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Cited by 42Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsGenetics and Neurodevelopmental Disorders

Long-Lasting LTP Requires Neither Repeated Trains for Its Induction Nor Protein Synthesis for Its Development

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Villers, Agnès, Godaux, Emile, Ris, Laurence·2012·PLoS ONE
DOI 10.1371/journal.pone.0040823PMC PMC3394721
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Abstract

Current thinking about LTP triggered in the area CA1 of hippocampal slices is ruled by two "dogmas": (1) A single train of high-frequency stimulation is sufficient to trigger short-lasting LTP (1-3 h), whereas multiple trains are required to induce long-lasting LTP (L-LTP, more than 4 h). (2) The development of the late phase of L-LTP requires the synthesis of new proteins. In this study, we found that a single high-frequency train could trigger an LTP lasting more than 8 h that was not affected by either anisomycin or cycloheximide (two inhibitors of protein synthesis). We ascertained that the induction of this L-LTP made use of the same mechanisms as those usually reported to be involved in LTP induction: it was dependent on NMDA receptors and on the activation of two "core" kinases, CaMKII and PI3K. These findings call into question the two "dogmas" about LTP.

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  • Two rigorously controlled studies failed to find any role for protein synthesis in late LTP.

    “Furthermore, although rarely cited, there are two rigorously controlled studies that failed to find any role for protein synthesis in late LTP (59, 60).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [60]

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Authors
Villers, A., Godaux, E., & Ris, L.
Affiliations
University of Mons (BE)
Corresponding author
Ris, Laurence
ORCID
Ris, Laurence
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2012-07-11
Volume
7
Issue
7
Pages
e40823
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0040823
PMC
PMC3394721
OpenAlex
W2148011117
Cited by
42
References
4
Citations by year
2026: 1 · 2025: 3 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 6 · 2013: 8 · 2012: 2
FWCI
2.77
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • ORBi UMONS (submittedVersion)
Funders
Fonds De La Recherche Scientifique - FNRS
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
long-term potentiation, high-frequency stimulation, protein synthesis, NMDA receptor, CaMKII, phosphatidylinositol 3-kinase, anisomycin, cycloheximide, hippocampal CA1, synaptic plasticity
MeSH terms
Animals, Electric Stimulation, Hippocampus, Memory, Phosphorylation, Protein Synthesis Inhibitors, Protein Biosynthesis, Receptors, N-Methyl-D-Aspartate, N-Methylaspartate, Long-Term Potentiation, Receptors, AMPA, Phosphatidylinositol 3-Kinases, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2

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