chung, K. M., Wu, N., Wong, K., Roy, S., Suciu, C., et al. (2010) · Nature Protocols · doi:10.1038/nprot.2010.140 · Cited by 695
Self-citationAnxiolytic effects of nicotine in zebrafish
Levin, E. D., Bencan, Z., & Cerutti, D. T. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.08.026 · Cited by 620
Scototaxis as anxiety-like behavior in fish
Maximino, C., Marques de Brito, T., Dias, C. A. G. D. M., Gouveia, A., & Morato, S. (2010) · Nature Protocols · doi:10.1038/nprot.2009.225 · Cited by 547
Measuring anxiety in zebrafish: A critical review
Maximino, C., de Brito, T. M., da Silva Batista, A. W., Herculano, A. M., Morato, S., & Gouveia, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.05.031 · Cited by 545
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Automated image-based tracking and its application in ecology
Dell, A. I., Bender, J. A., Branson, K., Couzin, I. D., de Polavieja, G. G., Noldus, L. P. J. J., Pérez-Escudero, A., Perona, P., Straw, A. D., Wikelski, M., et al. (2014) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2014.05.004 · Cited by 492
Acute toxic effects of polyethylene microplastic on adult zebrafish
Mak, C. W., Ching-Fong Yeung, K., & Chan, K. M. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.109442 · Cited by 303
Analysis and visualisation of movement: an interdisciplinary review
Demšar, U., Buchin, K., Cagnacci, F., Safi, K., Speckmann, B., Van de Weghe, N., Weiskopf, D., & Weibel, R. (2015) · Movement Ecology · doi:10.1186/s40462-015-0032-y · Cited by 128
Metadata
- Authors
- Cachat, J., Stewart, A., Utterback, E., Hart, P., Gaikwad, S., Wong, K., Kyzar, E., Wu, N., & Kalueff, A. V.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-03-07
- Volume
- 6
- Issue
- 3
- Pages
- e17597
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2061657453
- Cited by
- 320
- References
- 73
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cachat, J., Stewart, A., Utterback, E., Hart, P., Gaikwad, S., Wong, K., Kyzar, E., Wu, N., & Kalueff, A. V. (2011). Three-Dimensional Neurophenotyping of Adult Zebrafish Behavior. PLoS ONE. https://doi.org/10.1371/journal.pone.0017597
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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