The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Gene Knockout Study Reveals That Cytosolic Ascorbate Peroxidase 2(OsAPX2) Plays a Critical Role in Growth and Reproduction in Rice under Drought, Salt and Cold Stresses
Open accessAbstract
Plant ascorbate peroxidases (APXs), enzymes catalyzing the dismutation of H2O2 into H2O and O2, play an important role in reactive oxygen species homeostasis in plants. The rice genome has eight OsAPXs, but their physiological functions remain to be determined. In this report, we studied the function of OsAPX2 gene using a T-DNA knockout mutant under the treatment of drought, salt and cold stresses. The Osapx2 knockout mutant was isolated by a genetic screening of a rice T-DNA insertion library under 20% PEG-2000 treatment. Loss of function in OsAPX2 affected the growth and development of rice seedlings, resulting in semi-dwarf seedlings, yellow-green leaves, leaf lesion mimic and seed sterility. OsAPX2 expression was developmental- and spatial-regulated, and was induced by drought, salt, and cold stresses. Osapx2 mutants had lower APX activity and were sensitive to abiotic stresses; overexpression of OsAPX2 increased APX activity and enhanced stress tolerance. H2O2 and MDA levels were high in Osapx2 mutants but low in OsAPX2-OX transgenic lines relative to wild-type plants after stress treatments. Taken together, the cytosolic ascorbate peroxidase OsAPX2 plays an important role in rice growth and development by protecting the seedlings from abiotic stresses through scavenging reactive oxygen species.
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Cited by
Abiotic Stress Tolerance in Plants: Myriad Roles of Ascorbate Peroxidase
Pandey, S., Fartyal, D., Agarwal, A., Shukla, T., James, D., Kaul, T., Negi, Y. K., Arora, S., & Reddy, M. K. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.00581 · Cited by 420
Catalase and ascorbate peroxidase—representative H2O2-detoxifying heme enzymes in plants
Anjum, N. A., Sharma, P., Gill, S. S., Hasanuzzaman, M., Khan, E. A., Kachhap, K., Mohamed, A. A., Thangavel, P., Devi, G. D., Vasudhevan, P., et al. (2016) · Environmental Science and Pollution Research · doi:10.1007/s11356-016-7309-6 · Cited by 401
The Impact of Drought Stress on Soil Microbial Community, Enzyme Activities and Plants
Bogati, K., & Walczak, M. (2022) · Agronomy · doi:10.3390/agronomy12010189 · Cited by 391
4-Coumarate 3-hydroxylase in the lignin biosynthesis pathway is a cytosolic ascorbate peroxidase
Barros, J., Escamilla-Trevino, L., Song, L., Rao, X., Serrani-Yarce, J. C., Palacios, M. D., Engle, N., Choudhury, F. K., Tschaplinski, T. J., Venables, B. J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10082-7 · Cited by 283
Metadata
- Authors
- Zhang, Z., Zhang, Q., Wu, J., Zheng, X., Zheng, S., Sun, X., Qiu, Q., & Lu, T.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-02-28
- Volume
- 8
- Issue
- 2
- Pages
- e57472
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2049402244
- Cited by
- 255
- References
- 31
- FWCI
- 13.46
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Gene Knockout Study Reveals That Cytosolic Ascorbate Peroxidase 2(OsAPX2) Plays a Critical Role in Growth and Reproduction in Rice under Drought, Salt and Cold Stresses. https://app.cochat.ai/papers/10.1371/journal.pone.0057472
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- Zhang, Z., Zhang, Q., Wu, J., Zheng, X., Zheng, S., Sun, X., Qiu, Q., & Lu, T. (2013). Gene Knockout Study Reveals That Cytosolic Ascorbate Peroxidase 2(OsAPX2) Plays a Critical Role in Growth and Reproduction in Rice under Drought, Salt and Cold Stresses. PLoS ONE. https://doi.org/10.1371/journal.pone.0057472
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