Selenium and human health
Abstract
Selenium is incorporated into selenoproteins that have a wide range of pleiotropic effects, ranging from antioxidant and anti-inflammatory effects to the production of active thyroid hormone. In the past 10 years, the discovery of disease-associated polymorphisms in selenoprotein genes has drawn attention to the relevance of selenoproteins to health. Low selenium status has been associated with increased risk of mortality, poor immune function, and cognitive decline. Higher selenium status or selenium supplementation has antiviral effects, is essential for successful male and female reproduction, and reduces the risk of autoimmune thyroid disease. Prospective studies have generally shown some benefit of higher selenium status on the risk of prostate, lung, colorectal, and bladder cancers, but findings from trials have been mixed, which probably emphasises the fact that supplementation will confer benefit only if intake of a nutrient is inadequate. Supplementation of people who already have adequate intake with additional selenium might increase their risk of type-2 diabetes. The crucial factor that needs to be emphasised with regard to the health effects of selenium is the inextricable U-shaped link with status; whereas additional selenium intake may benefit people with low status, those with adequate-to-high status might be affected adversely and should not take selenium supplements.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Selenium biofortification of food crops is practiced in selenium-deficient regions by adding inorganic selenium-containing fertilizers to soils, e.g., in Finland, the UK and New Zealand, or by adding organic sources of selenium to soils, e.g., in the USA.
“The strategy of Se biofortification of food crops is practiced in Se-deficient regions by adding inorganic Se-containing fertilizers to soils, e.g., in Finland [26,27], UK [28,29], and New Zealand [30], or by adding organic sources of Se to soils, e.g., in the USA [23].”
From Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review (2015) · cites this paper as [29]
A European randomized trial not included in that analysis suggests the clinical effect of a combination of antioxidants is apparent after five days of administration.
“A European randomized trial which was not included in this analysis suggests that the clinical effect of a combination of antioxidants is already apparent after five days of administration (287).”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [287]
Observational studies revealed that both high and low intake of Se is associated with an increased risk of cardiovascular disease.
“Observational studies revealed that both high and low intake of Se is associated with an increased risk of cardiovascular disease (Rayman 2012).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Rayman 2012
Cites
The importance of selenium to human health
Rayman, M. P. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02490-9 · Cited by 4,163 · see citing works
Self-citationReactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works
Characterization of Mammalian Selenoproteomes
Kryukov, G. V., Castellano, S., Novoselov, S. V., Lobanov, A. V., Zehtab, O., Guigó, R., & Gladyshev, V. N. (2003) · Science · doi:10.1126/science.1083516 · Cited by 2,353 · see citing works
Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers
Lippman, S. M., Klein, E. A., Goodman, P. J., Lucia, M. S., Thompson, I. M., Ford, L. G., Parnes, H. L., Minasian, L. M., Gaziano, J. M., Hartline, J. A., et al. (2008) · JAMA · doi:10.1001/jama.2008.864 · Cited by 2,120 · see citing works
Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin
Clark, L. C. (1996) · JAMA · doi:10.1001/jama.1996.03540240035027 · Cited by 1,936 · see citing works
Selenium in human health and disease
Fairweather-Tait, S. J., Bao, Y., Broadley, M. R., Collings, R., Ford, D., Hesketh, J. E., & Hurst, R. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3275 · Cited by 1,330 · see citing works
Dual Function of the Selenoprotein PHGPx During Sperm Maturation
Ursini, F., Heim, S., Kieß, M., Maiorino, M., Roveri, A., Wissing, J. B., & Flohé, L. (1999) · Science · doi:10.1126/science.285.5432.1393 · Cited by 902 · see citing works
Selenium in cancer prevention: a review of the evidence and mechanism of action
Rayman, M. P. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2005467 · Cited by 858 · see citing works
Self-citationFood-chain selenium and human health: emphasis on intake
Rayman, M. P. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508939830 · Cited by 798 · see citing works
Self-citationEffects of Long-Term Selenium Supplementation on the Incidence of Type 2 Diabetes
Stranges, S., Marshall, J. R., Natarajan, R., Donahue, R. P., Trevisan, M., Combs, G. F., Cappuccio, F. P., Ceriello, A., & Reid, M. E. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-4-200708210-00175 · Cited by 715 · see citing works
"Selenium: Its Molecular Biology and Role in Human Health"
Hatfield, D. L. (2002) · Free Radical Research · doi:10.1080/10715760290006394 · Cited by 653 · see citing works
Selenium and the Course of Mild Graves' Orbitopathy
Marcocci, C., Kahaly, G. J., Krassas, G. E., Bartalena, L., Prummel, M. F., Stahl, M. M. S., Altea, M. A., Nardi, M., Pitz, S., Boboridis, K. G., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1012985 · Cited by 645 · see citing works
Bjelaković, G., Nikolova, D., Simonetti, R. G., & Gluud, C. N. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17138-9 · Cited by 612 · see citing works
Glutathione Peroxidase 1 Activity and Cardiovascular Events in Patients with Coronary Artery Disease
Blankenberg, S., Rupprecht, H. J., Bickel, C., Torzewski, M., Hafner, G., Tiret, L., Smieja, M., Cambien, F., Meyer, J., & Lackner, K. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030535 · Cited by 596 · see citing works
A liver-derived secretory protein, selenoprotein P, causes insulin resistance
Misu, H., Takamura, T., Takayama, H., Hayashi, H., Matsuzawa-Nagata, N., Kurita, S., Ishikura, K., Ando, H., Takeshita, Y., Ota, T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.015 · Cited by 583 · see citing works
The use of high-selenium yeast to raise selenium status: how does it measure up?
Rayman, M. P. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041251 · Cited by 542 · see citing works
Self-citationDuffield‐Lillico, A. J., Reid, M. E., Turnbull, B. W., Combs, G. F., Slate, E. H., Fischbach, L. A., Marshall, J. R., & Clark, L. C. (2002) · PubMed · Cited by 541 · see citing works
Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase
McClung, J. P., Roneker, C. A., Mu, W., Lisk, D. J., Langlais, P., Liu, F., & Lei, X. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308096101 · Cited by 536 · see citing works
The human selenoproteome: recent insights into functions and regulation
Reeves, M. A., & Hoffmann, P. R. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0032-4 · Cited by 531 · see citing works
Selenoprotein P—Expression, functions, and roles in mammals
Burk, R. F., & Hill, K. E. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.026 · Cited by 516 · see citing works
Duffield‐Lillico, A. J., Dalkin, B. L., Reid, M. E., Turnbull, B. W., Slate, E. H., Jacobs, E. T., Marshall, J. R., Clark, L. C., & for the Nutritional Prevention of Cancer Study Group (2003) · British Journal of Urology · doi:10.1046/j.1464-410x.2003.04167.x · Cited by 514 · see citing works
Food-chain selenium and human health: spotlight on speciation
Rayman, M. P., Infante, H. G., & Sargent, M. (2008) · British Journal of Nutrition · doi:10.1017/s0007114508922522 · Cited by 479 · see citing works
Self-citationThe argument for increasing selenium intake
Rayman, M. P. (2002) · Proceedings of The Nutrition Society · doi:10.1079/pns2002153 · Cited by 462 · see citing works
Self-citationSelenium bioavailability: current knowledge and future research requirements
Fairweather‐Tait, S. J., Collings, R., & Hurst, R. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28674j · Cited by 436 · see citing works
Selenium and coronary heart disease: a meta-analysis
Flores‐Mateo, G., Navas‐Acién, A., Pastor‐Barriuso, R., & Güallar, E. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.4.762 · Cited by 417 · see citing works
Broome, C. S., McArdle, F., Kyle, J. A. M., Andrews, F., Lowe, N. M., Hart, C. A., Arthur, J. R., & Jackson, M. J. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.1.154 · Cited by 402 · see citing works
Selenium Deficiency and Viral Infection
Beck, M. A., Levander, O. A., & Handy, J. (2003) · Journal of Nutrition · doi:10.1093/jn/133.5.1463s · Cited by 392 · see citing works
Serum Selenium and Diabetes in U.S. Adults
Bleys, J., Navas‐Acién, A., & Güallar, E. (2007) · Diabetes Care · doi:10.2337/dc06-1726 · Cited by 384 · see citing works
Genetic variation in selenoprotein S influences inflammatory response
Curran, J. E., Jowett, J. B. M., Elliott, K., Gao, Y., Gluschenko, K., Wang, J., Azim, D. M. A., Cai, G., Mahaney, M. C., Comuzzie, A. G., et al. (2005) · Nature Genetics · doi:10.1038/ng1655 · Cited by 375 · see citing works
Serum Selenium Levels and All-Cause, Cancer, and Cardiovascular Mortality Among US Adults
Bleys, J. (2008) · Archives of Internal Medicine · doi:10.1001/archinternmed.2007.74 · Cited by 372 · see citing works
Negro, R., Greco, G., Mangieri, T., Pezzarossa, A., Dazzi, D., & Hassan, H. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1821 · Cited by 368 · see citing works
Selenium and brain function: a poorly recognized liaison
Schweizer, U., Bräuer, A. U., Köhrle, J., Nitsch, R., & Savaskan, N. E. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.03.004 · Cited by 347 · see citing works
Schoenmakers, E., Agostini, M., Mitchell, C., Schoenmakers, N., Papp, L., Rajanayagam, O., Padidela, R., Ceron-Gutierrez, L., Doffinger, R., Prevosto, C., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43653 · Cited by 315 · see citing works
Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial
Duffield-Lillico, A. J. (2003) · CancerSpectrum Knowledge Environment · doi:10.1093/jnci/djg061 · Cited by 301 · see citing works
Supplementation with selenium and human immune cell functions
Kiremidjian-Schumacher, L., Roy, M., Wishe, H. I., Cohen, M. W., & Stotzky, G. (1994) · Biological Trace Element Research · doi:10.1007/bf02917222 · Cited by 295 · see citing works
Host nutritional status: the neglected virulence factor
Beck, M. A., Handy, J., & Levander, O. A. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.07.007 · Cited by 292 · see citing works
An estimation of selenium requirements for New Zealanders
Duffield‐Lillico, A. J., Thomson, C. D., Hill, K. E., & Williams, S. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.5.896 · Cited by 290 · see citing works
Hurst, R., Armah, C. N., Dainty, J. R., Hart, D. J., Teucher, B., Goldson, A. J., Broadley, M. R., Motley, A. K., & Fairweather‐Tait, S. J. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28169 · Cited by 283 · see citing works
Male Fertility Is Linked to the Selenoprotein Phospholipid Hydroperoxide Glutathione Peroxidase1
Foresta, C., Flohé, L., Garolla, A., Roveri, A., Ursini, F., & Maiorino, M. (2002) · Biology of Reproduction · doi:10.1095/biolreprod.102.003822 · Cited by 282 · see citing works
Cognitive Decline Is Associated with Systemic Oxidative Stress: The EVA Study
Berr, C., Balansard, B., Arnaud, J., Roussel, A., Alpérovitch, A., & EVA Study Group (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb02603.x · Cited by 279 · see citing works
Schomburg, L., & Köhrle, J. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700465 · Cited by 278 · see citing works
Laclaustra, M., Navas‐Acién, A., Stranges, S., Ordovás, J. M., & Güallar, E. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0900704 · Cited by 272 · see citing works
Wei, W., Abnet, C. C., Qiao, Y., Dawsey, S. M., Dong, Z., Sun, X., Fan, J., Gunter, E. W., Taylor, P. R., & Mark, S. D. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.1.80 · Cited by 252 · see citing works
Dietary sources of nutrients among US adults, 1994 to 1996
Cotton, P. A., Subar, A. F., Friday, J., & Cook, A. (2004) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2004.03.019 · Cited by 250 · see citing works
Yamashita, Y., & Yamashita, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.c110.106377 · Cited by 240 · see citing works
Xia, Y., Hill, K. E., Li, P., Xu, J., Zhou, D., Motley, A. K., Wang, L., Byrne, D. W., & Burk, R. F. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29642 · Cited by 234 · see citing works
Hurwitz, B. E., Klaus, J. R., Llabre, M. M., Gonzalez, A., Lawrence, P. J., Maher, K. J., Greeson, J. M., Baum, M. K., Shor‐Posner, G., Skyler, J. S., et al. (2007) · PubMed · doi:10.1001/archinte.167.2.148 · Cited by 231 · see citing works
Johnson, C. C., Fordyce, F. M., & Rayman, M. P. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109991807 · Cited by 222 · see citing works
Self-citationReid, M. E., Duffield‐Lillico, A. J., Garland, L. L., Turnbull, B. W., Clark, L. C., & Marshall, J. R. (2002) · PubMed · Cited by 218 · see citing works
Toulis, K. A., Anastasilakis, A. D., Tzellos, T., Goulis, D. G., & Kouvelas, D. (2010) · Thyroid · doi:10.1089/thy.2009.0351 · Cited by 213 · see citing works
Hoffmann, F. W., Hashimoto, A. C., Shafer, L. A., Dow, S., Berry, M. J., & Hoffmann, P. R. (2010) · The Journal of Nutrition · doi:10.3945/jn.109.120725 · Cited by 213 · see citing works
Imai, H., Suzuki, K., Ishizaka, K., Ichinose, S., Oshima, H., Okayasu, I., Emoto, K., Umeda, M., & Nakagawa, Y. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.2.674 · Cited by 213 · see citing works
Increased biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae
Vanderlelie, J. J., Venardos, K. M., Clifton, V. L., Gude, N. M., Clarke, F. M., & Perkins, A. V. (2004) · Placenta · doi:10.1016/j.placenta.2004.04.002 · Cited by 202 · see citing works
Steinbrenner, H., Speckmann, B., Pinto, A. V., & Sies, H. (2010) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.11-002fr · Cited by 202 · see citing works
Selenoproteins and human health: Insights from epidemiological data
Rayman, M. P. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.014 · Cited by 199 · see citing works
Self-citationReduced Selenium Concentrations and Glutathione Peroxidase Activity in Preeclamptic Pregnancies
Mistry, H. D., Wilson, V., Ramsay, M., Symonds, M. E., & Pipkin, F. B. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.116103 · Cited by 198 · see citing works
Selenium Level and Cognitive Function in Rural Elderly Chinese
Gao, S., Jin, Y., Hall, K. S., Liang, C., Unverzagt, F. W., Ji, R., Murrell, J. R., Cao, J., Shen, J., Ma, F., et al. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwk073 · Cited by 192 · see citing works
Selenium and Mortality in the Elderly: Results from the EVA Study
Akbaraly, T. N., Arnaud, J., Hininger‐Favier, I., Gourlet, V., Roussel, A., & Berr, C. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.055301 · Cited by 191 · see citing works
Yang, S. J., Hwang, S. Y., Choi, H. Y., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., & Choi, K. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0620 · Cited by 191 · see citing works
Labunskyy, V. M., Lee, B. C., Handy, D. E., Loscalzo, J., Hatfield, D. L., & Gladyshev, V. N. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3526 · Cited by 189 · see citing works
Plasma Selenium Over Time and Cognitive Decline in the Elderly
Akbaraly, T. N., Hininger‐Favier, I., re, I. C., Arnaud, J., Gourlet, V., Roussel, A., & Berr, C. (2006) · Epidemiology · doi:10.1097/01.ede.0000248202.83695.4e · Cited by 178 · see citing works
Stranges, S., Marshall, J. R., Trevisan, M., Natarajan, R., Donahue, R. P., Combs, G. F., Farinaro, E., Clark, L. C., & Reid, M. E. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj097 · Cited by 176 · see citing works
Zhuo, H., Smith, A. H., & Steinmaus, C. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.771.13.5 · Cited by 175 · see citing works
Yu, M., Horng, I.-S., Hsu, K., Chiang, Y., Liaw, Y., & Chen, C. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010016 · Cited by 164 · see citing works
Supplementation with selenium and human immune cell functions
Roy, M., Kiremidjian-Schumacher, L., Wishe, H. I., Cohen, M. W., & Stotzky, G. (1994) · Biological Trace Element Research · doi:10.1007/bf02917221 · Cited by 161 · see citing works
Selenoprotein P Is Required for Mouse Sperm Development1
Olson, G. E., Winfrey, V. P., Nagdas, S. K., Hill, K. E., & Burk, R. F. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.040360 · Cited by 157 · see citing works
Association of selenium with thyroid volume and echostructure in 35- to 60-year-old French adults
Derumeaux, H., Valeix, P., Castetbon, K., Bensimon, M., Boutron‐Ruault, M., Arnaud, J., & Herçberg, S. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480309 · Cited by 156 · see citing works
Renko, K., Hofmann, P. J., Stoedter, M., Hollenbach, B., Behrends, T., Köhrle, J., Schweizer, U., & Schomburg, L. (2009) · The FASEB Journal · doi:10.1096/fj.08-119370 · Cited by 153 · see citing works
Rayman, M. P., Bode, P., & Redman, C. W. G. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/s0002-9378(03)00723-3 · Cited by 152 · see citing works
Self-citationCzernichow, S., Couthouis, A., Bertrais, S., Vergnaud, A., Dauchet, L., Galan, P., & Herçberg, S. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.394 · Cited by 150 · see citing works
Loss of GPx2 increases apoptosis, mitosis, and GPx1 expression in the intestine of mice
Florian, S., Krehl, S., Löwinger, M., Kipp, A. P., Banning, A., Esworthy, R. S., Chu, F., & Brigelius‐Flohé, R. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.08.029 · Cited by 144 · see citing works
Effects of Dietary Selenium on Sperm Motility in Healthy Men
Hawkes, W. C., & Turek, P. J. (2001) · Journal of Andrology · doi:10.1002/j.1939-4640.2001.tb02579.x · Cited by 144 · see citing works
Role of selenium-containing proteins in T-cell and macrophage function
Carlson, B. A., Yoo, M., Shrimali, R. K., Irons, R., Gladyshev, V. N., Hatfield, D. L., & Park, J. M. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s002966511000176x · Cited by 143 · see citing works
Intake of Selenium in the Prevention of Prostate Cancer: a Systematic Review and Meta-analysis*
Etminan, M., FitzGerald, J. M., Gleave, M. E., & Chambers, K. (2005) · Cancer Causes & Control · doi:10.1007/s10552-005-0334-2 · Cited by 142 · see citing works
Prediagnostic Serum Selenium in a Case-Control Study of Thyroid Cancer
Glattre, E., Thomassen, Y., Thoresen, S., Haldorsen, T., Lund‐Larsen, P. G., Theodorsen, L., & Aaseth, J. (1989) · International Journal of Epidemiology · doi:10.1093/ije/18.1.45 · Cited by 141 · see citing works
Ray, A. L., Semba, R. D., Walston, J. D., Ferrucci, L., Cappola, A. R., Ricks, M. O., Xue, Q., & Fried, L. P. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.172 · Cited by 137 · see citing works
Mechanisms by which selenium influences immune responses
Hoffmann, P. R. (2007) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-007-0036-4 · Cited by 135 · see citing works
Ashrafi, M. R., Shams, S., Nouri, M., Mohseni, M., Shabanian, R., Yekaninejad, M. S., Chegini, N., Khodadad, A., & Safaralizadeh, R. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01143.x · Cited by 133 · see citing works
Akbaraly, T. N., Arnaud, J., Rayman, M. P., Hininger‐Favier, I., Roussel, A., Berr, C., & Fontbonne, A. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-21 · Cited by 133 · see citing works
Self-citationHomocysteine and cognitive function in healthy elderly community dwellers in Italy
Ravaglia, G., Forti, P., Maioli, F., Muscari, A., Sacchetti, L., Arnone, G., Nativio, V., Talerico, T., & Mariani, E. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.3.668 · Cited by 131 · see citing works
Effect of Supplementation With High-Selenium Yeast on Plasma Lipids
Rayman, M. P., Stranges, S., Griffin, B. A., Pastor‐Barriuso, R., & Güallar, E. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-154-10-201105170-00005 · Cited by 131 · see citing works
Self-citationSchmutzler, C., Mentrup, B., Schomburg, L., Hoang‐Vu, C., Herzog, V., & Köhrle, J. (2007) · Biological Chemistry · doi:10.1515/bc.2007.122 · Cited by 129 · see citing works
The Effects of Dietary Selenium on the Immune System in Healthy Men
Hawkes, W. C., Kelley, D. S., & Taylor, P. C. (2001) · Biological Trace Element Research · doi:10.1385/bter:81:3:189 · Cited by 127 · see citing works
Steinbrecher, A., Méplan, C., Hesketh, J. E., Schomburg, L., Endermann, T., Jansen, E., Åkesson, B., Rohrmann, S., & Linseisen, J. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-0364 · Cited by 126 · see citing works
Rayman, M. P., Thompson, A. J., Bekaert, B., Catterick, J., Galassini, R., Hall, E., Warren-Perry, M., & Beckett, G. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.2.370 · Cited by 120 · see citing works
Self-citationToenail Selenium and Cardiovascular Disease in Men with Diabetes
Rajpathak, S. N., Rimm, E. B., Morris, J. S., & Hu, F. B. (2005) · Journal of the American College of Nutrition · doi:10.1080/07315724.2005.10719472 · Cited by 120 · see citing works
Nacamulli, D., Mian, C., Petricca, D., Lazzarotto, F., Barollo, S., Pozza, D., Masiero, S., Faggian, D., Plebani, M., Girelli, M. E., et al. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03758.x · Cited by 120 · see citing works
Selenium and the prevention of prostate and colorectal cancer
Peters, U., & Takata, Y. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800103 · Cited by 119 · see citing works
Cooper, M. L., Adami, H., Grönberg, H., Wiklund, F. E., Green, F. R., & Rayman, M. P. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1827 · Cited by 119 · see citing works
Self-citationBates, C. J., Thane, C. W., Prentice, A., & Delves, H. T. (2002) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/s0946-672x(02)80002-5 · Cited by 118 · see citing works
Maternal selenium status during early gestation and risk for preterm birth
Rayman, M., Wijnen, H. A. A., Vader, H. L., Kooistra, L., & Pop, V. J. (2011) · Canadian Medical Association Journal · doi:10.1503/cmaj.101095 · Cited by 116 · see citing works
Self-citationAre men with low selenium levels at increased risk of prostate cancer?
Brinkman, M. T., Reulen, R. C., Kellen, E., Buntinx, F., & Zeegers, M. P. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.02.027 · Cited by 116 · see citing works
Selenium and Bladder Cancer Risk: a Meta-analysis
Amaral, A. F. S., Cantor, K. P., Silverman, D. T., & Malats, N. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-0544 · Cited by 111 · see citing works
Ximena, B., Jose, M.-B. M., McCollister, K. E., Zhang, G., Rodriguez, A., Ruiz, P., Lecusay, R., & Shor‐Posner, G. (2002) · HIV Clinical Trials · doi:10.1310/a7lc-7c9v-ewkf-2y0h · Cited by 109 · see citing works
Shahar, A., Patel, K. V., Semba, R. D., Bandinelli, S., Shahar, D. R., Ferrucci, L., & Guralnik, J. M. (2010) · Movement Disorders · doi:10.1002/mds.23218 · Cited by 108 · see citing works
Chen, X., Scholl, T. O., Leskiw, M. J., Donaldson, M. R., & Stein, T. P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030544 · Cited by 106 · see citing works
Nichol, C., Herdman, J., Sattar, N. A., O’Dwyer, P. J., O’Reilly, D. S. J., Littlejohn, D., & Fell, G. S. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.8.1764 · Cited by 103 · see citing works
Navarro‐Alarcón, M., de la Serrana, H. L.-G., Perez‐Valero, V., & López-Martínez, C. (1999) · The Science of The Total Environment · doi:10.1016/s0048-9697(99)00034-0 · Cited by 102 · see citing works
Impact of Selenium on Mood and Quality of Life: A Randomized, Controlled Trial
Rayman, M. P., Thompson, A., Warren-Perry, M., Galassini, R., Catterick, J., Hall, E., Lawrence, D., & Bliss, J. M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.019 · Cited by 101 · see citing works
Self-citationPeters, U., Littman, A. J., Kristal, A. R., Patterson, R. E., Potter, J. D., & White, E. (2007) · Cancer Causes & Control · doi:10.1007/s10552-007-9072-y · Cited by 91 · see citing works
Kupka, R., Mugusi, F. M., Aboud, S., Msamanga, G., Finkelstein, J. L., Spiegelman, D. L., & Fawzi, W. W. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1802 · Cited by 90 · see citing works
Dietary zinc, copper and selenium, and risk of lung cancer
Mahabir, S., Spitz, M. R., Barrera, S. L., Beaver, S. H., Etzel, C. J., & Forman, M. R. (2006) · International Journal of Cancer · doi:10.1002/ijc.22451 · Cited by 90 · see citing works
Shor‐Posner, G., Míguez‐Burbano, M. J., Pineda, L., Rodriguez, A., Ruiz, P. G., Castillo, G., Burbano, X., Lecusay, R., & Baum, M. K. (2002) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00042560-200202010-00010 · Cited by 90 · see citing works
Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy
Lei, C., Niu, X., Wei, J., Zhu, J., & Zhu, Y. (2008) · Clinica Chimica Acta · doi:10.1016/j.cca.2008.09.025 · Cited by 89 · see citing works
β-Carotene and selenium supplementation enhances immune response in aged humans
Wood, S. M., Beckham, C. J., Yosioka, A., Darban, H., & WATSON, R. R. (2000) · Integrative medicine · doi:10.1016/s1096-2190(00)00009-3 · Cited by 88 · see citing works
Penney, K. L., Schumacher, F. R., Li, H., Kraft, P., Morris, J. S., Kurth, T., Mucci, L. A., Hunter, D. J., Kantoff, P. W., Stampfer, M. J., et al. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0216 · Cited by 88 · see citing works
Serum selenium and risk of prostate cancer—a nested case-control study
Peters, U., Foster, C. B., Chatterjee, N., Schatzkin, A. G., Reding, D. J., Andriole, G. L., Crawford, E. D., Stürup, S., Chanock, S. J., & Hayes, R. B. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.1.209 · Cited by 85 · see citing works
Selenium and Immunocompetence in Patients with Head and Neck Cancer
Kiremidjian-Schumacher, L., Roy, M.-C., Glickman, R. S., Schneider, K., Rothstein, S., Cooper, J., Höchster, H. S., Kim, M., & Newman, R. A. (2000) · Biological Trace Element Research · doi:10.1385/bter:73:2:97 · Cited by 84 · see citing works
Randomised, double blind, placebo-controlled trial of selenium supplementation in adult asthma
Shaheen, S. O., Newson, R. B., Rayman, M. P., Wong, A., Tumilty, M. K., Phillips, J. A., Potts, J. F., Kelly, F. J., White, P. T., & Burney, P. (2007) · Thorax · doi:10.1136/thx.2006.071563 · Cited by 84 · see citing works
Self-citationAllen, N. E., Appleby, P. N., Roddam, A., Tjønneland, A. M., Johnsen, N. F., Overvad, K., Boeing, H., Weikert, S., Kaaks, R., Linseisen, J., et al. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26205 · Cited by 84 · see citing works
Selenium and Glycogen Levels in Diabetic Patients
Kljai, K., & Runje, R. (2001) · Biological Trace Element Research · doi:10.1385/bter:83:3:223 · Cited by 82 · see citing works
Czernichow, S., Couthouis, A., Bertrais, S., Vergnaud, A., Dauchet, L., Galan, P., & Herçberg, S. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.395 · Cited by 82 · see citing works
Serum Trace Element Levels in Febrile Convulsion
Amiri, M., Farzin, L., Moassesi, M. E., & Sajadi, F. (2009) · Biological Trace Element Research · doi:10.1007/s12011-009-8487-6 · Cited by 77 · see citing works
Genetic association of preeclampsia to the inflammatory response gene SEPS1
Moses, E. K., Johnson, M. P., Tømmerdal, L. F., Forsmo, S., Curran, J. E., Abraham, L. J., Charlesworth, J., Brennecke, S. P., Blangero, J., & Austgulen, R. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.09.024 · Cited by 74 · see citing works
Selenium and Intractable Epilepsy: Is There Any Correlation?
Ashrafi, M. R., Shabanian, R., Abbaskhanian, A., Nasirian, A., Ghofrani, M., Mohammadi, M., Zamani, G., Kayhanidoost, Z., Ebrahimi, S. H., & Pourpak, Z. (2006) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2006.09.001 · Cited by 73 · see citing works
Gill, J. K., Franke, A. A., Morris, J. S., Cooney, R. V., Wilkens, L. R., Marchand, L. L., Goodman, M. T., Henderson, B. E., & Kolonel, L. N. (2009) · Cancer Causes & Control · doi:10.1007/s10552-009-9304-4 · Cited by 66 · see citing works
Epplein, M., Franke, A. A., Cooney, R. V., Morris, J. S., Wilkens, L. R., Goodman, M. T., Murphy, S. P., Henderson, B. E., Kolonel, L. N., & Marchand, L. L. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0003 · Cited by 65 · see citing works
Forceville, X. (2007) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2007.09.021 · Cited by 64 · see citing works
Mahabir, S., Forman, M. R., Dong, Y. Q., Park, Y., Hollenbeck, A. R., & Schatzkin, A. G. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-0067 · Cited by 63 · see citing works
Elevation in Tanis Expression Alters Glucose Metabolism and Insulin Sensitivity in H4IIE Cells
Gao, Y., Walder, K. R., Sunderland, T., Kantham, L., Feng, H. C., Quick, M., Bishara, N., de Silva, A. M., Augert, G., Tenne-Brown, J., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.4.929 · Cited by 63 · see citing works
Intervention trial with selenium for the prevention of lung cancer among tin miners in Yunnan, China
Yu, S.-Y., Mao, B., Xiao, P., Yu, W., Wang, Y.-L., Huang, C., Chen, W., & Xuan, X.-Z. (1990) · Biological Trace Element Research · doi:10.1007/bf02917199 · Cited by 52 · see citing works
Correlation Between Serum Selenium Level and Febrile Seizures
Mahyar, A., Ayazi, P., Fallahi, M., & Javadi, A. (2010) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2010.05.024 · Cited by 51 · see citing works
Selenium and Vitamin E Supplementation for Cancer Prevention
Hurst, R. (2009) · JAMA · doi:10.1001/jama.2009.626 · Cited by 48 · see citing works
Bioactive Compounds and Cancer
Milner, J. A., & Romagnolo, D. F. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-627-6 · Cited by 47 · see citing works
Selenium and Vitamin E Supplementation for Cancer Prevention
Rayman, M. P. (2009) · JAMA · doi:10.1001/jama.2009.625 · Cited by 46 · see citing works
Self-citationXun, P., Liu, K., Morris, J. S., Daviglus, M. L., & He, K. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.01.021 · Cited by 45 · see citing works
Hesse‐Bähr, K., Dreher, I., & Körle, J. (2000) · BioFactors · doi:10.1002/biof.5520110124 · Cited by 45 · see citing works
Pv, L., Sotaniemi, E. A., Korpela, H., & Kumpulainen, J. T. (1984) · PubMed · Cited by 43 · see citing works
Role of selenoprotein P in Alzheimer's disease.
Takemoto, A. S., Berry, M. J., & Bellinger, F. P. (2010) · PubMed · Cited by 41 · see citing works
Plasma Glutathione Peroxidase Activity as an Index of Renal Function
Schiavon, R., Guidi, G. C., Biasioli, S., Fanti, E. D., & Targa, L. (1994) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1994.32.10.759 · Cited by 33 · see citing works
Low serum albumin and the acute phase response predict low serum selenium in HIV-1 infected women
Drain, P. K., Baeten, J. M., Overbaugh, J. M., Wener, M. H., Bankson, D. D., Lavreys, L., Mandaliya, K. N., Ndinya‐Achola, J. O., & McClelland, R. S. (2006) · BMC Infectious Diseases · doi:10.1186/1471-2334-6-85 · Cited by 28 · see citing works
Selenium and Adverse Health Conditions of Human Pregnancy
Rayman, M. P. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1025-6_42 · Cited by 11 · see citing works
Self-citationPlasma selenium concentration and prostate cancer risk
Bekaert, B., & Rayman, M. P. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27443 · Cited by 7 · see citing works
Self-citationNdinya‐Achola, J. O. (2006) · BMC Infectious Diseases · Cited by 5 · see citing works
Flagged first, then by citations
1 of the 136 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
ESPEN guideline on clinical nutrition in the intensive care unit.
Singer, P., Blaser, A. R., Berger, M. M., Alhazzani, W., Calder, P. C., Casaer, M. P., Hiesmayr, M., Mayer, K., Montejo, J. C., Pichard, C., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.08.037 · Cited by 2,904 · see citing works
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
Heavy metal hyperaccumulating plants: how and why do they do it? And what makes them so interesting
Rascio, N., & Navari-Izzo, F. (2011) · Plant Science · doi:10.1016/j.plantsci.2010.08.016 · Cited by 2,012 · see citing works
Selenoproteins: Molecular Pathways and Physiological Roles
Labunskyy, V. M., Hatfield, D. L., & Gladyshev, V. N. (2014) · Physiological Reviews · doi:10.1152/physrev.00039.2013 · Cited by 1,412 · see citing works
Potential interventions for novel coronavirus in China: A systematic review
Zhang, L., & Liu, Y. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25707 · Cited by 1,354 · see citing works
Selenium in human health and disease
Fairweather-Tait, S. J., Bao, Y., Broadley, M. R., Collings, R., Ford, D., Hesketh, J. E., & Hurst, R. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3275 · Cited by 1,330 · see citing works
Antioxidant responses and cellular adjustments to oxidative stress
Espinosa-Diez, C., Miguel, V., Mennerich, D., Kietzmann, T., Sánchez-Pérez, P., Cadenas, S., & Lamas, S. (2015) · Redox Biology · doi:10.1016/j.redox.2015.07.008 · Cited by 1,046 · see citing works
Bartalena, L., Baldeschi, L., Boboridis, K., Eckstein, A., Kahaly, G. J., Marcocci, C., Perros, P., Salvi, M., & Wiersinga, W. M. (2016) · European Thyroid Journal · doi:10.1159/000443828 · Cited by 943 · see citing works
A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients
Heyland, D., Muscedere, J., Wischmeyer, P. E., Cook, D., Jones, G., Albert, M., Elke, G., Berger, M. M., & Day, A. G. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1212722 · Cited by 904 · see citing works
Selenium, Selenoproteins, and Immunity
Avery, J., & Hoffmann, P. R. (2018) · Nutrients · doi:10.3390/nu10091203 · Cited by 913 · see citing works
Selenium biochemistry and its role for human health
Roman, M., Jitaru, P., & Barbante, C. (2014) · Metallomics · doi:10.1039/c3mt00185g · Cited by 823 · see citing works
Selenium in the Environment, Metabolism and Involvement in Body Functions
Mehdi, Y., Hornick, J., Istasse, L., & Dufrasne, I. (2013) · Molecules · doi:10.3390/molecules18033292 · Cited by 755 · see citing works
Gharibzahedi, S. M. T., & Jafari, S. M. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.02.017 · Cited by 715 · see citing works
Nutrients, foods, and colorectal cancer prevention
Song, M., Garrett, W. S., & Chan, A. T. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.035 · Cited by 700 · see citing works
Selenium Deficiency and Toxicity in the Environment
Fordyce, F. (2013) · Springer eBooks · doi:10.1007/978-94-007-4375-5_16 · Cited by 602 · see citing works
Selenium for preventing cancer
Vinceti, M., Filippini, T., Del Giovane, C., Dennert, G., Zwahlen, M., Brinkman, M., Zeegers, M. P., Horneber, M., D'Amico, R., & Crespi, C. M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005195.pub4 · Cited by 649 · see citing works
Weekley, C. M., & Harris, H. H. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60272a · Cited by 634 · see citing works
Berger, M. M., Shenkin, A., Schweinlin, A., Amrein, K., Augsburger, M., Biesalski, H.-K., Bischoff, S. C., Casaer, M. P., Gundogan, K., Lepp, H.-L., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.02.015 · Cited by 615 · see citing works
Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction
Paithankar, J. G., Saini, S., Dwivedi, S., Sharma, A., & Chowdhuri, D. K. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128350 · Cited by 592 · see citing works
Selenium distribution in the Chinese environment and its relationship with human health: A review
Dinh, Q. T., Cui, Z., Huang, J., Tran, T. A. T., Wang, D., Yang, W., Zhou, F., Wang, M., Yu, D., & Liang, D. (2018) · Environment International · doi:10.1016/j.envint.2017.12.035 · Cited by 588 · see citing works
Enhancing immunity in viral infections, with special emphasis on COVID-19: A review
Jayawardena, R., Sooriyaarachchi, P., Chourdakis, M., Jeewandara, C., & Ranasinghe, P. D. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.04.015 · Cited by 573 · see citing works
Parks, B. W., Nam, E., Org, E., Kostem, E., Norheim, F., Hui, S. T., Pan, C., Civelek, M., Rau, C. D., Bennett, B. J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.007 · Cited by 544 · see citing works
Childs, C. E., Calder, P. C., & Miles, E. A. (2019) · Nutrients · doi:10.3390/nu11081933 · Cited by 532 · see citing works
Selenium nanoparticles as a nutritional supplement
Skalíčková, S., Milosavljević, V., Číhalová, K., Horký, P., Richtera, L., & Adam, V. (2016) · Nutrition · doi:10.1016/j.nut.2016.05.001 · Cited by 495 · see citing works
Natasha, N., Shahid, M. A. R., Niazi, N. K., Khalid, S., Murtaza, B., Bibi, I., & Rashid, M. I. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.12.019 · Cited by 490 · see citing works
Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review
Winkel, L., Vriens, B., Jones, G., Schneider, L., Pilon-Smits, E., & Bañuelos, G. (2015) · Nutrients · doi:10.3390/nu7064199 · Cited by 476 · see citing works
Selenium-Dependent Antioxidant Enzymes: Actions and Properties of Selenoproteins
Zoidis, E., Seremelis, I., Kontopoulos, N., & Danezis, G. P. (2018) · Antioxidants · doi:10.3390/antiox7050066 · Cited by 475 · see citing works
Selenium: environmental significance, pollution, and biological treatment technologies
Tan, L. C., Nancharaiah, Y. V., van Hullebusch, E. D., & Lens, P. N. L. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.05.005 · Cited by 470 · see citing works
Current Knowledge on the Importance of Selenium in Food for Living Organisms: A Review
Kieliszek, M., & Błażejak, S. (2016) · Molecules · doi:10.3390/molecules21050609 · Cited by 448 · see citing works
Selenium accumulation by plants
White, P. J. (2015) · Annals of Botany · doi:10.1093/aob/mcv180 · Cited by 445 · see citing works
Selenium intake, status, and health: a complex relationship
Rayman, M. P. (2019) · HORMONES · doi:10.1007/s42000-019-00125-5 · Cited by 444 · see citing works
Self-citationSelenium, Selenoproteins and Viral Infection
Guillin, O., Vindry, C., Ohlmann, T., & Chavatte, L. (2019) · Nutrients · doi:10.3390/nu11092101 · Cited by 444 · see citing works
Nutritional Aspects of Essential Trace Elements in Oral Health and Disease: An Extensive Review
Bhattacharya, P. T., Misra, S. R., & Hussain, M. (2016) · Scientifica · doi:10.1155/2016/5464373 · Cited by 439 · see citing works
Environmental risk factors for dementia: a systematic review
Killin, L. O. J., Starr, J. M., Shiue, I., & Russ, T. C. (2016) · BMC Geriatrics · doi:10.1186/s12877-016-0342-y · Cited by 442 · see citing works
Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications
Lei, X. G., Zhu, J., Cheng, W.-H., Bao, Y., Ho, Y.-S., Reddi, A. R., Holmgren, A., & Arnér, E. S. J. (2015) · Physiological Reviews · doi:10.1152/physrev.00010.2014 · Cited by 437 · see citing works
Current progress on understanding the impact of mercury on human health
Ha, E., Basu, N., Böse‐O’Reilly, S., Dórea, J. G., McSorley, E. M., Sakamoto, M., & Chan, H. M. (2016) · Environmental Research · doi:10.1016/j.envres.2016.06.042 · Cited by 431 · see citing works
Schiavon, M., & Pilon‐Smits, E. A. H. (2016) · New Phytologist · doi:10.1111/nph.14378 · Cited by 421 · see citing works
Metabolic and nutritional support of critically ill patients: consensus and controversies
Preiser, J.-C., van Zanten, A. R., Berger, M. M., Biolo, G., Casaer, M. P., Doig, G. S., Griffiths, R. D., Heyland, D. K., Hiesmayr, M., Iapichino, G., et al. (2015) · Critical Care · doi:10.1186/s13054-015-0737-8 · Cited by 416 · see citing works
Selenium‐Doped Carbon Quantum Dots for Free‐Radical Scavenging
Li, F., Li, T., Sun, C., Xia, J., Jiao, Y., & Xu, H. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201705989 · Cited by 413 · see citing works
Biological Activity of Selenium and Its Impact on Human Health
Genchi, G., Lauria, G., Catalano, A. A., Sinicropi, M. S., & Carocci, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032633 · Cited by 399 · see citing works
Regulatory Phenomena in the Glutathione Peroxidase Superfamily
Brigelius‐Flohé, R., & Flohé, L. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7905 · Cited by 400 · see citing works
The Role of Selenium in Pathologies: An Updated Review
Barchielli, G., Capperucci, A., & Tanini, D. (2022) · Antioxidants · doi:10.3390/antiox11020251 · Cited by 373 · see citing works
Duntas, L., & Benvenga, S. (2015) · Endocrine · doi:10.1007/s12020-014-0477-6 · Cited by 379 · see citing works
A Review of Dietary Selenium Intake and Selenium Status in Europe and the Middle East
Stoffaneller, R., & Morse, N. (2015) · Nutrients · doi:10.3390/nu7031494 · Cited by 363 · see citing works
Association between regional selenium status and reported outcome of COVID-19 cases in China
Zhang, J., Taylor, E. W., Bennett, K., Saad, R., & Rayman, M. P. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa095 · Cited by 361 · see citing works
Self-citationSelenium Deficiency Is Associated with Mortality Risk from COVID-19
Moghaddam, A., Heller, R. A., Sun, Q., Seelig, J., Cherkezov, A., Seibert, L., Hackler, J., Seemann, P., Diegmann, J., Pilz, M., et al. (2020) · Nutrients · doi:10.3390/nu12072098 · Cited by 361 · see citing works
MECHANISMS IN ENDOCRINOLOGY: Autoimmune thyroid disease: old and new players
Effraimidis, G., & Wiersinga, W. M. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0047 · Cited by 349 · see citing works
Os PT 2, a phosphate transporter, is involved in the active uptake of selenite in rice
Zhang, L., Hu, B., Li, W., Che, R., Deng, K., Li, H., Yu, F., Ling, H., Li, Y., & Chu, C. (2013) · New Phytologist · doi:10.1111/nph.12596 · Cited by 349 · see citing works
Scientific Opinion on Dietary Reference Values for selenium
EFSA Panel on Dietetic Products, N. A. A. (. (2014) · EFSA Journal · doi:10.2903/j.efsa.2014.3846 · Cited by 346 · see citing works
Selenium and Thyroid Disease: From Pathophysiology to Treatment
Ventura, M., Melo, M., & Carrilho, F. (2017) · International Journal of Endocrinology · doi:10.1155/2017/1297658 · Cited by 338 · see citing works
Revised reference values for selenium intake
Kipp, A. P., Strohm, D., Brigelius‐Flohé, R., Schomburg, L., Bechthold, A., Leschik‐Bonnet, E., & Heseker, H. (2015) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2015.07.005 · Cited by 337 · see citing works
Chaker, L., Razvi, S., Bensenor, I. M., Azizi, F., Pearce, E. N., & Peeters, R. P. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00357-7 · Cited by 330 · see citing works
The Role of Minerals in the Optimal Functioning of the Immune System
Weyh, C., Krüger, K., Peeling, P., & Castell, L. M. (2022) · Nutrients · doi:10.3390/nu14030644 · Cited by 349 · see citing works
Soil and Human Health: Current Status and Future Needs
Brevik, E. C., Slaughter, L. C., Singh, B. R., Steffan, J. J., Collier, D. N., Barnhart, P. R., & Pereira, P. A. D. S. (2020) · Air Soil and Water Research · doi:10.1177/1178622120934441 · Cited by 328 · see citing works
The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature
Zwolak, I. (2019) · Biological Trace Element Research · doi:10.1007/s12011-019-01691-w · Cited by 324 · see citing works
Application of Nanoparticles Alleviates Heavy Metals Stress and Promotes Plant Growth: An Overview
Zhou, P., Adeel, M., Shakoor, N., Guo, M., Hao, Y., Azeem, I., Li, M., Liu, M., & Rui, Y. (2020) · Nanomaterials · doi:10.3390/nano11010026 · Cited by 306 · see citing works
Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic
Gasmi, A., Noor, S., Tippairote, T., Dadar, M., Menzel, A., & Bjørklund, G. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108409 · Cited by 310 · see citing works
Selenium biofortification in the 21st century: status and challenges for healthy human nutrition
Schiavon, M., Nardi, S., Vecchia, F. D., & Ertani, A. (2020) · Plant and Soil · doi:10.1007/s11104-020-04635-9 · Cited by 304 · see citing works
Dietary Selenium in Adjuvant Therapy of Viral and Bacterial Infections
Steinbrenner, H., Al-Quraishy, S., Dkhil, M. A., Wunderlich, F. T., & Sies, H. (2015) · Advances in Nutrition · doi:10.3945/an.114.007575 · Cited by 299 · see citing works
Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant
Wang, N., Tan, H., Li, S., Xu, Y., Guo, W., & Feng, Y. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7478523 · Cited by 293 · see citing works
Selenium in thyroid disorders—essential knowledge for clinicians
Winther, K. H., Rayman, M. P., Bonnema, S. J., & Hegedüs, L. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0311-6 · Cited by 288 · see citing works
Self-citationMehdi, Y., & Dufrasne, I. (2016) · Molecules · doi:10.3390/molecules21040545 · Cited by 288 · see citing works
Solovyev, N. D. (2015) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2015.09.003 · Cited by 282 · see citing works
van Dronkelaar, C., van Velzen, A., Abdelrazek, M., van der Steen, A., Weijs, P. J. M., & Tieland, M. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.05.026 · Cited by 279 · see citing works
Selenium transport and metabolism in plants: Phytoremediation and biofortification implications
Trippe, R. C., & Pilon‐Smits, E. A. H. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124178 · Cited by 279 · see citing works
Low Population Selenium Status Is Associated With Increased Prevalence of Thyroid Disease
Wu, Q., Rayman, M. P., Lv, H., Schomburg, L., Cui, B., Gao, C., Chen, P., Zhuang, G., Zhang, Z., Peng, X., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2222 · Cited by 266 · see citing works
Self-citationSelenium Biofortification: Roles, Mechanisms, Responses and Prospects
Hossain, A., Skalický, M., Brestič, M., Maitra, S., Sarkar, S., Ahmad, Z., Vemuri, H., Garai, S., Mondal, M., Bhatt, R., et al. (2021) · Molecules · doi:10.3390/molecules26040881 · Cited by 273 · see citing works
Biological activity of selenium: Revisited
Wrobel, J. K., Power, R. F., & Toborek, M. J. (2015) · IUBMB Life · doi:10.1002/iub.1466 · Cited by 260 · see citing works
Selenium biomineralization for biotechnological applications
Nancharaiah, Y. V., & Lens, P. N. L. (2015) · Trends in biotechnology · doi:10.1016/j.tibtech.2015.03.004 · Cited by 253 · see citing works
Hierarchically designed bone scaffolds: From internal cues to external stimuli
Du, Y., Guo, J. L., Wang, J., Mikos, A. G., & Zhang, S. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119334 · Cited by 253 · see citing works
Small molecule selenium-containing compounds: Recent development and therapeutic applications
Chuai, H., Zhang, S., Bai, H., Li, J., Wang, Y., Sun, J., Wen, E., Zhang, J., & Xin, M. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113621 · Cited by 253 · see citing works
Rayman, M. P. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118001192 · Cited by 251 · see citing works
Self-citationA State-of-the-Science Review on Metal Biomarkers
Martínez-Morata, I., Sobel, M., Téllez-Plaza, M., Navas‐Acién, A., Howe, C. G., & Sanchez, T. R. (2023) · Current Environmental Health Reports · doi:10.1007/s40572-023-00402-x · Cited by 250 · see citing works
Lee, B. C., Péterfi, Z., Hoffmann, F. W., Moore, R. E., Kaya, A., Avanesov, A. S., Tarrago, L., Zhou, Y., Weerapana, E., Fomenko, D. E., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.06.019 · Cited by 244 · see citing works
Toxicology and pharmacology of synthetic organoselenium compounds: an update
Nogueira, C. W., Barbosa, N. V., & da Rocha, J. B. T. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03003-5 · Cited by 242 · see citing works
Shao, D., Zhang, F., Chen, F., Zheng, X., Hu, H., Yang, C., Tu, Z., Wang, Z., Chang, Z., Lu, J., et al. (2020) · Advanced Materials · doi:10.1002/adma.202004385 · Cited by 238 · see citing works
Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression
Cai, X., Wang, C., Yu, W., Fan, W., Wang, S., Shen, N., Wu, P., Li, X., & Wang, F. (2016) · Scientific Reports · doi:10.1038/srep19213 · Cited by 235 · see citing works
Antioxidant supplements and mortality
Bjelakovic, G., Nikolova, D., & Gluud, C. (2013) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000009 · Cited by 234 · see citing works
Effects of selenium biofortification on crop nutritional quality
Malagoli, M., Schiavon, M., Dall’Acqua, S., & Pilon‐Smits, E. A. H. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00280 · Cited by 236 · see citing works
Chen, W., Li, Y., Yang, S., Yue, L., Jiang, Q., & Xia, W. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.06.064 · Cited by 232 · see citing works
Sources and Deficiency Diseases of Mineral Nutrients in Human Health and Nutrition: A Review
Gupta, U. C., & Gupta, S. C. (2014) · Pedosphere · doi:10.1016/s1002-0160(13)60077-6 · Cited by 232 · see citing works
Ferreira, R. L. U., Sena‐Evangelista, K. C. M., de Azevedo, E. P., Pinheiro, F. I., Cobucci, R. N., & Pedrosa, L. F. C. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.685317 · Cited by 228 · see citing works
Accumulation and metabolism of selenium by yeast cells
Kieliszek, M., Błażejak, S., Gientka, I., & Bzducha‐Wróbel, A. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6650-x · Cited by 223 · see citing works
Wichman, J. E. M., Winther, K. H., Bonnema, S. J., & Hegedűs, L. D. (2016) · Thyroid · doi:10.1089/thy.2016.0256 · Cited by 223 · see citing works
Epidemiology of selenium and type 2 diabetes: Can we make sense of it?
Rayman, M. P., & Stranges, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.003 · Cited by 220 · see citing works
Self-citationSelenium and nano-selenium in plant nutrition
El-Ramady, H. R., Abdalla, N. A., Taha, H. S., Alshaal, T., El-Henawy, A. S., Faizy, S. E.-D. A., Shams, M. S., Youssef, S., Shalaby, T., Bayoumi, Y. A., et al. (2015) · Environmental Chemistry Letters · doi:10.1007/s10311-015-0535-1 · Cited by 219 · see citing works
Keunen, K., van Elburg, R. M., van Bel, F., & Benders, M. J. N. L. (2014) · Pediatric Research · doi:10.1038/pr.2014.171 · Cited by 220 · see citing works
Newsholme, P., Keane, K. N., Carlessi, R., & Cruzat, V. F. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00141.2019 · Cited by 226 · see citing works
The role of selenium in human conception and pregnancy
Pieczyńska, J. M., & Grajeta, H. (2014) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2014.07.003 · Cited by 219 · see citing works
Steinbrenner, H., & Sies, H. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.02.021 · Cited by 217 · see citing works
The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities
Steinbrenner, H., Duntas, L. H., & Rayman, M. P. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102236 · Cited by 217 · see citing works
Self-citationBioactive glasses incorporating less-common ions to improve biological and physical properties
Pantulap, U., Arango‐Ospina, M., & Boccaccini, A. R. (2021) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-021-06626-3 · Cited by 216 · see citing works
Diet and Nutrient Factors in Colorectal Cancer Risk
Vargas, A. J., & Thompson, P. A. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533612454885 · Cited by 213 · see citing works
Hill, K. E., Xia, Y., Åkesson, B., Boeglin, M. E., & Burk, R. F. (1996) · Journal of Nutrition · doi:10.1093/jn/126.1.138 · Cited by 212 · see citing works
Role for Selenium in Metabolic Homeostasis and Human Reproduction
Mojadadi, A., Au, A., Salah, W., Witting, P. K., & Ahmad, G. (2021) · Nutrients · doi:10.3390/nu13093256 · Cited by 209 · see citing works
Bioavailability of selenium in soil-plant system and a regulatory approach
Dinh, Q. T., Wang, M., Tran, T. A. T., Zhou, F., Wang, D., Zhai, H., Peng, Q., Xue, M., Du, Z., Bañuelos, G. S., et al. (2018) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2018.1550987 · Cited by 208 · see citing works
Lampis, S., Zonaro, E., Bertolini, C., Cecconi, D., Monti, F., Micaroni, M., Turner, R. J., Butler, C. S., & Vallini, G. (2016) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2016.02.035 · Cited by 207 · see citing works
Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis
Hu, S., & Rayman, M. P. (2017) · Thyroid · doi:10.1089/thy.2016.0635 · Cited by 207 · see citing works
Self-citationZhang, B., Ge, C., Yao, J., Liu, Y., Xie, H., & Fang, J. (2015) · Journal of the American Chemical Society · doi:10.1021/ja5099676 · Cited by 206 · see citing works
In Vitro and in Vivo Mechanism of Bone Tumor Inhibition by Selenium-Doped Bone Mineral Nanoparticles
Wang, Y., Wang, J., Hao, H., Cai, M., Wang, S., Ma, J., Li, Y., Mao, C., & Zhang, S. (2016) · ACS Nano · doi:10.1021/acsnano.6b03835 · Cited by 206 · see citing works
- Authors
- Rayman, M. P.
- Affiliations
- University of Surrey (GB)
- Corresponding author
- Rayman, Margaret P
- ORCID
- Rayman, Margaret P
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 379
- Issue
- 9822
- Pages
- 1256-1268
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2013131201
- Cited by
- 3,563
- References
- 136
- Citations by year
- 2026: 305 · 2025: 334 · 2024: 310 · 2023: 339 · 2022: 369 · 2021: 337 · 2020: 311 · 2019: 221 · 2018: 199 · 2017: 173 · 2016: 187 · 2015: 153 · 2014: 158 · 2013: 120 · 2012: 33
- FWCI
- 137.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Organoselenium and organotellurium chemistry
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- selenium, selenoproteins, selenium status, selenium supplementation, antioxidant activity, thyroid hormones, immune function, cognitive decline, antiviral activity, reproductive health, autoimmune thyroid disease, cancer risk, type 2 diabetes, U-shaped dose-response
- MeSH terms
- Adult, Animals, Cause of Death, Cross-Cultural Comparison, Female, Humans, Immunocompetence, Longitudinal Studies, Male, Middle Aged, Neoplasms, Nutritional Requirements, Reference Values, Selenium, Survival Rate, Proportional Hazards Models, Selenoproteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
