The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.
Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease
Open accessAbstract
BACKGROUND: We previously showed that activation of the bile salt nuclear receptor Farnesoid X Receptor (FXR) protects against intestinal inflammation in mice. Reciprocally, these inflammatory mediators may decrease FXR activation. We investigated whether FXR activation is repressed in the ileum and colon of inflammatory bowel disease (IBD) patients in remission. Additionally, we evaluated whether genetic variation in FXR is associated with IBD. METHODS: mRNA expression of FXR and FXR target gene SHP was determined in ileal and colonic biopsies of patients with Crohn's colitis (n = 15) and ulcerative colitis (UC; n = 12), all in clinical remission, and healthy controls (n = 17). Seven common tagging SNPs and two functional SNPs in FXR were genotyped in 2355 Dutch IBD patients (1162 Crohn's disease (CD) and 1193 UC) and in 853 healthy controls. RESULTS: mRNA expression of SHP in the ileum is reduced in patients with Crohn's colitis but not in patients with UC compared to controls. mRNA expression of villus marker Villin was correlated with FXR and SHP in healthy controls, a correlation that was weaker in UC patients and absent in CD patients. None of the SNPs was associated with IBD, UC or CD, nor with clinical subgroups of CD. CONCLUSIONS: FXR activation in the ileum is decreased in patients with Crohn's colitis. This may be secondary to altered enterohepatic circulation of bile salts or transrepression by inflammatory signals but does not seem to be caused by the studied SNPs in FXR. Increasing FXR activity by synthetic FXR agonists may have benefit in CD patients.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A study evaluating genetic variations in NR1H4 found no association between single-nucleotide polymorphisms in this gene and IBD risk (Nijmeijer et al., 2011).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Nijmeijer et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038
Haploview: analysis and visualization of LD and haplotype maps
Barrett, J. C., Fry, B., Maller, J., & Daly, M. J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth457 · Cited by 14,551
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Silverberg, M. S., Satsangi, J., Ahmad, T., Arnott, I. D., Bernstein, C. N., Brant, S. R., Caprilli, R., Colombel, J., Gasché, C., Geboes, K., et al. (2005) · Canadian Journal of Gastroenterology · doi:10.1155/2005/269076 · Cited by 3,410
Podolsky, D. K. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020831 · Cited by 3,183
Abraham, C., & Cho, J. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804647 · Cited by 2,712
Franke, A., McGovern, D. P. B., Barrett, J. C., Wang, K., Radford-Smith, G. L., Ahmad, T., Lees, C. W., Balschun, T., Lee, J., Roberts, R., et al. (2010) · Nature Genetics · doi:10.1038/ng.717 · Cited by 2,520
Self-citationNuclear Receptors and Lipid Physiology: Opening the X-Files
Chawla, A., Repa, J. J., Evans, R. M., & Mangelsdorf, D. J. (2001) · Science · doi:10.1126/science.294.5548.1866 · Cited by 2,085
Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis
Sartor, R. B. (2006) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0528 · Cited by 1,806
Anderson, C., Boucher, G., Lees, C., Franke, A., D'Amato, M., Taylor, K., Lee, J., Goyette, P., Imieliński, M., Latiano, A., et al. (2011) · Nature Genetics · doi:10.1038/ng.764 · Cited by 1,361
Self-citation
Flagged first, then by citations
1 of the 35 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–123 of 123
Bile Acid Receptors and Liver Regeneration
Fan, M., Ding, L., & Huang, W. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420128-6.00009-9 · Cited by 1
Design, synthesis, and biological evaluation of novel FXR agonists based on auraptene
Qiu, Q., Wang, Y., Gu, G., Fan, Y., Zhang, S., Zhao, Y., & Ling, B. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105198 · Cited by 1
Investigating Fibroblast Growth Factor 19 expression in primary and secondary bile acid diarrhoea
Nolan, J. (2016) · doi:10.25560/41879 · Cited by 1
Saxena, R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-42873-6.00029-9 · Cited by 1
Discovery, Structural Refinement and Therapeutic Potential of Farnesoid X Receptor Activators
Lamers, C., & Merk, D. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781788015783-00076 · Cited by 1
Hnf4a mediates microbial control of intestinal gene expression and inflammationPreprint
Davison, J. M., Lickwar, C. R., Song, L., Breton, G., Crawford, G. E., & Rawls, J. F. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/097055 · Cited by 1
New insights into inflammatory bowel disease and colitis-associated neoplasia
van Schaik, F. D. M. (2012) · Utrecht University Repository (Utrecht University)
Future Therapies for Primary Sclerosing Cholangitis
Lammert, C. S., & Vuppalanchi, R. (2016) · Springer eBooks · doi:10.1007/978-3-319-40908-5_12
Kitamura, T., & Watanabe, S. (2017) · Springer eBooks · doi:10.1007/978-4-431-56062-3_10
Bile Acids and Bilirubin in Liver Immunology
Zhu, C., Claudel, T., & Trauner, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-51709-0_7
The gut/liver axis, inflammation, and the pathogenesis of metabolic syndrome
Soeters, P. B., & de Leeuw, P. W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820205-0.00002-5
The Relationship between Bile Acid Metabolism and Colorectal Polyps
董, 书. (2021) · Advances in Clinical Medicine · doi:10.12677/acm.2021.116369
You, Y. N., & Bednarski, B. K. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717969142.793471431
Stepanov, Y. M., Zavhorodnia, N. Y., Кленіна, І. А., Hrabovska, O. I., & Yagmur, V. (2022) · Acta Medica (Hradec Kralove Czech Republic) · doi:10.14712/18059694.2022.26
Influence of bile acids metabolism on hepatic immunity in mice
Guinot, V. (2022) · theses.fr (ABES) · doi:10.70675/b69bb11eza30fz4874z9af2za6e31b2d5ad8
Altered bile acid metabolism in people with HIV correlates with systemic and intestinal inflammation
Irwin, S. L., Elliott, J. E., Li, F., Ruiz, P., Pr, A., Du, X., & Fulcher, J. A. (2026) · AIDS · doi:10.1097/qad.0000000000004585
SMRT regulation of nuclear receptors orchestrates bile acid homeostasis
Kim, K., Fang, S., Hong, S.-H., Cho, H., Leblanc, M., Jacinto, S., Schnabl, B., Atkins, A. R., Yu, R. T., Liddle, C., et al. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01823-y
Bile acid signaling in health and disease
Fan, Z., He, M., Liang, T., 张必利, Zhao, N., & Li, P. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00603-4
BindingDB (2015) · UC San Diego · doi:10.7270/q2z89dz0
Rowe, J. C., & Winston, J. A. (2026) · npj gut and liver. · doi:10.1038/s44355-026-00084-w
Metadata
- Authors
- Nijmeijer, R. M., Gadaleta, R. M., van Mil, S. W. C., van Bodegraven, A. A., Crusius, J. B. A., Dijkstra, G., Hommes, D. W., de Jong, D. J., Stokkers, P. C. F., Verspaget, H. W., Weersma, R. K., van der Woude, C. J., Stapelbroek, J. M., Schipper, M. E. I., Wijmenga, C., van Erpecum, K. J., Oldenburg, B., & on behalf of the Dutch Initiative on Crohn, C. (.
- Affiliations
- University Medical Center Utrecht (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- University Medical Center Groningen (NL)
- Leiden University Medical Center (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Oldenburg, Bas
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-08-22
- Volume
- 6
- Issue
- 8
- Pages
- e23745
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3161760
- OpenAlex
- W2119543164
- Cited by
- 119
- References
- 35
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 2 · 2022: 11 · 2021: 13 · 2020: 11 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 9 · 2014: 12 · 2013: 9 · 2012: 8
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by)
- UvA-DARE (University of Amsterdam) (acceptedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Leiden Repository (Leiden University) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Figshare (submittedVersion, cc-by)
- Radboud Repository (Radboud University) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Universiteit Utrecht
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- farnesoid X receptor, FXR activation, inflammatory bowel disease, Crohn's disease, ulcerative colitis, SHP, ileum, villin, genetic variation, single nucleotide polymorphisms, FXR agonists, intestinal inflammation
- MeSH terms
- Receptor, Farnesoid X-Activated, Colitis, Ulcerative, Colon, Female, Humans, Ileum, Male, RNA, Messenger, Genetic Variation, Inflammatory Bowel Diseases, Gene Expression, Case-Control Studies, Receptors, Cytoplasmic and Nuclear, Polymorphism, Single Nucleotide
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
