Minocycline Attenuates Cognitive Impairment Induced by Isoflurane Anesthesia in Aged Rats
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Postoperative cognitive dysfunction (POCD) is a clinical phenomenon characterized by cognitive deficits in patients after anesthesia and surgery, especially in geriatric surgical patients. Although it has been documented that isoflurane exposure impaired cognitive function in several aged animal models, there are few clinical interventions and treatments available to prevent this disorder. Minocycline has been well established to exert neuroprotective effects in various experimental animal models and neurodegenerative diseases. Therefore, we hypothesized that pretreatment with minocycline attenuates isoflurane-induced cognitive decline in aged rats. In the present study, twenty-month-old rats were administered minocycline or an equal volume of saline by intraperitoneal injection 12 h before exposure to isoflurane. Then the rats were exposed to 1.3% isoflurane for 4 h. Two weeks later, spatial learning and memory of the rats were examined using the Morris Water Maze. We found that pretreatment with minocycline mitigated isoflurane-induced cognitive deficits and suppressed the isoflurane-induced excessive release of IL-1β and caspase-3 in the hippocampal CA1 region at 4 h after isoflurane exposure, as well as the number of TUNEL-positive nuclei. In addition, minocycline treatment also prevented the changes of synaptic ultrastructure in the hippocampal CA1 region induced by isoflurane. In conclusion, pretreatment with minocycline attenuated isoflurane-induced cognitive impairment in aged rats.
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Preclinical evidence suggests that minocycline may reduce cognitive impairment.
“Preclinical evidence suggests that minocycline may reduce cognitive impairment [103, 104].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [103]
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- Authors
- Kong, F., Chen, S., Cheng, Y., Ma, L., Lu, H., Zhang, H., & Hu, W.
- Affiliations
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Corresponding author
- Ma, Leilei
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-04-17
- Volume
- 8
- Issue
- 4
- Pages
- e61385
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3629183
- OpenAlex
- W2071328094
- Cited by
- 58
- References
- 48
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 12 · 2016: 8 · 2015: 9 · 2014: 5 · 2013: 4
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Zhejiang University
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- minocycline, isoflurane, postoperative cognitive dysfunction, cognitive impairment, aging, neuroprotection, hippocampal CA1, IL-1β, caspase-3, apoptosis, synaptic ultrastructure, spatial learning and memory, neuroinflammation
- MeSH terms
- Aging, Anesthesia, Animals, Cognition Disorders, Heart Rate, Isoflurane, Male, Minocycline, Synapses, Tumor Necrosis Factor-alpha, Rats, Sprague-Dawley, Apoptosis, Maze Learning, Rats, Caspase 3, Interleukin-1beta, CA1 Region, Hippocampal, Arterial Pressure
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