The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Uremic Toxins Induce Kidney Fibrosis by Activating Intrarenal Renin–Angiotensin–Aldosterone System Associated Epithelial-to-Mesenchymal Transition
Open accessAbstract
BACKGROUND: Uremic toxins are considered to have a determinant pathological role in the progression of chronic kidney disease. The aim of this study was to define the putative pathological roles of the renal renin-angiotensin-aldosterone system (RAAS) and renal tubular epithelial-to-mesenchymal transition (EMT) in kidney fibrosis induced by (indoxyl sulfate) IS and (p-cresol sulfate) PCS. METHODS: Mouse proximal renal tubular cells (PKSV-PRs) treated with IS or PCS were used. Half-nephrectomized B-6 mice were treated with IS or PCS for 4 weeks. In the losartan treatment study, the study animal was administrated with IS+losartan or PCS+losartan for 4 weeks. RESULTS: IS and PCS significantly activated the intrarenal RAAS by increasing renin, angiotensinogen, and angiotensin 1 (AT1) receptor expression, and decreasing AT2 receptor expression in vitro and in vivo. IS and PCS significantly increased transforming growth factor-β1 (TGF-β1) expression and activated the TGF-β pathway by increasing Smad2/Smad2-P, Smad3/Smad3-P, and Smad4 expression. The expression of the EMT-associated transcription factor Snail was increased by IS and PCS treatment. IS and PCS induced the phenotype of EMT-like transition in renal tubules by increasing the expression of fibronectin and α-smooth muscle actin and decreasing the expression of E-cadherin. Losartan significantly attenuated the expression of TGF-β1 and Snail, and decreased kidney fibrosis induced by IS and PCS in vivo. CONCLUSION: Activating the renal RAAS/TGF-β pathway has an important pathological role in chronic kidney injury caused by IS and PCS. IS and PCS may increase Snail expression and induce EMT-like transition.
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Micalizzi, D. S., Farabaugh, S. M., & Ford, H. L. (2010) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-010-9178-9 · Cited by 984
Barreto, F. C., Barreto, D. V., Liabeuf, S., Meert, N., Glorieux, G., Temmar, M., Choukroun, G., Vanholder, R., & Massy, Z. A. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03980609 · Cited by 929
New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis
Liu, Y. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008121226 · Cited by 870
p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease
Wu, I.-W., Hsu, K.-H., Lee, C.-C., Sun, C.-Y., Hsu, H.-J., Tsai, C.-J., Tzen, C.-Y., Wang, Y.-C., Lin, C.-Y., & Wu, M.-S. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq580 · Cited by 510
Self-citationThe role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease
Remuzzi, G., Perico, N., Macia, M., & Ruggenenti, P. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.09911.x · Cited by 505
Renin-Angiotensin-Aldosterone System and Progression of Renal Disease
Rüster, C., & Wolf, G. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006040356 · Cited by 463
Liabeuf, S., Barreto, D. V., Barreto, F. C., Meert, N., Glorieux, G., Schepers, E., Temmar, M., Choukroun, G., Vanholder, R., Massy, Z. A., et al. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfp592 · Cited by 431
Kaimori, A., Potter, J., Kaimori, J.-Y., Wang, C., Mezey, E., & Koteish, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700998200 · Cited by 355
Transforming growth factor‐β and Smad signalling in kidney diseases: Review Article
WANG, W., KOKA, V., & LAN, H. Y. (2005) · Nephrology · doi:10.1111/j.1440-1797.2005.00334.x · Cited by 347
Yu, M., Kim, Y. J., & Kang, D.-H. (2011) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05340610 · Cited by 314
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The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease
Yang, T., Richards, E. M., Pepine, C. J., & Raizada, M. K. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0018-2 · Cited by 753
Role of the Gut Microbiome in Uremia: A Potential Therapeutic Target
Ramezani, A., Massy, Z. A., Meijers, B., Evenepoel, P., Vanholder, R., & Raj, D. S. (2016) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2015.09.027 · Cited by 394
Evenepoel, P., Poesen, R., & Meijers, B. (2017) · Pediatric Nephrology · doi:10.1007/s00467-016-3527-x · Cited by 305
Protein nutrition and malnutrition in CKD and ESRD
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Metadata
- Authors
- Sun, C.-Y., Chang, S.-C., & Wu, M.-S.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-03-30
- Volume
- 7
- Issue
- 3
- Pages
- e34026
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W1971266941
- Cited by
- 310
- References
- 41
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- gold
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