Role of the Gut Microbiome in Uremia: A Potential Therapeutic Target

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

Structure, function and diversity of the healthy human microbiome

The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726 · see citing works

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works

Diversity of the Human Intestinal Microbial Flora

Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works

Human gut microbiome viewed across age and geography

Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works

Changes of Intestinal Functions in Liver Cirrhosis

Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works

A metagenome-wide association study of gut microbiota in type 2 diabetes

Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works

Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works

The gut microbiota as an environmental factor that regulates fat storage

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works

Host-Bacterial Mutualism in the Human Intestine

Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works

Functional interactions between the gut microbiota and host metabolism

Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386 · see citing works

Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk

Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,402 · see citing works

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677 · see citing works

A framework for human microbiome research

The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11209 · Cited by 2,650 · see citing works

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

Dethlefsen, L., & Relman, D. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000087107 · Cited by 2,421 · see citing works

The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing

Dethlefsen, L., Huse, S., Sogin, M. L., & Relman, D. A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060280 · Cited by 2,361 · see citing works

Inducible Foxp3 ⁺ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233 · see citing works

Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans

Muegge, B. D., Kuczynski, J., Knights, D., Clemente, J. C., González, A., Fontana, L., Henrissat, B., Knight, R., & Gordon, J. I. (2011) · Science · doi:10.1126/science.1198719 · Cited by 1,988 · see citing works

Environmental Exposure to Endotoxin and Its Relation to Asthma in School-Age Children

Braun‐Fahrländer, C., Riedler, J., Herz, U., Eder, W., Waser, M., Grize, L., Maisch, S., Carr, D., Gerlach, F., Bufe, A., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020057 · Cited by 1,810 · see citing works

H OW H OST -M ICROBIAL I NTERACTIONS S HAPE THE N UTRIENT E NVIRONMENT OF THE M AMMALIAN I NTESTINE

Hooper, L. V., Midtvedt, T., & Gordon, J. I. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.011602.092259 · Cited by 1,623 · see citing works

Interactions between commensal intestinal bacteria and the immune system

Macpherson, A. J., & Harris, N. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1373 · Cited by 1,607 · see citing works

Gut Microbiota-Dependent Trimethylamine <i>N</i> -Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

Tang, W. H. W., Wang, Z., Kennedy, D. J., Wu, Y., Buffa, J. A., Agatisa-Boyle, B., Li, X. S., Levison, B. S., & Hazen, S. L. (2015) · Circulation Research · doi:10.1161/circresaha.116.305360 · Cited by 1,223 · see citing works

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

Pluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L.-X., Rey, F., Wang, T., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215927110 · Cited by 1,191 · see citing works

Chronic kidney disease alters intestinal microbial flora

Vaziri, N. D., Wong, J., Pahl, M., Piceno, Y. M., Yuan, J., DeSantis, T. Z., Ni, Z., Nguyen, T.-H., & Andersen, G. L. (2013) · Kidney International · doi:10.1038/ki.2012.345 · Cited by 1,164 · see citing works

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

Clarke, T. B., Davis, K. M., Lysenko, E. S., Zhou, A. Y., Yu, Y., & Weiser, J. N. (2010) · Nature Medicine · doi:10.1038/nm.2087 · Cited by 1,154 · see citing works

Symbiotic gut microbes modulate human metabolic phenotypes

Li, M., Wang, B., Zhang, M., Rantalainen, M., Wang, S., Zhou, H., Zhang, Y., Shen, J., Pang, X., Zhang, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712038105 · Cited by 1,144 · see citing works

Long-term impacts of antibiotic exposure on the human intestinal microbiota

Jernberg, C., Löfmark, S., Edlund, C., & Jansson, J. K. (2010) · Microbiology · doi:10.1099/mic.0.040618-0 · Cited by 1,067 · see citing works

Bacterial Iron Sources: From Siderophores to Hemophores

Wandersman, C., & Delepelaire, P. (2004) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123811 · Cited by 1,056 · see citing works

Toxicology Of Hydrogen Sulfide

Reiffenstein, R. J., Hulbert, W. C., & Roth, S. (1992) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.32.040192.000545 · Cited by 971 · see citing works

Normal and Pathologic Concentrations of Uremic Toxins

Duranton, F., Cohen, G., Smet, R. D., Rodríguez, M., Jankowski, J., Vanholder, R. C., & Argilés, À. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011121175 · Cited by 965 · see citing works

Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients

Barreto, F. C., Barreto, D. V., Liabeuf, S., Meert, N., Glorieux, G., Temmar, M., Choukroun, G. J., Vanholder, R. C., & Massy, Z. A. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03980609 · Cited by 932 · see citing works

Honor thy symbionts

Xu, J., & Gordon, J. I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1734063100 · Cited by 856 · see citing works

The Gut Microbiome, Kidney Disease, and Targeted Interventions

Ramezani, A., & Raj, D. S. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013080905 · Cited by 752 · see citing works

CD14 Is a pattern recognition receptor

Pugin, J., Heumann, D., Tomasz, A., Kravchenko, V. V., Akamatsu, Y., Nishijima, M., Glauser, M. P., Tobias, P. S., & Ulevitch, R. J. (1994) · Immunity · doi:10.1016/1074-7613(94)90093-0 · Cited by 699 · see citing works

Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure

Tang, W. H. W., Wang, Z., Fan, Y., Levison, B., Hazen, J. E., Donahue, L. M., Wu, Y., & Hazen, S. L. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.02.617 · Cited by 681 · see citing works

Expansion of Urease- and Uricase-Containing, Indole- and p-Cresol-Forming and Contraction of Short-Chain Fatty Acid-Producing Intestinal Microbiota in ESRD

Wong, J., Piceno, Y. M., DeSantis, T. Z., Pahl, M. V., Andersen, G. L., & Vaziri, N. D. (2014) · American Journal of Nephrology · doi:10.1159/000360010 · Cited by 638 · see citing works

Metagenomics: DNA sequencing of environmental samples

Green, S., & Rubin, E. M. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1709 · Cited by 634 · see citing works

Intestinal Dysbiosis Associated with Systemic Lupus Erythematosus

Hevia, A., Milani, C., López, P., Cuervo, A., Arboleya, S., Duranti, S., Turroni, F., González, S., Suárez, A., Gueimonde, M., et al. (2014) · mBio · doi:10.1128/mbio.01548-14 · Cited by 620 · see citing works

Intestinal flora and endogenous vitamin synthesis

Hill, M. J. (1997) · European Journal of Cancer Prevention · doi:10.1097/00008469-199703001-00009 · Cited by 551 · see citing works

Circulating Endothelial Microparticles Are Associated with Vascular Dysfunction in Patients with End-Stage Renal Failure

Amabile, N., Guérin, A. P., Leroyer, A. S., Mallat, Z., Nguyen, C., Boddaert, J., London, G. M., Tedgui, A., & Boulanger, C. M. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005050535 · Cited by 550 · see citing works

Infectious History

Lederberg, J. (2000) · Science · doi:10.1126/science.288.5464.287 · Cited by 523 · see citing works

p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease

Wu, I., Hsu, K., Lee, C., Sun, C., Hsu, H.-J., Tsai, C.-J., Tzen, C., Wang, Y.-C., Lin, C.-Y., & Wu, M.-S. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq580 · Cited by 510 · see citing works

Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion

Andrade‐Oliveira, V., Amano, M. T., Corrêa-Costa, M., Castoldi, Â., Felizardo, R. J. F., de Almeida, D. C., Bassi, Ê. J., Moraes‐Vieira, P. M., Hiyane, M. I., Rodas, A. C. D., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014030288 · Cited by 504 · see citing works

The Human Microbiome Project: A Community Resource for the Healthy Human Microbiome

Gevers, D., Knight, R., Petrosino, J. F., Huang, K., McGuire, A. L., Birren, B. W., Nelson, K. E., White, O., Methé, B. A., & Huttenhower, C. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001377 · Cited by 493 · see citing works

The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair

Dou, L., Bertrand, E., Cérini, C., Faure, V., Sampol, J., Vanholder, R., Berland, Y., & Brunet, P. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00399.x · Cited by 487 · see citing works

The Gut as a Source of Inflammation in Chronic Kidney Disease

Lau, W. L., Kalantar‐Zadeh, K., & Vaziri, N. D. (2015) · The Nephron journals/Nephron journals · doi:10.1159/000381990 · Cited by 462 · see citing works

Serum Uric Acid and Cardiovascular Events in Successfully Treated Hypertensive Patients

Alderman, M. H., Cohen, H. W., Madhavan, S., & Kivlighn, S. D. (1999) · Hypertension · doi:10.1161/01.hyp.34.1.144 · Cited by 441 · see citing works

The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells

Dou, L., Jourde‐Chiche, N., Faure, V., Cérini, C., Berland, Y., Dignat‐George, F., & Brunet, P. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02540.x · Cited by 432 · see citing works

Free p-cresylsulphate is a predictor of mortality in patients at different stages of chronic kidney disease

Liabeuf, S., Barreto, D. V., Barreto, F. C., Meert, N., Glorieux, G., Schepers, E., Temmar, M., Choukroun, G. J., Vanholder, R. C., Massy, Z. A., et al. (2009) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfp592 · Cited by 431 · see citing works

UREA METABOLISM IN MAN*

Walser, M., & Bodenlos, L. J. (1959) · Journal of Clinical Investigation · doi:10.1172/jci103940 · Cited by 430 · see citing works

Colonic Contribution to Uremic Solutes

Aronov, P. A., Luo, F. J.-G., Plummer, N. S., Quan, Z., Holmes, S., Hostetter, T. H., & Meyer, T. W. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010121220 · Cited by 423 · see citing works

High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease

Raj Krishnamurthy, V. M., Wei, G., Baird, B. C., Murtaugh, M., Chonchol, M. B., Raphael, K. L., Greene, T., & Beddhu, S. (2012) · Kidney International · doi:10.1038/ki.2011.355 · Cited by 409 · see citing works

p -Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase

Watanabe, H., Miyamoto, Y., Honda, D., Tanaka, H., Wu, Q., Endo, M., Noguchi, T., Kadowaki, D., Ishima, Y., Kotani, S., et al. (2013) · Kidney International · doi:10.1038/ki.2012.448 · Cited by 391 · see citing works

Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients

Bammens, B., Evenepoel, P., Keuleers, H., Verbeke, K., & Vanrenterghem, Y. F. C. (2006) · Kidney International · doi:10.1038/sj.ki.5000115 · Cited by 388 · see citing works

Role of Urea in Intestinal Barrier Dysfunction and Disruption of Epithelial Tight Junction in Chronic Kidney Disease

Vaziri, N. D., Yuan, J. J., & Norris, K. C. (2012) · American Journal of Nephrology · doi:10.1159/000345969 · Cited by 385 · see citing works

The causes of intestinal dysbiosis: a review.

Hawrelak, J. A., & Myers, S. P. (2004) · PubMed · Cited by 368 · see citing works

Short chain fatty acids and their receptors: new metabolic targets

Layden, B. T., Angueira, A. R., Brodsky, M. R., Durai, V., & Lowe, W. L. (2012) · Translational research · doi:10.1016/j.trsl.2012.10.007 · Cited by 357 · see citing works

Fermentation in the human large intestine: evidence and implications for health

Cummings, J. (1983) · The Lancet · doi:10.1016/s0140-6736(83)92478-9 · Cited by 336 · see citing works

The gut-kidney axis: indoxyl sulfate, p-cresyl sulfate and CKD progression

Meijers, B. K. I., & Evenepoel, P. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq818 · Cited by 329 · see citing works

The Cardiovascular Effect of the Uremic Solute Indole-3 Acetic Acid

Dou, L., Sallée, M., Cérini, C., Poitevin, S., Gondouin, B., Jourde‐Chiche, N., Fallague, K., Brunet, P., Calaf, R., Dussol, B., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013121283 · Cited by 329 · see citing works

MYTH OF THE MARSUPIAL MOTHER: HOME CARE OF VERY LOW BIRTH WEIGHT BABIES IN BOGOTA, COLOMBIA

Whitelaw, A. C., & Sleath, K. (1985) · The Lancet · doi:10.1016/s0140-6736(85)92877-6 · Cited by 324 · see citing works

p-Cresol and Cardiovascular Risk in Mild-to-Moderate Kidney Disease

Meijers, B. K. I., Claes, K. J., Bammens, B., de Loor, H., Viaene, L., Verbeke, K., Kuypers, D. R. J., Vanrenterghem, Y. F. C., & Evenepoel, P. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.07971109 · Cited by 316 · see citing works

Uremic Toxins Induce Kidney Fibrosis by Activating Intrarenal Renin–Angiotensin–Aldosterone System Associated Epithelial-to-Mesenchymal Transition

Sun, C., Chang, S., & Wu, M.-S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034026 · Cited by 310 · see citing works

A Combined Epidemiologic and Metabolomic Approach Improves CKD Prediction

Rhee, E. P., Clish, C. B., Ghorbani, A., Larson, M. G., Elmariah, S., McCabe, E., Yang, Q., Cheng, S., Pierce, K., Deik, A., et al. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012101006 · Cited by 307 · see citing works

Disintegration of colonic epithelial tight junction in uremia: a likely cause of CKD-associated inflammation

Vaziri, N. D., Yuan, J. J., Rahimi, A., Ni, Z., Said, H., & Subramanian, V. S. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr624 · Cited by 306 · see citing works

p-Cresyl sulfate serum concentrations in haemodialysis patients are reduced by the prebiotic oligofructose-enriched inulin

Meijers, B. K. I., Preter, V. D., Verbeke, K., Vanrenterghem, Y. F. C., & Evenepoel, P. (2009) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfp414 · Cited by 301 · see citing works

Effect of Increasing Dietary Fiber on Plasma Levels of Colon-Derived Solutes in Hemodialysis Patients

Sirich, T. L., Plummer, N. S., Gardner, C. D., Hostetter, T. H., & Meyer, T. W. (2014) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00490114 · Cited by 297 · see citing works

Inhibition of the Accumulation of Uremic Toxins in the Blood and Their Precursors in the Feces after Oral Administration of Lebenin®, a Lactic Acid Bacteria Preparation, to Uremic Patients Undergoing Hemodialysis

Hida, M., Aiba, Y., Sawamura, S., Suzuki, N., Satoh, T., & Koga, Y. (2008) · Nephron · doi:10.1159/000189334 · Cited by 295 · see citing works

The influence of dialysis treatment modality on the decline of remaining renal function.

Lysaght, M. J., Vonesh, E. F., Gotch, F. A., Ibels, L. S., Keen, M. L., Lindholm, B., Nolph, K. D., Pollock, C. A., Prowant, B. F., & Farrell, P. C. (1991) · PubMed · Cited by 295 · see citing works

Randomized Placebo-Controlled EPPIC Trials of AST-120 in CKD

Schulman, G., Berl, T., Beck, G. J., Remuzzi, G., Ritz, E., Arita, K., Kato, A., & Shimizu, M. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014010042 · Cited by 288 · see citing works

Uremic Toxicity: Present State of the Art

Vanholder, R. C., Argilés, À., Baurmeister, U., Brunet, P., Clark, W. R., Cohen, G., Dedeyn, P. P., Deppisch, R. M., Descamps‐Latscha, B., Henle, T., et al. (2001) · The International Journal of Artificial Organs · doi:10.1177/039139880102401004 · Cited by 279 · see citing works

Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-κB and free radical in proximal tubular cells

Motojima, M., Hosokawa, A., Yamato, H., Muraki, T., & Yoshioka, T. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00906.x · Cited by 278 · see citing works

High Amylose Resistant Starch Diet Ameliorates Oxidative Stress, Inflammation, and Progression of Chronic Kidney Disease

Vaziri, N. D., Liu, S.-M., Lau, W. L., Khazaeli, M., Nazertehrani, S., Farzaneh, S. H., Kieffer, D. A., Adams, S. H., & Martin, R. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114881 · Cited by 274 · see citing works

p-Cresyl Sulfate Promotes Insulin Resistance Associated with CKD

Koppe, L., Pillon, N. J., Vella, R., Croze, M. L., Pelletier, C. C., Chambert, S., Massy, Z. A., Glorieux, G., Vanholder, R. C., Dugenet, Y., et al. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012050503 · Cited by 272 · see citing works

Removal of P-Cresol Sulfate by Hemodialysis

Martinez, A. W., Recht, N. S., Hostetter, T. H., & Meyer, T. W. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005030310 · Cited by 261 · see citing works

D-Lactic Acidosis in a Man with the Short-Bowel Syndrome

Oh, M. S., Phelps, K. R., Traube, M., Barbosa-Saldivar, J. L., Boxhill, C., & Carroll, H. J. (1979) · New England Journal of Medicine · doi:10.1056/nejm197908023010505 · Cited by 254 · see citing works

Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells

Yamamoto, H., Tsuruoka, S., Ioka, T., Ando, H., Ito, C., Akimoto, T., Fujimura, A., Asano, Y., & Kusano, E. (2006) · Kidney International · doi:10.1038/sj.ki.5000340 · Cited by 248 · see citing works

Formation of Phenolic and Indolic Compounds by Anaerobic Bacteria in the Human Large Intestine

Smith, E. A., & Macfarlane, G. T. (1997) · Microbial Ecology · doi:10.1007/s002489900020 · Cited by 246 · see citing works

Microbiota and Metabolome Associated with Immunoglobulin A Nephropathy (IgAN)

Angelis, M. D., Montemurno, E., Píccolo, M. C., Vannini, L., Lauriero, G., Maranzano, V., Gozzi, G., Serrazanetti, D. I., Dalfino, G., Gobbetti, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099006 · Cited by 236 · see citing works

The effect of probiotics on serum levels of cytokine and endotoxin in peritoneal dialysis patients: a randomised, double-blind, placebo-controlled trial

Wang, I. ‐., Wu, Y. Y., Yang, Y., Ting, I., Lin, C. C., Yen, T., Chen, J.-H., Wang, C., Huang, C.-F., & Lin, H. (2015) · Beneficial Microbes · doi:10.3920/bm2014.0088 · Cited by 223 · see citing works

Role of the intestinal tract in the elimination of uric acid

Sorensen, L. B. (1965) · Arthritis & Rheumatism · doi:10.1002/art.1780080429 · Cited by 221 · see citing works

Effects of synbiotic treatment on serum level of p-cresol in haemodialysis patients: a preliminary study

Nakabayashi, I., Nakamura, M., Kawakami, K., Ohta, T., Kato, I., Uchida, K., & Yoshida, M. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq624 · Cited by 215 · see citing works

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study of AST-120 (Kremezin) in Patients With Moderate to Severe CKD

Schulman, G., Agarwal, R., Acharya, M., Berl, T., Blumenthal, S. S., & Kopyt, N. P. (2006) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.12.036 · Cited by 200 · see citing works

Microencapsulated genetically engineered live E. coli DH5 cells administered orally to maintain normal plasma urea level in uremic rats

Prakash, S., & Chang, T. M. S. (1996) · Nature Medicine · doi:10.1038/nm0896-883 · Cited by 199 · see citing works

Indoxyl sulfate induces skeletal resistance to parathyroid hormone in cultured osteoblastic cells

Nii‐Kono, T., Iwasaki, Y., Uchida, M., Fujieda, A., Hosokawa, A., Motojima, M., Yamato, H., Kurokawa, K., & Fukagawa, M. (2007) · Kidney International · doi:10.1038/sj.ki.5002097 · Cited by 194 · see citing works

Indoxyl sulfate increases the gene expressions of TGF-beta 1, TIMP-1 and pro-alpha 1(I) collagen in uremic rat kidneys.

Miyazaki, T., Ise, M., Seo, H., & Niwa, T. (1997) · PubMed · Cited by 192 · see citing works

Oxalobacter formigenes and Its Potential Role in Human Health

Duncan, S. H., Richardson, A. J., Kaul, P., Holmes, R. P., Allison, M. J., & Stewart, C. S. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.8.3841-3847.2002 · Cited by 188 · see citing works

Accumulation of indoxyl sulfate, an inhibitor of drug-binding, in uremic serum as demonstrated by internal-surface reversed-phase liquid chromatography.

Niwa, T., Takeda, N., Tatematsu, A., & Maeda, K. (1988) · Clinical Chemistry · doi:10.1093/clinchem/34.11.2264 · Cited by 188 · see citing works

Gas Chromatographic–Mass Spectrometric Analysis for Measurement of p-Cresol and Its Conjugated Metabolites in Uremic and Normal Serum

de Loor, H., Bammens, B., Evenepoel, P., Preter, V. D., & Verbeke, K. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.050781 · Cited by 184 · see citing works

Creatinine Metabolism in Humans with Decreased Renal Function: Creatinine Deficit

Jones, J. D., & Burnett, P. C. (1974) · Clinical Chemistry · doi:10.1093/clinchem/20.9.1204 · Cited by 166 · see citing works

Uremic Plasma Impairs Barrier Function and Depletes the Tight Junction Protein Constituents of Intestinal Epithelium

Vaziri, N. D., Goshtasbi, N., Yuan, J. J., Jellbauer, S., Moradi, H., Raffatellu, M., & Kalantar‐Zadeh, K. (2012) · American Journal of Nephrology · doi:10.1159/000343886 · Cited by 166 · see citing works

Gut Bacterial Translocation May Aggravate Microinflammation in Hemodialysis Patients

Shi, K., Wang, F., Jiang, H., Liu, H., Wei, M., Wang, Z., & Xie, L. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3202-7 · Cited by 165 · see citing works

The deleterious metabolic and genotoxic effects of the bacterial metabolite p-cresol on colonic epithelial cells

Andriamihaja, M., Lan, A., Beaumont, M., Audebert, M., Wong, X., Yamada, K., Yin, Y., Tomé, D., Carrasco‐Pozo, C., Gotteland, M., et al. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.004 · Cited by 162 · see citing works

Effect of short-term synbiotic treatment on plasma p-cresol levels in patients with chronic renal failure: A randomized clinical trial

Guida, B., Germanò, R., Trio, R., Russo, D., Memoli, B., Grumetto, L., Barbato, F., & Cataldi, M. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.04.007 · Cited by 161 · see citing works

p-cresylsulfate and indoxyl sulfate level at different stages of chronic kidney disease

Lin, C., Chen, H., Pan, C., Chuang, C., Wang, T.-J., Sun, F., & Wu, C. (2011) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.20456 · Cited by 159 · see citing works

Biotransformation of monoterpenes, bile acids, and other isoprenoids in anaerobic ecosystems

Hylemon, P. B., & Harder, J. (1998) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1998.tb00382.x · Cited by 156 · see citing works

Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner

Chiang, C., Tanaka, T., Inagi, R., Fujita, T., & Nangaku, M. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2011.114 · Cited by 155 · see citing works

Colonic transit time in long-term dialysis patients

Wu, M.-J., Chang, C., Cheng, C.-H., Chen, C., Lee, W., Hsu, Y.-H., Shu, K., & Tang, M. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2004.04.048 · Cited by 153 · see citing works

Randomized Controlled Trial of Strain-Specific Probiotic Formulation (Renadyl) in Dialysis Patients

Ranganathan, N., Pechenyak, B., Vyas, U., Ranganathan, P., Weinberg, A. D., Liang, P., Mallappallil, M. C., Norin, A. J., Friedman, E. A., & Saggi, S. J. (2014) · BioMed Research International · doi:10.1155/2014/568571 · Cited by 150 · see citing works

Significance of microflora in proteolysis in the colon

Gibson, S. A., McFarlan, C., Hay, S., & Macfarlane, G. T. (1989) · Applied and Environmental Microbiology · doi:10.1128/aem.55.3.679-683.1989 · Cited by 147 · see citing works

Downregulation of the renal and hepatic hydrogen sulfide (H2S)-producing enzymes and capacity in chronic kidney disease

Aminzadeh, M. A., & Vaziri, N. D. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr560 · Cited by 146 · see citing works

Biomodulation of the toxic and nutritional effects of small bowel bacterial overgrowth in end-stage kidney disease using freeze-dried Lactobacillus acidophilus.

Simenhoff, M. L., Dunn, S., Zollner, G. P., Fitzpatrick, M. E., Emery, S. M., Sandine, W. E., & Ayres, J. W. (1996) · PubMed · Cited by 143 · see citing works

Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity

Freudenberg, M. A., Tchaptchet, S., Keck, S., Fejér, G., Huber, M., Schütze, N., Beutler, B., & Galanos, C. (2008) · Immunobiology · doi:10.1016/j.imbio.2007.11.008 · Cited by 143 · see citing works

Pathology of gastrointestinal tract in chronic hemodialysis patients: an autopsy study of 78 cases.

Vaziri, N. D., Dure-Smith, B., Miller, R., & Mirahmadi, M. K. (1985) · PubMed · Cited by 140 · see citing works

Urea nitrogen salvage mechanisms and their relevance to ruminants, non-ruminants and man

Stewart, G. S., & Smith, C. P. (2005) · Nutrition Research Reviews · doi:10.1079/nrr200498 · Cited by 135 · see citing works

Ammonia production by human faecal bacteria, and the enumeration, isolation and characterization of bacteria capable of growth on peptides and amino acids

Richardson, A. J., McKain, N., & Wallace, R. J. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-6 · Cited by 134 · see citing works

Hydrogen sulfide inhibits the renal fibrosis of obstructive nephropathy

Song, K., Wang, F., Li, Q., Shi, Y.-B., Zheng, H.-F., Peng, H., Shen, H.-Y., Liu, C., & Hu, L.-F. (2013) · Kidney International · doi:10.1038/ki.2013.449 · Cited by 131 · see citing works

Uremic Toxins Overload Accelerates Renal Damage in a Rat Model of Chronic Renal Failure

Satoh, M., Hayashi, H., WATANABE, M., Ueda, K., Yamato, H., Yoshioka, T., & Motojima, M. (2003) · Nephron Experimental Nephrology · doi:10.1159/000074327 · Cited by 121 · see citing works

Evidence for impaired assimilation of protein in chronic renal failure

Bammens, B., Verbeke, K., Vanrenterghem, Y. F. C., & Evenepoel, P. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00314.x · Cited by 118 · see citing works

Polyamines in renal failure

Igarashi, K., Ueda, S., Yoshida, K., & Kashiwagi, K. (2006) · Amino Acids · doi:10.1007/s00726-006-0264-7 · Cited by 116 · see citing works

Uraemic toxins induce proximal tubular injury via organic anion transporter 1‐mediated uptake

Motojima, M., Hosokawa, A., Yamato, H., Muraki, T., & Yoshioka, T. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704482 · Cited by 115 · see citing works

Podocyte Injury Caused by Indoxyl Sulfate, a Uremic Toxin and Aryl-Hydrocarbon Receptor Ligand

Ichii, O., Otsuka-Kanazawa, S., Nakamura, T., Masaaki, U., Kon, Y., Chen, W., Rosenberg, A. Z., & Kopp, J. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108448 · Cited by 114 · see citing works

Renal Clearance and Intestinal Generation of p-Cresyl Sulfate and Indoxyl Sulfate in CKD

Poesen, R., Viaene, L., Verbeke, K., Claes, K. J., Bammens, B., Sprangers, B., Naesens, M., Vanrenterghem, Y. F. C., Kuypers, D. R. J., Evenepoel, P., et al. (2013) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00300113 · Cited by 111 · see citing works

Gas chromatographic characterization of free d-amino acids in the blood serum of patients with renal disorders and of healthy volunteers

Brückner, H. J., & Hausch, M. (1993) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(93)80218-s · Cited by 103 · see citing works

Effect of the super-flux cellulose triacetate dialyser membrane on the removal of non-protein-bound and protein-bound uraemic solutes

Smet, R. D., Dhondt, A., Eloot, S., Galli, F., Waterloos, M., & Vanholder, R. C. (2007) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfm065 · Cited by 103 · see citing works

Oral Activated Charcoal Adsorbent (AST-120) Ameliorates Chronic Kidney Disease-Induced Intestinal Epithelial Barrier Disruption

Vaziri, N. D., Yuan, J. J., Khazaeli, M., Masuda, Y., Ichii, H., & Liu, S. (2013) · American Journal of Nephrology · doi:10.1159/000351171 · Cited by 103 · see citing works

Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney

Miyamoto, Y., Watanabe, H., Noguchi, T., Kotani, S., Nakajima, M., Kadowaki, D., Otagiri, M., & Maruyama, T. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq785 · Cited by 102 · see citing works

Patients with Chronic Renal Failure Have Abnormal Small Intestinal Motility and a High Prevalence of Small Intestinal Bacterial Overgrowth

Strid, H., Simrén, M., Stotzer, P., Ringström, G., Abrahamsson, H., & Björnsson, E. S. (2003) · Digestion · doi:10.1159/000071292 · Cited by 101 · see citing works

P-cresol, a uremic retention solute, alters the endothelial barrier function in vitro

Dou, L., Anfosso, F. J., Sabatier, F., Moal, V., Glorieux, G., Smet, R. D., Vanholder, R., Dignat‐George, F., Sampol, J., Berland, Y., et al. (2004) · Thrombosis and Haemostasis · doi:10.1160/th03-07-0491 · Cited by 99 · see citing works

Indoxyl sulphate inhibits osteoclast differentiation and function

Mozar, A., Louvet, L., Godin, C., Mentaverri, R., Brazier, M., Kamel, S., & Massy, Z. A. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr647 · Cited by 90 · see citing works

Soluble CD14 Levels, Interleukin 6, and Mortality Among Prevalent Hemodialysis Patients

Raj, D. S., Carrero, J. J., Shah, V. O., Qureshi, A. R., Barany, P. F., Heimbürger, O., Lindholm, B., Ferguson, J., Moseley, P. L., & Stenvinkel, P. (2009) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2009.06.022 · Cited by 89 · see citing works

Hydrogen sulphide-generating pathways in haemodialysis patients: a study on relevant metabolites and transcriptional regulation of genes encoding for key enzymes

Perna, A. F., Luciano, M. G., Ingrosso, D., Pulzella, P., Sepe, I., Lanza, D., Violetti, E., Capasso, R., Lombardi, C., & Santo, N. G. D. (2009) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfp378 · Cited by 87 · see citing works

Bacterial translocation in experimental uremia

Duarte, J. B. D. A., de Aguilar‐Nascimento, J. E., Nascimento, M., & Nochi, R. J. (2003) · Urological Research · doi:10.1007/s00240-003-0381-7 · Cited by 85 · see citing works

Indoxyl sulfate, a uremic toxin, promotes cell senescence in aorta of hypertensive rats

Adijiang, A., Higuchi, Y., Nishijima, F., Shimizu, H., & Niwa, T. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.130 · Cited by 77 · see citing works

Associations of Soluble CD14 and Endotoxin with Mortality, Cardiovascular Disease, and Progression of Kidney Disease among Patients with CKD

Poesen, R., Ramezani, A., Claes, K. J., Augustijns, P., Kuypers, D. R. J., Barrows, I. R., Jagadeesan, M., Evenepoel, P., Meijers, B. K. I., & Raj, D. S. (2015) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03100315 · Cited by 73 · see citing works

Enhanced Enteric Excretion of Urate in Rats with Chronic Renal Failure

Hatch, M., & Vaziri, N. D. (1994) · Clinical Science · doi:10.1042/cs0860511 · Cited by 71 · see citing works

Optimized Metabolomic Approach to Identify Uremic Solutes in Plasma of Stage 3–4 Chronic Kidney Disease Patients

Mutsaers, H. A. M., Engelke, U. F. H., Wilmer, M. J. G., Wetzels, J. F. M., Wevers, R. A., van den Heuvel, L. P., Hoenderop, J. G. J., & Masereeuw, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071199 · Cited by 70 · see citing works

Acarbose treatment lowers generation and serum concentrations of the protein-bound solute p-cresol: A pilot study

Evenepoel, P., Bammens, B., Verbeke, K., & Vanrenterghem, Y. F. C. (2006) · Kidney International · doi:10.1038/sj.ki.5001523 · Cited by 69 · see citing works

Association between indoxyl sulfate and bone histomorphometry in pre-dialysis chronic kidney disease patients

Barreto, F. C., Barreto, D. V., Canziani, M. E. F., Tomiyama, C., Higa, A., Mozar, A., Glorieux, G., Vanholder, R. C., Massy, Z. A., & Carvalho, A. B. (2014) · Brazilian Journal of Nephrology · doi:10.5935/0101-2800.20140042 · Cited by 65 · see citing works

Association of Soluble Endotoxin Receptor CD14 and Mortality Among Patients Undergoing Hemodialysis

Raj, D. S., Shah, V. O., Rambod, M., Kovesdy, C. P., & Kalantar‐Zadeh, K. (2009) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2009.06.028 · Cited by 57 · see citing works

The determination of urinary phenylacetylglutamine as phenylacetic acid.

Seakins, J. W. T. (1971) · Clinica Chimica Acta · doi:10.1016/0009-8981(71)90302-0 · Cited by 55 · see citing works

Polyamines in the anemia of end-stage renal disease

Kushner, D. S., Beckman, B., Nguyen, L., Chen, S., Santina, C. D., Husserl, F. E., Rice, J. C., & Fisher, J. W. (1991) · Kidney International · doi:10.1038/ki.1991.88 · Cited by 55 · see citing works

Distortion of endothelial repair The effect of hypercholesterolaemia on regeneration of aortic endothelium following injury by endotoxin A scanning electron microscope study

Reidy, M. A., & Bowyer, D. E. (1978) · Atherosclerosis · doi:10.1016/0021-9150(78)90174-0 · Cited by 54 · see citing works

SYNbiotics Easing Renal failure by improving Gut microbiologY (SYNERGY): a protocol of placebo-controlled randomised cross-over trial

Rossi, M., Johnson, D. W., Morrison, M., Pascoe, E. M., Coombes, J. S., Forbes, J. M., McWhinney, B. C., Ungerer, J. P. J., Dimeski, G., & Campbell, K. L. (2014) · BMC Nephrology · doi:10.1186/1471-2369-15-106 · Cited by 50 · see citing works

Chromatography of urinary indole derivatives

van Haard, P. M. M., & Pavel, S. (1988) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)83867-0 · Cited by 48 · see citing works

The uraemic toxin phenylacetic acid increases the formation of reactive oxygen species in vascular smooth muscle cells

Schmidt, S. H., Westhoff, T. H., Krauser, P., Zidek, W., & van der Giet, M. (2007) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfm475 · Cited by 46 · see citing works

TOXICITY OF PHENYLACETIC ACID

Sherwin, C. P., & Kennard, K. S. (1919) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)87245-3 · Cited by 44 · see citing works

Blood levels of urea nitrogen, phenol, guanidine and creatinine in uremia

Olsen, N. S., & Bassett, J. W. (1951) · The American Journal of Medicine · doi:10.1016/0002-9343(51)90218-5 · Cited by 42 · see citing works

THE ROLE OF THE MICROBIAL FLORA IN UREMIA

Einheber, A., & Carter, D. (1966) · The Journal of Experimental Medicine · doi:10.1084/jem.123.2.239 · Cited by 42 · see citing works

The uraemic toxin phenylacetic acid impairs macrophage function

Schmidt, S. H., Westhoff, T. H., Krauser, P., Ignatius, R., Jankowski, J., Jankowski, V., Zidek, W., & van der Giet, M. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn266 · Cited by 40 · see citing works

Renal impairment and gout.

Gibson, T., Highton, J., Potter, C., & Simmonds, H. A. (1980) · Annals of the Rheumatic Diseases · doi:10.1136/ard.39.5.417 · Cited by 37 · see citing works

Effect of diet on serum accumulation and renal excretion of aryl acids and secretory activity in normal and uremic man

Cathcart-Rake, W. F., Porter, R. S., Whittier, F., Stein, P., Carey, M., & Grantham, J. J. (1975) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/28.10.1110 · Cited by 34 · see citing works

Assay of the Human Liver Citric Acid Cycle Probe Phenylacetylglutamine and of Phenylacetate in Plasma by Gas Chromatography-Mass Spectrometry

Yang, D. W., Beylot, M., Agarwal, K. C., Soloviev, M. V., & Brunengraber, H. (1993) · Analytical Biochemistry · doi:10.1006/abio.1993.1323 · Cited by 33 · see citing works

Paleolithic diet, sweet potato eaters, and potential renal acid load

Remer, T., & Manz, F. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.4.802 · Cited by 33 · see citing works

Comparison of Toxic Effects of Methylguanidine, Guanidinosuccinic Acid and Creatinine in Rats with Adenine-Induced Chronic Renal Failure

Yokozawa, T., Mo, Z. L., & Oura, H. (2008) · ˜The œNephron journals/Nephron journals · doi:10.1159/000185328 · Cited by 32 · see citing works

The uraemic toxin phenylacetic acid inhibits osteoblastic proliferation and differentiation: an implication for the pathogenesis of low turnover bone in chronic renal failure

Yano, S., Yamaguchi, T., Kanazawa, I., Ogawa, N., Hayashi, K., Yamauchi, M., & Sugimoto, T. (2007) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfm455 · Cited by 32 · see citing works

New Methods and Technologies for Measuring Uremic Toxins and Quantifying Dialysis Adequacy

Vanholder, R. C., Boelaert, J., Glorieux, G., & Eloot, S. (2014) · Seminars in Dialysis · doi:10.1111/sdi.12331 · Cited by 27 · see citing works

Basolateral transport of the uraemic toxin p-cresyl sulfate: role for organic anion transporters?

Mutsaers, H. A. M., Wilmer, M. J. G., van den Heuvel, L. P., Hoenderop, J. G. J., & Masereeuw, R. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr562 · Cited by 27 · see citing works

Benzoate-induced changes in glycine and urea metabolism in patients with chronic renal failure.

Mitch, W. E., & Brusilow, S. W. (1982) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33242-8 · Cited by 24 · see citing works

The conversion of creatinine by creatininase of bacterial origin.

van Eyk, H. G., van, Rj, V., Leijnse-Ybema, H. J., & Leijnse, B. (1968) · PubMed · Cited by 24 · see citing works

Identification and determination of phenylacetylglutamine, a major nitrogenous metabolite in plasma of uremic patients.

Zimmerman, L., Egestad, B., Jörnvall, H., & Bergström, J. P. (1989) · PubMed · Cited by 21 · see citing works

[Effect of oral intake of an enteric capsule preparation containing Bifidobacterium longum on the progression of chronic renal failure].

Ando, Y., Miyata, Y., Tanba, K., Saitô, O., Muto, S., Kurosu, M., Homma, S., Kusano, E., & Asano, Y. (2003) · PubMed · Cited by 19 · see citing works

Gut Feeling in AKI

Barrows, I. R., Ramezani, A., & Raj, D. S. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014111157 · Cited by 19 · see citing works

Hydrogen Sulfide, a Toxic Gas with Cardiovascular Properties in Uremia: How Harmful Is It?

Perna, A. F., Lanza, D., Sepe, I., Raiola, I., Capasso, R., Santo, N. G. D., & Ingrosso, D. (2011) · Blood Purification · doi:10.1159/000321838 · Cited by 19 · see citing works

Homocysteine in uremia

Perna, A. F., Ingrosso, D., Lombardi, C., Cesare, C. M., Acantora, F., Satta, E., & Santo, N. G. D. (2003) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2003.50100 · Cited by 18 · see citing works

The relationship between colonization of Oxalobacter formigenes serum oxalic acid and endothelial dysfunction in hemodialysis patients: From impaired colon to impaired endothelium

Türkmen, K., & Erdur, F. M. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.01.010 · Cited by 15 · see citing works

LPS induced procoagulant activity and plasminogen activator activity in mononuclear cells from persons with high or low levels of HDL lipoprotein

Eggesbø, J. B., Hjermann, I., Øvstebø, R., Joø, G. B., & Kierulf, P. (1995) · Thrombosis Research · doi:10.1016/0049-3848(95)93880-9 · Cited by 15 · see citing works

Hippuric Acid as a Marker

Vanholder, R. C., Schoots, A., Cramers, C. A. M. G., Smet, R. D., Landschoot, N. V., Wizemann, V., Botella, J., & Ringoir, S. M. (1987) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5445-1_8 · Cited by 12 · see citing works

Genetically Engineered E. COLI Cells Containing K. AEROGENES Gene, Microencapsulated in Artificial Cells for Urea and Ammonia Removal

Prakash, S., & Chang, T. M. S. (1993) · Artificial Cells Blood Substitutes and Biotechnology · doi:10.3109/10731199309117387 · Cited by 11 · see citing works

Uremic polyamine dysmetabolism.

Campbell, R. A., Grettie, D. P., Bartos, F., Bartos, D., & Marton, L. J. (1978) · PubMed · Cited by 11 · see citing works

PROTEIN METABOLISM FROM THE STANDPOINT OF BLOOD AND TISSUE ANALYSIS

Folin, O., & Lyman, H. M. (1912) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88700-2 · Cited by 2 · see citing works

The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease

Yang, T., Richards, E. M., Pepine, C. J., & Raizada, M. K. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0018-2 · Cited by 753 · see citing works

Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

Wang, X., Yang, S., Li, S., Zhao, L., Hao, Y., Qin, J., Zhang, L., Zhang, C., Bian, W., Zuo, L., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319766 · Cited by 542 · see citing works

Trimethylamine N-oxide: the good, the bad and the unknown.

Velasquez, M., Ramezani, A., Manal, A., & Raj, D. (2016) · Toxins · doi:10.3390/toxins8110326 · Cited by 504 · see citing works

Microbial modulation of cardiovascular disease

Brown, J. M., & Hazen, S. L. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.149 · Cited by 440 · see citing works

Microbiome–metabolome reveals the contribution of gut–kidney axis on kidney disease

Chen, Y., Chen, D., Chen, L., Liu, J., Vaziri, N. D., Guo, Y. P., & Zhao, Y. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-018-1756-4 · Cited by 430 · see citing works

Gut Microbiota and Complications of Type-2 Diabetes

Iatcu, O. C., Steen, A., & Covașă, M. (2021) · Nutrients · doi:10.3390/nu14010166 · Cited by 433 · see citing works

The Impact of CKD on Uremic Toxins and Gut Microbiota

Rysz, J., Franczyk, B., Ławiński, J., Olszewski, R., Ciałkowska-Rysz, A. D., & Gluba-Brzózka, A. (2021) · Toxins · doi:10.3390/toxins13040252 · Cited by 314 · see citing works

Distant Organ Dysfunction in Acute Kidney Injury: A Review

Lee, S. A., Cozzi, M., Bush, E. L., & Rabb, H. (2018) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2018.03.028 · Cited by 294 · see citing works

Protein nutrition and malnutrition in CKD and ESRD

Zha, Y., & Qian, Q. (2017) · Nutrients · doi:10.3390/nu9030208 · Cited by 292 · see citing works

Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury

Saeedi, B. J., Liu, K. H., Owens, J. A., Hunter-Chang, S., Camacho, M. C., Eboka, R. U., Chandrasekharan, B., Baker, N. F., Darby, T. M., Robinson, B. S., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.03.006 · Cited by 295 · see citing works

Obesity and chronic kidney disease

Jiang, Z., Wang, Y., Zhao, X., Cui, H., Han, M., Ren, X., Gang, X., & Wang, G. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00179.2022 · Cited by 267 · see citing works

Gut microbiome in chronic kidney disease: challenges and opportunities

Nallu, A., Sharma, S., Ramezani, A., Jagadeesan, M., & Raj, D. (2016) · Translational research · doi:10.1016/j.trsl.2016.04.007 · Cited by 256 · see citing works

Membrane transporters in drug development and as determinants of precision medicine

Galetin, A., Brouwer, K. L. R., Tweedie, D., Yoshida, K. J., Sjöstedt, N., Aleksunes, L. M., Chu, X., Evers, R., Hafey, M. J., Lai, Y., et al. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00877-1 · Cited by 246 · see citing works

Inflammation and premature aging in advanced chronic kidney disease

Kooman, J. P., Dekker, M. J. E., Usvyat, L. A., Kotanko, P., SANDE, F. M. V. D., Schalkwijk, C. G., Shiels, P. G., & Stenvinkel, P. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00256.2017 · Cited by 242 · see citing works

Protein-energy wasting and nutritional supplementation in patients with end-stage renal disease on hemodialysis

Sabatino, A., Regolisti, G., Karupaiah, T., Sahathevan, S., Singh, B. K. S., Khor, B., Salhab, N., Karavetian, M., Cupisti, A., & Fiaccadori, E. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.06.007 · Cited by 219 · see citing works

Indoxyl Sulfate: A Novel Cardiovascular Risk Factor in Chronic Kidney Disease

Hung, S., Kuo, K., Wu, C., & Tarng, D. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.005022 · Cited by 216 · see citing works

Role of Gut Microbiota on Onset and Progression of Microvascular Complications of Type 2 Diabetes (T2DM)

Tănase, D. M., Gosav, E. M., Neculae, E., Costea, C. F., Ciocoiu, M., Hurjui, L. L., Tărniceriu, C. C., Maranducă, M. A., Lăcătușu, C.-M., Floria, M., et al. (2020) · Nutrients · doi:10.3390/nu12123719 · Cited by 209 · see citing works

Pathobiont release from dysbiotic gut microbiota biofilms in intestinal inflammatory diseases: a role for iron?

Buret, A. G., Motta, J., Allain, T., Ferraz, J. G., & Wallace, J. L. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-018-0495-4 · Cited by 205 · see citing works

Intestinal Microbiota in Type 2 Diabetes and Chronic Kidney Disease

Sabatino, A., Regolisti, G., Cosola, C., Gesualdo, L., & Fiaccadori, E. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0841-z · Cited by 201 · see citing works

Gut Microbiota-Dependent Trimethylamine-N-oxide and Serum Biomarkers in Patients with T2DM and Advanced CKD

Al-Obaide, M. A. I., Singh, R., Datta, P., Rewers-Felkins, K., Salguero, M. V., Al‐Obaidi, I., Kottapalli, K. R., & Vasylyeva, T. L. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6090086 · Cited by 200 · see citing works

The impact of gut microbiota on kidney function and pathogenesis

Mahmoodpoor, F., Saadat, Y. R., Barzegari, A., Ardalan, M., & Vahed, S. Z. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.06.066 · Cited by 171 · see citing works

Immune Dysfunction in Uremia 2020

Cohen, G. (2020) · Toxins · doi:10.3390/toxins12070439 · Cited by 172 · see citing works

Diabetic gut microbiota dysbiosis as an inflammaging and immunosenescence condition that fosters progression of retinopathy and nephropathy

Fernandes, R., Viana, S., Nunes, S., & Reis, F. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.032 · Cited by 172 · see citing works

Gut microbiota&amp;ndash;derived short-chain fatty acids and kidney diseases

Li, L., Ma, L., & Fu, P. (2017) · Drug Design, Development and Therapy · doi:10.2147/dddt.s150825 · Cited by 164 · see citing works

Gut microbiota regulates oxidative stress and inflammation: a double-edged sword in renal fibrosis

Li, X., Shan, Q., Wu, X., Miao, H., & Zhao, Y. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05532-5 · Cited by 157 · see citing works

Dietary Components That May Influence the Disturbed Gut Microbiota in Chronic Kidney Disease

Mafra, D., Borges, N. A., Alvarenga, L., Esgalhado, M., Cardozo, L., Lindholm, B., & Stenvinkel, P. (2019) · Nutrients · doi:10.3390/nu11030496 · Cited by 152 · see citing works

Gut microbiota and chronic kidney disease: evidences and mechanisms that mediate a new communication in the gastrointestinal-renal axis

Mikusic, N. L. R., Kouyoumdzian, N. M., & Choi, M. R. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02352-x · Cited by 154 · see citing works

Impact of Altered Intestinal Microbiota on Chronic Kidney Disease Progression

Castillo-Rodríguez, E., Fernández-Prado, R., Esteras, R., Pérez-Gómez, M. V., Gracia-Iguacel, C., Fernández‐Fernández, B., Kanbay, M., Tejedor, A., Lázaro, A., Ruiz‐Ortega, M., et al. (2018) · Toxins · doi:10.3390/toxins10070300 · Cited by 150 · see citing works

Gut microbiota in renal physiology: focus on short-chain fatty acids and their receptors

Pluznick, J. L. (2016) · Kidney International · doi:10.1016/j.kint.2016.06.033 · Cited by 151 · see citing works

Constipation in CKD

Sumida, K., Yamagata, K., & Kovesdy, C. P. (2019) · Kidney International Reports · doi:10.1016/j.ekir.2019.11.002 · Cited by 148 · see citing works

The Gut Barrier, Intestinal Microbiota, and Liver Disease: Molecular Mechanisms and Strategies to Manage

Plaza‐Díaz, J., Solis‐Urra, P., Rodríguez‐Rodríguez, F., Arancibia, J. E. O., Navarro-Oliveros, M., Abadía‐Molina, F., & Álvarez‐Mercado, A. I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218351 · Cited by 147 · see citing works

Microbiota intestinal en la enfermedad renal crónica

Cigarrán, S., Parra, E. G., & Cases, A. (2016) · Nefrología · doi:10.1016/j.nefro.2016.05.008 · Cited by 142 · see citing works

The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice

Zhou, W., Wu, W., Si, Z.-L., Liu, H., Wang, H., Jiang, H., Liu, Y., Alolga, R. N., Chen, C., Liu, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33824-6 · Cited by 135 · see citing works

Immunology of the ageing kidney

Sato, Y., & Yanagita, M. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0185-9 · Cited by 126 · see citing works

Probiotics, prebiotics, and synbiotics for the improvement of metabolic profiles in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials

Zheng, H., Guo, J., Wang, Q., Wang, L., Wang, Y., Zhang, F., Huang, W., Zhang, W., Liu, W. J., & Wang, Y. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1740645 · Cited by 122 · see citing works

Metagenomic analysis identified microbiome alterations and pathological association between intestinal microbiota and polycystic ovary syndrome

Chu, W., Han, Q., Xu, J., Wang, J., Sun, Y., Li, W., Chen, Z.-J., & Du, Y. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.01.027 · Cited by 121 · see citing works

Role of uremic toxin indoxyl sulfate in the progression of cardiovascular disease

Gao, H., & Liu, S. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.07.027 · Cited by 117 · see citing works

Short-Chain Fatty Acids in Chronic Kidney Disease: Focus on Inflammation and Oxidative Stress Regulation

Magliocca, G., Mone, P., Iorio, B. R. D., Heidland, A., & Marzocco, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105354 · Cited by 121 · see citing works

Blood Microbiome Profile in CKD

Shah, N. B., Allegretti, A. S., Nigwekar, S. U., Kalim, S., Zhao, S. J., Lelouvier, B., Servant, F., Serena, G., Thadhani, R., Raj, D. S., et al. (2019) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.12161018 · Cited by 115 · see citing works

The gut microbiota profile of adults with kidney disease and kidney stones: a systematic review of the literature

Stanford, J., Charlton, K. E., Stefoska‐Needham, A., Ibrahim, R., & Lambert, K. (2020) · BMC Nephrology · doi:10.1186/s12882-020-01805-w · Cited by 118 · see citing works

Lymphocytes and innate immune cells in acute kidney injury and repair

Lee, K., Jang, H. R., & Rabb, H. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00875-5 · Cited by 120 · see citing works

Nutrients Turned into Toxins: Microbiota Modulation of Nutrient Properties in Chronic Kidney Disease

Fernández-Prado, R., Esteras, R., Pérez-Gómez, M., Gracia-Iguacel, C., González-Parra, E., Sanz, A., Ortiz, A., & Sánchez-Niño, M. (2017) · Nutrients · doi:10.3390/nu9050489 · Cited by 89 · see citing works

Gut Leakage of Fungal-Derived Inflammatory Mediators: Part of a Gut-Liver-Kidney Axis in Bacterial Sepsis

Amornphimoltham, P., Yuen, P. S. T., Star, R. A., & Leelahavanichkul, A. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05581-y · Cited by 108 · see citing works

Contribution of the Gut Microbiome to Drug Disposition, Pharmacokinetic and Pharmacodynamic Variability

Tsunoda, S. M., Gonzales, C., Jarmusch, A. K., Momper, J. D., & JOSEPH, D. R. (2021) · Clinical Pharmacokinetics · doi:10.1007/s40262-021-01032-y · Cited by 113 · see citing works

Characteristics of Colon-Derived Uremic Solutes

Mair, R. D., Sirich, T. L., Plummer, N. S., & Meyer, T. W. (2018) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03150318 · Cited by 104 · see citing works

Metabolic and genetic response to probiotics supplementation in patients with diabetic nephropathy: a randomized, double-blind, placebo-controlled trial

Mafi, A., Namazi, G., Soleimani, A., Bahmani, F., Aghadavod, E., & Asemi, Z. (2018) · Food & Function · doi:10.1039/c8fo00888d · Cited by 102 · see citing works

Microbiota metabolites: Pivotal players of cardiovascular damage in chronic kidney disease

Cosola, C., Rocchetti, M. T., Cupisti, A., & Gesualdo, L. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.03.003 · Cited by 99 · see citing works

The Immunomodulatory Effect of the Gut Microbiota in Kidney Disease

Chi, M., Ma, K., Wang, J., Ding, Z., Li, Y., Zhu, S., Liang, X., Zhang, Q., Song, L., & Liu, C. (2021) · Journal of Immunology Research · doi:10.1155/2021/5516035 · Cited by 98 · see citing works

Does Low-Protein Diet Influence the Uremic Toxin Serum Levels From the Gut Microbiota in Nondialysis Chronic Kidney Disease Patients?

Black, A. P., Anjos, J. S., Cardozo, L., Carmo, F. L., Dolenga, C., Nakao, L., Ferreira, D. D. C., Rosado, A., Carraro-Eduardo, J. C., & Mafra, D. (2018) · Journal of renal nutrition · doi:10.1053/j.jrn.2017.11.007 · Cited by 86 · see citing works

Aryl Hydrocarbon Receptor Activation in Chronic Kidney Disease: Role of Uremic Toxins

de Brito, J. S., Borges, N. A., Esgalhado, M., Magliano, D. C., Soulage, C. O., & Mafra, D. (2017) · The Nephron journals/Nephron journals · doi:10.1159/000476074 · Cited by 95 · see citing works

Obesity-related kidney disease: Beyond hypertension and insulin-resistance

Arabi, T. Z., Shafqat, A., Sabbah, B. N., Ashraf, N., Shah, H., Abdulkader, H. S., Razak, A., Sabbah, A. N., & Arabi, Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1095211 · Cited by 98 · see citing works

Uremic Toxin Clearance and Cardiovascular Toxicities

Mair, R. D., Sirich, T. L., & Meyer, T. W. (2018) · Toxins · doi:10.3390/toxins10060226 · Cited by 94 · see citing works

The Intestinal Microbiota and Metabolites in the Gut-Kidney-Heart Axis of Chronic Kidney Disease

Huang, Y., Xin, W., Xiong, J., Yao, M., Zhang, B., & Zhao, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.837500 · Cited by 92 · see citing works

Gut microbiome in chronic kidney disease

Wing, M. R., Patel, S. S., Ramezani, A., & Raj, D. S. (2015) · Experimental Physiology · doi:10.1113/ep085283 · Cited by 89 · see citing works

Modulation of the Gut Microbiota by Resistant Starch as a Treatment of Chronic Kidney Diseases: Evidence of Efficacy and Mechanistic Insights

Snelson, M., Kellow, N. J., & Coughlan, M. T. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy068 · Cited by 87 · see citing works

The Prospects for the Therapeutic Implications of Genetically Engineered Probiotics

Mazhar, S. F., Afzal, M., Almatroudi, A., Munir, S., Ashfaq, U. A., Rasool, M., Raza, H., Munir, H. M. W., Rajoka, M. S. R., & Khurshid, M. (2020) · Journal of Food Quality · doi:10.1155/2020/9676452 · Cited by 85 · see citing works

Effects of Probiotic Supplementation on Trimethylamine-N-Oxide Plasma Levels in Hemodialysis Patients: a Pilot Study

Borges, N. A., Stenvinkel, P., Bergman, P., Qureshi, A. R., Lindholm, B., Moraes, C., Stockler-Pinto, M. B., & Mafra, D. (2019) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-018-9411-1 · Cited by 83 · see citing works

Uremic Toxin-Producing Gut Microbiota in Rats with Chronic Kidney Disease

Kikuchi, M., Ueno, M., Itoh, Y., Suda, W., & Hattori, M. (2017) · Nephron · doi:10.1159/000450619 · Cited by 82 · see citing works

Organ crosstalk: the potent roles of inflammation and fibrotic changes in the course of organ interactions

Armutçu, F. (2019) · Inflammation Research · doi:10.1007/s00011-019-01271-7 · Cited by 82 · see citing works

Microphysiological Systems to Recapitulate the Gut–Kidney Axis

Giordano, L., Mihaila, S. M., Amirabadi, H. E., & Masereeuw, R. (2021) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.12.001 · Cited by 82 · see citing works

Inflammation: A Key Contributor to the Genesis and Progression of Chronic Kidney Disease

Qian, Q. (2017) · Contributions to nephrology · doi:10.1159/000479257 · Cited by 79 · see citing works

The gut–kidney–heart axis in chronic kidney disease

Sumida, K., & Kovesdy, C. P. (2019) · Physiology International · doi:10.1556/2060.106.2019.19 · Cited by 79 · see citing works

Modulation of gut‐microbiota through probiotics and dietary interventions to improve host health

Dasriya, V. L., Samtiya, M., Ranveer, S. A., Dhillon, H. S., Devi, N., Sharma, V., Nikam, P., Puniya, M., Chaudhary, P., Chaudhary, V., et al. (2024) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.13370 · Cited by 80 · see citing works

Impact of the Oral Adsorbent AST-120 on Organ-Specific Accumulation of Uremic Toxins: LC-MS/MS and MS Imaging Techniques

Sato, E., Saigusa, D., Mishima, E., Uchida, T., Miura, D., Morikawa, T., Kisu, K., Sekimoto, A., Saito, R., Oe, Y., et al. (2017) · Toxins · doi:10.3390/toxins10010019 · Cited by 79 · see citing works

Causal Effects of Specific Gut Microbiota on Chronic Kidney Diseases and Renal Function—A Two-Sample Mendelian Randomization Study

Li, N., Wang, Y., Wei, P., Yu, M., Yu, M., Zhou, G., Yuan, G., Sun, J., Dai, H., Zhou, E., et al. (2023) · Nutrients · doi:10.3390/nu15020360 · Cited by 77 · see citing works

Homeostasis in the Gut Microbiota in Chronic Kidney Disease

Bhargava, S., Merckelbach, E., Noels, H., Vohra, A., & Jankowski, J. (2022) · Toxins · doi:10.3390/toxins14100648 · Cited by 76 · see citing works

Chronic kidney disease and gut microbiota

Khiabani, S. A., Asgharzadeh, M., & Kafil, H. S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18991 · Cited by 76 · see citing works

Non-Traditional Aspects of Renal Diets: Focus on Fiber, Alkali and Vitamin K1 Intake

Cupisti, A., D’Alessandro, C., Gesualdo, L., Cosola, C., Gallieni, M. A., Egidi, M. F., & Fusaro, M. (2017) · Nutrients · doi:10.3390/nu9050444 · Cited by 74 · see citing works

Functional characteristic of microbial communities in large-scale biotreatment systems of food waste

Wang, P., Qiao, Z., Li, X., Su, Y., & Xie, B. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.141086 · Cited by 72 · see citing works

Rhubarb Enema Improved Colon Mucosal Barrier Injury in 5/6 Nephrectomy Rats May Associate With Gut Microbiota Modification

Ji, C., Deng, Y., Yang, A., Lu, Z., Chen, Y., Liu, X., Han, L., & Zou, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01092 · Cited by 72 · see citing works

An Innovative Synbiotic Formulation Decreases Free Serum Indoxyl Sulfate, Small Intestine Permeability and Ameliorates Gastrointestinal Symptoms in a Randomized Pilot Trial in Stage IIIb-IV CKD Patients

Cosola, C., Rocchetti, M. T., di Bari, I., Acquaviva, P. M., Maranzano, V., Corciulo, S., Ciaula, A. D., Palo, D. M. D., la Forgia, F. M., Fontana, S., et al. (2021) · Toxins · doi:10.3390/toxins13050334 · Cited by 71 · see citing works

Gut Microbiota in Chronic Kidney Disease: From Composition to Modulation towards Better Outcomes—A Systematic Review

Voroneanu, L. E., Burlacu, A., Brinza, C., Covic, A. S., Bălan, G. G., Nistor, I., Popa, C. A., Hogas, S. M., & Covic, A. C. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12051948 · Cited by 70 · see citing works

An open-label, randomized, placebo-controlled study on the effectiveness of a novel probiotics administration protocol (ProbiotiCKD) in patients with mild renal insufficiency (stage 3a of CKD)

Simeoni, M., Citraro, M. L., Cerantonio, A., Deodato, F., Provenzano, M., Cianfrone, P., Capria, M., Corrado, S., Libri, E., Comi, A., et al. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1785-z · Cited by 70 · see citing works

Linking strain engraftment in fecal microbiota transplantation with maintenance of remission in Crohn’s disease

Kong, L., Lloyd-Price, J., Vatanen, T., Seksik, P., Beaugerie, L., Simon, T., Vlamakis, H., Sokol, H., & Xavier, R. J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.08.045 · Cited by 69 · see citing works

Gastrointestinal Microbiota in Patients with Chronic Kidney Disease: A Systematic Review

Chung, S.-Y., Barnes, J. L., & Astroth, K. S. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz028 · Cited by 69 · see citing works

Gut microbiota in chronic kidney disease

Cigarrán, S., Parra, E. G., & Cases, A. (2017) · Nefrología (English Edition) · doi:10.1016/j.nefroe.2017.01.017 · Cited by 69 · see citing works

Chronic Kidney Disease, Gut Dysbiosis, and Constipation: A Burdensome Triplet

Ikee, R., Sasaki, N., Yasuda, T., & Fukazawa, S. (2020) · Microorganisms · doi:10.3390/microorganisms8121862 · Cited by 65 · see citing works

Gut Microbiome in Chronic Kidney Disease

Armani, R. G., Ramezani, A., Yasir, A., Sharama, S., Canziani, M. E., & Raj, D. S. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0727-0 · Cited by 66 · see citing works

From obesity through gut microbiota to cardiovascular diseases: a dangerous journey

Marzullo, P., Renzo, L. D., Pugliese, G., Siena, M. D., Barrea, L., Muscogiuri, G., Colao, A., & Savastano, S. (2020) · International Journal of Obesity Supplements · doi:10.1038/s41367-020-0017-1 · Cited by 64 · see citing works

Protein-bound uremic toxins impaired mitochondrial dynamics and functions

Sun, C., Cheng, M., Pan, H., Lee, J.-H., & Lee, C. (2017) · Oncotarget · doi:10.18632/oncotarget.20773 · Cited by 62 · see citing works

The Role of Probiotics in Purine Metabolism, Hyperuricemia and Gout: Mechanisms and Interventions

James, A., Ke, H., Yao, T., & Wang, Y. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1904412 · Cited by 62 · see citing works

Synbiotics Easing Renal Failure by Improving Gut Microbiology II (SYNERGY II): A Feasibility Randomized Controlled Trial

McFarlane, C. M., Krishnasamy, R., Stanton, T., Savill, E., Snelson, M., Mihala, G., Kelly, J. T., Morrison, M., Johnson, D. W., & Campbell, K. L. (2021) · Nutrients · doi:10.3390/nu13124481 · Cited by 61 · see citing works

Environmental Chemical Diethylhexyl Phthalate Alters Intestinal Microbiota Community Structure and Metabolite Profile in Mice

Lei, M., Menon, R., Manteiga, S., Alden, N., Hunt, C. L., Alaniz, R. C., Lee, K., & Jayaraman, A. (2019) · mSystems · doi:10.1128/msystems.00724-19 · Cited by 62 · see citing works

The Gut–Organ Axis within the Human Body: Gut Dysbiosis and the Role of Prebiotics

Saxami, G., Kerezoudi, E. N., Eliopoulos, C., Arapoglou, D., & Kyriacou, A. (2023) · Life · doi:10.3390/life13102023 · Cited by 60 · see citing works

The role of short-chain fatty acid in metabolic syndrome and its complications: focusing on immunity and inflammation

Yu, W., Sun, S., Yan, Y., Zhou, H., Liu, Z., & Fu, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1519925 · Cited by 66 · see citing works

Oral iron supplementation: Potential implications for the gut microbiome and metabolome in patients with CKD

Kortman, G. A. M., Reijnders, D., & Swinkels, D. W. (2017) · Hemodialysis International · doi:10.1111/hdi.12553 · Cited by 58 · see citing works

Effect of Dietary Inulin Supplementation on the Gut Microbiota Composition and Derived Metabolites of Individuals Undergoing Hemodialysis: A Pilot Study

Biruete, A., Cross, T.-W., Allen, J. M., Kistler, B. M., de Loor, H., Evenepoel, P., Fahey, G. C., Jr., Bauer, L. L., Swanson, K. S., & Wilund, K. R. (2021) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2020.10.003 · Cited by 59 · see citing works

Preventive Effects of Lactobacillus Mixture against Chronic Kidney Disease Progression through Enhancement of Beneficial Bacteria and Downregulation of Gut-Derived Uremic Toxins

Huang, H., Li, K., Lee, Y., & Chen, M. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c01547 · Cited by 58 · see citing works

Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance

Holle, J. B., Bartolomaeus, H., Löber, U., Behrens, F., Bartolomaeus, T. U. P., Anandakumar, H., Wimmer, M. I., Vu, D. L., Kuhring, M., Brüning, U., et al. (2022) · Journal of the American Society of Nephrology · doi:10.1681/asn.2022030378 · Cited by 57 · see citing works

Gut microbiome-related metabolic changes in plasma of antibiotic-treated rats

Behr, C., Kamp, H., Fabian, E. J., Krennrich, G., Mellert, W., Peter, R. E., Strauss, V., Walk, T. B., Rietjens, I. M. C. M., & van Ravenzwaay, B. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-1949-2 · Cited by 57 · see citing works

Inulin-type prebiotics reduce serum uric acid levels via gut microbiota modulation: a randomized, controlled crossover trial in peritoneal dialysis patients

He, S., Xiong, Q., Tian, C., Li, L., Zhao, J., Lin, X., Guo, X., He, Y., Liang, W., Zuo, X., et al. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02669-y · Cited by 56 · see citing works

Association between gut dysbiosis and chronic kidney disease: a narrative review of the literature

Feng, Z., Wang, T., Dong, S., Jiang, H., Zhang, J., Raza, H. K., & Lei, G. (2021) · Journal of International Medical Research · doi:10.1177/03000605211053276 · Cited by 56 · see citing works

Vascular Calcification: An Important Understanding in Nephrology

Vahed, S. Z., Mostafavi, S., Khatibi, S. M. H., Shoja, M. M., & Ardalan, M. (2020) · Vascular Health and Risk Management · doi:10.2147/vhrm.s242685 · Cited by 55 · see citing works

Microbiome modulation as a novel therapeutic approach in chronic kidney disease

Sumida, K., Lau, W. L., Kovesdy, C. P., Kalantar‐Zadeh, K., & Kalantar‐Zadeh, K. (2020) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000661 · Cited by 57 · see citing works

The Regulation of Host Intestinal Microbiota by Polyphenols in the Development and Prevention of Chronic Kidney Disease

Bao, N. T. Y., Chen, F., & Dai, D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02981 · Cited by 53 · see citing works

Gut microbiota and renal transplant outcome

Ardalan, M., & Vahed, S. Z. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.114 · Cited by 52 · see citing works

Gut Microbiome and Organ Fibrosis

Costa, C. F. F. A., Sampaio‐Maia, B., Araújo, R., Nascimento, D. S., Ferreira‐Gomes, J., Pestana, M., Azevedo, M. J., & Alencastre, I. S. (2022) · Nutrients · doi:10.3390/nu14020352 · Cited by 51 · see citing works

An Overview of Chronic Kidney Disease Pathophysiology: The Impact of Gut Dysbiosis and Oral Disease

Altamura, S., Pietropaoli, D., Lombardi, F., Pinto, R. D., & Ferri, C. (2023) · Biomedicines · doi:10.3390/biomedicines11113033 · Cited by 58 · see citing works

The Effect of Polyphenol-Rich Interventions on Cardiovascular Risk Factors in Haemodialysis: A Systematic Review and Meta-Analysis

Marx, W., Kelly, J. T., Marshall, S., Nakos, S., Campbell, K. L., & Itsiopoulos, C. (2017) · Nutrients · doi:10.3390/nu9121345 · Cited by 51 · see citing works

Circulating Bacterial Fragments as Cardiovascular Risk Factors in CKD

Szeto, C., McIntyre, C. W., & Li, P. K. (2018) · Journal of the American Society of Nephrology · doi:10.1681/asn.2018010068 · Cited by 51 · see citing works

Gut Microbiome in Chronic Kidney Disease

Armani, R. G., Ramezani, A., Yasir, A., Sharama, S., Canziani, M. E., & Raj, D. S. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0727-0 · Cited by 66 · see citing works

Review: Uremic Toxins and Gut Microbiome

Suzuki, T., & Abe, T. (2020) · Springer eBooks · doi:10.1007/978-981-15-7793-2_2

The gut–kidney axis

Evenepoel, P., Poesen, R., & Meijers, B. (2017) · Pediatric Nephrology · doi:10.1007/s00467-016-3527-x · Cited by 305 · see citing works

The Gut Microbiome, Kidney Disease, and Targeted Interventions

Ramezani, A., & Raj, D. S. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013080905 · Cited by 752 · see citing works

Decreasing microbiota-derived uremic toxins to improve CKD outcomes

Beker, B. M., Colombo, I., González-Torres, H. J., & Musso, C. G. (2022) · Clinical Kidney Journal · doi:10.1093/ckj/sfac154 · Cited by 52 · see citing works