The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Flexibility of a Eukaryotic Lipidome – Insights from Yeast Lipidomics
Open accessAbstract
Mass spectrometry-based shotgun lipidomics has enabled the quantitative and comprehensive assessment of cellular lipid compositions. The yeast Saccharomyces cerevisiae has proven to be a particularly valuable experimental system for studying lipid-related cellular processes. Here, by applying our shotgun lipidomics platform, we investigated the influence of a variety of commonly used growth conditions on the yeast lipidome, including glycerophospholipids, triglycerides, ergosterol as well as complex sphingolipids. This extensive dataset allowed for a quantitative description of the intrinsic flexibility of a eukaryotic lipidome, thereby providing new insights into the adjustments of lipid biosynthetic pathways. In addition, we established a baseline for future lipidomic experiments in yeast. Finally, flexibility of lipidomic features is proposed as a new parameter for the description of the physiological state of an organism.
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Cites
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KNIME: The Konstanz Information Miner
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Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry
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Self-citationLipid intermolecular hydrogen bonding: influence on structural organization and membrane function
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Self-citationLipidomics: New Tools and Applications
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Glucose Signaling in Saccharomyces cerevisiae
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Cited by
Homeoviscous Adaptation and the Regulation of Membrane Lipids
Ernst, R., Ejsing, C. S., & Antonny, B. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.08.013 · Cited by 506
Foresti, O., Ruggiano, A., Hannibal-Bach, H. K., Ejsing, C. S., & Carvalho, P. (2013) · eLife · doi:10.7554/elife.00953 · Cited by 205
Lipid saturation controls nuclear envelope function
Romanauska, A., & Köhler, A. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01207-8 · Cited by 65
Castro, I. G., Shortill, S. P., Dziurdzik, S. K., Cadou, A., Ganesan, S., Valenti, R., David, Y., Davey, M., Mattes, C., Thomas, F. B., et al. (2022) · eLife · doi:10.7554/elife.74602 · Cited by 60
Osh Proteins Control Nanoscale Lipid Organization Necessary for PI(4,5)P2 Synthesis
Nishimura, T., Gecht, M., Covino, R., Hummer, G., Surma, M. A., Klose, C., Arai, H., Kono, N., & Stefan, C. J. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.06.037 · Cited by 56
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Metadata
- Authors
- Klose, C., Surma, M. A., Gerl, M. J., Meyenhofer, F., Shevchenko, A., & Simons, K.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-04-18
- Volume
- 7
- Issue
- 4
- Pages
- e35063
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2093629098
- Cited by
- 301
- References
- 56
- FWCI
- 7.16
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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