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Rab11 regulates recycling through the pericentriolar recycling endosome.
Abstract
Small GTPases of the rab family are crucial elements of the machinery that controls membrane traffic. In the present study, we examined the distribution and function of rab11. Rab11 was shown by confocal immunofluorescence microscopy and EM to colocalize with internalized transferrin in the pericentriolar recycling compartment of CHO and BHK cells. Expression of rab11 mutants that are preferentially in the GTP- or GDP-bound state caused opposite effects on the distribution of transferrin-containing elements; rab11-GTP expression caused accumulation of labeled elements in the perinuclear area of the cell, whereas rab11-GDP caused a dispersion of the transferrin labeling. Functional studies showed that the early steps of uptake and recycling for transferrin were not affected by overexpression of rab11 proteins. However, recycling from the later recycling endosome was inhibited in cells overexpressing the rab11-GDP mutant. Rab5, which regulates early endocytic trafficking, acted before rab11 in the transferrin-recycling pathway as expression of rab5-GTP prevented transport to the rab11-positive recycling endosome. These results suggest a novel role for rab11 in controlling traffic through the recycling endosome.
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Rab11 regulates trafficking of numerous receptors and transporters to cell surfaces.
“Rab11 regulates numerous receptors and transporters trafficking onto cell surfaces; its diminished activity in HD cells affects the recycling of transferrin receptor and neuronal glutamate/cysteine transporter EAAC1.”
From Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington’s disease mice (2014) · cites this paper as [19]
Rab11 is a key regulator of recycling pathways from endosomes to the plasma membrane.
“Rab11 is a key regulator of recycling pathways from endosomes to the plasma membrane (Ullrich et al., 1996) and consists of two isoforms, Rab11a and Rab11b, which are encoded by different genes and mainly differ in their C-termini.”
From SH3TC2, a protein mutant in Charcot–Marie–Tooth neuropathy, links peripheral nerve myelination to endosomal recycling (2010) · cites this paper as Ullrich et al., 1996
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Cites
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pH-induced microtubule-dependent redistribution of late endosomes in neuronal and epithelial cells
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Rab Proteins and the Compartmentalization of the Endosomal System
Wandinger-Ness, A., & Zerial, M. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022616 · Cited by 586
Self-citationORGANELLES AND TRAFFICKING MACHINERY FOR POSTSYNAPTIC PLASTICITY
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Clathrin-independent pathways do not contribute significantly to endocytic flux
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Antigen processing and presentation
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Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease
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The kinesin KIF16B mediates apical transcytosis of transferrin receptor in AP-1B-deficient epithelia
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UNC-108/Rab2 Regulates Postendocytic Trafficking in Caenorhabditis elegans
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Autolysosomal Membrane-associated Betaine Homocysteine Methyltransferase
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Toll-like receptor 2 utilizes RAB11A for melanosome transfer from melanocytes to keratinocytes
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Metadata
- Authors
- Ullrich, O., Reinsch, S., Urbé, S., Zerial, M., & Parton, R. G.
- Affiliations
- European Molecular Biology Laboratory, Heidelberg, Germany.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1996-11-15
- Volume
- 135
- Issue
- 4
- Pages
- 913-924
- ISSN
- 0021-9525
- 1540-8140
- PMC
- PMC2133374
- Cited by
- 1,197
- References
- 2
- Language
- en
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