CoChat
Sign Up
Cited by 57Pituitary Gland Disorders and TreatmentsHypothalamic control of reproductive hormonesGrowth Hormone and Insulin-like Growth Factors

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Pituitary Stalk Interruption Syndrome in Chinese People: Clinical Characteristic Analysis of 55 Cases

Open access
Guo, Qinghua, Yang, Yan, Mu, Yiming, Lu, Jvming, Pan, Changyu, Dou, Jingtao, Lv, Zhaohui, Ba, Jianming, Wang, Baoan, Zou, Xiaoman, Yang, Lijuan, Ouyang, Jinzhi, Yang, Guoqing, Wang, Xianling, Du, Jin, Gu, Weijun, Jin, Nan, Chen, Kang, Zang, Li, Erickson, Bradley J.·2013·PLoS ONE
DOI 10.1371/journal.pone.0053579PMC PMC3544917
Open this paper in CoChat — free accountOpen PDF

Abstract

OBJECTIVE: Pituitary stalk interruption syndrome (PSIS) is characterized by the absence of pituitary stalk, pituitary hypoplasia, and ectopic posterior pituitary. Due to the rarity of PSIS, clinical data are limited, especially in Chinese people. Herein, we analyzed the clinical characteristics of patients diagnosed with PSIS from our center over 10 years. PATIENTS AND METHODS: We retrospectively analyzed the clinical manifestations and laboratory and MRI findings in 55 patients with PSIS. RESULTS: Of the 55 patients with PSIS, 48 (87.3%) were male. The average age was 19.7±6.7 years and there was no familial case. A history of breech delivery was documented in 40 of 45 patients (88.9%) and 19 of 55 patients (34.5%) had a history of dystocia. Short stature was found in 47 of 55 patients (85.5%) and bone age delayed 7.26±5.37 years. Secondary sex characteristics were poor or undeveloped in most patients. The prevalence of deficiencies in growth hormone, gonadotropins, corticotropin, and thyrotropin were 100%, 95.8%, 81.8%, 76.3%, respectively. Hyperprolactinemia was found in 36.4% of patients. Three or more pituitary hormone deficiencies were found in 92.7% of the patients. All patients had normal posterior pituitary function and absent pituitary stalk on imaging. The average height of anterior pituitary was 28 mm, documented anterior pituitary hypoplasia. Midline abnormalities were presented in 9.1% of patients. CONCLUSIONS: The clinical features of our Chinese PSIS patients seem to be different from other reported patients in regarding to the higher degree of hypopituitarism and lower prevalence of midline defects. In addition, our patients were older at the time of case detection and the bone age was markedly delayed. We also had no cases of familial PSIS.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0053579

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Growth hormone deficiency occurs in nearly 100% of patients with CCPHD, and hypogonadotropic hypogonadism occurs in 96% of patients.

    “Growth hormone deficiency (GHD) happens in nearly 100% of patients with CCPDH, and hypogonadotropic hypogonadism (HH) occurs in 96% of patients (2).”

    From Growth Hormone Is Beneficial for Induction of Spermatogenesis in Adult Patients With Congenital Combined Pituitary Hormone Deficiency (2022) · cites this paper as [2]

    The Discussion reports 100% growth hormone deficiency and 95.8% gonadotropin deficiency in the authors’ series, matching the quoted percentages. But that series comprised 55 patients with pituitary stalk interruption syndrome; the paper does not establish those rates for patients with CCPHD generally. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 3

  1. M Zhao, 2005, A case of pituitary stalk interruption syndrome, Chin J Endocrinol and Metab, 21, 280
  2. Y Liu, 2004, A report of a case of pituitary stalk interruption syndrome, Chinese Journal of Clinical Neurosciences, 17, 456
  3. QH Guo, 2008, Analysis of 5 cases of pituitary stalk interruption syndrome and literature review, Chin J Endocrinol and Metab, 24, 480

Cited by

Sorted by citations

Related

Metadata

Authors
Guo, Q., Yang, Y., Mu, Y., Lu, J., Pan, C., Dou, J., Lv, Z., Ba, J., Wang, B., Zou, X., Yang, L., Ouyang, J., Yang, G., Wang, X., Du, J., Gu, W., Jin, N., Chen, K., Zang, L., & Erickson, B. J.
Affiliations
  • Chinese PLA General Hospital (CN)
  • Mayo Clinic (US)
Corresponding author
Mu, Yiming
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-01-14
Volume
8
Issue
1
Pages
e53579
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0053579
PMC
PMC3544917
OpenAlex
W2023872839
Cited by
57
References
31
Citations by year
2026: 4 · 2025: 2 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 2 · 2015: 4 · 2014: 4
FWCI
2.63
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (81270866)
  • General Hospital of People’s Liberation Army
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
pituitary stalk interruption syndrome, pituitary hypoplasia, ectopic posterior pituitary, hypopituitarism, short stature, delayed bone age, hyperprolactinemia, growth hormone deficiency, gonadotropin deficiency, corticotropin deficiency, thyrotropin deficiency, breech delivery, dystocia, midline defects, Chinese patients
MeSH terms
Adolescent, Adult, Child, China, Female, Humans, Magnetic Resonance Imaging, Male, Pituitary Diseases, Pituitary Gland, Syndrome, Asian People, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review