The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
PEDF Expression Is Inhibited by Insulin Treatment in Adipose Tissue via Suppressing 11β-HSD1
Open accessAbstract
Early intensive insulin therapy improves insulin sensitivity in type 2 diabetic patients; while the underlying mechanism remains largely unknown. Pigment epithelium-derived factor (PEDF), an anti-angiogenic factor, is believed to be involved in the pathogenesis of insulin resistance. Here, we hypothesize that PEDF might be down regulated by insulin and then lead to the improved insulin resistance in type 2 diabetic patients during insulin therapy. We addressed this issue by investigating insulin regulation of PEDF expression in diabetic conditions. The results showed that serum PEDF was reduced by 15% in newly diagnosed type 2 diabetic patients after insulin therapy. In adipose tissue of diabetic Sprague-Dawley rats, PEDF expression was associated with TNF-α elevation and it could be decreased both in serum and in adipose tissue by insulin treatment. In adipocytes, PEDF was induced by TNF-α through activation of NF-κB. The response was inhibited by knockdown and enhanced by over expression of NF-κB p65. However, PEDF expression was indirectly, not directly, induced by NF-κB which promoted 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) expression in adipocytes. 11β-HSD1 is likely to stimulate PEDF expression through production of active form of glucocorticoids as dexamethasone induced PEDF expression in adipose tissue. Insulin inhibited PEDF by down-regulating 11β-HSD1 expression. The results suggest that PEDF activity is induced by inflammation and decreased by insulin through targeting 11β-HSD1/glucocorticoid pathway in adipose tissue of diabetic patients.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Additional genes outside the classic lipolytic pathway have been implicated in the lipolytic effects of glucocorticoids, such as phosphodiesterase 3b, pigment epithelium derived factor, and angiopoietin-like 4.
“Additional genes outside the classic lipolytic pathway have been implicated in the lipolytic effects of glucocorticoids, such as phosphodiesterase 3b,4 pigment epithelium derived factor24 and angiopoietin‐like 4;25”
From Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct (2017) · cites this paper as [24]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Banumathi, E., Ravinarayannan, H., Pasha, S. P. B. S., Lee, K., & Gurunathan, S. (2009) · Angiogenesis · doi:10.1007/s10456-009-9153-5 · Cited by 41
RetractedA transgenic model of visceral obesity and the metabolic syndrome
Masuzaki, H., Paterson, J., Shinyama, H., Morton, N. M., Mullins, J. J., Seckl, J. R., & Flier, J. S. (2001) · Science · doi:10.1126/science.1066285 · Cited by 1,766
Kotelevtsev, Y. V., Holmes, M. C., Burchell, A. N., Houston, P., Schmoll, D., Jamieson, P. M., Best, R., Brown, R., Edwards, C. R. W., Seckl, J. R., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14924 · Cited by 863
Weng, J., Li, Y., Xu, W., Shi, L., Zhang, Q., Zhu, D., Hu, Y., Zhou, Z., Yan, X., Tian, H., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60762-x · Cited by 780
Self-citationPEDF: A pigment epithelium-derived factor with potent neuronal differentiative activity
Tombran‐Tink, J., Chader, G. J., & Johnson, L. V. (1991) · Experimental Eye Research · doi:10.1016/0014-4835(91)90248-d · Cited by 575
Treins, C., Giorgetti‐Peraldi, S., Murdaca, J., Semenza, G. L., & OBBERGHEN, E. V. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204152200 · Cited by 554
Paterson, J. M., Morton, N. M., Fiévet, C., Kenyon, C. J., Holmes, M. C., Staels, B., Seckl, J. R., & Mullins, J. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305524101 · Cited by 430
Unbalanced expression of VEGF and PEDF in ischemia‐induced retinal neovascularization
Gao, G., Li, Y., Zhang, D., Gee, S., Crosson, C. E., & Ma, J.-X. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02110-x · Cited by 302
Neuronal differentiation of retinoblastoma cells induced by medium conditioned by human RPE cells.
Tombran‐Tink, J., & Johnson, L. V. (1989) · PubMed · Cited by 265
Loss of the Antiangiogenic Pigment Epithelium-Derived Factor in Patients With Angiogenic Eye Disease
Spranger, J., Osterhoff, M. A., Reimann, M., Möhlig, M., Ristow, M., Francis, M. K., Cristofalo, V. J., Hammes, H., SMITH, G. M., Boulton, M. E., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2641 · Cited by 242
Elevated Serum Levels of Pigment Epithelium-Derived Factor in the Metabolic Syndrome
Yamagishi, S., Adachi, H., Abe, A., Yashiro, T., Enomoto, M., Furuki, K., Hino, A., Jinnouchi, Y., Takenaka, K., Matsui, T., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2654 · Cited by 181
Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity
Crowe, S., Wu, L. E., Economou, C., Turpin-Nolan, S. M., Matzaris, M., Hoehn, K. L., Hevener, A. L., James, D. E., Duh, E. J., & Watt, M. J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.06.001 · Cited by 179
Tang, T., Zhang, J., Yin, J., Staszkiewicz, J., Gawrońska‐Kozak, B., Jung, D. Y., Ko, H. J., Ong, H., Kim, J. K., Mynatt, R., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.068007 · Cited by 164
Gao, Z., He, Q., Peng, B., Chiao, P. J., & Ye, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507784200 · Cited by 141
11&Bgr;-Hydroxysteroid Dehydrogenase Type 1 and Obesity
Morton, N. M., & Seckl, J. R. (2008) · KARGER eBooks · doi:10.1159/000115363 · Cited by 132
Pigment Epithelium–Derived Factor Regulates Lipid Metabolism via Adipose Triglyceride Lipase
Borg, M. L., Andrews, Z. B., Duh, E. J., Zechner, R., Meikle, P. J., & Watt, M. J. (2011) · Diabetes · doi:10.2337/db10-0845 · Cited by 131
Sabater, M., Moreno‐Navarrete, J. M., Ortega, F. J., Pardo, G., Salvador, J., Ricart, W., Frühbeck, G., & Fernández‐Real, J. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0630 · Cited by 104
Choi, K. M., Hwang, S. Y., Hong, H. C., Yang, S. J., Choi, H. Y., Yoo, H. J., Lee, K. W., Nam, M. S., Park, Y. S., Woo, J., et al. (2012) · Diabetes · doi:10.2337/db12-0217 · Cited by 87
Jenkins, A. J., Zhang, S. X., Rowley, K., Karschimkus, C. S., Nelson, C., Chung, J. S., O'Neal, D. N., Januszewski, A. S., Croft, K. D., Mori, T. A., et al. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02281.x · Cited by 82
Plasma Concentration of Pigment Epithelium-Derived Factor in Patients with Diabetic Retinopathy
Ogata, N., Matsuoka, M., Matsuyama, K., Shima, C., Tajika, A., Nishiyama, T., Wada, M., Jo, N., Higuchi, A., Minamino, K., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2249 · Cited by 82
Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients
Jenkins, A. J., Zhang, S. X., Gosmanova, A. K., Aston, C. E., Dashti, A., Baker, M. Z., Lyons, T. J., & Ma, J. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.06.019 · Cited by 80
Park, K., Jin, J., Hu, Y., Zhou, K., & Ma, J. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.10.014 · Cited by 79
Wang, M., Wang, J. J., Li, J., Park, K., Qian, X., Ma, J., & Zhang, S. X. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00252.2009 · Cited by 78
Nakamura, K., Yamagishi, S., Adachi, H., Kurita‐Nakamura, Y., Matsui, T., & Inoue, H. (2008) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.820 · Cited by 67
Identification of Pigment Epithelium-Derived Factor as an Adipocyte-Derived Inflammatory Factor
Chavan, S. S., Hudson, L., Li, J. H., Ochani, M., Harris, Y., Patel, N. B., Katz, D., Scheinerman, J. A., Pavlov, V. A., & Tracey, K. J. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00156 · Cited by 44
Yamagishi, S., Matsui, T., Nakamura, K., Ueda, S., Noda, Y., & Imaizumi, T. (2008) · Current Drug Targets · doi:10.2174/138945008786786154 · Cited by 40
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy.
Matsuoka, M., Ogata, N., Minamino, K., & Matsumura, M. (2007) · PubMed Central · Cited by 38
Anti-Atherothrombogenic Properties of PEDF
Yamagishi, S., & Matsui, T. (2010) · Current Molecular Medicine · doi:10.2174/156652410791065264 · Cited by 37
High levels of pigment epithelium-derived factor in the retina of a rat model of type 2 diabetes
Matsuoka, M., Ogata, N., Minamino, K., Higuchi, A., & Matsumura, M. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.05.011 · Cited by 34
Böhm, A., Ordelheide, A., Machann, J., Heni, M., Ketterer, C., Machicao, F. E., Schick, F., Stefan, N., Fritsche, A., Häring, H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034035 · Cited by 32
Lee, J. H., Gao, Z., & Ye, J. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00029.2013 · Cited by 27
Angiogenesis and Metastasis Inhibitors for the Treatment of Malignant Melanoma
Abe, R., Fujita, Y., & Yamagishi, S. (2007) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955707780859440 · Cited by 27
Bi, Y., Sun, W., Chen, X., Li, M., Liang, H., Cai, M., Zhu, Y., He, X., Xu, F. L., & Weng, J. (2008) · Acta Diabetologica · doi:10.1007/s00592-008-0038-7 · Cited by 26
Self-citationSunderland, K., Tryggestad, J. B., Wang, J. J., Teague, A. M., Pratt, L. V., Zhang, S. X., Thompson, D. M., & Short, K. R. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1894 · Cited by 21
Dexamethasone Increases Pigment Epithelium-Derived Factor in Perfused Human Eyes
Perruccio, E. M., Rowlette, L. L. S., Comes, N., Locatelli‐Hoops, S., Notari, L., Becerra, S. P., & Borrás, T. (2008) · Current Eye Research · doi:10.1080/02713680802110208 · Cited by 11
Flagged first, then by citations
Cited by
Sorted by citations
He, X., Cheng, R., Benyajati, S., & Ma, J. (2015) · Clinical Science · doi:10.1042/cs20130463 · Cited by 154
Stimson, R. H., Anderson, A. J., Ramage, L. E., Macfarlane, D. P., de Beaux, A. C., Mole, D. J., Andrew, R., & Walker, B. R. (2017) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12899 · Cited by 63
PEDF-induced alteration of metabolism leading to insulin resistance
Carnagarin, R., Dharmarajan, A., & Dass, C. R. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.006 · Cited by 41
Acute Wnt pathway activation positively regulates leptin gene expression in mature adipocytes
Chen, Z., Shao, W., Xu, F. L., Liu, L., Lin, B., Wei, X., Song, Z., Lu, H., Fantus, I. G., Weng, J., et al. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.12.012 · Cited by 32
Self-citationChen, Y., Carlessi, R., Walz, N. L., Cruzat, V. F., Keane, K. N., John, A. N., Jiang, F., Carnagarin, R., Dass, C. R., & Newsholme, P. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.02.004 · Cited by 15
Tang, D., Li, C., Xu, K., Wu, Q., Qi-you, C., Lv, J.-J., Ji, J., Zang, B., Chen, C., Gu, B., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01520 · Cited by 11
RetractedEmetine Di-HCl Attenuates Type 1 Diabetes Mellitus in Mice
Hudson, L., Dancho, M. E., Li, J., Bruchfeld, J. B., Ragab, A. A. Y., He, M., Bragg, M., Lenaghan, D., Quinn, M. D., Fritz, J. R., et al. (2016) · Molecular Medicine · doi:10.2119/molmed.2016.00082 · Cited by 7
Brook, N., Gill, J., Dharmarajan, A., Chan, A., & Dass, C. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415641 · Cited by 7
Ikwuobe, J., Bellary, S., & Griffiths, H. R. (2016) · Biogerontology · doi:10.1007/s10522-016-9634-z · Cited by 6
Brook, N., Dharmarajan, A., Chan, A., & Dass, C. R. (2023) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgad039 · Cited by 5
Ghadimi, D., Nielsen, A., Hassan, M. F. Y., Fölster-Holst, R., Ebsen, M., Frahm, S. O., Röcken, C., de Vrese, M., & Heller, K. J. (2020) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/1871523019999201029115618 · Cited by 3
DHA-promoted repair of human corneal epithelial cells in high-glucose environment
Huang, C., Cheng, H., Zhang, J., & ZHANG, D. (2021) · Food Science and Technology · doi:10.1590/fst.77221 · Cited by 1
Metadata
- Authors
- Zhou, Y., Xu, F., Deng, H., Bi, Y., Sun, W., Zhao, Y., Chen, Z., & Weng, J.
- Affiliations
- Key Laboratory of Guangdong Province (CN)
- Corresponding author
- Weng, Jianping
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-12-18
- Volume
- 8
- Issue
- 12
- Pages
- e84016
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3867502
- OpenAlex
- W1999643046
- Cited by
- 12
- References
- 35
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 2
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (81000324, 82000)
- Sun Yat-sen University (82000)
- Tokyo Medical and Dental University
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- pigment epithelium-derived factor, insulin resistance, type 2 diabetes, 11β-hydroxysteroid dehydrogenase type 1, adipose tissue, adipocytes, TNF-α, NF-κB p65, glucocorticoids, dexamethasone, inflammation, anti-angiogenic factors, intensive insulin therapy
- MeSH terms
- Pigment Epithelium-Derived Factor, Adipose Tissue, Animals, Dexamethasone, Diabetes Mellitus, Type 2, Eye Proteins, Female, Gene Expression Regulation, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Nerve Growth Factors, Tumor Necrosis Factor-alpha, Serpins, NF-kappa B, Rats, Sprague-Dawley, 3T3-L1 Cells, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
