The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation
Open accessAbstract
Behavioral Profiling: The complexity of the brain makes it difficult to predict how a drug will affect behavior without direct testing in live animals. Rihel et al. (p. 348 ) developed a high-throughput assay to assess the effects of thousands of drugs on sleep/wake behaviors of zebrafish larvae. The data set reveals a broad conservation of zebrafish and mammalian sleep/wake pharmacology and identifies pathways that regulate sleep. Moreover, the biological targets of poorly characterized small molecules can be predicted by matching their behavioral profiles to those of well-known drugs. Thus, behavioral profiling in zebrafish offers a cost-effective way to characterize neuroactive drugs and to predict biological targets of novel compounds.
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Cites
How (and why) the immune system makes us sleep
Imeri, L., & Opp, M. R. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2576 · Cited by 710
How can drug discovery for psychiatric disorders be improved?
Agid, Y., Buzsáki, G., Diamond, D. M., Frackowiak, R., Giedd, J., Girault, J.-A., Grace, A., Lambert, J. J., Manji, H., Mayberg, H., et al. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2217 · Cited by 240
Anxiolytic-like effects of sinapic acid in mice
Yoon, B. H., Jung, J. W., Lee, J.-J., Cho, Y.-W., Jang, C.-G., Jin, C., Oh, T. H., & Ryu, J. H. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.05.007 · Cited by 129
Cited by
Resting-state connectivity biomarkers define neurophysiological subtypes of depression
Drysdale, A. T., Grosenick, L., Downar, J., Dunlop, K., Mansouri, F., Meng, Y., Fetcho, R. N., Zebley, B., Oathes, D. J., Etkin, A., et al. (2017) · Nature Medicine · doi:10.1038/nm.4246 · Cited by 2,170
Strähle, U., Scholz, S., Geisler, R., Greiner, P., Hollert, H., Rastegar, S., Schumacher, A., Selderslaghs, I., Weiss, C., Witters, H., et al. (2012) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.06.121 · Cited by 673
Use of Zebrafish in Drug Discovery Toxicology
Cassar, S., Adatto, I., Freeman, J. L., Gamse, J. T., Iturria, I., Lawrence, C., Muriana, A., Peterson, R. T., Van Cruchten, S., & Zon, L. I. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00335 · Cited by 561
Self-citationThree-Dimensional Neurophenotyping of Adult Zebrafish Behavior
Cachat, J., Stewart, A., Utterback, E., Hart, P., Gaikwad, S., Wong, K., Kyzar, E., Wu, N., & Kalueff, A. V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017597 · Cited by 320
Structure of the Zebrafish Locomotor Repertoire Revealed with Unsupervised Behavioral Clustering
Marques, J. C., Lackner, S., Félix, R., & Orger, M. B. (2018) · Current Biology · doi:10.1016/j.cub.2017.12.002 · Cited by 245
Metadata
- Authors
- Rihel, J., Prober, D. A., Arvanites, A., Lam, K., Zimmerman, S., Jang, S., Haggarty, S. J., Kokel, D., Rubin, L. L., Peterson, R. T., & Schier, A. F.
- Venue
- Science
- Published
- 2010-01-15
- Volume
- 327
- Issue
- 5963
- Pages
- 348-351
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2105728643
- Cited by
- 778
- References
- 3
- FWCI
- 26.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Rihel, J., Prober, D. A., Arvanites, A., Lam, K., Zimmerman, S., Jang, S., Haggarty, S. J., Kokel, D., Rubin, L. L., Peterson, R. T., & Schier, A. F. (2010). Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation. Science. https://doi.org/10.1126/science.1183090
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
