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Cited by 15Vitamin C and Antioxidants ResearchGenetic Associations and EpidemiologyNutrition, Genetics, and Disease

Variation in the Sodium-Dependent Vitamin C Transporter 2 Gene Is Associated with Risk of Acute Coronary Syndrome among Women

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Dalgård, Christine, Christiansen, Lene, Vogel, Ulla, Dethlefsen, Claus, Tjønneland, Anne, Overvad, Kim·2013·PLoS ONE
DOI 10.1371/journal.pone.0070421PMC PMC3749152
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Abstract

BACKGROUND: Vitamin C is associated with a lower risk of coronary heart disease possibly due to its anti-oxidative effects, beneficial effects on endothelial function and importance in collagen synthesis. The sodium-dependent vitamin C transporter 2 is responsible for the transport of vitamin C into various cells and malfunction of this protein leads to reduced vitamin C in tissue, including the arterial wall. We tested the hypothesis that candidate variations rs6139591 and rs1776964 in the gene coding for sodium-dependent vitamin C transporter 2 are associated with development of acute coronary syndrome. DESIGN: In the Danish Diet, Cancer and Health cohort study, we performed a case-cohort study among 57,053 subjects aged 50-64 years. RESULTS: During a mean follow-up period of 6.4 years, we identified 936 cases and randomly selected a sub-cohort (n = 1,580) with full information on genotypes and covariates. Using Cox proportional hazard models, we found that women with the rs6139591 TT genotype and a lower than median dietary vitamin C intake had a higher risk of acute coronary syndrome compared with those with the CC genotype (adjusted HR 5.39, 95% confidence interval, 2.01-14.50). We also observed a not as strong but positive although inconsistent association for women at a higher than median intake of vitamin C rich food. For the rs1776964 polymorphism, we found a higher risk (adjusted HR 3.45, 95% CI, 1.16-10.28) among TT-homozygous women with higher than median vitamin C intake compared with the CC genotype and low vitamin C intake. Among men, weaker and non-significant associations were observed for both polymorphisms. CONCLUSION: Genetic variation in the sodium-dependent vitamin C transporter 2 is associated with risk of incident acute coronary syndrome in women. The genotype effects may not be fully compensated by a higher intake of vitamin C rich food.

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  • Common variations of SLC23A2 are linked to acute coronary syndrome in women.

    “Common variations of SLC23A2 were linked to increased or decreased risk of gastric cancer depending on a discrete genotype [85,90], decreased risk of colorectal adenocarcinoma [91], HPV16-positive head and neck cancer [92], increased risk of bladder cancer [93], non-Hodgkin lymphoma [87], chronic lymphocytic leukemia [94], preterm delivery [84], open-angle glaucoma [95], and acute coronary syndrom”

    From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [96]

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Authors
Dalgård, C., Christiansen, L., Vogel, U., Dethlefsen, C., Tjønneland, A., & Overvad, K.
Affiliations
  • University of Southern Denmark (DK)
  • National Research Centre for the Working Environment (DK)
  • Aalborg University Hospital (DK)
  • Danish Cancer Society (DK)
  • Aarhus University (DK)
Corresponding author
Dalgård, Christine
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-08-21
Volume
8
Issue
8
Pages
e70421
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0070421
PMC
PMC3749152
OpenAlex
W1966422355
Cited by
15
References
35
Citations by year
2025: 1 · 2021: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 3
FWCI
1.86
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
  • 141st APHA Annual Meeting and Exposition (November 2 - November 6, 2013)
Funders
Hjerteforeningen
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords
SVCT2, SLC27A4, acute coronary syndrome, genetic polymorphism, vitamin C intake, coronary heart disease risk, sex differences, women
MeSH terms
Ascorbic Acid, Diet, Female, Genetic Markers, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk, Genetic Variation, Cohort Studies, Proportional Hazards Models, Genetic Predisposition to Disease, Acute Coronary Syndrome, Sodium-Coupled Vitamin C Transporters

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