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The Involvement of Thaumatin-Like Proteins in Plant Food Cross-Reactivity: A Multicenter Study Using a Specific Protein Microarray

Palacín, Arantxa, Rivas, Luis A., Gómez-Casado, Cristina, Aguirre, Jacobo, Tordesillas, Leticia, Bartra, Joan, Blanco, Carlos, Carrillo, Teresa, Cuesta-Herranz, Javier, Bonny, José A. Cumplido, Flores, Enrique, García-Alvarez-Eire, Mar G., García-Nuñez, Ignacio, Fernández, Francisco J., Gamboa, Pedro, Muñoz, Rosa, Sánchez-Monge, Rosa, Torres, Maria, Losada, Susana Varela, Villalba, Mayte, Vega, Francisco, Parro, Victor, Blanca, Miguel, Salcedo, Gabriel, Díaz-Perales, Araceli·2012·PLoS ONE
DOI 10.1371/journal.pone.0044088PMC PMC3436791
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Figure 1 Frequency of sensitization obtained by the TLP microarray using sera from both fruit-allergic (FAG) patients, and non-food pollen allergic (PAG) subjects. Odds ratios are presented in parentheses (95% CI; p<0.001).
Figure 1 Frequency of sensitization obtained by the TLP microarray using sera from both fruit-allergic (FAG) patients, and non-food pollen allergic (PAG) subjects. Odds ratios are presented in parentheses (95% CI; p<0.001).CC BY · PubMed Central
Figure 2 IgE binding inhibition of the TLP microarray, when serum pool (n = 21; three per area) or individual sera were preincubated for 3 h at room temperature with increasing amounts of Pru p 2.0201, and chestnut and plane -pollen TLPs.
Figure 2 IgE binding inhibition of the TLP microarray, when serum pool (n = 21; three per area) or individual sera were preincubated for 3 h at room temperature with increasing amounts of Pru p 2.0201, and chestnut and plane -pollen TLPs.CC BY · PubMed Central
Figure 3 Frequency of sensitization in the different geographical areas using the homemade microarray and sera from fruit-allergic (FAG) patients, and non-food pollen-allergic (PAG) subjects. Only TLPs with more than 10% positive response were represented: Pru p 2.0201, Pru p 2.0101, chestnut, plane, lettuce and cabbage TLPs.
Figure 3 Frequency of sensitization in the different geographical areas using the homemade microarray and sera from fruit-allergic (FAG) patients, and non-food pollen-allergic (PAG) subjects. Only TLPs with more than 10% positive response were represented: Pru p 2.0201, Pru p 2.0101, chestnut, plane, lettuce and cabbage TLPs.CC BY · PubMed Central
Figure 4 Co-sensitization graph of TLP allergens. Each node represents one allergen (TLP as white ellipses, non-TLP allergens as blue square nodes, and LTP-allergen Pru p 3 as a green diamond) and the links represent co-sensitization of one or more sera for the linked allergens. The weight of each link, ranging between 0 and 1, measures the degree of co-sensitization. For the sake of clarity, only the 25 links of weight greater than 0.50 out of the total 253 existing links were plotted.
Figure 4 Co-sensitization graph of TLP allergens. Each node represents one allergen (TLP as white ellipses, non-TLP allergens as blue square nodes, and LTP-allergen Pru p 3 as a green diamond) and the links represent co-sensitization of one or more sera for the linked allergens. The weight of each link, ranging between 0 and 1, measures the degree of co-sensitization. For the sake of clarity, only the 25 links of weight greater than 0.50 out of the total 253 existing links were plotted.CC BY · PubMed Central

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Research works printed but not linked: 37

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Metadata

Authors
Palacín, A., Rivas, L. A., Gómez-Casado, C., Aguirre, J., Tordesillas, L., Bartra, J., Blanco, C., Carrillo, T., Cuesta-Herranz, J., Bonny, J. A. C., Flores, E., García-Alvarez-Eire, M. G., García-Nuñez, I., Fernández, F. J., Gamboa, P., Muñoz, R., Sánchez-Monge, R., Torres, M., Losada, S. V., Villalba, M., Vega, F., Parro, V., Blanca, M., Salcedo, G., & Díaz-Perales, A.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2012-09-07
Volume
7
Issue
9
Pages
e44088
ISSN
1932-6203
DOI
10.1371/journal.pone.0044088
PMC
PMC3436791
Cited by
79
References
0
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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