Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity.

Edelmann, Elke; Leßmann, Volkmar; Brigadski, Tanja

doi:10.1016/j.neuropharm.2013.05.043

Cited by 248Neuroscience and Neuropharmacology ResearchNerve injury and regenerationNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 245 of the 246 references it cites were found in a registry or an index.

Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity.

Edelmann, Elke, Leßmann, Volkmar, Brigadski, Tanja·2014·Neuropharmacology

DOI 10.1016/j.neuropharm.2013.05.043

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Abstract

Overwhelming evidence collected since the early 1990's strongly supports the notion that BDNF is among the key regulators of synaptic plasticity in many areas of the mammalian central nervous system. Still, due to the extremely low expression levels of endogenous BDNF in most brain areas, surprisingly little data i) pinpointing pre- and postsynaptic release sites, ii) unraveling the time course of release, and iii) elucidating the physiological levels of synaptic activity driving this secretion are available. Likewise, our knowledge regarding pre- and postsynaptic effects of endogenous BDNF at the single cell level in mediating long-term potentiation still is sparse. Thus, our review will discuss the data currently available regarding synaptic BDNF secretion in response to physiologically relevant levels of activity, and will discuss how endogenously secreted BDNF affects synaptic plasticity, giving a special focus on spike timing-dependent types of LTP and on mossy fiber LTP. We will attempt to open up perspectives how the remaining challenging questions regarding synaptic BDNF release and action might be addressed by future experiments. This article is part of the Special Issue entitled 'BDNF Regulation of Synaptic Structure, Function, and Plasticity'.

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In the hippocampus, BDNF acts on both pre- and post-synaptic compartments, modulating synaptic efficacy either by changing pre-synaptic transmitter release or by increasing post-synaptic transmitter sensitivity to induce a long-lasting increase in synaptic plasticity.
“Especially in the hippocampus, this neurotrophin is thought to act on both the pre- and post-synaptic compartments, modulating synaptic efficacy, either by changing the pre-synaptic transmitter release, or by increasing post-synaptic transmitter sensitivity [15,16] to induce a long-lasting increase in synaptic plasticity.”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [16]
The effects of BDNF on LTP are mediated by the TrkB receptor.
“The effects of BDNF on LTP are mediated by the TrkB receptor.”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [16]
BDNF is an important regulator of synaptic transmission and long-term potentiation (LTP) in the hippocampus and in other brain regions.
“In addition, studies also show that BDNF is an important regulator of synaptic transmission and long-term potentiation (LTP) in the hippocampus and in other brain regions.”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [16]
In the hippocampus, BDNF is thought to act at pre- and post-synaptic levels, modulating synaptic efficacy either by changes in pre-synaptic transmitter release or by increased post-synaptic transmitter sensitivity to induce a long-lasting increase in synaptic plasticity.
“In particular, in the hippocampus the neurotrophin is thought to act at pre- and post-synaptic levels, modulating synaptic efficacy either by changes in pre-synaptic transmitter release, or by increased post-synaptic transmitter sensitivity (see e.g., [15,16]) to induce a long-lasting increase in synaptic plasticity.”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [16]
Brain-derived neurotrophic factor interacts with energy metabolism to facilitate both pre- and post-synaptic mechanisms and the induction of long-term potentiation.
“The protein is thought to interact with energy metabolism to facilitate both pre- and post-synaptic mechanisms and the induction of LTP (Gomez-Pinilla and Hillman, 2013; Edelmann et al., 2014), as well as promoting the proliferation and survival of adult-born granule cells (Korol et al., 2013; Park and Poo, 2013).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Edelmann et al., 2014

A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
LTP and LTD
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00035-7 · Cited by 3,888
Neurotrophin regulation of neural circuit development and function
Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060
Spike Timing–Dependent Plasticity: A Hebbian Learning Rule
Caporale, N., & Dan, Y. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125639 · Cited by 1,997
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
Coull, J. A. M., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., Gravel, C., Salter, M. W., & De Koninck, Y. (2005) · Nature · doi:10.1038/nature04223 · Cited by 1,965
Synaptic tagging and long-term potentiation
Frey, U., & Morris, R. G. M. (1997) · Nature · doi:10.1038/385533a0 · Cited by 1,736
Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
Vaynman, S., Ying, Z., & Gomez‐Pinilla, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03720.x · Cited by 1,460
Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
Smith, M., Makino, S., Květňanský, R., & Post, R. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01768.1995 · Cited by 1,449
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
Chen, Z.-Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C.-J., Herrera, D. G., Toth, M., Yang, C., McEwen, B. S., et al. (2006) · Science · doi:10.1126/science.1129663 · Cited by 1,340
Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice
Patterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233
BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
Bramham, C. R., & Messaoudi, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.003 · Cited by 1,193
Metaplasticity: tuning synapses and networks for plasticity
Abraham, W. C. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2356 · Cited by 1,166
Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity
Pang, P. T., Teng, H. K., Zaitsev, E., Woo, N. T., Sakata, K., Zhen, S., Teng, K. K., Yung, W.-H., Hempstead, B. L., & Lu, B. (2004) · Science · doi:10.1126/science.1100135 · Cited by 1,136
Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus
Figurov, A., Pozzo-Miller, L. D., Olafsson, P., Wang, T., & Lu, B. (1996) · Nature · doi:10.1038/381706a0 · Cited by 1,106
Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport
Conner, J. M., Lauterborn, J. C., Yan, Q., Gall, C. M., & Varon, S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02295.1997 · Cited by 1,097
Definition of the readily releasable pool of vesicles at hippocampal synapses.
Rosenmund, C., & Stevens, C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80146-4 · Cited by 1,084
The Spike-Timing Dependence of Plasticity
Feldman, D. E. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.001 · Cited by 1,071
Regional distribution of brain‐derived neurotrophic factor mRNA in the adult mouse brain.
Hofer, M., Pagliusi, S. R., Hohn, A., Leibrock, J., & Barde, Y. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07423.x · Cited by 1,039
Multiple promoters direct tissue-specific expression of the rat BDNF gene
Timmusk, T., Palm, K., Metsis, M., Reintam, T., Paalme, V., Saarma, M., & Persson, H. (1993) · Neuron · doi:10.1016/0896-6273(93)90335-o · Cited by 858
Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family
Ernfors, P., Wetmore, C., Olson, L., & Persson, H. (1990) · Neuron · doi:10.1016/0896-6273(90)90090-3 · Cited by 819
BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?
Lü, Y., Christian, K. M., & Lu, B. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.018 · Cited by 807
Making memories last: the synaptic tagging and capture hypothesis
Redondo, R. L., & Morris, R. G. M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2963 · Cited by 792
Brain-derived Neurotrophic Factor Is Stored in Human Platelets and Released by Agonist Stimulation
Fujimura, H., Chen, R., Nakamura, T., Nakahashi, T., Kambayashi, J.-I., Sun, B., Altar, C., & Tandon, N. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613072 · Cited by 777
Postsynaptic BDNF‐TrkB signaling in synapse maturation, plasticity, and disease
Yoshii, A., & Constantine‐Paton, M. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20765 · Cited by 744
Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons
An, J. J., Gharami, K., Liao, G., Woo, N. H., Lau, A. G., Vanevski, F., Torre, E. R., Jones, K. R., Feng, Y., Lu, B., et al. (2008) · Cell · doi:10.1016/j.cell.2008.05.045 · Cited by 698
Neurotrophin secretion: current facts and future prospects
Leßmann, V., Gottmann, K., & Malcangio, M. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00019-4 · Cited by 683
Self-citation
Synaptic plasticity at hippocampal mossy fibre synapses
Nicoll, R. A., & Schmitz, D. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1786 · Cited by 653
Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines
Tanaka, J.-I., Horiike, Y., Matsuzaki, M., Miyazaki, T., Ellis-Davies, G. C. R., & Kasai, H. (2008) · Science · doi:10.1126/science.1152864 · Cited by 615
Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors
Levine, E. S., Dreyfus, C. F., Black, I. B., & Plummer, M. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.8074 · Cited by 611
Translational Regulatory Mechanisms in Persistent Forms of Synaptic Plasticity
Kelleher, R. J., Govindarajan, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.013 · Cited by 592
Neurotrophin expression in rat hippocampal slices: A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs
Patterson, S. L., Grover, L. M., Schwartzkroin, P. A., & Bothwell, M. (1992) · Neuron · doi:10.1016/0896-6273(92)90067-n · Cited by 555
Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain
Ickes, B. R., Pham, T. M., Sanders, L., Albeck, D. S., Mohammed, A. H. S., & Granholm, A. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7415 · Cited by 541
Widespread Expression of BDNF But Not NT3 by Target Areas of Basal Forebrain Cholinergic Neurons
PHILLIPS, H. S., Hains, J. M., Laramee, G. R., Rosenthal, A., & Winslow, J. W. (1990) · Science · doi:10.1126/science.1688328 · Cited by 539
The role of neuronal growth factors in neurodegenerative disorders of the human brain
Connor, B. J., & Dragunow, M. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00004-6 · Cited by 538
Synaptic secretion of BDNF after high‐frequency stimulation of glutamatergic synapses
Hartmann, M., Heumann, R., & Leßmann, V. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.5887 · Cited by 528
Self-citation
Nerve Growth Factor Treatment Increases Brain-Derived Neurotrophic Factor Selectively in TrkA-Expressing Dorsal Root Ganglion Cells and in Their Central Terminations within the Spinal Cord
Michael, G. J., Averill, S., Nitkunan, A., Rattray, M., Bennett, D., Yan, Q., & Priestley, J. V. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08476.1997 · Cited by 512
Mechanism of TrkB-Mediated Hippocampal Long-Term Potentiation
Minichiello, L., Calella, A. M., Medina, D. L., Bonhoeffer, T., Klein, R., & Korte, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00942-x · Cited by 506
Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization.Preprint
Huang, Y.-Y., & Kandel, E. (1994) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.1.1.74 · Cited by 499
Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system
Yan, Q., Rosenfeld, R. D., Matheson, C. R., Hawkins, N., Lopez, O. T., Bennett, L., & Welcher, A. A. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00613-6 · Cited by 498
Neurotrophins and Time: Different Roles for TrkB Signaling in Hippocampal Long-Term Potentiation
Kang, H., Welcher, A. A., Shelton, D., & Schuman, E. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80378-5 · Cited by 481
P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation
Trang, T., Beggs, S., Wan, X., & Salter, M. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5714-08.2009 · Cited by 474
Impairments in High-Frequency Transmission, Synaptic Vesicle Docking, and Synaptic Protein Distribution in the Hippocampus of BDNF Knockout Mice
Pozzo‐Miller, L. D., Gottschalk, W., Zhang, L., McDermott, K., Du, J., Gopalakrishnan, R., Oho, C., Sheng, Z., & Lu, B. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04972.1999 · Cited by 471
A history of spike-timing-dependent plasticity
Markram, H. (2011) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2011.00004 · Cited by 454
Neuronal release of proBDNF
Yang, J., Siao, C.-J., Nagappan, G., Marinic, T., Jing, D., McGrath, K., Chen, Z.-Y., Mark, W., Tessarollo, L., Lee, F. S., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2244 · Cited by 449
Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis
Ferrini, F., Trang, T., Mattioli, T.-A. M., Laffray, S., Del’Guidice, T., Lorenzo, L.-É., Castonguay, A., Doyon, N., Zhang, W., Godin, A. G., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3295 · Cited by 441
Brain-Derived Neurotrophic Factor Modulates Nociceptive Sensory Inputs and NMDA-Evoked Responses in the Rat Spinal Cord
Kerr, B. J., Bradbury, E. J., Bennett, D., Trivedi, P. M., Dassan, P., French, J., Shelton, D., McMahon, S. B., & Thompson, S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05138.1999 · Cited by 439
Dopamine Receptor Activation Is Required for Corticostriatal Spike-Timing-Dependent Plasticity
Pawlak, V., & Kerr, J. N. D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4402-07.2008 · Cited by 430
Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity
Seol, G. H., Ziburkus, J., Huang, S., Song, L., Kim, I. T., Takamiya, K., Huganir, R. L., Lee, H.-K., & Kirkwood, A. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.013 · Cited by 429
Cellular Mechanisms Regulating Activity-Dependent Release of Native Brain-Derived Neurotrophic Factor from Hippocampal Neurons
Bałkowiec, A., & Katz, D. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10399.2002 · Cited by 405
The Role of Brain-Derived Neurotrophic Factor Receptors in the Mature Hippocampus: Modulation of Long-Term Potentiation through a Presynaptic Mechanism involving TrkB
Xu, B., Gottschalk, W., Chow, A., Wilson, R. I., Schnell, E., Zang, K., Wang, D., Nicoll, R. A., Lu, B., & Reichardt, L. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06888.2000 · Cited by 404
Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins
Shelton, D., Sutherland, J. S., Gripp, J. T., Camerato, T., Armanini, M. P., Phillips, H., Carroll, K., Spencer, S., & Levinson, A. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00477.1995 · Cited by 403
Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization
Wetmore, C., Ernfors, P., Persson, H., & Olson, L. (1990) · Experimental Neurology · doi:10.1016/0014-4886(90)90068-4 · Cited by 370
Spike-Timing-Dependent Plasticity: A Comprehensive Overview
Markram, H., Gerstner, W., & Sjöström, P. J. (2012) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2012.00002 · Cited by 367
Mechanisms, locations, and kinetics of synaptic BDNF secretion: An update
Leßmann, V., & Brigadski, T. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.06.004 · Cited by 360
Self-citation
BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons
Dieni, S., Matsumoto, T., Dekkers, M. P. J., Rauskolb, S., Ionescu, M. S., Deogracias, R., Gundelfinger, E. D., Kojima, M., Nestel, S., Frotscher, M., et al. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201201038 · Cited by 360
Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF
Pang, P. T., & Lu, B. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.07.002 · Cited by 356
Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF
Matsumoto, T., Rauskolb, S., Polack, M., Klose, J., Kolbeck, R., Körte, M., & Barde, Y. (2008) · Nature Neuroscience · doi:10.1038/nn2038 · Cited by 355
Activity-Dependent Transfer of Brain-Derived Neurotrophic Factor to Postsynaptic Neurons
Kohara, K., Kitamura, A., Morishima, M., & Tsumoto, T. (2001) · Science · doi:10.1126/science.1057415 · Cited by 354
Natural patterns of activity and long-term synaptic plasticity
Paulsen, O. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00076-3 · Cited by 354
Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice.
Korte, M., Griesbeck, O., Gravel, C., Carroll, P., Staiger, V, Thoenen, H., & Bonhoeffer, T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12547 · Cited by 351
Presynaptic BDNF Required for a Presynaptic but Not Postsynaptic Component of LTP at Hippocampal CA1-CA3 Synapses
Zakharenko, S. S., Patterson, S. L., Dragatsis, I., Zeitlin, S. O., Siegelbaum, S. A., Kandel, E. R., & Morozov, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00543-9 · Cited by 334
Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase
Patterson, S. L., Pittenger, C., Morozov, A., Martin, K. C., Scanlin, H., Drake, C., & Kandel, E. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00443-3 · Cited by 334
Long-term potentiation in the amygdala: A cellular mechanism of fear learning and memory
Sigurdsson, T., Doyère, V., Cain, C. K., & LeDoux, J. E. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.06.022 · Cited by 333
Activity-Dependent Release of Endogenous Brain-Derived Neurotrophic Factor from Primary Sensory Neurons Detected by ELISAIn Situ
Bałkowiec, A., & Katz, D. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07417.2000 · Cited by 330
Activity-Dependent Dendritic Targeting of BDNF and TrkB mRNAs in Hippocampal Neurons
Tongiorgi, E., Righi, M., & Cattaneo, A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-24-09492.1997 · Cited by 328
Regulated Release and Polarized Localization of Brain-Derived Neurotrophic Factor in Hippocampal Neurons
Goodman, L. J., Valverde, J., Lim, F., Geschwind, M. D., Federoff, H. J., Geller, A. I., & Hefti, F. F. (1996) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0017 · Cited by 323
BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses
Gottmann, K., Mittmann, T., & Leßmann, V. (2009) · Experimental Brain Research · doi:10.1007/s00221-009-1994-z · Cited by 314
Self-citation
PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory
Volk, L. J., Bachman, J. L., Johnson, R., Yu, Y., & Huganir, R. L. (2013) · Nature · doi:10.1038/nature11802 · Cited by 310
Blockade of Endogenous Ligands of TrkB Inhibits Formation of Ocular Dominance Columns
Cabelli, R. J., Shelton, D. L., Segal, R. A., & Shatz, C. J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80348-7 · Cited by 306
Gene Expression Profiling of Facilitated L-LTP in VP16-CREB Mice Reveals that BDNF Is Critical for the Maintenance of LTP and Its Synaptic Capture
Barco, A., Patterson, S., Alarcon, J. M., Gromova, P., Mata-Roig, M., Morozov, A., & Kandel, E. R. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.005 · Cited by 305
Brain-Derived Neurotrophic Factor Is Released in the Dorsal Horn by Distinctive Patterns of Afferent Fiber Stimulation
Lever, I. J., Bradbury, E. J., Cunningham, J. R., Adelson, D. W., Jones, M. G., McMahon, S. B., Marvizón, J. C. G., & Malcangio, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04469.2001 · Cited by 300
BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission
Waterhouse, E. G., An, J. J., Orefice, L. L., Baydyuk, M., Liao, G.-Y., Zheng, K., Lu, B., & Xu, B. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0709-12.2012 · Cited by 287
Brain-Derived Neurotrophic Factor Enhances Long-Term Potentiation in Rat Visual Cortex
Akaneya, Y., Tsumoto, T., Kinoshita, S., & Hatanaka, H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-17-06707.1997 · Cited by 286
Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation
Griesbach, G. S., Hovda, D. A., & Gómez‐Pinilla, F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.045 · Cited by 282
AMPA receptor-induced local brain-derived neurotrophic factor signaling mediates motor recovery after stroke
Clarkson, A. N., Overman, J. J., Zhong, S., Mueller, R., Lynch, G., & Carmichael, S. T. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5780-10.2011 · Cited by 276
Zinc-Mediated Transactivation of TrkB Potentiates the Hippocampal Mossy Fiber-CA3 Pyramid Synapse
Huang, Y. Z., Pan, E., Xiong, Z., & McNamara, J. O. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.026 · Cited by 275
Associative long-term potentiation in hippocampal slices.
Barrionuevo, G., & Brown, T. H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.23.7347 · Cited by 273
A role for BDNF in the late-phase of hippocampal long-term potentiation
Körte, M., Kang, H., Bonhoeffer, T., & Schuman, E. M. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00035-5 · Cited by 269
Differential Activity-Dependent Secretion of Brain-Derived Neurotrophic Factor from Axon and Dendrite
Matsuda, N., Lü, H., Fukata, Y., Noritake, J., Gao, H., Mukherjee, S., Nemoto, T., Fukata, M., & Poo, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1863-09.2009 · Cited by 268
Neurotrophin release by neurotrophins: Implications for activity-dependent neuronal plasticity
Canossa, M., Griesbeck, O., Berninger, B., Campana, G., Kolbeck, R., & Thoenen, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13279 · Cited by 268
Control of extracellular cleavage of ProBDNF by high frequency neuronal activity
Nagappan, G., Zaitsev, E. N., Senatorov, V. V., Yang, J., Hempstead, B. L., & Lu, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807322106 · Cited by 267
Prkcz null mice show normal learning and memory
Lee, A. M., Kanter, B. R., Wang, D., Lim, J. P., Zou, M. E., Qiu, C., McMahon, T., Dadgar, J., Fischbach-Weiss, S., & Messing, R. O. (2013) · Nature · doi:10.1038/nature11803 · Cited by 259
Brain-derived Neurotrophic Factor Regulates the Expression and Synaptic Delivery ofα-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor Subunits in Hippocampal Neurons
Caldeira, M. V., Melo, C. V., Pereira, D. B., Carvalho, R., Correia, S. S., Backos, D. S., Carvalho, A. L., Esteban, J. A., & Duarte, C. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700607200 · Cited by 251
Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor
Aicardi, G., Argilli, E., Cappello, S., Santi, S., Riccio, M., Thoenen, H., & Canossa, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406960101 · Cited by 246
Relative Contribution of Endogenous Neurotrophins in Hippocampal Long-Term Potentiation
Chen, G., Kolbeck, R., Barde, Y., Bonhoeffer, T., & Kossel, A. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-18-07983.1999 · Cited by 244
Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia
Gomes, C. A., Ferreira, R., George, J., Sanches, R., Rodrigues, D. I., Gonçalves, N., & Cunha, R. A. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-16 · Cited by 244
Gain in sensitivity and loss in temporal contrast of STDP by dopaminergic modulation at hippocampal synapses
Zhang, J.-C., Lau, P.-M., & Bi, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900546106 · Cited by 241
Distinct 3′UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF)
Lau, A. G., Irier, H. A., Gu, J., Tian, D., Ku, L., Liu, G., Xia, M., Fritsch, B., Zheng, J. Q., Dingledine, R. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002929107 · Cited by 225
TRPC3 channels are necessary for brain-derived neurotrophic factor to activate a nonselective cationic current and to induce dendritic spine formation
Amaral, M. D., & Pozzo-Miller, L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5499-06.2007 · Cited by 214
Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release
Dean, C., Liu, H., Dunning, F. M., Chang, P. Y., Jackson, M. B., & Chapman, E. R. (2009) · Nature Neuroscience · doi:10.1038/nn.2315 · Cited by 214
Delay between Fusion Pore Opening and Peptide Release from Large Dense-Core Vesicles in Neuroendocrine Cells
Barg, S., Olofsson, C. S., Schriever-Abeln, J., Wendt, A., Gebre-Medhin, S., Renström, E., & Rorsman, P. (2002) · Neuron · doi:10.1016/s0896-6273(02)00563-9 · Cited by 210
Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin
Liao, G., An, J. J., Gharami, K., Waterhouse, E. G., Vanevski, F., Jones, K. R., & Xu, B. (2012) · Nature Medicine · doi:10.1038/nm.2687 · Cited by 207
Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors
Wetmore, C., Olson, L., & Bean, A. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01688.1994 · Cited by 207
Postsynaptic Secretion of BDNF and NT-3 from Hippocampal Neurons Depends on Calcium–Calmodulin Kinase II Signaling and Proceeds via Delayed Fusion Pore Opening
Kolarow, R., Brigadski, T., & Lessmann, V. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0692-07.2007 · Cited by 203
Self-citation
Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex
Sakata, K., Woo, N. H., Martinowich, K., Greene, J. S., Schloesser, R. J., Shen, L., & Lu, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811431106 · Cited by 200
Synaptic Tagging and Cross-Tagging: The Role of Protein Kinase M in Maintaining Long-Term Potentiation But Not Long-Term Depression
Sajikumar, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1104-05.2005 · Cited by 199
Neurotrophin secretion from hippocampal neurons evoked by long-term-potentiation-inducing electrical stimulation patterns
Gärtner, A., & Staiger, V. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092129699 · Cited by 195
Synaptic Tagging and Capture: Differential Role of Distinct Calcium/Calmodulin Kinases in Protein Synthesis-Dependent Long-Term Potentiation
Redondo, R. L., Okuno, H., Spooner, P. A., Frenguelli, B. G., Bito, H., & Morris, R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3140-09.2010 · Cited by 186
Sorting and Activity-Dependent Secretion of BDNF Require Interaction of a Specific Motif with the Sorting Receptor Carboxypeptidase E
Lou, H., Kim, S., Zaitsev, E. N., SNELL, C. R., Lu, B., & Loh, Y. P. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.037 · Cited by 185
Brain-derived neurotrophic factor and control of synaptic consolidation in the adult brain
Soule, J. D., Messaoudi, E., & Bramham, C. R. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340600 · Cited by 174
The Involvement of N‐Methyl‐D‐Aspartate Receptors in Induction and Maintenance of Long‐Term Potentiation in Rat Visual Cortex
Artola, A., & Singer, W. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00417.x · Cited by 173
Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes
Bergami, M., Santi, S., Formaggio, E., Cagnoli, C. M., Verderio, C., Blum, R., Berninger, B., Matteoli, M., & Canossa, M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200806137 · Cited by 173
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory
Lai, K., Wong, A. S. L., Cheung, M. C., Xu, P., Liang, Z., Lok, K.-C., Xie, H., Palko, M. E., Yung, W., Tessarollo, L., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3237 · Cited by 172
Local Presynaptic Activity Gates Homeostatic Changes in Presynaptic Function Driven by Dendritic BDNF Synthesis
Jakawich, S. K., Nasser, H. B., Strong, M. J., McCartney, A. J., Perez, A. S., Rakesh, N., Carruthers, C. J. L., & Sutton, M. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.034 · Cited by 171
BDNF-GFP containing secretory granules are localized in the vicinity of synaptic junctions of cultured cortical neurons
Haubensak, W. E., Narz, F., Heumann, R., & Lemann, V. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.11.1483 · Cited by 167
Self-citation
Spike Timing-Dependent LTP/LTD Mediates Visual Experience-Dependent Plasticity in a Developing Retinotectal System
Mu, Y., & Poo, M.-M. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.009 · Cited by 164
Brain‐derived neurotrophic factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord
Slack, S. E., Pezet, S., McMahon, S. B., Thompson, S., & Malcangio, M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03656.x · Cited by 159
The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex
Pattwell, S. S., Bath, K. G., Perez-Castro, R., Lee, F. S., Chao, M. V., & Ninan, I. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5205-11.2012 · Cited by 156
Trks: Signal transduction and intracellular pathways
Klesse, L. J., & Parada, L. F. (1999) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(19990515/01)45:4/5 · Cited by 151
Brain-Derived Neurotrophic Factor mRNA and Protein Are Targeted to Discrete Dendritic Laminas by Events That Trigger Epileptogenesis
Tongiorgi, E., Armellin, M., Giulianini, P. G., Bregola, G., Zucchini, S., Paradiso, B., Steward, O., Cattaneo, A., & Simonato, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5471-03.2004 · Cited by 143
Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitrostudy
Lin, Y., Ro, L. S., Wang, H., & Chen, J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-126 · Cited by 143
Backpropagating Action Potentials Trigger Dendritic Release of BDNF during Spontaneous Network Activity
Kuczewski, N., Porcher, C., Ferrand, N., Fiorentino, H., Pellegrino, C., Kolarow, R., Leßmann, V., Medina, I., & Gaïarsa, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1673-08.2008 · Cited by 142
Self-citation
Differential Vesicular Targeting and Time Course of Synaptic Secretion of the Mammalian Neurotrophins
Brigadski, T., Hartmann, M., & Leßmann, V. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1776-05.2005 · Cited by 142
Self-citation
Brain-derived neurotrophic factor: subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies.
Wetmore, C., Cao, Y. H., Pettersson, R. F., & Olson, L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9843 · Cited by 141
COMPARATIVE STUDY OF BRAIN-DERIVED NEUROTROPHIC FACTOR MESSENGER RNA AND PROTEIN AT THE CELLULAR LEVEL SUGGESTS MULTIPLE ROLES IN HIPPOCAMPUS, STRIATUM AND CORTEX
Schmidt‐Kastner, R., Wetmore, C., & OLSON, L. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00093-0 · Cited by 139
Hippocampal Long-Term Potentiation Is Supported by Presynaptic and Postsynaptic Tyrosine Receptor Kinase B-Mediated Phospholipase Cγ Signaling
Gärtner, A., Polnau, D. G., Staiger, V., Sciarretta, C., Minichiello, L., Thoenen, H., Bonhoeffer, T., & Körte, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3792-05.2006 · Cited by 138
Elevated BDNF after Cocaine Withdrawal Facilitates LTP in Medial Prefrontal Cortex by Suppressing GABA Inhibition
Lü, H., Cheng, P., Lim, B. K., Khoshnevisrad, N., & Poo, M. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.012 · Cited by 137
BDNF–exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats
Ying, Z., Roy, R. R., Zhong, H., Zdunowski, S., Edgerton, V. R., & Gómez‐Pinilla, F. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.057 · Cited by 136
Anterograde Axonal Transport, Transcytosis, and Recycling of Neurotrophic Factors
von Bartheld, C. S., Wang, X., & Butowt, R. (2001) · Molecular Neurobiology · doi:10.1385/mn:24:1-3:001 · Cited by 135
TrkB as a Potential Synaptic and Behavioral Tag
Lü, Y., Ji, Y., Ganesan, S., Schloesser, R. J., Martinowich, K., Sun, M., Mei, F., Chao, M. V., & Lu, B. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2707-11.2011 · Cited by 133
Noxious Stimulation Induces Trk Receptor and Downstream ERK Phosphorylation in Spinal Dorsal Horn
Pezet, S. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1205 · Cited by 133
Interfering with the Actin Network and Its Effect on Long-Term Potentiation and Synaptic Tagging in Hippocampal CA1 Neurons in SlicesIn Vitro
Ramachandran, B., & Frey, J. U. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2045-09.2009 · Cited by 133
BDNF increases release probability and the size of a rapidly recycling vesicle pool within rat hippocampal excitatory synapses
Tyler, W. J., Zhang, X., Hartman, K. N., Winterer, J., Müller, W. S., Stanton, P. K., & Pozzo‐Miller, L. D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.111310 · Cited by 132
Pro-BDNF–induced synaptic depression and retraction at developing neuromuscular synapses
Yang, F., Je, H.-S., Ji, Y., Nagappan, G., Hempstead, B., & Lu, B. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200811147 · Cited by 130
Timing and efficacy of transmitter release at mossy fiber synapses in the hippocampal network
Bischofberger, J., Engel, D., Frotscher, M., & Jónás, P. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0093-2 · Cited by 129
Detection of Brain-derived Neurotrophic Factor in a Vesicular Fraction of Brain Synaptosomes
Fawcett, J. P., Aloyz, R. S., McLean, J. H., Pareek, S., Miller, F. D., McPherson, P. S., & Murphy, R. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.8837 · Cited by 127
Biological characterization and optical imaging of brain‐derived neurotrophic factor‐green fluorescent protein suggest an activity‐dependent local release of brain‐derived neurotrophic factor in neurites of cultured hippocampal neurons
Kojima, M., Takei, N., Numakawa, T., Ishikawa, Y., Suzuki, S., Matsumoto, T., Katoh‐Semba, R., Nawa, H., & Hatanaka, H. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1080 · Cited by 127
Novel presynaptic mechanisms for coincidence detection in synaptic plasticity
Duguid, I., & Sjöström, P. J. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.05.008 · Cited by 127
Metaplasticity governs compartmentalization of synaptic tagging and capture through brain-derived neurotrophic factor (BDNF) and protein kinase Mζ (PKMζ)
Sajikumar, S., & Körte, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016849108 · Cited by 126
A Local Reduction in Cortical GABAergic Synapses after a Loss of Endogenous Brain-Derived Neurotrophic Factor, as Revealed by Single-Cell Gene Knock-Out Method
Kohara, K., Yasuda, H., Huang, Y. Y., Adachi, N., Sohya, K., & Tsumoto, T. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1943-07.2007 · Cited by 124
Anterograde transport of endogenous brain-derived neurotrophic factor in hippocampal mossy fibers
Smith, M. A., Zhang, L., Lyons, W. E., & Mamounas, L. A. (1997) · Neuroreport · doi:10.1097/00001756-199705260-00008 · Cited by 122
Presynaptic BDNF Promotes Postsynaptic Long-Term Potentiation in the Dorsal Striatum
Jia, Y., Gall, C. M., & LYNCH, G. S. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3310-10.2010 · Cited by 122
Brain-Derived Neurotrophic Factor (BDNF) Induces Dendritic Targeting of BDNF and Tyrosine Kinase B mRNAs in Hippocampal Neurons through a Phosphatidylinositol-3 Kinase-Dependent Pathway
Righi, M., Tongiorgi, E., & Cattaneo, A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03165.2000 · Cited by 121
Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors
Fortin, D. A., Srivastava, T., Dwarakanath, D., Pierre, P., Nygaard, S., Derkach, V. A., & Soderling, T. R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6034-11.2012 · Cited by 120
Brain-derived neurotrophic factor-dependent unmasking of “silent” synapses in the developing mouse barrel cortex
Itami, C., Kimura, F., Kohno, T., Matsuoka, M., Ichikawa, M., Tsumoto, T., & Nakamura, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2131948100 · Cited by 120
Regulation of Amygdala-Dependent Learning by Brain-Derived Neurotrophic Factor is Mediated by Extracellular Signal-Regulated Kinase and Phosphatidylinositol-3-Kinase
Ou, L.-C., & Gean, P. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300830 · Cited by 117
Human Immunodeficiency Virus Type 1 Alters Brain-Derived Neurotrophic Factor Processing in Neurons
Bachis, A., Avdoshina, V., Zecca, L., Parsadanian, M., & Mocchetti, I. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0865-12.2012 · Cited by 117
Activity-dependent expression of brain-derived neurotrophic factor in dendrites: Facts and open questions
Tongiorgi, E. (2008) · Neuroscience Research · doi:10.1016/j.neures.2008.04.013 · Cited by 116
Altering BDNF expression by genetics and/or environment: Impact for emotional and depression-like behaviour in laboratory mice
Chourbaji, S., Brandwein, C., & Gass, P. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.003 · Cited by 114
Calcitonin gene‐related peptide enhances release of native brain‐derived neurotrophic factor from trigeminal ganglion neurons
Buldyrev, I., Tanner, N. M., Hsieh, H., Dodd, E. G., Nguyen, L. T., & Bałkowiec, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04161.x · Cited by 114
Correlated network activity enhances synaptic efficacy via BDNF and the ERK pathway at immature CA3–CA1 connections in the hippocampus
Mohajerani, M. H., Sivakumaran, S., Zacchi, P., Aguilera, P. A., & Cherubini, E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704533104 · Cited by 113
The production, storage and release of the neurotrophins nerve growth factor, brain‐derived neurotrophic factor and neurotrophin‐3 by human peripheral eosinophils in allergics and non‐allergics
Noga, O., Englmann, C., Hanf, G., Grützkau, A., Seybold, J., & Kunkel, G. (2003) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2003.01586.x · Cited by 113
Adult Mammalian Sensory and Motor Neurons: Roles of Endogenous Neurotrophins and Rescue by Exogenous Neurotrophins after Axotomy
Munson, J. B., Shelton, D. L., & McMahon, S. B. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00470.1997 · Cited by 111
Hippocampal neurons recycle BDNF for activity‐dependent secretion and LTP maintenance
Santi, S., Cappello, S., Riccio, M., Bergami, M., Aicardi, G., Schenk, U., Matteoli, M., & Canossa, M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601303 · Cited by 110
Nitric oxide down-regulates brain-derived neurotrophic factor secretion in cultured hippocampal neurons
Canossa, M., Giordano, E., Cappello, S., Guarnieri, C., & Ferri, S. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042504299 · Cited by 110
Glutamate elicits release of BDNF from basal forebrain astrocytes in a process dependent on metabotropic receptors and the PLC pathway
Jean, Y. Y., Lercher, L. D., & Dreyfus, C. F. (2008) · Neuron Glia Biology · doi:10.1017/s1740925x09000052 · Cited by 107
Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI) and Trk receptor activation is mediated via phospholipase C signalling pathways
Canossa, M., Gärtner, A., Campana, G., Inagaki, N., & Thoenen, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.7.1640 · Cited by 105
Memory maintenance by PKMζ — an evolutionary perspective
Sacktor, T. C. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-31 · Cited by 102
Progesterone Increases the Release of Brain-Derived Neurotrophic Factor from Glia via Progesterone Receptor Membrane Component 1 (Pgrmc1)-Dependent ERK5 Signaling
Su, C., Cunningham, R. L., Rybalchenko, N., & Singh, M. (2012) · Endocrinology · doi:10.1210/en.2011-2177 · Cited by 101
GABA B Receptor Activation Triggers BDNF Release and Promotes the Maturation of GABAergic Synapses
Fiorentino, H., Kuczewski, N., Diabira, D., Ferrand, N., Pangalos, M. N., Porcher, C., & Gaïarsa, J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3587-09.2009 · Cited by 100
Presynaptic and Postsynaptic NMDA Receptors Mediate Distinct Effects of Brain-Derived Neurotrophic Factor on Synaptic Transmission
Madara, J. C., & Levine, E. S. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90880.2008 · Cited by 98
Input-specific synaptic plasticity in the amygdala is regulated by neuroligin-1 via postsynaptic NMDA receptors
Jung, S., Kim, J., Kwon, O. B., Jung, J. H., An, K., Jeong, A. Y., Lee, C. J., Choi, Y., Bailey, C. H., Kandel, E. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001084107 · Cited by 97
Immunohistochemical Visualization of Brain‐derived Neurotrophic Factor in the Rat Brain
Dugich‐Djordjevic, M. M., Peterson, C. M., Isono, F., Ohsawa, F., Widmer, H. R., Denton, T. L., Bennett, G. L., & Hefti, F. F. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00703.x · Cited by 97
A caged Ab reveals an immediate/instructive effect of BDNF during hippocampal synaptic potentiation
Kossel, A. H., Cambridge, S. B., Wagner, U., & Bonhoeffer, T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251326998 · Cited by 96
Gangliosides Activate Trk Receptors by Inducing the Release of Neurotrophins
Rabin, S. J., Bachis, A., & Mocchetti, I. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203240200 · Cited by 91
Synaptic Targeting of Retrogradely Transported Trophic Factors in Motoneurons: Comparison of Glial Cell Line-Derived Neurotrophic Factor, Brain-Derived Neurotrophic Factor, and Cardiotrophin-1 with Tetanus Toxin
Rind, H. B., Butowt, R., & von Bartheld, C. S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4322-04.2005 · Cited by 91
Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network
Shinoda, Y., Sadakata, T., Nakao, K., Katoh‐Semba, R., Kinameri, E., Furuya, A., Yanagawa, Y., Hirase, H., & Furuichi, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012220108 · Cited by 89
Costorage of BDNF and neuropeptides within individual dense‐core vesicles in central and peripheral neurons
Salio, C., Averill, S., Priestley, J. V., & Merighi, A. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20358 · Cited by 89
Ceramide activates microglia to enhance the production/secretion of brain‐derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro
Nakajima, K., Tohyama, Y., Kohsaka, S., & Kurihara, T. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00752.x · Cited by 88
Synaptic plasticity: Going through phases with LTP
Huang, E. P. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70219-2 · Cited by 87
At Immature Mossy-Fiber–CA3 Synapses, Correlated Presynaptic and Postsynaptic Activity Persistently Enhances GABA Release and Network Excitability via BDNF and cAMP-Dependent PKA
Sivakumaran, S., Mohajerani, M. H., & Cherubini, E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5019-08.2009 · Cited by 84
Sorting of Internalized Neurotrophins into an Endocytic Transcytosis Pathway via the Golgi System: Ultrastructural Analysis in Retinal Ganglion Cells
Butowt, R., & von Bartheld, C. S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-22-08915.2001 · Cited by 83
Secretion of brain‐derived neurotrophic factor from brain microvascular endothelial cells
Wang, H., Ward, N., Boswell, M., & Katz, D. M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04682.x · Cited by 81
Synapse-specific stabilization of plasticity processes: The synaptic tagging and capture hypothesis revisited 10 years later
Barco, Á., de Armentia, M. L., & Alarcón, J. M. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.01.002 · Cited by 81
Priming of short-term potentiation and synaptic tagging/capture mechanisms by ryanodine receptor activation in rat hippocampal CA1Preprint
Sajikumar, S., Li, Q., Abraham, W. C., & Xiao, Z. (2009) · Learning & Memory · doi:10.1101/lm.1255909 · Cited by 80
Ultrastructural localization of brain-derived neurotrophic factor in rat primary sensory neurons
Luo, X., Rush, R. A., & Zhou, X. (2001) · Neuroscience Research · doi:10.1016/s0168-0102(00)00238-8 · Cited by 79
Postsynaptic BDNF signalling regulates long‐term potentiation at thalamo‐amygdala afferents
Meis, S., Endres, T., & Leßmann, V. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.220434 · Cited by 78
Self-citation
Huntingtin-associated Protein-1 Interacts with Pro-brain-derived Neurotrophic Factor and Mediates Its Transport and Release
Wu, L. L., Fan, Y., Li, S., Li, X., & Zhou, X. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.073197 · Cited by 78
Testosterone depletion in adult male rats increases mossy fiber transmission, LTP, and sprouting in area CA3 of hippocampus
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Late expression of brain-derived neurotrophic factor in the amygdala is required for persistence of fear memory
Ou, L.-C., Yeh, S.-H., & Gean, P. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.12.003 · Cited by 77
Synaptic network activity induces neuronal differentiation of adult hippocampal precursor cells through BDNF signaling
Babu, H. (2009) · Frontiers in Neuroscience · doi:10.3389/neuro.22.001.2009 · Cited by 76
Voluntary exercise ameliorates cognitive deficits in morphine dependent rats: The role of hippocampal brain-derived neurotrophic factor
Miladi‐Gorji, H., Rashidy‐Pour, A., Fathollahi, Y., Akhavan, M. M., Semnanian, S., & Safari, M. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.001 · Cited by 76
The activity requirements for spike timing-dependent plasticity in the hippocampus
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Exercise normalizes levels of MAG and Nogo‐A growth inhibitors after brain trauma
Chytrova, G., Ying, Z., & Gómez‐Pinilla, F. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05982.x · Cited by 75
Developmental expression of brain derived neurotrophic factor mRNA by neurons of fetal and adult monkey prefrontal cortex
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GABAA Receptor Blockade Enhances Memory Consolidation by Increasing Hippocampal BDNF Levels
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Matrix-Dependent Local Retention of Secretory Vesicle Cargo in Cortical Neurons
de Wit, J., Toonen, R. F. G., & Verhage, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3931-08.2009 · Cited by 75
Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice
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BDNF Facilitates L-LTP Maintenance in the Absence of Protein Synthesis through PKMζ
Mei, F., Nagappan, G., Ke, Y., Sacktor, T. C., & Lu, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021568 · Cited by 73
Single-Cell Characterization of Retrograde Signaling by Brain-Derived Neurotrophic Factor
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Imaging of evoked dense-core-vesicle exocytosis in hippocampal neurons reveals long latencies and kiss-and-run fusion events
Xia, X., Leßmann, V., & Martin, T. F. J. (2008) · Journal of Cell Science · doi:10.1242/jcs.034603 · Cited by 70
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Early Presynaptic and Late Postsynaptic Components Contribute Independently to Brain-Derived Neurotrophic Factor-Induced Synaptic Plasticity
Alder, J., Thakker‐Varia, S., Crozier, R. A., Shaheen, A., Plummer, M. R., & Black, I. B. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2970-04.2005 · Cited by 70
NMDA receptor–dependent metaplasticity at hippocampal mossy fiber synapses
Rebola, N., Carta, M., Lanore, F., Blanchet, C., & Mulle, C. (2011) · Nature Neuroscience · doi:10.1038/nn.2809 · Cited by 68
Region-Specific Involvement of BDNF Secretion and Synthesis in Conditioned Taste Aversion Memory Formation
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Release reaction of brain-derived neurotrophic factor (BDNF) through PAR1 activation and its two distinct pools in human platelets
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Co-infusion with a TrkB-Fc Receptor Body Carrier Enhances BDNF Distribution in the Adult Rat Brain
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The effects of enriched environment on BDNF expression in the mouse cerebellum depending on the length of exposure
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Activity-Dependent Release of Endogenous BDNF From Mossy Fibers Evokes a TRPC3 Current and Ca2+Elevations in CA3 Pyramidal Neurons
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Activation of Adenosine A2A Receptor Up-Regulates BDNF Expression in Rat Primary Cortical Neurons
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Synergistic Activation of Dopamine D1 and TrkB Receptors Mediate Gain Control of Synaptic Plasticity in the Basolateral Amygdala
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Long-range retrograde spread of LTP and LTD from optic tectum to retina
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Nerve growth factor, brain‐derived neurotrophic factor, and neurotrophin‐3 are sorted to dense‐core vesicles and released via the regulated pathway in primary rat cortical neurons
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Effects of BDNF and NT-3 on Development of Ia/Motoneuron Functional Connectivity in Neonatal Rats
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Immunolesioning of basal forebrain cholinergic neurons facilitates hippocampal kindling and perturbs neurotrophin messenger RNA regulation
Kokaia, M., Ferencz, I., Leanza, G., Elmér, E., METSIS, M. L., Kokaia, Z., Wiley, R. G., & Lindvall, O. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00384-3 · Cited by 58
Distinct Subsets of Syt-IV/BDNF Vesicles Are Sorted to Axons versus Dendrites and Recruited to Synapses by Activity
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Brain-derived neurotrophic factor promotes adaptive plasticity within the spinal cord and mediates the beneficial effects of controllable stimulation
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What Is the Biological Significance of BDNF mRNA Targeting in the Dendrites?: Clues From Epilepsy and Cortical Development
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The effects of amyloid-β42 oligomer on the proliferation and activation of astrocytes in vitro
Hou, L., Liu, Y., Wang, X., Ma, H., He, J., Zhang, Y., Yu, C.-H., Guan, W., & Ma, Y.-H. (2011) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-011-9439-y · Cited by 57

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The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
Kowiański, P., Lietzau, G., Czuba, E., Waśkow, M., Steliga, A., & Moryś, J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0510-4 · Cited by 1,359
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Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750
BDNF and Hippocampal Synaptic Plasticity
Leal, G., Bramham, C. R., & Duarte, C. B. (2017) · Vitamins and Hormones · doi:10.1016/bs.vh.2016.10.004 · Cited by 425
Regulation of hippocampal synaptic plasticity by BDNF
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Self-citation
Neuromodulation of Spike-Timing-Dependent Plasticity: Past, Present, and Future
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Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?
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JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions
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Self-citation
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Self-citation
The Aerobic and Cognitive Exercise Study (ACES) for Community-Dwelling Older Adults With or At-Risk for Mild Cognitive Impairment (MCI): Neuropsychological, Neurobiological and Neuroimaging Outcomes of a Randomized Clinical Trial
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Self-citation
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Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention
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Moderate treadmill exercise ameliorates amyloid-β-induced learning and memory impairment, possibly via increasing AMPK activity and up-regulation of the PGC-1α/FNDC5/BDNF pathway
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BDNF impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses
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Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples
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Elevated Plasma microRNA-206 Levels Predict Cognitive Decline and Progression to Dementia from Mild Cognitive Impairment
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Targeting BDNF signaling by natural products: Novel synaptic repair therapeutics for neurodegeneration and behavior disorders
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BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation
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Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice
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Ketamine-induced changes in plasma brain-derived neurotrophic factor (BDNF) levels are associated with the resting-state functional connectivity of the prefrontal cortex
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Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain
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Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis.
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“Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamin, 5-HT) are two distinct signaling systems, which are involved in the development and plasticity of neuronal networks (Edelmann et al., 2014; Gaspar et al., 2003; Park and Poo, 2013; Sasi et al., 2017), and are reported to be dysregulated in psy…”
Self-citation
Modulation of Spike-Timing Dependent Plasticity: Towards the Inclusion of a Third Factor in Computational Models
Foncelle, A., Mendes, A., Jędrzejewska‐Szmek, J., Valtcheva, S., Berry, H., Blackwell, K. T., & Venance, L. (2018) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2018.00049 · Cited by 67
PAR2-Mediated Upregulation of BDNF Contributes to Central Sensitization in Bone Cancer Pain
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Oxidative stress in drug-naïve first episode patients with schizophrenia and major depression: effects of disease acuity and potential confounders
Jordan, W., Dobrowolny, H., Bahn, S., Bernstein, H., Brigadski, T., Frodl, T., Isermann, B., Leßmann, V., Pilz, J., Rodenbeck, A., et al. (2016) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-016-0749-7 · Cited by 58
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Use it and boost it with physical and mental activity.
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Self-citation
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Self-citation

Activity‐dependent dendritic secretion of brain‐derived neurotrophic factor modulates synaptic plasticity
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Self-citation
BDNF induces its own release to mediate presynaptic plasticityPreprint
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Role of Brain-Derived Neurotrophic Factor as a Modulator of Synaptic Plasticity
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Authors: Edelmann, E., Leßmann, V., & Brigadski, T.
Affiliations: Otto-von-Guericke-Universität Magdeburg (DE)
Center for Behavioral Brain Sciences (DE)
Corresponding author: Leßmann, Volkmar
ORCID: Edelmann, Elke
Leßmann, Volkmar
Brigadski, Tanja
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2014-01
Volume: 76
Pages: 610-627
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2013.05.043
OpenAlex: W1973883693
Cited by: 248
References: 246
Citations by year: 2026: 9 · 2025: 10 · 2024: 23 · 2023: 23 · 2022: 19 · 2021: 24 · 2020: 18 · 2019: 22 · 2018: 23 · 2017: 20 · 2016: 24 · 2015: 12 · 2014: 14
FWCI: 1.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: brain-derived neurotrophic factor, BDNF secretion, synaptic plasticity, long-term potentiation, spike-timing-dependent plasticity, presynaptic neurotransmitter release, postsynaptic effects, central nervous system
MeSH terms: Animals, Neuronal Plasticity, Presynaptic Terminals, Brain-Derived Neurotrophic Factor, Post-Synaptic Density

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Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity.

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