Gastrointestinal-sparing effects of novel NSAIDs in rats with compromised mucosal defence
Open accessAbstract
Nonsteroidal anti-inflammatory drugs are among the most commonly used prescription and over-the-counter medications, but they often produce significant gastrointestinal ulceration and bleeding, particularly in elderly patients and patients with certain co-morbidities. Novel anti-inflammatory drugs are seldom tested in animal models that mimic the high risk human users, leading to an underestimate of the true toxicity of the drugs. In the present study we examined the effects of two novel NSAIDs and two commonly used NSAIDs in models in which mucosal defence was expected to be impaired. Naproxen, celecoxib, ATB-346 (a hydrogen sulfide- and naproxen-releasing compound) and NCX 429 (a nitric oxide- and naproxen-releasing compound) were evaluated in healthy, arthritic, obese, and hypertensive rats and in rats of advanced age (19 months) and rats co-administered low-dose aspirin and/or omeprazole. In all models except hypertension, greater gastric and/or intestinal damage was observed when naproxen was administered in these models than in healthy rats. Celecoxib-induced damage was significantly increased when co-administered with low-dose aspirin and/or omeprazole. In contrast, ATB-346 and NCX 429, when tested at doses that were as effective as naproxen and celecoxib in reducing inflammation and inhibiting cyclooxygenase activity, did not produce significant gastric or intestinal damage in any of the models. These results demonstrate that animal models of human co-morbidities display the same increased susceptibility to NSAID-induced gastrointestinal damage as observed in humans. Moreover, two novel NSAIDs that release mediators of mucosal defence (hydrogen sulfide and nitric oxide) do not induce significant gastrointestinal damage in these models of impaired mucosal defence.
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H2S has been demonstrated to be a critical mediator of gastric and intestinal mucosal protection and repair.
“Hydrogen sulfide has been demonstrated to be a critical mediator of gastric and intestinal mucosal protection and repair.”
From Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis (2014) · cites this paper as [14]
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Differential visceral pain sensitivity and colonic morphology in four common laboratory rat strains
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H2S confers colonoprotection against TNBS-induced colitis by HO-1 upregulation in rats
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M378 exhibits anti-inflammatory activities through NLRP3 signaling pathway
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Hidrojen Sülfür’ün Fizyolojik ve Patolojik Olaylara Katkısı ve Klinikte Kullanımı
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- Authors
- Blackler, R., Syer, S., Bolla, M., Ongini, E., & Wallace, J. L.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Wallace, John L.
- ORCID
- Wallace, John L.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-04-09
- Volume
- 7
- Issue
- 4
- Pages
- e35196
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3322164
- OpenAlex
- W2010356890
- Cited by
- 93
- References
- 47
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 6 · 2021: 13 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 7 · 2016: 12 · 2015: 16 · 2014: 16 · 2013: 11
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- MacSphere (McMaster University) (submittedVersion)
- MacSphere (McMaster University)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- naproxen, celecoxib, mucosal protection, obesity, hypertension, aging, aspirin, omeprazole, cyclooxygenase inhibition, drug toxicity
- MeSH terms
- Celecoxib, Animals, Anti-Inflammatory Agents, Non-Steroidal, Arthritis, Aspirin, Drug Therapy, Combination, Gastric Mucosa, Gastrointestinal Diseases, Hypertension, Male, Naproxen, Nitrates, Obesity, Omeprazole, Pyrazoles, Rats, Inbred SHR, Rats, Zucker, Sulfonamides, Rats, Wistar, Gastrointestinal Tract, Rats
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