The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
The Role of SDF-1-CXCR4/CXCR7 Axis in the Therapeutic Effects of Hypoxia-Preconditioned Mesenchymal Stem Cells for Renal Ischemia/Reperfusion Injury
Open accessAbstract
In vitro hypoxic preconditioning (HP) of mesenchymal stem cells (MSCs) could ameliorate their viability and tissue repair capabilities after transplantation into the injured tissue through yet undefined mechanisms. There is also experimental evidence that HP enhances the expression of both stromal-derived factor-1 (SDF-1) receptors, CXCR4 and CXCR7, which are involved in migration and survival of MSCs in vitro, but little is known about their role in the in vivo therapeutic effectiveness of MSCs in renal ischemia/reperfusion (I/R) injury. Here, we evaluated the role of SDF-1-CXCR4/CXCR7 pathway in regulating chemotaxis, viability and paracrine actions of HP-MSCs in vitro and in vivo. Compared with normoxic preconditioning (NP), HP not only improved MSC chemotaxis and viability but also stimulated secretion of proangiogenic and mitogenic factors. Importantly, both CXCR4 and CXCR7 were required for the production of paracrine factors by HP-MSCs though the former was only responsible for chemotaxis while the latter was for viability. SDF-1α expression was upregulated in postischemic kidneys. After 24 h systemical administration following I/R, HP-MSCs but not NP-MSCs were selectively recruited to ischemic kidneys and this improved recruitment was abolished by neutralization of CXCR4, but not CXCR7. Furthermore, the increased recruitment of HP-MSCs was associated with enhanced functional recovery, accelerated mitogenic response, and reduced apoptotic cell death. In addition, neutralization of either CXCR4 or CXCR7 impaired the improved therapeutic potential of HP-MSCs. These results advance our knowledge about SDF-1-CXCR4/CXCR7 axis as an attractive target pathway for improving the beneficial effects of MSC-based therapies for renal I/R.
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Cites
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C. (2004) · Nature Medicine · doi:10.1038/nm1075 · Cited by 2,600
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Tögel, F., Hu, Z., Weiss, K., Isaac, J., Lange, C., & Westenfelder, C. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00007.2005 · Cited by 1,178
The Dynamic in vivo Distribution of Bone Marrow-Derived Mesenchymal Stem Cells after Infusion
Gao, J., Dennis, J. E., Muzic, R. F., Lundberg, M., & Caplan, A. I. (2001) · Cells Tissues Organs · doi:10.1159/000047856 · Cited by 951
Incidence and Outcomes in Acute Kidney Injury: A Comprehensive Population-Based Study
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Jin, D. K., Shido, K., Kopp, H.-G., Petit, I., Shmelkov, S. V., Young, L. M., Hooper, A. T., Amano, H., Avecilla, S. T., Heissig, B., et al. (2006) · Nature Medicine · doi:10.1038/nm1400 · Cited by 646
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Cited by
Mesenchymal Stem Cells in Tissue Repair
DiMarino, A. M., Caplan, A. I., & Bonfield, T. L. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00201 · Cited by 438
Enhancing the Migration Ability of Mesenchymal Stromal Cells by Targeting the SDF-1/CXCR4 Axis
Marquez-Curtis, L. A., & Janowska-Wieczorek, A. (2013) · BioMed Research International · doi:10.1155/2013/561098 · Cited by 287
Kulesza, A., Paczek, L., & Burdzinska, A. (2023) · Biomedicines · doi:10.3390/biomedicines11020445 · Cited by 163
Ma, H.-C. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i40.14884 · Cited by 75
Metadata
- Authors
- Liu, H., Liu, S., Li, Y., Wang, X., Xue, W., Ge, G., & Luo, X.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-04-12
- Volume
- 7
- Issue
- 4
- Pages
- e34608
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2123753106
- Cited by
- 262
- References
- 55
- FWCI
- 12.63
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liu, H., Liu, S., Li, Y., Wang, X., Xue, W., Ge, G., & Luo, X. (2012). The Role of SDF-1-CXCR4/CXCR7 Axis in the Therapeutic Effects of Hypoxia-Preconditioned Mesenchymal Stem Cells for Renal Ischemia/Reperfusion Injury. PLoS ONE. https://doi.org/10.1371/journal.pone.0034608
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