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Odin (ANKS1A) Modulates EGF Receptor Recycling and Stability

Tong, Jiefei, Sydorskyy, Yaroslav, St-Germain, Jonathan R., Taylor, Paul, Tsao, Ming S., Moran, Michael F.·2013·PLoS ONE

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Crossref · 10.1371/journal.pone.0064817

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  • Ligand-stimulated EGFR is recycled back to the plasma membrane through Rab11-positive endosomes.

    “Since AP-1 has been shown to localize to Rab11-positive recycling endosomes [28], and ligand-stimulated EGFR is recycled back to the PM through Rab11-positive endosomes [29, 30], we examined if three molecules, EGFR, AP-1, and Rab11, could show colocalization in the cytoplasm.”
  • Ligand-stimulated EGFR is recycled back to the plasma membrane through Rab11-positive endosomes, promoted by the short form of EPS15 and Odin.

    “Previous studies have demonstrated that ligand-stimulated EGFR is recycled back to the PM through Rab11-positive endosomes, which is promoted by the short form of EPS15 [30] and a tyrosine-phosphorylated component, Odin [29, 30].”

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Research works printed but not linked: 57

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Metadata

Authors
Tong, J., Sydorskyy, Y., St-Germain, J. R., Taylor, P., Tsao, M. S., & Moran, M. F.
Venue
PLoS ONE
Published
2013-06-25
Volume
8
Issue
6
Pages
e64817
ISSN
1932-6203
Cited by
25
References
3
Language
en

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