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Cited by 108Selenium in Biological SystemsSepsis Diagnosis and TreatmentClinical Nutrition and Gastroenterology

Effect of Parenteral Selenium Supplementation in Critically Ill Patients: A Systematic Review and Meta-Analysis

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Huang, Ting-Shuo, Shyu, Yu-Chiau, Chen, Huang-Yang, Lin, Li-Mei, Lo, Chia-Ying, Yuan, Shin-Sheng, Chen, Pei-Jer·2013·PLoS ONE
DOI 10.1371/journal.pone.0054431PMC PMC3555933
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Abstract

BACKGROUND: It is currently unclear whether parenteral selenium supplementation should be recommended in the management of critically ill patients. Here we conducted a systematic review and meta-analysis to assess the efficacy of parenteral selenium supplementation on clinical outcomes. METHODS/PRINCIPAL FINDINGS: Randomized trials investigating parenteral selenium supplementation administered in addition to standard of care to critically ill patients were included. CENTRAL, Medline, EMBASE, the Science Citation Index, and CINAHL were searched with complementary manual searches. The primary outcome was all-cause mortality. Trials published in any language were included. Two authors independently extracted data and assessed trial quality. A third author was consulted to resolve disagreements and for quality assurance. Twelve trials were included and meta-analysis was performed on nine trials that recruited critically ill septic patients. These comprised 965 participants in total. Of these, 148 patients (30.7%) in the treatment groups, and 180 patients (37.3%) in control groups died. Parenteral selenium treatment significantly reduced all-cause mortality in critically ill patients with sepsis (relative risk [RR] 0.83, 95% CI 0.70-0.99, p = 0.04, I(2) = 0%). Subgroup analyses demonstrated that the administration schedule employing longer duration (RR 0.77, 95% CI 0.63-0.94, p = 0.01, I(2) = 0%), loading boluses (RR 0.73, 95% CI 0.58-0.94, p = 0.01, I(2) = 0%) or high-dose selenium treatment (RR 0.77, 95% CI 0.61-0.99, p = 0.04, I(2) = 0%) might be associated with a lower mortality risk. There was no evidence of adverse events. CONCLUSIONS/SIGNIFICANCE: Parenteral selenium supplementation reduces risk of mortality among critically ill patients with sepsis. Owing to the varied methodological quality of the studies, future high-quality randomized trials that directly focus on the effect of adequate-duration of parenteral selenium supplementation for severe septic patients are needed to confirm our results. Clinicians should consider these findings when treating this high-risk population. SYSTEMATIC REVIEW REGISTRATION: PROSPERO 2011; CRD42011001768.

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  • Three meta-analyses showed a beneficial effect of selenium supplementation on mortality in septic patients.

    “Three meta-analyses showed a beneficial effect of selenium supplementation on mortality in septic patients [72,73,74].”

    From Nutrition in Sepsis: A Bench-to-Bedside Review. (2020) · cites this paper as [74]

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Authors
Huang, T.-S., Shyu, Y.-C., Chen, H.-Y., Lin, L.-M., Lo, C.-Y., Yuan, S.-S., & Chen, P.-J.
Affiliations
  • Chang Gung Memorial Hospital (TW)
  • Taipei Municipal YangMing Hospital (TW)
  • National Taiwan University (TW)
Corresponding author
Chen, Pei-Jer
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-01-25
Volume
8
Issue
1
Pages
e54431
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0054431
PMC
PMC3555933
OpenAlex
W1967004287
Cited by
108
References
4
Citations by year
2025: 2 · 2024: 2 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 8 · 2017: 11 · 2016: 17 · 2015: 12 · 2014: 19 · 2013: 11
FWCI
2.22
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
Funders
Chang Gung Medical Foundation
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords
selenium supplementation, critically ill patients, sepsis, all-cause mortality, adverse events, septic shock treatment
MeSH terms
Adolescent, Adult, Aged, Drug Administration Schedule, Female, Humans, Infusions, Parenteral, Male, Middle Aged, Selenium, Survival Rate, Randomized Controlled Trials as Topic, Critical Illness, Treatment Outcome, Sepsis, Dietary Supplements

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