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Cited by 56HIV/AIDS Research and InterventionsHIV, Drug Use, Sexual RiskHIV Research and Treatment

High and persistent HIV seroincidence in men who have sex with men across 47 U.S. cities.

Open access
Ackers, Marta-Louise, Greenberg, Alan E., Lin, Carol Y., Bartholow, Bradford N., Goodman, Adrian Hirsch, Longhi, Michael, Gurwith, Marc·2012·PLoS ONE
DOI 10.1371/journal.pone.0034972PMC PMC3329535
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Abstract

OBJECTIVE: To provide HIV seroincidence data among men who have sex with men (MSM) in the United States and to identify predictive factors for seroconversion. METHODS: From 1998-2002, 4684 high-risk MSM, age 18-60 years, participated in a randomized, placebo-controlled HIV vaccine efficacy trial at 56 U.S. clinical trial sites. Demographics, behavioral data, and HIV status were assessed at baseline and 6 month intervals. Since no overall vaccine efficacy was detected, data were combined from both trial arms to calculate HIV incidence based on person-years (py) of follow-up. Predictors of seroconversion, adjusted hazards ratio (aHR), were evaluated using a Cox proportional hazard model with time-varying covariates. RESULTS: Overall, HIV incidence was 2.7/100 py and was relatively uniform across study sites and study years. HIV incidence was highest among young men and men reporting unprotected sex, recreational drug use, and a history of a sexually transmitted infection. Independent predictors of HIV seroconversion included: age 18-30 years (aHR = 2.4; 95% CI 1.4,4.0), having >10 partners (aHR = 2.4; 95% CI 1.7,3.3), having a known HIV-positive male sex partner (aHR = 1.6; 95% CI 1.2, 2.0), unprotected anal intercourse with HIV positive/unknown male partners (aHR = 1.7; 95% CI 1.3, 2.3), and amphetamine (aHR = 1.6; 95% CI 1.1, 2.1) and popper (aHR = 1.7; 95% CI 1.3, 2.2) use. CONCLUSIONS: HIV seroincidence was high among MSM despite repeated HIV counseling and reported declines in sexual risk behaviors. Continuing development of new HIV prevention strategies and intensification of existing efforts will be necessary to reduce the rate of new HIV infections, especially among young men.

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  • Similar to other STIs, multiple partners, anonymous partners, condomless sex, and substance use are all associated with HIV infection.

    “Similar to other STIs, multiple partners, anonymous partners, condomless sex, and substance use are all associated with HIV infection (193–196).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [194]

    The Results, particularly Table 2 (page not provided), associate greater numbers of male partners, unprotected anal intercourse, and amphetamine and popper use with HIV seroconversion among men who have sex with men. The paper does not establish an association for anonymous partners; a partner’s unknown HIV status is not the same as anonymity. Its findings are also specific to the studied population, rather than HIV infection generally. (LLM, conf=0.88)

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1 of the 65 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. [8]CDC 2003 Primary and secondary syphilis–United States, 2002. MMWR 52 46 1117 1120 14627949

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Authors
Ackers, M.-L., Greenberg, A. E., Lin, C. Y., Bartholow, B. N., Goodman, A. H., Longhi, M., & Gurwith, M.
Affiliations
Centers for Disease Control and Prevention (US)
Corresponding author
Ackers, Marta-Louise
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2012-04-18
Volume
7
Issue
4
Pages
e34972
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0034972
PMC
PMC3329535
OpenAlex
W2161926360
Cited by
55
References
65
Citations by year
2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 6 · 2018: 7 · 2017: 2 · 2016: 9 · 2015: 6 · 2014: 9 · 2013: 5
FWCI
4.66
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, public-domain)
  • Europe PMC (PubMed Central) (publishedVersion, public-domain)
  • PubMed Central (publishedVersion, public-domain)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • U.S. Department of Health and Human Services
  • Centers for Disease Control and Prevention
Topics
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
men who have sex with men, HIV seroconversion, unprotected anal intercourse, recreational drug use, amphetamine use, number of sexual partners, sexually transmitted infections, young men, HIV prevention, HIV vaccine trials
MeSH terms
Adolescent, Adult, Cities, HIV Seropositivity, Humans, Male, Middle Aged, Risk Factors, Sexual Partners, Sexually Transmitted Diseases, United States, HIV Seroprevalence, HIV Infections, Incidence, Homosexuality, Male, Young Adult

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