The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Copy Number Variation Affecting the Photoperiod-B1 and Vernalization-A1 Genes Is Associated with Altered Flowering Time in Wheat (Triticum aestivum)
Open accessAbstract
The timing of flowering during the year is an important adaptive character affecting reproductive success in plants and is critical to crop yield. Flowering time has been extensively manipulated in crops such as wheat (Triticum aestivum L.) during domestication, and this enables them to grow productively in a wide range of environments. Several major genes controlling flowering time have been identified in wheat with mutant alleles having sequence changes such as insertions, deletions or point mutations. We investigated genetic variants in commercial varieties of wheat that regulate flowering by altering photoperiod response (Ppd-B1 alleles) or vernalization requirement (Vrn-A1 alleles) and for which no candidate mutation was found within the gene sequence. Genetic and genomic approaches showed that in both cases alleles conferring altered flowering time had an increased copy number of the gene and altered gene expression. Alleles with an increased copy number of Ppd-B1 confer an early flowering day neutral phenotype and have arisen independently at least twice. Plants with an increased copy number of Vrn-A1 have an increased requirement for vernalization so that longer periods of cold are required to potentiate flowering. The results suggest that copy number variation (CNV) plays a significant role in wheat adaptation.
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Cites
Origins and functional impact of copy number variation in the human genome
The Wellcome Trust Case Control Consortium, Conrad, D. F., Pinto, D., Redon, R., Feuk, L., Gokcumen, O., Zhang, Y., Aerts, J., Andrews, T. D., Barnes, C., et al. (2010) · Nature · doi:10.1038/nature08516 · Cited by 1,970
Positional cloning of the wheat vernalization gene VRN1
Yan, L., Loukoianov, A., Tranquilli, G., Helguera, M., Fahima, T., & Dubcovsky, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0937399100 · Cited by 1,406
The Wheat VRN2 Gene Is a Flowering Repressor Down-Regulated by Vernalization
Yan, L., Loukoianov, A., Blechl, A., Tranquilli, G., Ramakrishna, W., SanMiguel, P., Bennetzen, J. L., Echenique, V., & Dubcovsky, J. (2004) · Science · doi:10.1126/science.1094305 · Cited by 1,159
The wheat and barley vernalization gene VRN3 is an orthologue of FT
Yan, L., Fu, D., Li, C., Blechl, A., Tranquilli, G., Bonafede, M., Sanchez, A., Valarik, M., Yasuda, S., & Dubcovsky, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607142103 · Cited by 1,121
Genome Plasticity a Key Factor in the Success of Polyploid Wheat Under Domestication
Dubcovsky, J., & Dvorak, J. (2007) · Science · doi:10.1126/science.1143986 · Cited by 1,082
Whole-genome sequencing of multiple Arabidopsis thaliana populations
Cao, J., Schneeberger, K., Ossowski, S., Günther, T., Bender, S., Fitz, J., Koenig, D., Lanz, C., Stegle, O., Lippert, C., et al. (2011) · Nature Genetics · doi:10.1038/ng.911 · Cited by 950
The Pseudo-Response Regulator Ppd-H1 Provides Adaptation to Photoperiod in Barley
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Self-citationThomas, B., & Vince‐Prue, D. (1975) · Cited by 918
Beales, J., Turner, A., Griffiths, S., Snape, J. W., & Laurie, D. A. (2007) · Theoretical and Applied Genetics · doi:10.1007/s00122-007-0603-4 · Cited by 861
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Cited by
A chromosome-based draft sequence of the hexaploid bread wheat ( Triticum aestivum ) genome
The International Wheat Genome Sequencing Consortium (IWGSC), Mayer, K. F. X., Rogers, J., Doležel, J., Pozniak, C., Eversole, K., Feuillet, C., Gill, B., Friebe, B., Lukaszewski, A. J., et al. (2014) · Science · doi:10.1126/science.1251788 · Cited by 1,583
Bogard, M., Ravel, C., Paux, E., Bordes, J., Balfourier, F., Chapman, S. C., Le Gouis, J., & Allard, V. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru328 · Cited by 87
Yaqoob, H., Tariq, A., Bhat, B. A., Bhat, K. A., Nehvi, I. B., Raza, A., Djalovic, I., Prasad, P. V., & Mir, R. A. (2023) · GM Crops & Food · doi:10.1080/21645698.2022.2146952 · Cited by 64
Bogard, M., Biddulph, B., Zheng, B., Hayden, M., Kuchel, H., Mullan, D., Allard, V., Gouis, J. L., & Chapman, S. C. (2020) · Crop Science · doi:10.1002/csc2.20113 · Cited by 29
Metadata
- Authors
- Díaz, A., Zikhali, M., Turner, A. S., Isaac, P., & Laurie, D. A.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-03-22
- Volume
- 7
- Issue
- 3
- Pages
- e33234
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2051147812
- Cited by
- 438
- References
- 30
- FWCI
- 29.21
- Type
- journal article
- Language
- en
- Open access
- gold
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- Díaz, A., Zikhali, M., Turner, A. S., Isaac, P., & Laurie, D. A. (2012). Copy Number Variation Affecting the Photoperiod-B1 and Vernalization-A1 Genes Is Associated with Altered Flowering Time in Wheat (Triticum aestivum). PLoS ONE. https://doi.org/10.1371/journal.pone.0033234
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