The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
High-Resolution Analysis of Cytosine Methylation in Ancient DNA
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Bisulfite conversion is also extremely harmful to DNA and, thus, generally not recommended for aDNA, despite a few successes on limited numbers of samples.
“However, bisulfite conversion is also extremely harmful to DNA and, thus, generally not recommended for aDNA, despite a few successes on limited numbers of samples 244,245 .”
From Ancient DNA analysis (2021) · cites this paper as [244]
The Results section (page unavailable) reports successful bisulphite sequencing in only one of six ancient DNA samples; the other five, with lower DNA integrity, could not be amplified despite different treatment protocols. This supports the limited-success qualifier, but the paper does not say that bisulphite conversion itself is extremely harmful to DNA or generally not recommended for ancient DNA. Its Introduction instead says methylation patterns can be resolved when nuclear DNA can be amplified. (LLM, conf=0.85)
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Citations
Cites
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Cited by
Sorted by citations
Orlando, L., Allaby, R., Skoglund, P., Der Sarkissian, C., Stockhammer, P. W., Ávila-Arcos, M. C., Fu, Q., Krause, J., Willerslev, E., Stone, A. C., et al. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-020-00011-0 · Cited by 411
Genomic structure in Europeans dating back at least 36,200 years
Seguin-Orlando, A., Korneliussen, T. S., Sikora, M., Malaspinas, A.-S., Manica, A., Moltke, I., Albrechtsen, A., Ko, A., Margaryan, A., Moiseyev, V., et al. (2014) · Science · doi:10.1126/science.aaa0114 · Cited by 315
Human evolution: a tale from ancient genomes
Llamas, B., Willerslev, E., & Orlando, L. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0484 · Cited by 100
Self-citationAssessing DNA sequence alignment methods for characterizing ancient genomes and methylomes
Poullet, M., & Orlando, L. (2020) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2020.00105 · Cited by 61
Metadata
- Authors
- Llamas, B., Holland, M. L., Chen, K., Cropley, J. E., Cooper, A., & Suter, C. M.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-01-19
- Volume
- 7
- Issue
- 1
- Pages
- e30226
- ISSN
- 1932-6203
- PMC
- PMC3261890
- Cited by
- 90
- References
- 3
- Language
- en
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