Reliability of serum metabolite concentrations over a 4-month period using a targeted metabolomic approach
Open accessAbstract
Metabolomics is a promising tool for discovery of novel biomarkers of chronic disease risk in prospective epidemiologic studies. We investigated the between- and within-person variation of the concentrations of 163 serum metabolites over a period of 4 months to evaluate the metabolite reliability expressed by the intraclass-correlation coefficient (ICC: the ratio of between-person variance and total variance). The analyses were performed with the BIOCRATES AbsoluteIDQ™ targeted metabolomics technology, including acylcarnitines, amino acids, glycerophospholipids, sphingolipids and hexose in 100 healthy individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study who had provided two fasting blood samples 4 months apart. Overall, serum reliability of metabolites over a 4-month period was good. The median ICC of the 163 metabolites was 0.57. The highest ICC was observed for hydroxysphingomyelin C14:1 (ICC = 0.85) and the lowest was found for acylcarnitine C3:1 (ICC = 0). Reliability was high for hexose (ICC = 0.76), sphingolipids (median ICC = 0.66; range: 0.24-0.85), amino acids (median ICC = 0.58; range: 0.41-0.72) and glycerophospholipids (median ICC = 0.58; range: 0.03-0.81). Among acylcarnitines, reliability of short and medium chain saturated compounds was good to excellent (ICC range: 0.50-0.81). Serum reliability was lower for most hydroxyacylcarnitines and monounsaturated acylcarnitines (ICC range: 0.11-0.45 and 0.00-0.63, respectively). For most of the metabolites a single measurement may be sufficient for risk assessment in epidemiologic studies with healthy subjects.
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On the basis of a previous evaluation of measurement reliability, metabolites below the limit of detection and those with very high analytic variance were excluded.
“On the basis of a previous evaluation of the reliability of measurements (23), we excluded metabolites below the limit of detection (n = 30) and those with very high analytic variance (n = 6).”
From Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes (2015) · cites this paper as [23]
FFQs showed good reliability and relative validity to assess meat intake, and investigated metabolites showed good reliability in validation studies.
“However, FFQs showed good reliability and relative validity to assess meat intake, and investigated metabolites showed good reliability in validation studies (23).”
From Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes (2015) · cites this paper as [23]
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- Authors
- Floegel, A., Drogan, D., Wang-Sattler, R., Prehn, C., Illig, T., Adamski, J., Joost, H.-G., Boeing, H., & Pischon, T.
- Affiliations
- German Institute of Human Nutrition (DE)
- Helmholtz Munich (DE)
- Max Delbrück Center (DE)
- Corresponding author
- Floegel, Anna
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-06-15
- Volume
- 6
- Issue
- 6
- Pages
- e21103
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3115978
- OpenAlex
- W2042418561
- Cited by
- 135
- References
- 38
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 14 · 2020: 9 · 2019: 7 · 2018: 14 · 2017: 15 · 2016: 14 · 2015: 6 · 2014: 13 · 2013: 7 · 2012: 7
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Site cant be reached (submittedVersion, cc-by)
- Funders
- Bundesministerium für Bildung und Forschung (01GI0922)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- serum metabolites, intraclass correlation coefficient, between-person variation, within-person variability, targeted metabolomics, acylcarnitines, sphingolipids, glycerophospholipids, amino acids, hexoses, biomarkers, chronic disease risk
- MeSH terms
- Female, Humans, Male, Middle Aged, Reproducibility of Results, Serum, Metabolomics
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