Inflammatory bowel disease

Abraham, Clara; Cho, Judy H.

doi:10.1056/nejmra0804647

Cited by 2,712Inflammatory Bowel DiseaseOcular Diseases and Behçet’s SyndromeAutoimmune and Inflammatory Disorders

Inflammatory bowel disease

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Abraham, Clara, Cho, Judy H.·2009·New England Journal of Medicine

DOI 10.1056/nejmra0804647PMC PMC3491806

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more than 50 distinct clinical collections, which can be used as convenient entry points to clinical content.In each collection, articles are cited in reverse chronologic order, with the most recent first.

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IBD pathogenesis involves an abnormal immune response to environmental factors in genetically susceptible people.
“The pathogenesis of IBD involves an abnormal immune response, likely to environmental factors, in genetically susceptible individuals62.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [62]

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Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
Fisher, S. A., Tremelling, M., Anderson, C. A., Gwilliam, R., Bumpstead, S., Prescott, N. J., Nimmo, E. R., Massey, D. C. O., Berzuini, C., Johnson, C., et al. (2008) · Nature Genetics · doi:10.1038/ng.145 · Cited by 424 · see citing works
Deletion of TLR5 results in spontaneous colitis in mice
Vijay–Kumar, M., Sanders, C. J., Taylor, R. T., Kumar, A., Aitken, J. D., Sitaraman, S. V., Neish, A. S., Uematsu, S., Akira, S., Williams, I. R., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci33084 · Cited by 420 · see citing works
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
Kabashima, K., Saji, T., Murata, T., Nagamachi, M., Matsuoka, T., Segi‐Nishida, E., Tsuboi, K., Sugimoto, Y., Kobayashi, T., Miyachi, Y., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214459 · Cited by 418 · see citing works
Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis
Ízcue, A., Hüe, S., Buonocore, S. M., Arancibia-Cárcamo, C. V., Ahern, P. P., Iwakura, Y., Maloy, K. J., & Powrie, F. M. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.019 · Cited by 411 · see citing works
Ulcerative colitis–risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
Silverberg, M. S., Cho, J. H., Rioux, J. D., McGovern, D. P. B., Wu, J. Q., Annese, V., Achkar, J. P., Goyette, P., Scott, R., Xu, W., et al. (2009) · Nature Genetics · doi:10.1038/ng.275 · Cited by 396 · see citing works
Toll-Like Receptor 4 Signaling by Intestinal Microbes Influences Susceptibility to Food Allergy
Bashir, M. E. H., Louie, S., Shi, H. N., & Nagler‐Anderson, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.6978 · Cited by 387 · see citing works
Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition
Robinson, A., Keely, S., Karhausen, J., Gerich, M. E., Furuta, G. T., & Colgan, S. P. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.09.033 · Cited by 368 · see citing works
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
Franke, A., Balschun, T. C., Karlsen, T. H., Hedderich, J., May, S., Lu, T. T., Schuldt, D., Nikolaus, S., Rosenstiel, P. C., Krawczak, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.148 · Cited by 352 · see citing works
Recognition of Host Immune Activation by Pseudomonas aeruginosa
Wu, L., Estrada, O., Zaborina, O. Y., Bains, M., Shen, L., Kohler, J. E., Patel, N. J., Musch, M. W., Chang, E. B., Fu, Y., et al. (2005) · Science · doi:10.1126/science.1112422 · Cited by 330 · see citing works
Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis
Watanabe, T., Asano, N., Murray, P. J., Ozato, K., Tailor, P. B., Fuss, I. J., Kitani, A., & Strober, W. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33145 · Cited by 326 · see citing works
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease
Kugathasan, S., Baldassano, R. N., Bradfield, J. P., Abou‐Sleiman, P. M., Imielinski, M. B., Guthery, S. L., Cucchiara, S., Kim, C. E., Frackelton, E. C., Annaiah, K., et al. (2008) · Nature Genetics · doi:10.1038/ng.203 · Cited by 318 · see citing works
T-cell homing specificity and plasticity: new concepts and future challenges
Mora, J. R., & von Andrian, U. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.03.007 · Cited by 306 · see citing works
IFN-γ-Induced TNFR2 Expression Is Required for TNF-Dependent Intestinal Epithelial Barrier Dysfunction
Wang, F., Schwarz, B. T., Graham, W. V., Wang, Y., Su, L., Clayburgh, D. R., Abraham, C., & Turner, J. R. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.08.022 · Cited by 305 · see citing works
Interleukin-10 Blocked Endoplasmic Reticulum Stress in Intestinal Epithelial Cells: Impact on Chronic Inflammation
Shkoda, A., Ruiz, P. A., Daniel, H., Kim, S. C., Rogler, G., Sartor, R. B., & Haller, D. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.10.030 · Cited by 278 · see citing works
Chronic stimulation of Nod2 mediates tolerance to bacterial products
Hedl, M., Li, J., Cho, J. H., & Abraham, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706097104 · Cited by 269 · see citing works
CD4+CD25bright T Cells in Human Intestinal Lamina Propria as Regulatory Cells
Makita, S., Kanai∥, T., Oshima, S., Uraushihara, K., Totsuka, T., Sawada, T., Nakamura, T., Koganei, K., Fukushima, T., & Watanabe, M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.3119 · Cited by 264 · see citing works
Reduced α-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn’s disease
Simms, L. A., Doecke, J. D., Walsh, M., Huang, N., Fowler, E. V., & Radford‐Smith, G. L. (2008) · Gut · doi:10.1136/gut.2007.142588 · Cited by 243 · see citing works
Cutting Edge: IL-23 Cross-Regulates IL-12 Production in T Cell-Dependent Experimental Colitis
Becker, C., Dornhoff, H., Neufert, C. F., Fantini, M. C., Wirtz, S. J., Huebner, S., Nikolaev, A., Lehr, H., Murphy, A. J., Valenzuela, D. M., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.2760 · Cited by 225 · see citing works
Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1–dependent pathway
Hegazi, R. A. F., Rao, K. N., Mayle, A., Sepulveda, A. R., Otterbein, L. E., & Plevy, S. E. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051047 · Cited by 219 · see citing works
The Role of Microbes in Crohn's Disease
Eckburg, P. B., & Relman, D. A. (2006) · Clinical Infectious Diseases · doi:10.1086/510385 · Cited by 206 · see citing works
T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase
Musch, M. W., Clarke, L. L., Mamah, D. T., Gawenis, L. R., Zhang, Z., Ellsworth, W., Shalowitz, D. I., Mittal, N., Efthimiou, P., Alnadjim, Z., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15695 · Cited by 185 · see citing works
Isolated Lymphoid Follicles Can Function as Sites for Induction of Mucosal Immune Responses
Lorenz, R. G., & Newberry, R. D. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1309.006 · Cited by 152 · see citing works
The link between IL-23 and Th17 cell-mediated immune pathologies
McGeachy, M. J., & Cua, D. J. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.012 · Cited by 151 · see citing works
Functional consequences of NOD2 (CARD15) mutations
Abraham, C., & Cho, J. H. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000225332.83861.5f · Cited by 130 · see citing works
Post-transcriptional Regulation of Smad7 in the Gut of Patients With Inflammatory Bowel Disease
Monteleone, G., Blanco, G. D. V., Monteleone, I., Fina, D., Caruso, R., Gioia, V., Ballerini, S., Federici, G., Bernardini, S., Pallone, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.09.005 · Cited by 107 · see citing works
Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease
Olson, T. S., Bamias, G., Naganuma, M., Rivera–Nieves, J., Burcin, T. L., Ross, W., MORRIS, M. A., Pizarro, T. T., Ernst, P. B., Cominelli, F., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20855 · Cited by 106 · see citing works
Phenotype and function of intestinal dendritic cells
Johansson, C., & Kelsall, B. L. (2005) · Seminars in Immunology · doi:10.1016/j.smim.2005.05.010 · Cited by 105 · see citing works
Absence of bacterially induced RELMβ reduces injury in the dextran sodium sulfate model of colitis
McVay, L. D., Keilbaugh, S. A., Wong, T., Kierstein, S., Shin, M. E., Lehrke, M., Lefterova, M. I., Shifflett, D. E., Barnes, S. L., Cominelli, F., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28121 · Cited by 95 · see citing works
Phenotype and Effector Function of CC Chemokine Receptor 9-Expressing Lymphocytes in Small Intestinal Crohn’s Disease
Saruta, M., Yu, Q., Avanesyan, A., Fleshner, P. R., Targan, S. R., & Papadakis, K. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.3293 · Cited by 94 · see citing works
Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment
Habtezion, A., Toivola, D. M., Butcher, E. C., & Omary, M. B. (2005) · Journal of Cell Science · doi:10.1242/jcs.02316 · Cited by 88 · see citing works
The Intestinal Microvasculature as a Therapeutic Target in Inflammatory Bowel Disease
Hatoum, O. A., Heidemann, J., & Binion, D. G. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1326.003 · Cited by 87 · see citing works
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
Nedjic, J., Aichinger, M., Emmerich, J., Mizushima, N., & Klein, L. (2008) · Nature · doi:10.1038/nature07208 · Cited by 81 · see citing works
Lymphocyte-Dependent and Th2 Cytokine-Associated Colitis in Mice Deficient in Wiskott-Aldrich Syndrome Protein
Nguyen, D. D., Maillard, M. H., Cotta-de-Almeida, V., Mizoguchi, E., Klein, C., Fuss, I. J., Nagler‐Anderson, C., Mizoguchi, A., Bhan, A. K., & Snapper, S. B. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.07.010 · Cited by 80 · see citing works
Epithelial: Lamina Propria Lymphocyte Interactions Promote Epithelial Cell Differentiation
Dahan, S., Roda, G., Pinn, D. M., Roth‐Walter, F., Kamalu, O., Martin, A. P., & Mayer, L. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.10.022 · Cited by 74 · see citing works
Helminths and Mucosal Immune Modulation
Weinstock, J. V. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1326.033 · Cited by 50 · see citing works
Generation of regulatory gut-homing human T lymphocytes using ex vivo interleukin 10 gene transfer
van Montfrans, C., Hooijberg, E., Rodríguez-Peña, M. S., de Jong, E. C., Spits, H., Velde, A. A. T., & van Deventer, S. J. H. (2002) · Gastroenterology · doi:10.1053/gast.2002.37066 · Cited by 40 · see citing works
Surveillance B lymphocytes and mucosal immunoregulation
Vel�zquez, P., Wei, B., & Braun, J. G. (2004) · Springer Seminars in Immunopathology · doi:10.1007/s00281-004-0189-8 · Cited by 25 · see citing works

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NF-κB signaling in inflammation
Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.23 · Cited by 8,791 · see citing works
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
Khera, A. V., Chaffin, M., Aragam, K. G., Haas, M. E., Roselli, C., Choi, S. H., Natarajan, P., Lander, E. S., Lubitz, S. A., Ellinor, P. T., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0183-z · Cited by 2,953 · see citing works
Ulcerative colitis
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Epidemiology and risk factors for IBD
Ananthakrishnan, A. N. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.34 · Cited by 1,741 · see citing works
Inflammatory bowel disease: Pathogenesis
Zhang, Y.-Z. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i1.91 · Cited by 1,529 · see citing works
Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease
Palm, N. W., de Zoete, M. R., Cullen, T. W., Barry, N. A., Stefanowski, J., Hao, L., Degnan, P. H., Hu, J., Peter, I., Zhang, W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.006 · Cited by 1,286 · see citing works
Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab
Chaput, N., Lepage, P., Coutzac, C., Soularue, E., Le Roux, K., Monot, C., Boselli, L., Routier, E., Cassard, L., Collins, M., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx108 · Cited by 1,310 · see citing works
Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
Bevins, C. L., & Salzman, N. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2546 · Cited by 1,238 · see citing works
Ulcerative Colitis
Danese, S., & Fiocchi, C. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1102942 · Cited by 1,113 · see citing works
A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease
Guan, Q. (2019) · Journal of Immunology Research · doi:10.1155/2019/7247238 · Cited by 1,072 · see citing works
Crohn’s disease
Roda, G., Ng, S. C., Kotze, P. G., ARGOLLO, M. C., Panaccione, R., Spinelli, A., Kaser, A., Peyrin‐Biroulet, L., & Danese, S. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0156-2 · Cited by 1,067 · see citing works
Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis
Eichele, D. D., & Kharbanda, K. K. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i33.6016 · Cited by 888 · see citing works
Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation
Sinha, S. R., Haileselassie, Y., Nguyen, L. P., Tropini, C., Wang, M., Becker, L. S., Sim, D., Jarr, K. J., Bishop, E. S., Singh, G., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2020.01.021 · Cited by 857 · see citing works
Colorectal Cancer in Inflammatory Bowel Disease: Mechanisms and Management
Shah, S. C., & Itzkowitz, S. H. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.10.035 · Cited by 849 · see citing works
Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease
Imhann, F., Vich Vila, A., Bonder, M. J., Fu, J., Gevers, D., Visschedijk, M. C., Spekhorst, L. M., Alberts, R., Franke, L., van Dullemen, H. M., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-312135 · Cited by 788 · see citing works
Alteration of gut microbiota in inflammatory bowel disease (IBD): cause or consequence? IBD treatment targeting the gut microbiome
Khan, I., Ullah, N., Zha, L., Bai, Y., Khan, A., Zhao, T., Che, T., & Zhang, C. (2019) · Pathogens · doi:10.3390/pathogens8030126 · Cited by 771 · see citing works
Obesity in autoimmune diseases: Not a passive bystander
Versini, M., Jeandel, P.-Y., Rosenthal, E., & Shoenfeld, Y. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.07.001 · Cited by 694 · see citing works
Paneth Cells: Maestros of the Small Intestinal Crypts
Clevers, H. C., & Bevins, C. L. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183744 · Cited by 698 · see citing works
The light and dark sides of intestinal intraepithelial lymphocytes
Cheroutre, H., Lambolez, F., & Mucida, D. (2011) · Nature Reviews Immunology · doi:10.1038/nri3007 · Cited by 693 · see citing works
The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases
Russo, R. C., Garcia, C. C., Teixeira, M. M., & Amaral, F. A. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.894886 · Cited by 652 · see citing works
Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease
Albenberg, L. G., & Wu, G. D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.058 · Cited by 606 · see citing works
Differences in gut microbiota in patients with vs without inflammatory bowel diseases: A systematic review
Pittayanon, R., Lau, J. T., Leontiadis, G. I., Tse, F., Yuan, Y., Surette, M., & Moayyedi, P. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.294 · Cited by 623 · see citing works
Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome
Vich Vila, A., Imhann, F., Collij, V., Jankipersadsing, S. A., Gurry, T., Mujagic, Z., Kurilshikov, A., Bonder, M. J., Jiang, X., Tigchelaar, E. F., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aap8914 · Cited by 587 · see citing works
NF‐κB signaling in inflammation and cancer
Zhang, T., Ma, C., Zhang, Z., Zhang, H., & Hu, H. (2021) · MedComm · doi:10.1002/mco2.104 · Cited by 615 · see citing works
Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases
Frank, D. N., Robertson, C. E., Hamm, C. M., Kpadeh, Z. Z., Zhang, T., Chen, H., Zhu, W., Sartor, R. B., Boedeker, E. C., Harpaz, N., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21339 · Cited by 594 · see citing works
Antibiotic therapy in inflammatory bowel disease: A systematic review and meta-analysis
Khan, K. J., Ullman, T. A., Ford, A. C., Abreu, M. T., Abadir, A., Marshall, J. K., Talley, N. J., & Moayyedi, P. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.72 · Cited by 569 · see citing works
The Integrative Human Microbiome Project: Dynamic Analysis of Microbiome-Host Omics Profiles during Periods of Human Health and Disease
(2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.08.014 · Cited by 536 · see citing works
The gut as a sensory organ
Furness, J. B., Rivera, L. R., Cho, H., Bravo, D. M., & Callaghan, B. P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.180 · Cited by 549 · see citing works
Multifunctional nanoparticle-mediated combining therapy for human diseases
Li, X., Peng, X., Zoulikha, M., Boafo, G. F., Magar, K. T., Ju, Y., & He, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01668-1 · Cited by 546 · see citing works
Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease
Ananthakrishnan, A. N., Khalili, H., Konijeti, G. G., Higuchi, L. M., de Silva, P. S., Fuchs, C. S., Willett, W. C., Richter, J. M., & Chan, A. T. (2013) · Gut · doi:10.1136/gutjnl-2013-305304 · Cited by 518 · see citing works
An Update on Inflammatory Bowel Disease
Sairenji, T., Collins, K. L., & Evans, D. (2017) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2017.07.010 · Cited by 501 · see citing works
Hidradenitis suppurativa
Goldburg, S. R., Strober, B. E., & Payette, M. J. (2019) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2019.08.090 · Cited by 490 · see citing works
Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease
Cimmino, I., Fiory, F., Perruolo, G., Miele, C., Bèguinot, F., Formisano, P., & Oriente, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165761 · Cited by 486 · see citing works
Development and validation of the Nancy histological index for UC
Bressenot, A., Salleron, J., Boulagnon‐Rombi, C., Bastien, C., Cahn, V., Cadiot, G., Diébold, M.-D., Danese, S., Reinisch, W., Schreiber, S., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-310187 · Cited by 484 · see citing works
Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome
Knights, D., Lassen, K. G., & Xavier, R. J. (2013) · Gut · doi:10.1136/gutjnl-2012-303954 · Cited by 468 · see citing works
Loss of Interleukin-10 Signaling and Infantile Inflammatory Bowel Disease: Implications for Diagnosis and Therapy
Kotlarz, D., Beier, R., Murugan, D., Diestelhorst, J., Jensen, O., Boztuǧ, K., Pfeifer, D., Kreipe, H. H., Pfister, E., Baumann, U., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.045 · Cited by 469 · see citing works
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology
Rossin, E. J., Lage, K., Raychaudhuri, S., Xavier, R. J., Tatar, D., Benita, Y., Constortium, I. I. B. D. G., Cotsapas, C., & Daly, M. J. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001273 · Cited by 438 · see citing works
Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease
Weingarden, A. R., & Vaughn, B. P. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1290757 · Cited by 469 · see citing works
Environmental enteropathy: critical implications of a poorly understood condition
Korpe, P. S., & Petri, W. A. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.04.007 · Cited by 449 · see citing works
Higher Predicted Vitamin D Status Is Associated With Reduced Risk of Crohn's Disease
Ananthakrishnan, A. N., Khalili, H., Higuchi, L. M., Bao, Y., Korzenik, J. R., Giovannucci, E. L., Richter, J. M., Fuchs, C. S., & Chan, A. T. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.11.040 · Cited by 441 · see citing works
Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: updated experimental and clinical evidence
Zhu, H., & Li, Y. R. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.011358 · Cited by 432 · see citing works
Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases
Plaza‐Díaz, J., Ruiz‐Ojeda, F. J., Vilchez-Padial, L. M., & Gil, Á. (2017) · Nutrients · doi:10.3390/nu9060555 · Cited by 432 · see citing works
Expression of the IL-23/Th17 pathway in lesions of hidradenitis suppurativa
Schlapbach, C., Hänni, T., Yawalkar, N., & Hunger, R. E. (2011) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2010.07.010 · Cited by 425 · see citing works
The spectrum of T cell metabolism in health and disease
Bantug, G. R., Galluzzi, L., Kroemer, G., & Hess, C. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.99 · Cited by 421 · see citing works
Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier
Barbara, G., Barbaro, M. R., Fuschi, D., Palombo, M., Falangone, F., Cremon, C., Marasco, G., & Stanghellini, V. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.718356 · Cited by 419 · see citing works
Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer
Rubin, D. C., Shaker, A., & Levin, M. S. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00107 · Cited by 406 · see citing works
Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease
Bourgonje, A. R., Feelisch, M., Faber, K. N., Pasch, A., Dijkstra, G. D. H., & van Goor, H. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.06.006 · Cited by 399 · see citing works
“Both are characterized by inflammation of the gut mucosa caused by an inappropriate immune response triggered by the gut microbiome in genetically susceptible individuals [1].”
Background
Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease
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Authors: Abraham, C., & Cho, J. H.
Affiliations: Yale University (US)
ORCID: Abraham, Clara
Cho, Judy H.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2009-11-19
Volume: 361
Issue: 21
Pages: 2066-2078
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra0804647
PMC: PMC3491806
OpenAlex: W4244626580
Cited by: 2,712
References: 104
Citations by year: 2026: 94 · 2025: 137 · 2024: 169 · 2023: 151 · 2022: 171 · 2021: 184 · 2020: 237 · 2019: 189 · 2018: 193 · 2017: 182 · 2016: 171 · 2015: 217 · 2014: 174 · 2013: 142 · 2012: 120
FWCI: 9.21
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Crohn's and Colitis Foundation of America (DK062422, R01DK077905)
Crohn's and Colitis Foundation
National Institutes of Health (DK P30-34989, U01 DK62429)
Takeda Oncology
National Institute of Diabetes and Digestive and Kidney Diseases (DK P30 34989, U01-DK62429, R01DK072373, R01DK077905, RC1DK086800, U01DK062429, P30DK034989, U01DK062422)
National Center for Research Resources (UL1RR024139)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Health Sciences › Medicine › Epidemiology › Autoimmune and Inflammatory Disorders
Keywords: inflammatory bowel disease
MeSH terms: Animals, Colitis, Ulcerative, Crohn Disease, Humans, Immunity, Innate, Intestinal Mucosa, T-Lymphocytes, Inflammatory Bowel Diseases, Interleukin-23, Metagenome

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